Incidence of bipolar affective disorder in three UK cities: results from the ÆSOP Study

Lloyd, T., Kennedy, N., Fearon, P., Kirkbride, J.B., Mallett, R.M., Leff, J., Holloway, J., Harrison, G., Dazzan, P., Morgan, K.D., Murray, R.M. and Jones, P.B. 2005. Incidence of bipolar affective disorder in three UK cities: results from the ÆSOP Study. British Journal of Psychiatry. 186 (2), pp. 126-131.

TitleIncidence of bipolar affective disorder in three UK cities: results from the ÆSOP Study
AuthorsLloyd, T., Kennedy, N., Fearon, P., Kirkbride, J.B., Mallett, R.M., Leff, J., Holloway, J., Harrison, G., Dazzan, P., Morgan, K.D., Murray, R.M. and Jones, P.B.
Abstract

Background : There has been a relative dearth of epidemiological research into bipolar affective disorder. Furthermore, incidence studies of bipolar disorder have been predominantly retrospective and most only included hospital admission cases.

Aims To determine the incidence of operationally defined bipolar disorder in three areas of the UK and to investigate any differences in gender and ethnicity.

Method : All patients who contacted mental health services with first-episode psychosis or non-psychotic mania between September 1997 and August 1999 were identified and diagnosed according to ICD-10 criteria. Incidence rates of bipolar affective disorder were standardised for age and stratified by gender and ethnic group across the three areas.

Results : The incidence rate per 100 000 per year in south-east London was over twice that in Nottingham and Bristol. There was no significant difference in the rates of disorder in men and women. Incidence rates of bipolar disorder in the combined Black and minority ethnic groups in all three areas were significantly higher than those of the comparison White groups.

Conclusions : The incidence of bipolar disorder was higher in south-east London than in the other two areas, and was higher among Black and minority ethnic groups than in the White population.

JournalBritish Journal of Psychiatry
Journal citation186 (2), pp. 126-131
ISSN0007-1250
YearFeb 2005
Web address (URL)http://bjp.rcpsych.org/cgi/content/full/186/2/126
Publication dates
PublishedFeb 2005

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Insight in psychosis and neuropsychological function: meta-analysis
Aleman, A., Agrawal, N., Morgan, K.D. and David, A.S. 2006. Insight in psychosis and neuropsychological function: meta-analysis. British Journal of Psychiatry. 189 (3), pp. 204-212. https://doi.org/10.1192/bjp.189.3.204

The structural brain correlates of neurological soft signs in healthy individuals
Dazzan, P., Morgan, K.D., Chitnis, X., Suckling, J., Morgan, C., Fearon, P., McGuire, P.K., Jones, P.B., Leff, J. and Murray, R.M. 2006. The structural brain correlates of neurological soft signs in healthy individuals. Cerebral Cortex. 16 (8), pp. 1225-1231. https://doi.org/10.1093/cercor/bhj063

Insight and cognition
Morgan, K.D. 2006. Insight and cognition. in: Morgan, K.D., David, A.S., Murray, R.M. and Eberhard, J. (ed.) Cognition and schizophrenia: improving real life function Cambridge, UK Cambridge Medical Communication. pp. 37-43

Increased pituitary volume in antipsychotic-free and antipsychotic-treated patients of the sop first-onset psychosis study
Pariante, C.M., Dazzan, P., Danese, A., Morgan, K.D., Brudaglio, F., Morgan, C., Fearon, P., Orr, K.G., Hutchinson, G., Pantelis, C., Velakoulis, D., Jones, P.B., Leff, J. and Murray, R.M. 2005. Increased pituitary volume in antipsychotic-free and antipsychotic-treated patients of the sop first-onset psychosis study. Neuropsychopharmacology. 30 (10), pp. 1923-1931. https://doi.org/10.1038/sj.npp.1300766

Pathways to care and ethnicity. 2: source of referral and help-seeking: report from the AESOP study
Morgan, C., Mallett, R.M., Hutchinson, G., Bagalkote, H., Morgan, K.D., Fearon, P., Dazzan, P., Boydell, J., McKenzie, K., Harrison, G., Murray, R.M., Jones, P.B., Craig, T.K.J. and Leff, J. 2005. Pathways to care and ethnicity. 2: source of referral and help-seeking: report from the AESOP study. British Journal of Psychiatry. 186 (4), pp. 290-296.

Pathways to care and ethnicity. 1: sample characteristics and compulsory admission: report from the ÆSOP Study
Morgan, C., Mallett, R.M., Hutchinson, G., Bagalkote, H., Morgan, K.D., Fearon, P., Dazzan, P., Boydell, J., McKenzie, K., Harrison, G., Murray, R.M., Jones, P.B., Craig, T.K.J. and Leff, J. 2005. Pathways to care and ethnicity. 1: sample characteristics and compulsory admission: report from the ÆSOP Study. British Journal of Psychiatry. 186 (4), pp. 281-289.

Different effects of typical and atypical antipsychotics on grey matter in first episode psychosis: the ÆSOP Study
Dazzan, P., Morgan, K.D., Orr, K.G., Hutchinson, G., Chitnis, X., Suckling, J., Fearon, P., McGuire, P.K., Mallett, R.M., Jones, P.B., Leff, J. and Murray, R.M. 2005. Different effects of typical and atypical antipsychotics on grey matter in first episode psychosis: the ÆSOP Study. Neuropsychopharmacology. 30 (4), pp. 765-774. https://doi.org/10.1038/sj.npp.1300603

A study of hippocampal shape anomaly in schizophrenia and in families multiply affected by schizophrenia or bipolar disorder
Connor, S.E.J., Ng, V., McDonald, C., Schulze, K., Morgan, K.D., Dazzan, P. and Murray, R.M. 2004. A study of hippocampal shape anomaly in schizophrenia and in families multiply affected by schizophrenia or bipolar disorder. Neuroradiology. 46 (7), pp. 523-534. https://doi.org/10.1007/s00234-004-1224-0

Neuropsychological studies of insight in psychosis
Morgan, K.D. and David, A.S. 2004. Neuropsychological studies of insight in psychosis. in: Amador, X.S. and David, A.S. (ed.) Insight and psychosis: awareness of illness in schizophrenia and related disorders. 2nd edition Oxford, UK Oxford University Press.

Perception of psychosis in patients
Morgan, K.D. 2004. Perception of psychosis in patients. Epidemiologia e Psichiatria Sociale. 13 (4), pp. 222-226.

Normal cerebral asymmetry in familial and non-familial schizophrenic probands and their unaffected relatives
Chapple, B., Grech, A., Sham, P., Toulopoulou, T., Walshe, M., Schulze, K., Morgan, K.D., Murray, R.M. and McDonald, C. 2004. Normal cerebral asymmetry in familial and non-familial schizophrenic probands and their unaffected relatives. Schizophrenia Research. 67 (1), pp. 33-40. https://doi.org/10.1016/S0920-9964(03)00095-1

The structural brain correlates of neurological soft signs in ÆSOP first-episode psychoses study
Dazzan, P., Morgan, K.D., Orr, K.G., Hutchinson, G., Chitnis, X., Suckling, J., Fearon, P., Salvo, J., McGuire, P.K., Mallett, R.M., Jones, P.B., Leff, J. and Murray, R.M. 2003. The structural brain correlates of neurological soft signs in ÆSOP first-episode psychoses study. Brain. 127 (1), pp. 143-153. https://doi.org/10.1093/brain/awh015

A functional magnetic resonance imaging study of overt letter verbal fluency using a clustered acquisition sequence: greater anterior cingulate activation with increased task demand
Fu, C.H.Y., Morgan, K.D., Suckling, J., Williams, S.C.R., Andrew, C., Vythelingum, G.N. and McGuire, P.K. 2002. A functional magnetic resonance imaging study of overt letter verbal fluency using a clustered acquisition sequence: greater anterior cingulate activation with increased task demand. NeuroImage. 17 (2), pp. 871-879. https://doi.org/10.1016/S1053-8119(02)91189-4

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