Clements, M.O., Eriksson, S., Thompson, A., Lucchini, S., Hinton, J.C.D., Normark, S.J. and Rhen, M. 2002. Polynucleotide phosphorylase is a global regulator of virulence and persistency in Salmonella enterica. Proceedings of the National Academy of Sciences of the United States of America. 99 (13), pp. 8784-8789.
| Title | Polynucleotide phosphorylase is a global regulator of virulence and persistency in Salmonella enterica |
|---|---|
| Authors | Clements, M.O., Eriksson, S., Thompson, A., Lucchini, S., Hinton, J.C.D., Normark, S.J. and Rhen, M. |
| Abstract | For many pathogens, the ability to regulate their replication in host cells is a key element in establishing persistency. Here, we identified a single point mutation in the gene for polynucleotide phosphorylase (PNPase) as a factor affecting bacterial invasion and intracellular replication, and which determines the alternation between acute or persistent infection in a mouse model for Salmonella enterica infection. In parallel, with microarray analysis, PNPase was found to affect the mRNA levels of a subset of virulence genes, in particular those contained in Salmonella pathogenicity islands 1 and 2. The results demonstrate a connection between PNPase and Salmonella virulence and show that alterations in PNPase activity could represent a strategy for the establishment of persistency. Copyright (2002) National Academy of Sciences, U.S.A. |
| Journal | Proceedings of the National Academy of Sciences of the United States of America |
| Journal citation | 99 (13), pp. 8784-8789 |
| ISSN | 0027-8424 |
| Year | 25 Jun 2002 |
| Digital Object Identifier (DOI) | doi:10.1073/pnas.132047099 |
| Web address (URL) | http://www.pnas.org/cgi/doi/10.1073/pnas.132047099 |
| Publication dates | |
| Published | 25 Jun 2002 |
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Enhancing electricity production from wastewater using microbial fuel cells
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Quantitative proteomic analysis of the response of the wood-rot fungus, Schizophyllum commune to the biocontrol fungus, Trichoderma viride
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Genetic analysis of the pnp–deaD genetic region reveals membrane lipoprotein NlpI as an independent participant in cold acclimatization of Salmonella enterica serovar Typhimurium
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Raina, S., De Vizio, D., Odell, M., Clements, M.O., Vanhulle, S. and Keshavarz, T. 2009. Microbial quorum sensing: a tool or a target for antimicrobial therapy? Biotechnology and Applied Biochemistry. 54 (2), pp. 65-84.
The student voice in biosciences
Kerrigan, M.J.P., Clements, M.O. and Rumpus, A. 2009. The student voice in biosciences. University of Westminster Teaching & Learning Symposium. University of Westminster, London 2009 Association for Learning Technology.
Listening to the student voices in biosciences modules
Kerrigan, M.J.P., Clements, M.O. and Rumpus, A. 2009. Listening to the student voices in biosciences modules. Hearing the Student Voice Conference: Enabling students' voices to shape the curriculum. Leeds Metropolitan University 14 May 2009
eReflect: enhancing student support through a reflective online process
Kerrigan, M.J.P., Clements, M.O., Oradini, F., Saunders, G. and Bond, A. 2009. eReflect: enhancing student support through a reflective online process. BbWorld'09. National Harbor, Maryland 14 - 16 Jul 2009
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Making assessment count – integrating feedback and reflection through eReflect
Kerrigan, M.J.P., Clements, M.O., Bond, A., Oradini, F., Nedelcheva, Y. and Saunders, G. 2009. Making assessment count – integrating feedback and reflection through eReflect. in: Terry, E.B., Jefferies, A.L. and Bracq, A. (ed.) Proceedings of the Fourth International Blended Learning Conference "Engaging Students in the Curriculum" Hatfield University of Hertfordshire.
University of westminster, Making assessment count: a JISC funded project
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University of Westminster, Making assessment count: a JISC funded project
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University of Westminster, Making assessment count: a JISC funded project
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Putative human liver progenitor cells in explanted liver
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PerR controls oxidative stress resistance and iron storage proteins and is required for virulence in Staphylococcus aureus
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