Interplay Between Childhood Physical Abuse and Familial Risk in the Onset of Psychotic Disorders

Fisher, H., McGuffin, P., Boydell, J., Fearon, P., Craig, T., Dazzan, P., Morgan, K.D., Doody, G., Jones, P., Leff, J., Murray, R. and Morgan, C. 2014. Interplay Between Childhood Physical Abuse and Familial Risk in the Onset of Psychotic Disorders. Schizophrenia Bulletin. 40 (6), p. 1443–1451. https://doi.org/10.1093/schbul/sbt201

TitleInterplay Between Childhood Physical Abuse and Familial Risk in the Onset of Psychotic Disorders
TypeJournal article
AuthorsFisher, H., McGuffin, P., Boydell, J., Fearon, P., Craig, T., Dazzan, P., Morgan, K.D., Doody, G., Jones, P., Leff, J., Murray, R. and Morgan, C.
Abstract

Background: Childhood abuse is considered one of the main environmental risk factors for the development of psychotic symptoms and disorders. However, this association could be due to genetic factors influencing exposure to such risky environments or increasing sensitivity to the detrimental impact of abuse. Therefore, using a large epidemiological case-control sample, we explored the interplay between a specific form of childhood abuse and family psychiatric history (a proxy for genetic risk) in the onset of psychosis. Methods: Data were available on 172 first presentation psychosis cases and 246 geographically matched controls from the Aetiology and Ethnicity of Schizophrenia and Other Psychoses study. Information on childhood abuse was obtained retrospectively using the Childhood Experience of Care and Abuse Questionnaire and occurrence of psychotic and affective disorders in first degree relatives with the Family Interview for Genetic Studies. Results: Parental psychosis was more common among psychosis cases than unaffected controls (adjusted OR = 5.96, 95% CI: 2.09–17.01, P = .001). Parental psychosis was also associated with physical abuse from mothers in both cases (OR = 3.64, 95% CI: 1.06–12.51, P = .040) and controls (OR = 10.93, 95% CI: 1.03–115.90, P = .047), indicative of a gene-environment correlation. Nevertheless, adjusting for parental psychosis did not measurably impact on the abuse-psychosis association (adjusted OR = 3.31, 95% CI: 1.22–8.95, P= .018). No interactions were found between familial liability and maternal physical abuse in determining psychosis caseness. Conclusions: This study found no evidence that familial risk accounts for associations between childhood physical abuse and psychotic disorder nor that it substantially increases the odds of psychosis among individuals reporting abuse.

JournalSchizophrenia Bulletin
Journal citation40 (6), p. 1443–1451
ISSN0586-7614
Year2014
PublisherOxford University Press
Publisher's version
Digital Object Identifier (DOI)https://doi.org/10.1093/schbul/sbt201
Publication dates
Published in printNov 2014
Published online07 Jan 2014
LicenseCC BY 3.0

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Insight in psychosis and neuropsychological function: meta-analysis
Aleman, A., Agrawal, N., Morgan, K.D. and David, A.S. 2006. Insight in psychosis and neuropsychological function: meta-analysis. British Journal of Psychiatry. 189 (3), pp. 204-212. https://doi.org/10.1192/bjp.189.3.204

The structural brain correlates of neurological soft signs in healthy individuals
Dazzan, P., Morgan, K.D., Chitnis, X., Suckling, J., Morgan, C., Fearon, P., McGuire, P.K., Jones, P.B., Leff, J. and Murray, R.M. 2006. The structural brain correlates of neurological soft signs in healthy individuals. Cerebral Cortex. 16 (8), pp. 1225-1231. https://doi.org/10.1093/cercor/bhj063

Insight and cognition
Morgan, K.D. 2006. Insight and cognition. in: Morgan, K.D., David, A.S., Murray, R.M. and Eberhard, J. (ed.) Cognition and schizophrenia: improving real life function Cambridge, UK Cambridge Medical Communication. pp. 37-43

Increased pituitary volume in antipsychotic-free and antipsychotic-treated patients of the sop first-onset psychosis study
Pariante, C.M., Dazzan, P., Danese, A., Morgan, K.D., Brudaglio, F., Morgan, C., Fearon, P., Orr, K.G., Hutchinson, G., Pantelis, C., Velakoulis, D., Jones, P.B., Leff, J. and Murray, R.M. 2005. Increased pituitary volume in antipsychotic-free and antipsychotic-treated patients of the sop first-onset psychosis study. Neuropsychopharmacology. 30 (10), pp. 1923-1931. https://doi.org/10.1038/sj.npp.1300766

Pathways to care and ethnicity. 2: source of referral and help-seeking: report from the AESOP study
Morgan, C., Mallett, R.M., Hutchinson, G., Bagalkote, H., Morgan, K.D., Fearon, P., Dazzan, P., Boydell, J., McKenzie, K., Harrison, G., Murray, R.M., Jones, P.B., Craig, T.K.J. and Leff, J. 2005. Pathways to care and ethnicity. 2: source of referral and help-seeking: report from the AESOP study. British Journal of Psychiatry. 186 (4), pp. 290-296.

Pathways to care and ethnicity. 1: sample characteristics and compulsory admission: report from the ÆSOP Study
Morgan, C., Mallett, R.M., Hutchinson, G., Bagalkote, H., Morgan, K.D., Fearon, P., Dazzan, P., Boydell, J., McKenzie, K., Harrison, G., Murray, R.M., Jones, P.B., Craig, T.K.J. and Leff, J. 2005. Pathways to care and ethnicity. 1: sample characteristics and compulsory admission: report from the ÆSOP Study. British Journal of Psychiatry. 186 (4), pp. 281-289.

Different effects of typical and atypical antipsychotics on grey matter in first episode psychosis: the ÆSOP Study
Dazzan, P., Morgan, K.D., Orr, K.G., Hutchinson, G., Chitnis, X., Suckling, J., Fearon, P., McGuire, P.K., Mallett, R.M., Jones, P.B., Leff, J. and Murray, R.M. 2005. Different effects of typical and atypical antipsychotics on grey matter in first episode psychosis: the ÆSOP Study. Neuropsychopharmacology. 30 (4), pp. 765-774. https://doi.org/10.1038/sj.npp.1300603

Incidence of bipolar affective disorder in three UK cities: results from the ÆSOP Study
Lloyd, T., Kennedy, N., Fearon, P., Kirkbride, J.B., Mallett, R.M., Leff, J., Holloway, J., Harrison, G., Dazzan, P., Morgan, K.D., Murray, R.M. and Jones, P.B. 2005. Incidence of bipolar affective disorder in three UK cities: results from the ÆSOP Study. British Journal of Psychiatry. 186 (2), pp. 126-131.

A study of hippocampal shape anomaly in schizophrenia and in families multiply affected by schizophrenia or bipolar disorder
Connor, S.E.J., Ng, V., McDonald, C., Schulze, K., Morgan, K.D., Dazzan, P. and Murray, R.M. 2004. A study of hippocampal shape anomaly in schizophrenia and in families multiply affected by schizophrenia or bipolar disorder. Neuroradiology. 46 (7), pp. 523-534. https://doi.org/10.1007/s00234-004-1224-0

Neuropsychological studies of insight in psychosis
Morgan, K.D. and David, A.S. 2004. Neuropsychological studies of insight in psychosis. in: Amador, X.S. and David, A.S. (ed.) Insight and psychosis: awareness of illness in schizophrenia and related disorders. 2nd edition Oxford, UK Oxford University Press.

Perception of psychosis in patients
Morgan, K.D. 2004. Perception of psychosis in patients. Epidemiologia e Psichiatria Sociale. 13 (4), pp. 222-226.

Normal cerebral asymmetry in familial and non-familial schizophrenic probands and their unaffected relatives
Chapple, B., Grech, A., Sham, P., Toulopoulou, T., Walshe, M., Schulze, K., Morgan, K.D., Murray, R.M. and McDonald, C. 2004. Normal cerebral asymmetry in familial and non-familial schizophrenic probands and their unaffected relatives. Schizophrenia Research. 67 (1), pp. 33-40. https://doi.org/10.1016/S0920-9964(03)00095-1

The structural brain correlates of neurological soft signs in ÆSOP first-episode psychoses study
Dazzan, P., Morgan, K.D., Orr, K.G., Hutchinson, G., Chitnis, X., Suckling, J., Fearon, P., Salvo, J., McGuire, P.K., Mallett, R.M., Jones, P.B., Leff, J. and Murray, R.M. 2003. The structural brain correlates of neurological soft signs in ÆSOP first-episode psychoses study. Brain. 127 (1), pp. 143-153. https://doi.org/10.1093/brain/awh015

A functional magnetic resonance imaging study of overt letter verbal fluency using a clustered acquisition sequence: greater anterior cingulate activation with increased task demand
Fu, C.H.Y., Morgan, K.D., Suckling, J., Williams, S.C.R., Andrew, C., Vythelingum, G.N. and McGuire, P.K. 2002. A functional magnetic resonance imaging study of overt letter verbal fluency using a clustered acquisition sequence: greater anterior cingulate activation with increased task demand. NeuroImage. 17 (2), pp. 871-879. https://doi.org/10.1016/S1053-8119(02)91189-4

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