Common framework for “virtual lesion” and state-dependent TMS: the facilitatory/suppressive range model of online TMS effects on behavior Journal: Brain and Cognition

Silvanto, J. and Cattaneo, Z. 2017. Common framework for “virtual lesion” and state-dependent TMS: the facilitatory/suppressive range model of online TMS effects on behavior Journal: Brain and Cognition. Brain and Cognition. 119, pp. 32-38.

TitleCommon framework for “virtual lesion” and state-dependent TMS: the facilitatory/suppressive range model of online TMS effects on behavior Journal: Brain and Cognition
AuthorsSilvanto, J. and Cattaneo, Z.
Abstract

The behavioral effects of Transcranial Magnetic Stimulation (TMS) are often nonlinear; factors such as stimulation intensity and brain state can modulate the impact of TMS on observable behavior in qualitatively different manner. Here we propose a theoretical framework to account for these effects. In this model, there are distinct intensity ranges for facilitatory and suppressive effects of TMS – low intensities facilitate neural activity and behavior whereas high intensities induce suppression. The key feature of the model is that these ranges are shifted by changes in neural excitability: consequently, a TMS intensity, which normally induces suppression, can have a facilitatory effect if the stimulated neurons are being inhibited by ongoing task-related processes or preconditioning. For example, adaptation reduces excitability of adapted neurons; the outcome is that TMS intensities which inhibit non-adapted neurons induce a facilitation on adapted neural representations, leading to reversal of adaptation effects. In conventional “virtual lesion” paradigms, similar effects occur because neurons not involved in task-related processes are inhibited by the ongoing task. The resulting reduction in excitability can turn high intensity “inhibitory” TMS to low intensity “facilitatory” TMS for these neurons, and as task-related neuronal representations are in the inhibitory range, the outcome is a reduction in signal-to-noise ratio and behavioral impairment.

JournalBrain and Cognition
Journal citation119, pp. 32-38
ISSN0278-2626
Year2017
PublisherElsevier
Publisher's version1-s2.0-S0278262617302671-main.pdf
Digital Object Identifier (DOI)doi:10.1016/j.bandc.2017.09.007
Publication dates
Published28 Sep 2017
LicenseCC BY-NC-ND 4.0

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