Assessing residual reasoning ability in overtly non-communicative patients using fMRI

Hampshire, A., Parkin, B., Cusack, R., Fernández Espejo, D., Allanson, J., Kamau, E., Pickard, J.D. and Owen, A.M. 2013. Assessing residual reasoning ability in overtly non-communicative patients using fMRI. Neuroimage: Clinical. 2, pp. 174-183. doi:10.1016/j.nicl.2012.11.008

TitleAssessing residual reasoning ability in overtly non-communicative patients using fMRI
AuthorsHampshire, A., Parkin, B., Cusack, R., Fernández Espejo, D., Allanson, J., Kamau, E., Pickard, J.D. and Owen, A.M.
Abstract

It is now well established that some patients who are diagnosed as being in a vegetative state or a minimally conscious state show reliable signs of volition that may only be detected by measuring neural responses. A pertinent question is whether these patients are also capable of logical thought. Here, we validate an fMRI paradigm that can detect the neural fingerprint of reasoning processes and moreover, can confirm whether a participant derives logical answers. We demonstrate the efficacy of this approach in a physically non-communicative patient who had been shown to engage in mental imagery in response to simple audi- tory instructions. Our results demonstrate that this individual retains a remarkable capacity for higher cogni- tion, engaging in the reasoning task and deducing logical answers. We suggest that this approach is suitable for detecting residual reasoning ability using neural responses and could readily be adapted to assess other aspects of cognition.

JournalNeuroimage: Clinical
Journal citation2, pp. 174-183
ISSN2213-1582
Year2013
PublisherElsevier
Publisher's versionAssessingReasoningInNon-communicativePatients.pdf
Digital Object Identifier (DOI)doi:10.1016/j.nicl.2012.11.008
Publication dates
Published2013
Published29 Nov 2012

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