Preserved cognitive functions with age are determined by domain-dependent shifts in network responsivity

Samu, D., Campbell, K., Tsvetanov, K., Shafto, M., Cam-CAN Consortium, Tyler, L. and Parkin, B. 2017. Preserved cognitive functions with age are determined by domain-dependent shifts in network responsivity. Nature Communications . 8 14743. doi:10.1038/ncomms14743

TitlePreserved cognitive functions with age are determined by domain-dependent shifts in network responsivity
TypeJournal article
AuthorsSamu, D., Campbell, K., Tsvetanov, K., Shafto, M., Cam-CAN Consortium, Tyler, L. and Parkin, B.
Abstract

Healthy ageing has disparate effects on different cognitive domains. The neural basis of these differences, however, is largely unknown. We investigated this question by using Independent Components Analysis to obtain functional brain components from 98 healthy participants aged 23–87 years from the population-based Cam-CAN cohort. Participants performed two cognitive tasks that show age-related decrease (fluid intelligence and object naming) and a syntactic comprehension task that shows age-related preservation. We report that activation of task-positive neural components predicts inter-individual differences in performance in each task across the adult lifespan. Furthermore, only the two tasks that show performance declines with age show age-related decreases in task-positive activation of neural components and decreasing default mode (DM) suppression. Our results suggest that distributed, multi-component brain responsivity supports cognition across the adult lifespan, and the maintenance of this, along with maintained DM deactivation, characterizes successful ageing and may explain differential ageing trajectories across cognitive domains.

Article number14743
JournalNature Communications
Journal citation8
ISSN2041-1723
Year2017
PublisherNature Research
Publisher's version
Digital Object Identifier (DOI)doi:10.1038/ncomms14743
PubMed ID28480894
Publication dates
Published08 May 2017

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