Greenwell, P. 2010. Cytoplasmic hybrid clones (cybrids) for stem cell production: ground-breaking research or a technology too far? Law, Science and Policy. 3, pp. 287-308.
| Title | Cytoplasmic hybrid clones (cybrids) for stem cell production: ground-breaking research or a technology too far? |
|---|---|
| Authors | Greenwell, P. |
| Abstract | This paper addresses the issues, scientific, ethical and legal, surrounding the production of cytoplasmic hybrids (cybrids). Cybrids normally have the nucleus from one individual (animal or human) and the cytoplasm containing mitochondria from another (same or different species). In the press there has been much discussion on the production of animal-human cybrids for therapeutic stem cell transplantation. This paper uses work carried out in animals to show that there is little chance that scientists would use this technique to produce cybrid individuals. Nevertheless, legislation must be in place to ensure that such technologies are both discussed and well-regulated. Recent reports suggest that cybrids of animals and humans which held much promise for the production of stem cells for therapy will not be useful due to problems of compatibility. However, somatic cell cybrids have found a niche in the analysis of human mitochondrial disorders and present few problems in this context. The paper ends with a brief review of the production of “normal” babies to mothers with mitochondrial defects that are cybrids with nuclear and mitochondrial DNA from two different human sources. |
| Journal | Law, Science and Policy |
| Journal citation | 3, pp. 287-308 |
| ISSN | 1475-5335 |
| Year | 2010 |
| Publisher | AB Academic Publishers |
| Publication dates | |
| Published | 2010 |
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Presence and characterisation of ecotin in F. necrophorum
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Comparison of virulence genes found in draft genomes of F. necrophorum
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The in vitro assessment of the synergistic effects of antibiotics and wound dressings on biofilms from diabetic foot pathogens
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The N-glycans of Trichomonas vaginalis contain variable core and antennal modifications
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Application repository and science gateway for running molecular docking and dynamics simulations
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The lectin Helix pomatia agglutinin recognises O-GlcNAc containing glycoproteins in human breast cancer
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siRNA-mediated inhibition of Na^sup +^ -K^sup +^-2Cl^sup -^ cotransporter (NKCC1) and regulatory volume increase in the chondrocyte cell line C-20/A4
Qusous, A., Geewan, C., Greenwell, P. and Kerrigan, M.J.P. 2011. siRNA-mediated inhibition of Na^sup +^ -K^sup +^-2Cl^sup -^ cotransporter (NKCC1) and regulatory volume increase in the chondrocyte cell line C-20/A4. Journal of Membrane Biology. 243 (1-3), pp. 25-34. https://doi.org/10.1007/s00232-011-9389-z
Cation-π interactions induce kinking of a molecular hinge in the RNA polymerase bridge-helix domain
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Scientific workflow makespan reduction through cloud augmented desktop grids
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Development of user-friendly, high throughput screening for ligands and inhibitors of carbohydrate modifying enzymes
Heindl, H., Greenwell, P., Kiss, T., Reynolds, C.J., Farkas, D., Terstyanszky, G. and Winter, S. 2011. Development of user-friendly, high throughput screening for ligands and inhibitors of carbohydrate modifying enzymes. 2nd glyco-bioinformatics Beilstein-Institut symposium. Potsdam, Germany 27th June – 1st July 2011
Breast cancer invasion is mediated by beta-N-acetylglucosaminidase (beta-NAG) and associated with a dysregulation in the secretory pathway of cancer cells
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Molecular docking simulations on a combined desktop and service grid infrastructure
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Parameter sweep workflows for modelling carbohydrate recognition
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ProSim: development of a user-friendly molecular modelling package
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Expression of the c-myc oncogene and the presence of HPV 18: possible surrogate markers for cervical cancer?
Rughooputh, S., Manraj, S., Eddoo, R. and Greenwell, P. 2009. Expression of the c-myc oncogene and the presence of HPV 18: possible surrogate markers for cervical cancer? British Journal of Biomedical Science. 66 (2), pp. 74-78.
ABO reverse grouping: effect of varying concentrations of the enzyme bromelain
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Purification and analysis of DNases of Tritrichomonas foetus: evidence that these enzymes are glycoproteins
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Chikungunya virus: an emerging problem?
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Prevalence of human papillomavirus amongst cervical cancer sufferers amongst slum dwellers in India
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Cervical cancer and human papillomavirus among slum dwellers in India
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Proteome analysis of metastatic colorectal cancer cells recognized by the lectin Helix pomatia agglutinin (HPA)
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Detection of human papillomavirus from archival tissues in cervical cancer patients in Mauritius
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A proteomic approach to identify the integrins α 6 and α V as HPA binding partners in the metastatic colorectal cancer cell line HT29
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Association between HPV and C-MYC gene expression in cervical cancer
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Analysis of glycosidases activity in Chlamydia trachomatis L2 serotype
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Vaccination against cervical cancer
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Proteomics: more than just biochemistry
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Trichomonas vaginalis: paradigm of a successful sexually transmitted organism
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Application of recombinant phage display antibody system in study of Codakia orbicularis gill proteins
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The Unani system of medicine: does it have a scientific basis?
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Genetically modified food: good news but bad press
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Bioinformatics: a useful tool for the molecular microbiologist?
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Detection of human papillomavirus from liquid-based cytology specimens by in-house PCR: a pilot study
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Use of bioinformatics and PCR in the search for ABC transporter homology among various bacteria
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Trichomonas vaginalis: an irritating protozoan or an important viral co-factor
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Human papillomavirus: an overview
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Isolation of Neisseria gonorrhoeae-specific antibodies from a phage display library
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Bioinformatics in the identification of glycosidase genes in the Chlamydia genome
Greenwell, P. and Rughooputh, S. 2003. Bioinformatics in the identification of glycosidase genes in the Chlamydia genome. Molecular and Cellular Proteomics. 2 (9), p. 826.
Phage display antibody against gill proteins of the tropical clam
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Incidence and prognostic significance of C-MPL expression in acute myeloid leukemia
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Beyond hybridoma technology: production of monoclonal antibodies by phage display
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Isoforms of Na+, K+-ATPase in human prostate; specificity of expression and apical membrane polarization
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