Cognitive Change in Schizophrenia and Other Psychoses in the Decade Following the First Episode

Zanelli, J., Mollon, J., Sandin, S., Morgan, C., Dazzan, P., Pilecka, I, Marques, T.R., David, A.S., Morgan, K.D., Fearon, P., Doody, G.A., Jones, P.B., Murray, R.M and Reichenberg, A. 2019. Cognitive Change in Schizophrenia and Other Psychoses in the Decade Following the First Episode. American Journal of Psychiatry. 176 (10), pp. 811-819. https://doi.org/10.1176/appi.ajp.2019.18091088

TitleCognitive Change in Schizophrenia and Other Psychoses in the Decade Following the First Episode
TypeJournal article
AuthorsZanelli, J.
Mollon, J.
Sandin, S.
Morgan, C.
Dazzan, P.
Pilecka, I
Marques, T.R.
David, A.S.
Morgan, K.D.
Fearon, P.
Doody, G.A.
Jones, P.B.
Murray, R.M
Reichenberg, A.
Abstract

Objective: Schizophrenia is associated with a marked cognitive impairment that is widely believed to remain stable after illness onset. Yet, to date, 10-year prospective studies of cognitive functioning following the first episode with good methodology are rare. The authors examined whether schizophrenia patients experience cognitive decline after the first episode, whether this decline is generalized or confined to individual neuropsychological functions, and whether decline is specific to schizophrenia.

Methods: Participants were from a population-based case-control study of patients with first-episode psychosis who were followed prospectively up to 10 years after first admission. A neuropsychological battery was administered at index presentation and at follow-up to patients with a diagnosis of schizophrenia (N=65) or other psychoses (N=41) as well as to healthy comparison subjects (N=103).

Results: The schizophrenia group exhibited declines in IQ and in measures of verbal knowledge and of memory, but not processing speed or executive functions. Processing speed and executive function impairments were already present at the first episode and remained stable thereafter. The magnitude of declines ranged between 0.28 and 0.66 standard deviations. Decline in measures of memory was not specific to schizophrenia and was also apparent in the group of patients with other psychoses. Healthy individuals with low IQ showed no evidence of decline, suggesting that a decline is specific to psychosis.

Conclusions: Patients with schizophrenia and other psychoses experience cognitive decline after illness onset, but the magnitude of decline varies across cognitive functions. Distinct mechanisms consequent to the illness and/or psychosocial factors may underlie impairments across different cognitive functions.

KeywordsSchizophrenia, Psychosis, Cognitive Neuroscience
JournalAmerican Journal of Psychiatry
Journal citation176 (10), pp. 811-819
ISSN0002-953X
Year2019
PublisherAmerican Psychiatric Publishing, Inc.
Accepted author manuscript
Digital Object Identifier (DOI)https://doi.org/10.1176/appi.ajp.2019.18091088
Web address (URL)https://doi.org/10.1176/appi.ajp.2019.18091088
Publication dates
Published online01 Jul 2019
Published in printOct 2019
Supplementary data or files
File
Supplementary data or files
File
Supplementary data or files
File
Supplementary data or files
File
Supplementary data or files
File
Supplementary data or files
File
Supplementary data or files
File
Supplementary data or files
File
Supplementary data or files
File

Related outputs

Time Perception in First Year Undergraduates: Correlation with Stress, Anxiety and Depression
Koebeli, C., Edginton, T.L., Morgan, K.D. and Boubert, L. 2023. Time Perception in First Year Undergraduates: Correlation with Stress, Anxiety and Depression. 17th International Technology, Education and Development Conference. Valencia, Spain 06 - 08 Mar 2023 IATED Digital Library. https://doi.org/10.21125/inted.2023.1559

Dynamic and Static Cognitive Deficits in Schizophrenia and Bipolar Disorder After the First Episode
Zanelli, Jolanta, Reichenberg, Abraham, Sandin, Sven, Morgan, Craig, Dazzan, Paola, Pilecka, Izabela, Marques, Tiago Reis, Morgan, K.D., Young, Allan H and Mollon, J. 2022. Dynamic and Static Cognitive Deficits in Schizophrenia and Bipolar Disorder After the First Episode. Schizophrenia Bulletin. 48 (3), p. 590–598. https://doi.org/10.1093/schbul/sbab150

Clinical utility of magnetic resonance imaging in first-episode psychosis
Falkenberg, I., Benetti, S., Raffin, M., Wuyts, P., Pettersson-Yeo, W., Dazzan, P., Morgan, K.D., Murray, R., Marques, T., David, A., Jarosz, J., Simmons, A., Williams, S. and McGuire, P. 2018. Clinical utility of magnetic resonance imaging in first-episode psychosis. British Journal of Psychiatry. 211 (4), pp. 231-237. https://doi.org/10.1192/bjp.bp.116.195834

A Reassessment of the Higher-Order Factor Structure of the German Schizotypal Personality Questionnaire (SPQ-G) in German-Speaking Adults
Barron, D., Voracek, M., Tran, U.S., Hui San Ong, Morgan, K.D., Towell, A. and Swami, V. 2018. A Reassessment of the Higher-Order Factor Structure of the German Schizotypal Personality Questionnaire (SPQ-G) in German-Speaking Adults. Psychiatry Research. 269, pp. 328-336. https://doi.org/10.1016/j.psychres.2018.08.070

The Relationship Between Schizotypal Facets and Conspiracist Beliefs via Cognitive Processes
Barron, D., Furnham, A., Weis, L., Morgan, K.D., Towell, A. and Swami, V. 2018. The Relationship Between Schizotypal Facets and Conspiracist Beliefs via Cognitive Processes. Psychiatry Research. 259, pp. 15-20. https://doi.org/10.1016/j.psychres.2017.10.001

Self esteem and self agency in first episode psychosis: Ethnic variation and relationship with clinical presentation
Ciufolini, S., Morgan, C., Morgan, K.D., Fearon, P., Boydell, J., Hutchinson, G., Demjaha, A., Girardi, P., Doody, G.A., Jones, P.B., Murray, R.M. and Dazzan, P. 2015. Self esteem and self agency in first episode psychosis: Ethnic variation and relationship with clinical presentation. Psychiatry Research. 227 (2-3), pp. 213-218. https://doi.org/10.1016/j.psychres.2015.03.030

Gender differences in the association between childhood physical and sexual abuse, social support and psychosis
Gayer-Anderson, G., Fisher, H.L., Fearon, P., Hutchinson, G., Morgan, K.D., Dazzan, P., Boydell, J., Doody, G.A., Jones, P.B., Murray, R.M., Craig, T.K.J. and Morgan, C. 2015. Gender differences in the association between childhood physical and sexual abuse, social support and psychosis. Social Psychiatry and Psychiatric Epidemiology. 50 (10), pp. 1489-1500. https://doi.org/10.1007/s00127-015-1058-6

Examination of the factor structure of the Schizotypal Personality Questionnaire (SPQ) among British and Trinidadian adults
Barron, D., Towell, A., Swami, V. and Morgan, K.D. 2015. Examination of the factor structure of the Schizotypal Personality Questionnaire (SPQ) among British and Trinidadian adults. BioMed Research International. 2015 258275. https://doi.org/10.1155/2015/258275

Modelling the interplay between childhood and adult adversity in pathways to psychosis: initial evidence from the AESOP study
Morgan, C., Reininghaus, U., Fearon, P., Hutchinson, G., Morgan, K.D., Dazzan, P., Boydell, J., Kirkbride, J., Doody, G., Jones, P., Murray, R. and Craig, T. 2014. Modelling the interplay between childhood and adult adversity in pathways to psychosis: initial evidence from the AESOP study. Psychological Medicine. 44 (2), pp. 407-419. https://doi.org/10.1017/s0033291713000767

Interplay Between Childhood Physical Abuse and Familial Risk in the Onset of Psychotic Disorders
Fisher, H., McGuffin, P., Boydell, J., Fearon, P., Craig, T., Dazzan, P., Morgan, K.D., Doody, G., Jones, P., Leff, J., Murray, R. and Morgan, C. 2014. Interplay Between Childhood Physical Abuse and Familial Risk in the Onset of Psychotic Disorders. Schizophrenia Bulletin. 40 (6), p. 1443–1451. https://doi.org/10.1093/schbul/sbt201

The effect of the environment on symptom dimensions in the first episode of psychosis: a multilevel study
Oher, F.J., Demjaha, A., Jackson, D., Morgan, C., Dazzan, P., Morgan, K.D., Boydell, J., Doody, G.A., Murray, R.M., Bentall, R., Jones, P.B. and Kirkbride, J.B. 2014. The effect of the environment on symptom dimensions in the first episode of psychosis: a multilevel study. Psychological Medicine. 44 (11), pp. 2419-2430. https://doi.org/10.1017/S0033291713003188

Pre-morbid fertility in psychosis: Findings from the AESOP first episode study
Zimbron, J., Stahl, D., Hutchinson, G., Dazzan, P., Morgan, K.D., Doody, G.A., Jones, P., Murray, R.M., Fearon, P., Morgan, C. and MacCabe, J. 2014. Pre-morbid fertility in psychosis: Findings from the AESOP first episode study. Schizophrenia Research. 156 (2-3), pp. 168-173. https://doi.org/10.1016/j.schres.2014.04.007

Bilateral hippocampal increase following first-episode psychosis is associated with good clinical, functional and cognitive outcomes
Lappin, J.M., Morgan, C., Chalavi, S., Morgan, K.D., Reinders, A.A.T.S., Fearon, P., Heslin, M., Zanelli, J., Jones, P.B., Murray, R.M. and Dazzan, P. 2014. Bilateral hippocampal increase following first-episode psychosis is associated with good clinical, functional and cognitive outcomes. Psychological Medicine. 44 (6), pp. 1279-1291. https://doi.org/10.1017/S0033291713001712

Caregiving in first-episode psychosis: social characteristics associated with perceived ‘burden’ and associations with compulsory treatment
Boydell, J., Onwumere, J., Dutta, R., Bhavsar, V., Hill, N., Morgan, C., Dazzan, P., Morgan, K.D., Pararajan, M., Kuipers, E., Jones, P.B., Murray, R.M. and Fearon, P. 2014. Caregiving in first-episode psychosis: social characteristics associated with perceived ‘burden’ and associations with compulsory treatment. Early Intervention in Psychiatry. 8 (2), pp. 122-129. https://doi.org/10.1111/eip.12041

Associations between schizotypy and belief in conspiracist ideation
Barron, D., Morgan, K.D., Towell, A., Altemeyer, B. and Swami, V. 2014. Associations between schizotypy and belief in conspiracist ideation. Personality and Individual Differences. 70, pp. 156-159. https://doi.org/10.1016/j.paid.2014.06.040

Differential relationship between neurological and cognitive dysfunction in first episode psychosis patients and in healthy individuals
Mellacqua, Z., Eyeson, J., Orr, K.D., Morgan, K.D., Zanelli, J., Lloyd, T., Morgan, C., Fearon, P., Hutchinson, G., Doody, G.A., Chan, R.C.K., Harrison, G., Jones, P.B., Murray, R.M., Reichenberg, A. and Dazzan, P. 2012. Differential relationship between neurological and cognitive dysfunction in first episode psychosis patients and in healthy individuals. Schizophrenia Research. 142 (1-3), pp. 159-164. https://doi.org/10.1016/j.schres.2012.09.016

Linear and non-linear associations of symptom dimensions and cognitive function in first-onset psychosis
Kravariti, E., Russo, M., Vassos, E., Morgan, K.D., Fearon, P., Zanelli, J., Demjaha, A., Lappin, J.M., Tsakanikos, E., Dazzan, P., Morgan, C., Doody, G.A., Harrison, G., Jones, P.B., Murray, R.M. and Reichenberg, A. 2012. Linear and non-linear associations of symptom dimensions and cognitive function in first-onset psychosis. Schizophrenia Research. 140 (1-3), pp. 221-231. https://doi.org/10.1016/j.schres.2012.06.008

Individualized prediction of illness course at the first psychotic episode: a support vector machine MRI study
Mourao-Miranda, J., Reinders, A.A.T.S., Rocha-Rego, V., Lappin, J.M., Rondina, J., Morgan, C., Morgan, K.D., Fearon, P., Jones, P.B., Doody, G.A., Murray, R.M., Kapur, S. and Dazzan, P. 2012. Individualized prediction of illness course at the first psychotic episode: a support vector machine MRI study. Psychological Medicine. 42 (5), pp. 1037-1047. https://doi.org/10.1017/S0033291711002005

Is there a link between childhood trauma, cognition, and amygdala and hippocampus volume in first-episode psychosis?
Aas, M., Navari, S., Gibbs, A.A., Mondelli, V., Fisher, H.L., Morgan, C., Morgan, K.D., MacCabe, J., Reichenberg, A., Zanelli, J., Fearon, P., Jones, P.B., Murray, R.M., Pariante, C.M. and Dazzan, P. 2012. Is there a link between childhood trauma, cognition, and amygdala and hippocampus volume in first-episode psychosis? Schizophrenia Research. 137 (1-3), pp. 73-79. https://doi.org/10.1016/j.schres.2012.01.035

The differential effect of illicit drug use on cognitive function in first-episode psychosis and healthy controls
Donoghue, K., Mazzoncini, R., Hart, J., Zanelli, J., Morgan, C., Dazzan, P., Morgan, K.D., Murray, R.M., Jones, P.B. and Doody, G.A. 2012. The differential effect of illicit drug use on cognitive function in first-episode psychosis and healthy controls. Acta Psychiatrica Scandinavica. 125 (5), pp. 400-411. https://doi.org/10.1111/j.1600-0447.2011.01803.x

Satisfaction with inpatient treatment for first-episode psychosis among different ethnic groups: A report from the UK ÆSOP study
Boydell, J., Morgan, C., Dutta, R., Jones, B., Alemseged, F., Dazzan, P., Morgan, K.D., Doody, G.A., Harrison, G., Leff, J., Jones, P.B., Murray, R.M. and Fearon, P. 2012. Satisfaction with inpatient treatment for first-episode psychosis among different ethnic groups: A report from the UK ÆSOP study. International Journal of Social Psychiatry. 58 (1), pp. 98-105. https://doi.org/10.1177/0020764010382691

Assessment of posttraumatic symptoms in patients with first-episode psychosis
Schäfer, I., Morgan, C., Demjaha, A., Morgan, K.D., Dazzan, P., Fearon, P., Jones, P.B., Doody, G.A., Leff, J., Murray, R.M. and Fisher, H.L. 2011. Assessment of posttraumatic symptoms in patients with first-episode psychosis. Journal of Nervous and Mental Disease. 199 (11), pp. 896-898. https://doi.org/10.1097/NMD.0b013e318234a037

Childhood trauma and cognitive function in first-episode affective and non-affective psychosis
Aas, M., Dazzan, P., Fisher, H.L., Morgan, C., Morgan, K.D., Reichenberg, A., Zanelli, J., Fearon, P., Jones, P.B., Murray, R.M. and Pariante, C.M. 2011. Childhood trauma and cognitive function in first-episode affective and non-affective psychosis. Schizophrenia Research. 129 (1), pp. 12-19. https://doi.org/10.1016/j.schres.2011.03.017

Criminal offending and distinguishing features of offenders among persons experiencing a first episode of psychosis
Hodgins, S., Calem, M., Shimel, R., Williams, A., Harleston, D., Morgan, C., Dazzan, P., Fearon, P., Morgan, K.D., Lappin, J.M., Zanelli, J., Reichenberg, A. and Jones, P.B. 2011. Criminal offending and distinguishing features of offenders among persons experiencing a first episode of psychosis. Early Intervention in Psychiatry. 5 (1), pp. 15-23. https://doi.org/10.1111/j.1751-7893.2010.00256.x

The economic cost of pathways to care in first episode psychosis
Heslin, M., Mccrone, P., Flach, C., Fearon, P., Morgan, K.D., Jones, P.B., Murray, R.M., Dazzan, P., Doody, G.A. and Morgan, C. 2011. The economic cost of pathways to care in first episode psychosis. International Review of Psychiatry. 23 (1), pp. 55-60. https://doi.org/10.3109/09540261.2010.544644

Reliability and comparability of psychosis patients' retrospective reports of childhood abuse
Fisher, H.L., Craig, T.K.J., Fearon, P., Morgan, K.D., Dazzan, P., Lappin, J.M., Hutchinson, G., Doody, G.A., Jones, P.B., McGuffin, P., Murray, R.M., Leff, J. and Morgan, C. 2011. Reliability and comparability of psychosis patients' retrospective reports of childhood abuse. Schizophrenia Bulletin. 37 (3), pp. 546-553. https://doi.org/10.1093/schbul/sbp103

Insight, grey matter and cognitive function in first-onset psychosis
Morgan, K.D., Dazzan, P., Morgan, C., Lappin, J.M., Hutchinson, G., Suckling, J., Fearon, P., Jones, P.B., Leff, J., Murray, R.M. and David, A.S. 2010. Insight, grey matter and cognitive function in first-onset psychosis. British Journal of Psychiatry. 197 (2), pp. 141-148. https://doi.org/10.1192/bjp.bp.109.070888

Differing patterns of brain structural abnormalities between black and white patients with their first episode of psychosis
Morgan, K.D., Dazzan, P., Morgan, C., Lappin, J.M., Hutchinson, G., Chitnis, X., Suckling, J., Fearon, P., Jones, P.B., Leff, J. and Murray, R.M. 2010. Differing patterns of brain structural abnormalities between black and white patients with their first episode of psychosis. Psychological Medicine. 40 (7), pp. 1137-1147. https://doi.org/10.1017/S0033291709991565

Illicit substance use and its correlates in first episode psychosis
Mazzoncini, R., Donoghue, K., Hart, J., Morgan, C., Doody, G.A., Dazzan, P., Jones, P.B., Morgan, K.D., Murray, R.M. and Fearon, P. 2010. Illicit substance use and its correlates in first episode psychosis. Acta Psychiatrica Scandinavica. 121 (5), pp. 351-358. https://doi.org/10.1111/j.1600-0447.2009.01483.x

Examining evidence for neighbourhood variation in the duration of untreated psychosis
Kirkbride, J.B., Lunn, D.J., Morgan, C., Lappin, J.M., Dazzan, P., Morgan, K.D., Fearon, P., Murray, R.M. and Jones, P.B. 2010. Examining evidence for neighbourhood variation in the duration of untreated psychosis. Health & Place. 16 (2), pp. 219-225. https://doi.org/10.1016/j.healthplace.2009.09.013

Awareness is not the same as acceptance: exploring the thinking behind insight and compliance
Morgan, K.D. and David, A.S. 2010. Awareness is not the same as acceptance: exploring the thinking behind insight and compliance. in: Dimaggio, G. and Lysaker, P.H. (ed.) Metacognition and severe adult mental disorders: from research to treatment London & New York Routledge. pp. 95-114

Specific and generalized neuropsychological deficits: a comparison of patients with various first-episode psychosis presentations
Zanelli, J., Reichenberg, A., Morgan, K.D., Fearon, P., Kravariti, E., Dazzan, P., Morgan, C., Zanelli, C., Demjaha, A., Jones, P.B., Doody, G.A., Kapur, S. and Murray, R.M. 2010. Specific and generalized neuropsychological deficits: a comparison of patients with various first-episode psychosis presentations. American Journal of Psychiatry. 167 (1), pp. 78-85.

Ethnic identity, perceptions of disadvantage, and psychosis: findings from the ÆSOP study
Reininghaus, U.A., Craig, T.K.J., Fisher, H.L., Hutchinson, G., Fearon, P., Morgan, K.D., Dazzan, P., Doody, G.A., Jones, P.B., Murray, R.M. and Morgan, C. 2010. Ethnic identity, perceptions of disadvantage, and psychosis: findings from the ÆSOP study. Schizophrenia Research. 124 (1-3), pp. 43-48. https://doi.org/10.1016/j.schres.2010.08.038

The varying impact of type, timing and frequency of exposure to childhood adversity on its association with adult psychotic disorder
Fisher, H.L., Jones, P.B., Fearon, P., Craig, T.K.J., Dazzan, P., Morgan, K.D., Hutchinson, G., Doody, G.A., McGuffin, P., Leff, J., Murray, R.M. and Morgan, C. 2010. The varying impact of type, timing and frequency of exposure to childhood adversity on its association with adult psychotic disorder. Psychological Medicine. 40 (12), pp. 1967-1978. https://doi.org/10.1017/S0033291710000231

Combining dimensional and categorical representation of psychosis: the way forward for DSM-V and ICD-11?
Demjaha, A., Morgan, K.D., Morgan, C., Landau, S., Dean, K., Reichenberg, A., Sham, P., Fearon, P., Hutchinson, G., Jones, P.B., Murray, R.M. and Dazzan, P. 2009. Combining dimensional and categorical representation of psychosis: the way forward for DSM-V and ICD-11? Psychological Medicine. 39 (12), pp. 1943-1955. https://doi.org/10.1017/S0033291709990651

Neuropsychological functioning in first-episode schizophrenia
Kravariti, E., Morgan, K.D., Fearon, P., Zanelli, J., Lappin, J.M., Dazzan, P., Morgan, C., Doody, G.A., Harrison, G., Jones, P.B., Murray, R.M. and Reichenberg, A. 2009. Neuropsychological functioning in first-episode schizophrenia. British Journal of Psychiatry. 195 (4), pp. 336-345. https://doi.org/10.1192/bjp.bp.108.055590

Ethnicity, social disadvantage and psychotic-like experiences in a healthy population based sample
Morgan, C., Fisher, H.L., Hutchinson, G., Kirkbride, J.B., Craig, T.K.J., Morgan, K.D., Dazzan, P., Boydell, J., Doody, G.A., Jones, P.B., Murray, R.M., Leff, J. and Fearon, P. 2009. Ethnicity, social disadvantage and psychotic-like experiences in a healthy population based sample. Acta Psychiatrica Scandinavica. 119 (3), pp. 226-235. https://doi.org/10.1111/j.1600-0447.2008.01301.x

Selective deficits in semantic verbal fluency in patients with a first affective episode with psychotic symptoms and a positive history of mania
Kravariti, E., Reichenberg, A., Morgan, K.D., Dazzan, P., Morgan, C., Zanelli, J., Lappin, J.M., Doody, G.A., Harrison, G., Jones, P.B., Murray, R.M. and Fearon, P. 2009. Selective deficits in semantic verbal fluency in patients with a first affective episode with psychotic symptoms and a positive history of mania. Bipolar Disorders. 11 (3), pp. 323-329. https://doi.org/10.1111/j.1399-5618.2009.00673.x

Gender differences in the association between childhood abuse and psychosis
Fisher, H.L., Morgan, C., Dazzan, P., Craig, T.K.J., Morgan, K.D., Hutchinson, G., Jones, P.B., Doody, G.A., Pariante, C.M., McGuffin, P., Murray, R.M., Leff, J. and Fearon, P. 2009. Gender differences in the association between childhood abuse and psychosis. British Journal of Psychiatry. 194, pp. 319-325. https://doi.org/10.1192/bjp.bp.107.047985

Cumulative social disadvantage, ethnicity and first-episode psychosis: a case-control study
Morgan, C., Kirkbride, J.B., Hutchinson, G., Craig, T.K.J., Morgan, K.D., Dazzan, P., Boydell, J., Doody, G.A., Jones, P.B., Murray, R.M., Leff, J. and Fearon, P. 2008. Cumulative social disadvantage, ethnicity and first-episode psychosis: a case-control study. Psychological Medicine. 38 (12), pp. 1701-1715. https://doi.org/10.1017/S0033291708004534

Unemployment, social isolation, achievement–expectation mismatch and psychosis: findings from the ÆSOP Study
Reininghaus, U.A., Morgan, C., Simpson, J., Dazzan, P., Morgan, K.D., Doody, G.A., Bhugra, D., Leff, J., Jones, P.B., Murray, R.M., Fearon, P. and Craig, T.K.J. 2008. Unemployment, social isolation, achievement–expectation mismatch and psychosis: findings from the ÆSOP Study. Social Psychiatry and Psychiatric Epidemiology. 43 (9), pp. 743-751. https://doi.org/10.1007/s00127-008-0359-4

Sexually dimorphic changes in the amygdala in relation to delusional beliefs in first episode psychosis
Gibbs, A.A., Dazzan, P., Morgan, K.D., Naudts, K.H., Morgan, C., Hutchinson, G., Fearon, P., Leff, J., Murray, R.M. and David, A.S. 2008. Sexually dimorphic changes in the amygdala in relation to delusional beliefs in first episode psychosis. Journal of Psychiatric Research. 42 (11), pp. 913-919. https://doi.org/10.1016/j.jpsychires.2007.11.002

Neurological abnormalities and cognitive ability in first-episode psychosis
Dazzan, P., Lloyd, T., Morgan, K.D., Zanelli, J., Morgan, C., Orr, K.G., Hutchinson, G., Fearon, P., Allin, M., Rifkin, L., McGuire, P.K., Doody, G.A., Holloway, J., Leff, J., Harrison, G., Jones, P.B. and Murray, R.M. 2008. Neurological abnormalities and cognitive ability in first-episode psychosis. British Journal of Psychiatry. 193 (3), pp. 197-202. https://doi.org/10.1192/bjp.bp.107.045450

Self-harm in first-episode psychosis
Harvey, S.B., Dean, K., Morgan, C., Walsh, E., Demjaha, A., Dazzan, P. and Morgan, K.D. 2008. Self-harm in first-episode psychosis. British Journal of Psychiatry. 192 (3), pp. 178-184. https://doi.org/10.1192/bjp.bp.107.037192

Perceptions of disadvantage, ethnicity and psychosis
Cooper, C., Morgan, C., Byrne, M., Dazzan, P., Morgan, K.D., Hutchinson, G., Doody, G.A., Harrison, G., Leff, J., Jones, P.B., Ismail, K., Murray, R.M., Bebbington, P. and Fearon, P. 2008. Perceptions of disadvantage, ethnicity and psychosis. British Journal of Psychiatry. 192 (3), pp. 185-190. https://doi.org/10.1192/bjp.bp.107.042291

Minor physical anomalies in patients with first-episode psychosis: their frequency and diagnostic specificity
Lloyd, T., Dazzan, P., Dean, K., Park, S.B.G., Fearon, P., Doody, G.A., Tarrant, J., Morgan, K.D., Morgan, C., Hutchinson, G., Leff, J., Harrison, G., Murray, R.M. and Jones, P.B. 2008. Minor physical anomalies in patients with first-episode psychosis: their frequency and diagnostic specificity. Psychological Medicine. 38 (1), pp. 71-77. https://doi.org/10.1017/S0033291707001158

Grey matter abnormalties in first episode schizophrenia and affective psychosis
Morgan, K.D., Dazzan, P., Orr, K.G., Hutchinson, G., Chitnis, X., Suckling, J., Lythgoe, D., Pollock, S.J., Rossell, S., Shapleske, J., Fearon, P., Morgan, C., David, A.S., McGuire, P.K., Jones, P.B., Leff, J. and Murray, R.M. 2007. Grey matter abnormalties in first episode schizophrenia and affective psychosis. British Journal of Psychiatry. 191 (Supple), pp. s111-s116. https://doi.org/10.1192/bjp.191.51.s111

Illness perceptions in depersonalization disorder: testing an illness attribution model
Baker Towell, D.M., Earle, M., Medford, N., Sierra, M., Towell, A. and David, A.S. 2007. Illness perceptions in depersonalization disorder: testing an illness attribution model. Clinical Psychology & Psychotherapy. 14 (2), pp. 105-116. https://doi.org/10.1002/cpp.518

Minor physical anomalies across ethnic groups in a first episode psychosis sample
Dean, K., Dazzan, P., Lloyd, T., Morgan, C., Morgan, K.D., Doody, G.A., Hutchinson, G., Orr, K.G., Jones, P.B., Murray, R.M. and Fearon, P. 2007. Minor physical anomalies across ethnic groups in a first episode psychosis sample. Schizophrenia Research. 89 (1-3), pp. 86-90. https://doi.org/10.1016/j.schres.2006.08.019

Clinical and social determinants of duration of untreated psychosis in the AESOP first-episode psychosis study
Morgan, C., Abdul-Al, R., Lappin, J.M., Jones, P.B., Fearon, P., Leese, M., Croudace, T., Morgan, K.D., Dazzan, P., Craig, T.K.J., Leff, J. and Murray, R.M. 2006. Clinical and social determinants of duration of untreated psychosis in the AESOP first-episode psychosis study. British Journal of Psychiatry. 189 (5), pp. 446-452. https://doi.org/10.1192/bjp.bp.106.021303

Incidence of schizophrenia and other psychoses in ethnic minority groups: results from the MRC AESOP Study
Fearon, P., Kirkbride, J.B., Morgan, C., Dazzan, P., Morgan, K.D., Lloyd, T., Hutchinson, G., Tarrant, J., Fung, W.L.A., Holloway, J., Mallett, R.M., Harrison, G., Leff, J., Jones, P.B. and Murray, R.M. 2006. Incidence of schizophrenia and other psychoses in ethnic minority groups: results from the MRC AESOP Study. Psychological Medicine. 36 (11), pp. 1541-1550. https://doi.org/10.1017/S0033291706008774

Grey matter correlates of minor physical anomalies in the AESOP first-episode psychosis study
Dean, K., Fearon, P., Morgan, K.D., Hutchinson, G., Orr, K.G., Chitnis, X., Suckling, J., Mallett, R.M., Leff, J., Jones, P.B., Murray, R.M. and Dazzan, P. 2006. Grey matter correlates of minor physical anomalies in the AESOP first-episode psychosis study. British Journal of Psychiatry. 189 (3), pp. 221-228. https://doi.org/10.1192/bjp.bp.105.016337

Insight in psychosis and neuropsychological function: meta-analysis
Aleman, A., Agrawal, N., Morgan, K.D. and David, A.S. 2006. Insight in psychosis and neuropsychological function: meta-analysis. British Journal of Psychiatry. 189 (3), pp. 204-212. https://doi.org/10.1192/bjp.189.3.204

The structural brain correlates of neurological soft signs in healthy individuals
Dazzan, P., Morgan, K.D., Chitnis, X., Suckling, J., Morgan, C., Fearon, P., McGuire, P.K., Jones, P.B., Leff, J. and Murray, R.M. 2006. The structural brain correlates of neurological soft signs in healthy individuals. Cerebral Cortex. 16 (8), pp. 1225-1231. https://doi.org/10.1093/cercor/bhj063

Insight and cognition
Morgan, K.D. 2006. Insight and cognition. in: Morgan, K.D., David, A.S., Murray, R.M. and Eberhard, J. (ed.) Cognition and schizophrenia: improving real life function Cambridge, UK Cambridge Medical Communication. pp. 37-43

Increased pituitary volume in antipsychotic-free and antipsychotic-treated patients of the sop first-onset psychosis study
Pariante, C.M., Dazzan, P., Danese, A., Morgan, K.D., Brudaglio, F., Morgan, C., Fearon, P., Orr, K.G., Hutchinson, G., Pantelis, C., Velakoulis, D., Jones, P.B., Leff, J. and Murray, R.M. 2005. Increased pituitary volume in antipsychotic-free and antipsychotic-treated patients of the sop first-onset psychosis study. Neuropsychopharmacology. 30 (10), pp. 1923-1931. https://doi.org/10.1038/sj.npp.1300766

Pathways to care and ethnicity. 2: source of referral and help-seeking: report from the AESOP study
Morgan, C., Mallett, R.M., Hutchinson, G., Bagalkote, H., Morgan, K.D., Fearon, P., Dazzan, P., Boydell, J., McKenzie, K., Harrison, G., Murray, R.M., Jones, P.B., Craig, T.K.J. and Leff, J. 2005. Pathways to care and ethnicity. 2: source of referral and help-seeking: report from the AESOP study. British Journal of Psychiatry. 186 (4), pp. 290-296.

Pathways to care and ethnicity. 1: sample characteristics and compulsory admission: report from the ÆSOP Study
Morgan, C., Mallett, R.M., Hutchinson, G., Bagalkote, H., Morgan, K.D., Fearon, P., Dazzan, P., Boydell, J., McKenzie, K., Harrison, G., Murray, R.M., Jones, P.B., Craig, T.K.J. and Leff, J. 2005. Pathways to care and ethnicity. 1: sample characteristics and compulsory admission: report from the ÆSOP Study. British Journal of Psychiatry. 186 (4), pp. 281-289.

Different effects of typical and atypical antipsychotics on grey matter in first episode psychosis: the ÆSOP Study
Dazzan, P., Morgan, K.D., Orr, K.G., Hutchinson, G., Chitnis, X., Suckling, J., Fearon, P., McGuire, P.K., Mallett, R.M., Jones, P.B., Leff, J. and Murray, R.M. 2005. Different effects of typical and atypical antipsychotics on grey matter in first episode psychosis: the ÆSOP Study. Neuropsychopharmacology. 30 (4), pp. 765-774. https://doi.org/10.1038/sj.npp.1300603

Incidence of bipolar affective disorder in three UK cities: results from the ÆSOP Study
Lloyd, T., Kennedy, N., Fearon, P., Kirkbride, J.B., Mallett, R.M., Leff, J., Holloway, J., Harrison, G., Dazzan, P., Morgan, K.D., Murray, R.M. and Jones, P.B. 2005. Incidence of bipolar affective disorder in three UK cities: results from the ÆSOP Study. British Journal of Psychiatry. 186 (2), pp. 126-131.

A study of hippocampal shape anomaly in schizophrenia and in families multiply affected by schizophrenia or bipolar disorder
Connor, S.E.J., Ng, V., McDonald, C., Schulze, K., Morgan, K.D., Dazzan, P. and Murray, R.M. 2004. A study of hippocampal shape anomaly in schizophrenia and in families multiply affected by schizophrenia or bipolar disorder. Neuroradiology. 46 (7), pp. 523-534. https://doi.org/10.1007/s00234-004-1224-0

Neuropsychological studies of insight in psychosis
Morgan, K.D. and David, A.S. 2004. Neuropsychological studies of insight in psychosis. in: Amador, X.S. and David, A.S. (ed.) Insight and psychosis: awareness of illness in schizophrenia and related disorders. 2nd edition Oxford, UK Oxford University Press.

Perception of psychosis in patients
Morgan, K.D. 2004. Perception of psychosis in patients. Epidemiologia e Psichiatria Sociale. 13 (4), pp. 222-226.

Normal cerebral asymmetry in familial and non-familial schizophrenic probands and their unaffected relatives
Chapple, B., Grech, A., Sham, P., Toulopoulou, T., Walshe, M., Schulze, K., Morgan, K.D., Murray, R.M. and McDonald, C. 2004. Normal cerebral asymmetry in familial and non-familial schizophrenic probands and their unaffected relatives. Schizophrenia Research. 67 (1), pp. 33-40. https://doi.org/10.1016/S0920-9964(03)00095-1

Reality monitoring and visual hallucinations in Parkinson's disease
Barnes, J., Boubert, L., Harris, J.R., Lee, A. and David, A.S. 2003. Reality monitoring and visual hallucinations in Parkinson's disease. Neuropsychologia. 41 (5), pp. 565-574. https://doi.org/10.1016/S0028-3932(02)00182-3

The structural brain correlates of neurological soft signs in ÆSOP first-episode psychoses study
Dazzan, P., Morgan, K.D., Orr, K.G., Hutchinson, G., Chitnis, X., Suckling, J., Fearon, P., Salvo, J., McGuire, P.K., Mallett, R.M., Jones, P.B., Leff, J. and Murray, R.M. 2003. The structural brain correlates of neurological soft signs in ÆSOP first-episode psychoses study. Brain. 127 (1), pp. 143-153. https://doi.org/10.1093/brain/awh015

A functional magnetic resonance imaging study of overt letter verbal fluency using a clustered acquisition sequence: greater anterior cingulate activation with increased task demand
Fu, C.H.Y., Morgan, K.D., Suckling, J., Williams, S.C.R., Andrew, C., Vythelingum, G.N. and McGuire, P.K. 2002. A functional magnetic resonance imaging study of overt letter verbal fluency using a clustered acquisition sequence: greater anterior cingulate activation with increased task demand. NeuroImage. 17 (2), pp. 871-879. https://doi.org/10.1016/S1053-8119(02)91189-4

Permalink - https://westminsterresearch.westminster.ac.uk/item/qw4yw/cognitive-change-in-schizophrenia-and-other-psychoses-in-the-decade-following-the-first-episode


Share this

Usage statistics

308 total views
418 total downloads
These values cover views and downloads from WestminsterResearch and are for the period from September 2nd 2018, when this repository was created.