Association between Early Pregnancy Vitamin D Status and Changes in Serum Lipid Profiles throughout Pregnancy

Lepsch, J., Eshriqui, I., Rodrigues Farias, D., Vaz, J.S., Cunha Figueiredo, A.C., Adegboye, A.R., Brito, A., Mokhtar, R., Allen, L.H., Holick, M.F. and Kac, G. 2017. Association between Early Pregnancy Vitamin D Status and Changes in Serum Lipid Profiles throughout Pregnancy. Metabolism. 70, pp. 85-97. doi:10.1016/j.metabol.2017.02.004

TitleAssociation between Early Pregnancy Vitamin D Status and Changes in Serum Lipid Profiles throughout Pregnancy
AuthorsLepsch, J., Eshriqui, I., Rodrigues Farias, D., Vaz, J.S., Cunha Figueiredo, A.C., Adegboye, A.R., Brito, A., Mokhtar, R., Allen, L.H., Holick, M.F. and Kac, G.
Abstract

Objective

To evaluate the associations between first trimester 25-hydroxyvitamin D [25(OH)D] status and changes in high-density lipoprotein cholesterol (HDL-c), low-density lipoprotein cholesterol (LDL-c), total cholesterol (TC), triglyceride (TG) concentrations, TG/HDL-c, and TC/HDL-c ratios throughout pregnancy. We hypothesized that first trimester 25(OH)D inadequacy is associated with lower concentrations of HDL-c and higher LDL-c, TC, TG, TG/HDL-c, and TC/HDL-c ratios throughout pregnancy.
Methods

A prospective cohort study with 3 visits at 5–13 (baseline), 20–26, and 30–36 gestational weeks, recruited 194 pregnant women attending a public health care center in Rio de Janeiro, Brazil. Plasma 25(OH)D concentrations were measured in the first trimester using liquid chromatography–tandem mass spectrometry. 25(OH)D concentrations were classified as adequate (≥ 75 nmol/L) or inadequate (< 75 nmol/L). Serum TC, HDL-c, and TG concentrations were measured enzymatically. Crude and adjusted longitudinal linear mixed-effects models were employed to evaluate the association between the first trimester 25(OH)D status and changes in serum lipid concentrations throughout pregnancy. Confounders adjusted for in the multiple analysis were age, homeostatic model assessment (HOMA), early pregnancy BMI, leisure time physical activity before pregnancy, energy intake, and gestational age.
Results

At baseline, 69% of the women had inadequate concentrations of 25(OH)D. Women with 25(OH)D inadequacy had higher mean LDL-c than those with adequate concentrations (91.3 vs 97.5 mg/dL; P = 0.064) at baseline. TC, HDL-c, LDL-c TG, TG/HDL-c ratios, and TC/HDL-c ratios, increased throughout pregnancy independently of 25(OH)D concentrations (ANOVA for repeated measures P < 0.001). The adjusted models showed direct associations between the first trimester 25(OH)D status and changes in TC (β = 9.53; 95%CI = 1.12–17.94), LDL-c (β = 9.99; 95% CI = 3.62–16.36) concentrations, and TC/HDL-c ratios (β = 0.16; 95% CI = 0.01–0.31) throughout pregnancy.
Conclusions

Inadequate plasma 25(OH)D concentrations during early pregnancy were associated with more pronounced changes of TC, LDL-c concentrations, and TC/HDL-c ratios throughout pregnancy. Changes in these cardiovascular markers suggest the importance of ensuring adequate vitamin D status at the beginning of pregnancy.

JournalMetabolism
Journal citation70, pp. 85-97
ISSN0026-0495
Year2017
PublisherElsevier
Accepted author manuscript1-s2.0-S0026049517300513-main.pdf
Digital Object Identifier (DOI)doi:10.1016/j.metabol.2017.02.004
Publication dates
Published online12 Feb 2017
Published12 Feb 2017

Related outputs

Changes in plasma concentrations of 25-hydroxyvitamin D and 1,25-dihydroxyvitamin D during pregnancy: A Brazilian cohort
Cunha Figueiredo, A.C., Cocate, P.G., Adegboye, A.R., Franco-Sena, A.B., Farias, D.R., Trindade de Castro, M.B., Brito, A., Allen, L.H., Mokhtar, R.R., Holick, M.F. and Kac, G. 2018. Changes in plasma concentrations of 25-hydroxyvitamin D and 1,25-dihydroxyvitamin D during pregnancy: A Brazilian cohort. European Journal of Nutrition. 57 (3), pp. 1059-1072. doi:10.1007/s00394-017-1389-z

Understanding infant and young child feeding and oral health practices and perceptions in Tower Hamlets: moving from knowledge to practice and impact
Keith, R., Draper, A., Adegboye, A.R., Senior, L., Mba, E. and Azagba Nyako, J. 2017. Understanding infant and young child feeding and oral health practices and perceptions in Tower Hamlets: moving from knowledge to practice and impact. University of Westminster.

Omega-3 supplementation from pregnancy to postpartum to prevent depressive symptoms: a randomized placebo controlled trial
Vaz, J.D.S., Farias, D.R., Adegboye, A.R.A, Nardi, A.E. and Kac, G. 2017. Omega-3 supplementation from pregnancy to postpartum to prevent depressive symptoms: a randomized placebo controlled trial. BMC Pregnancy and Childbirth. 17 (1), p. 180. doi:10.1186/s12884-017-1365-x

Intake of dairy foods and oral health: review of epidemiological data
Adegboye, A.R., Rodrigues Tomaz, M., Jeavons, C.A. and Heitmann, B.L. 2017. Intake of dairy foods and oral health: review of epidemiological data. Tandlægebladet (Danish Dental Journal). 120 (12), pp. 884-891.

Risk Factors for Maternal Vitamin D Deficiency within the United Arab Emirates
Hussein, I., Taha, Z., Tewfik, I., Badawi, S., Siddieg, H., Adegboye, A.R. and McGrady, K. 2016. Risk Factors for Maternal Vitamin D Deficiency within the United Arab Emirates. Journal of Pregnancy and Child Health. 3 (5), p. 1000276. doi:10.4172/2376-127X.1000276

Calcium, vitamin D, casein and whey protein intakes and periodontitis among Danish adults
Adegboye, A.R., Boucher, B.J., Kongstad, J., Fiehn, N.E., Christensen, L.B. and Heitmann, B.L. 2016. Calcium, vitamin D, casein and whey protein intakes and periodontitis among Danish adults. Public Health Nutrition. 19 (3), pp. 503-10. doi:10.1017/S1368980015001202

Interventions for improving pregnancy outcome in antenatally diagnosed or suspected morbidly adherent placenta (Protocol)
Adegboye, A.R., Sengupta, R., Gimovsky, A., Wei, S., Bamigboye, A.A., Berghella, V. and Fraser, W.D. 2015. Interventions for improving pregnancy outcome in antenatally diagnosed or suspected morbidly adherent placenta (Protocol). The Cochrane Library.

The effect of alcohol consumption on periodontitis in older Danes
Adegboye, A.R., Hach, M., Holm-Pedersen, P. and Avlund, K. 2015. The effect of alcohol consumption on periodontitis in older Danes. International Journal of Dental Hygiene. 13 (4), p. 261–267. doi:10.1111/idh.12121

Associations between initial change in physical activity level and subsequent change in regional body fat distributions
Adegboye, A.R., Ezekwe, K.A., Gamborg, M. and Heitmann, B.L. 2013. Associations between initial change in physical activity level and subsequent change in regional body fat distributions. Obesity Facts. 6 (6), pp. 552-560. doi:10.1159/000357366

Intakes of calcium, vitamin D, and dairy servings and dental plaque in older Danish adults
Adegboye, A.R., Christensen, L.B., Holm-Pedersen, P., Boucher, B.J., Heitmann, B.L. and Avlund, K. 2013. Intakes of calcium, vitamin D, and dairy servings and dental plaque in older Danish adults. Nutrition Journal. 12 (61). doi:10.1186/1475-2891-12-61

C-reactive protein and later preeclampsia: systematic review and meta-analysis taking into account the weight status
Adegboye, A.R., Rebelo, F., Schlüssel, M.M., Vaz, J.S., Franco-Sena, A.B., Pinto, T.J., Bastos, F.I. and Kac, G. 2013. C-reactive protein and later preeclampsia: systematic review and meta-analysis taking into account the weight status. Journal of Hypertension. 31 (1), pp. 16-26. doi:10.1097/HJH.0b013e32835b0556

Diet or exercise, or both, for weight reduction in women after childbirth
Adegboye, A.R., Lourenço, P.M. and Linné, Y. 2013. Diet or exercise, or both, for weight reduction in women after childbirth. Cochrane Database Syst Rev.. doi:10.1002/14651858.CD005627.pub3

Diet or exercise, or both, for weight reduction in women carrying excess weight after childbirth
Adegboye, A.R. and Linné, Y. 2012. Diet or exercise, or both, for weight reduction in women carrying excess weight after childbirth. The Cochrane Library.

Short-term pre-pregnancy health education may improve maternal nutrition behavior, but not nutrition self-efficacy
Adegboye, A.R. 2012. Short-term pre-pregnancy health education may improve maternal nutrition behavior, but not nutrition self-efficacy. Zahedan University of Medical Sciences.

Intake of dairy products in relation to periodontitis in older Danish adults
Adegboye, A.R., Heitmann, B.L., Christensen, L.B., Holm-Pedersen, P. and Boucher, B.J. 2012. Intake of dairy products in relation to periodontitis in older Danish adults. Nutrients. 4 (9), p. 1219–1229. doi:10.3390/nu4091219

Influence of parental overweight on the association of birth weight and fat distribution later in childhood
Adegboye, A.R., Andersen, L.B., Wedderkopp, N. and Heitmann, B.L. 2012. Influence of parental overweight on the association of birth weight and fat distribution later in childhood. Obesity Facts. 5 (5), pp. 784-794. doi:10.1159/000343916

Intake of dairy calcium and tooth loss among adult Danish men and women
Adegboye, A.R., Twetman, S., Christensen, L.B. and Heitmann, B.L. 2012. Intake of dairy calcium and tooth loss among adult Danish men and women. Nutrition: The International Journal of Applied and Basic Nutritional Sciences. 28 (7-8), pp. 779-784. doi:10.1016/j.nut.2011.11.011

Systematic review of clinical trials on dietary interventions to prevent excessive weight gain during pregnancy among normal weight, overweight and obese women
Adegboye, A.R., Tanentsapf, I. and Heitmann, B.L. 2011. Systematic review of clinical trials on dietary interventions to prevent excessive weight gain during pregnancy among normal weight, overweight and obese women. BMC Pregnancy Childbirth. 11 (1). doi:10.1186/1471-2393-11-81

Recommended aerobic fitness level for metabolic health in children and adolescents: a study of diagnostic accuracy
Adegboye, A.R., Anderssen, S.A., Froberg, K., Sardinha, L.B., Heitmann, B.L., Steene-Johannessen, J., Kolle, E. and Andersen, L.B. 2011. Recommended aerobic fitness level for metabolic health in children and adolescents: a study of diagnostic accuracy. British Journal of Sports Medicine. 45 (9), pp. 722-728. doi:10.1136/bjsm.2009.068346

Low calcium intake is related to increased risk of tooth loss in men
Adegboye, A.R., Fiehn, N.E., Twetman, S., Christensen, L.B. and Heitmann, B.L. 2010. Low calcium intake is related to increased risk of tooth loss in men. Journal of Nutrition. 140 (10), pp. 1864-1868. doi:10.3945/jn.109.117770

Linking definition of childhood and adolescent obesity to current health outcomes
Adegboye, A.R., Andersen, L.B., Froberg, K., Sardinha, L.B. and Heitmann, B.L. 2010. Linking definition of childhood and adolescent obesity to current health outcomes. International Journal of Pediatric Obesity. 5 (2), pp. 130-142. doi:10.3109/17477160903111730

Relationships between prenatal smoking cessation, gestational weight gain and maternal lifestyle characteristics
Adegboye, A.R., Rössner, S., Neovius, M., Lourenço, P.M. and Linné, Y. 2010. Relationships between prenatal smoking cessation, gestational weight gain and maternal lifestyle characteristics. Women and Birth. 23 (1), pp. 29-35. doi:10.1016/j.wombi.2009.05.002

Can maternal leptin level at early gestation be used as a predictor of postpartum weight retention?
Adegboye, A.R. 2008. Can maternal leptin level at early gestation be used as a predictor of postpartum weight retention? The Indian Council of Medical Research (ICMR).

Accuracy and correlates of maternal recall of birthweight and gestational age
Adegboye, A.R. and Heitmann, B.L. 2008. Accuracy and correlates of maternal recall of birthweight and gestational age. BJOG: An International Journal of Obstetrics and Gynaecology. 115 (7), pp. 886-893. doi:10.1111/j.1471-0528.2008.01717.x

Assessment of weight changes during and after pregnancy: practical approaches
Adegboye, A.R., Linné, Y., Lourenço, P.M. and Kac, G. 2008. Assessment of weight changes during and after pregnancy: practical approaches. Maternal & Child Nutrition. 4 (1), pp. 1-13. doi:10.1111/j.1740-8709.2007.00093.x

Losing weight after pregnancy: diet plus exercise better than diet alone
Adegboye, A.R. 2007. Losing weight after pregnancy: diet plus exercise better than diet alone. The Cochrane Library.

Does weight gain during pregnancy predict future weight?
Adegboye, A.R. 2007. Does weight gain during pregnancy predict future weight? Frost & Sullivan.

The use and interpretation of anthropometric indicators of nutritonal status during preganancy
Adegboye, A.R., Kac, G. and Lacerda, E. 2007. The use and interpretation of anthropometric indicators of nutritonal status during preganancy. in: Kac, G., Sichieri, R. and Gigante, D.P. (ed.) Epidemiologia nutricional (Portuguese Edition of 'Nutritional Epidemiology') Ministry of Health, Brazil SciELO Editora FIOCRUZ.

Does excess pregnancy weight gain constitute a major risk for increasing long-term BMI?
Adegboye, A.R., Rössner, S., Neovius, M., Lourenço, P.M. and Linné, Y. 2007. Does excess pregnancy weight gain constitute a major risk for increasing long-term BMI? Obesity. 15 (5), pp. 1278-1286. doi:10.1038/oby.2007.149

Gestational weight gain differentials in the presence of intimate partner violence
Adegboye, A.R., Moraes, C.L. and Reichenheim, M.E. 2006. Gestational weight gain differentials in the presence of intimate partner violence. International Journal of Gynecology & Obstetrics. 95 (3), p. 254–260. doi:10.1016/j.ijgo.2006.08.015

Permalink - https://westminsterresearch.westminster.ac.uk/item/9zxyv/association-between-early-pregnancy-vitamin-d-status-and-changes-in-serum-lipid-profiles-throughout-pregnancy


Share this
Tweet
Email