Ageing increases reliance on sensorimotor prediction through structural and functional differences in frontostriatal circuits

Wolpe, N., Ingram, J., Tsvetanov, K., Geerligs, L., Kievit, R., Henson, R., Wolpert, D., Cam-CAN Consortium, Rowe, J. and Parkin, B. 2016. Ageing increases reliance on sensorimotor prediction through structural and functional differences in frontostriatal circuits. Nature Communications . 7, p. 13034. doi:10.1038/ncomms13034

TitleAgeing increases reliance on sensorimotor prediction through structural and functional differences in frontostriatal circuits
TypeJournal article
AuthorsWolpe, N.
Ingram, J.
Tsvetanov, K.
Geerligs, L.
Kievit, R.
Henson, R.
Wolpert, D.
Cam-CAN Consortium
Rowe, J.
Parkin, B.
Abstract

The control of voluntary movement changes markedly with age. A critical component of motor control is the integration of sensory information with predictions of the consequences of action, arising from internal models of movement. This leads to sensorimotor attenuation-a reduction in the perceived intensity of sensations from self-generated compared with external actions. Here we show that sensorimotor attenuation occurs in 98% of adults in a population-based cohort (n=325; 18-88 years; the Cambridge Centre for Ageing and Neuroscience). Importantly, attenuation increases with age, in proportion to reduced sensory sensitivity. This effect is associated with differences in the structure and functional connectivity of the pre-supplementary motor area (pre-SMA), assessed with magnetic resonance imaging. The results suggest that ageing alters the balance between the sensorium and predictive models, mediated by the pre-SMA and its connectivity in frontostriatal circuits. This shift may contribute to the motor and cognitive changes observed with age.

Article number13034
JournalNature Communications
Journal citation7, p. 13034
ISSN2041-1723
Year2016
PublisherNature Research
Publisher's version
Digital Object Identifier (DOI)doi:10.1038/ncomms13034
Publication dates
Published03 Oct 2016
LicenseCC BY 4.0

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Ageing increases reliance on sensorimotor prediction through structural and functional differences in frontostriatal circuits
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