Changes in plasma concentrations of 25-hydroxyvitamin D and 1,25-dihydroxyvitamin D during pregnancy: A Brazilian cohort

Cunha Figueiredo, A.C., Cocate, P.G., Adegboye, A.R., Franco-Sena, A.B., Farias, D.R., Trindade de Castro, M.B., Brito, A., Allen, L.H., Mokhtar, R.R., Holick, M.F. and Kac, G. 2018. Changes in plasma concentrations of 25-hydroxyvitamin D and 1,25-dihydroxyvitamin D during pregnancy: A Brazilian cohort. European Journal of Nutrition. 57 (3), pp. 1059-1072.

TitleChanges in plasma concentrations of 25-hydroxyvitamin D and 1,25-dihydroxyvitamin D during pregnancy: A Brazilian cohort
AuthorsCunha Figueiredo, A.C., Cocate, P.G., Adegboye, A.R., Franco-Sena, A.B., Farias, D.R., Trindade de Castro, M.B., Brito, A., Allen, L.H., Mokhtar, R.R., Holick, M.F. and Kac, G.
Abstract

Purpose. To characterize the physiological changes in 25-hydroxyvitamin D [25(OH)D] and 1,25-dihydroxivitamin
D [1,25(OH)2D] throughout pregnancy. Methods. Prospective cohort of 229 apparently healthy pregnant women followed at 5th-13th, 20th-26th and 30th-36th gestational weeks. 25(OH)D and 1,25(OH)2D concentrations were measured by LC-MS/MS. Statistical analyses included longitudinal linear mixed-effects models adjusted for parity, season, education, self-reported skin color and pre-pregnancy BMI. Vitamin D status was defined based on 25(OH)D concentrations according to the Endocrine Society Practice Guideline and Institute of Medicine (IOM) for adults. Results. The prevalence of 25(OH)D <75 nmol/L was 70.4%, 41.0% and 33.9%; the prevalence of 25(OH)D<50 nmol/L was 16.1%, 11.2% and 10.2%; and the prevalence of 25(OH)D <30 nmol/L was 2%, 0% and 0.6%, at the first, second and third trimester, respectively. Unadjusted analysis showed an increase in 25(OH)D (β=0.869;95%CI, 0.723-1.014; P<0.001) and 1,25(OH)2D (β=3.878; 95%CI, 3.136-4.620; P<0.001) throughout pregnancy.
Multiple adjusted analyses showed that women who started the study in winter (P<0.001), spring (P<0.001) or
autumn (P=0.028) presented a longitudinal increase in 25(OH)D concentrations, while women that started during
summer did not. Increase of 1,25(OH)2D concentrations over time in women with insufficient vitamin D (50-75
nmol/L) at baseline was higher compared to women with sufficient vitamin D (≥75 nmol/L) (P=0.006). Conclusions.
The prevalence of vitamin D inadequacy varied significantly according to the adopted criteria. There was a seasonal variation of 25(OH)D during pregnancy. The women with insufficient vitamin D status present greater longitudinal increases in the concentrations of 1,25(OH)2D in comparison to women with sufficiency.

KeywordsVitamin D; pregnancy; micronutrients; cohort; tropical country; seasons
JournalEuropean Journal of Nutrition
Journal citation57 (3), pp. 1059-1072
ISSN1436-6207
Year2018
PublisherSpringer
Accepted author manuscriptEJON-D-16-0034_Amanda F et al 2017-1.pdf
Digital Object Identifier (DOI)doi:10.1007/s00394-017-1389-z
Publication dates
Published in printApr 2018
Published online28 Mar 2017
Published28 Mar 2017

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