Translational regulation in mycobacteria and its implications for pathogenicity

Sawyer, E.B., Grabowska, A. and Cortes, T. 2018. Translational regulation in mycobacteria and its implications for pathogenicity. Nucleic Acids Research. 46 (14), pp. 6950-6961. https://doi.org/10.1093/nar/gky574

TitleTranslational regulation in mycobacteria and its implications for pathogenicity
TypeJournal article
AuthorsSawyer, E.B., Grabowska, A. and Cortes, T.
Abstract

Protein synthesis is a fundamental requirement of all cells for survival and replication. To date, vast numbers of genetic and biochemical studies have been performed to address the mechanisms of translation and its regulation in Escherichia coli, but only a limited number of studies have investigated these processes in other bacteria, particularly in slow growing bacteria like Mycobacterium tuberculosis, the causative agent of human tuberculosis. In this Review, we highlight important differences in the translational machinery of M. tuberculosis compared with E. coli, specifically the presence of two additional proteins and subunit stabilizing elements such as the B9 bridge. We also consider the role of leaderless translation in the ability of M. tuberculosis to establish latent infection and look at the experimental evidence that translational regulatory mechanisms operate in mycobacteria during stress adaptation, particularly focussing on differences in toxin-antitoxin systems between E. coli and M. tuberculosis and on the role of tuneable translational fidelity in conferring phenotypic antibiotic resistance. Finally, we consider the implications of these differences in the context of the biological adaptation of M. tuberculosis and discuss how these regulatory mechanisms could aid in the development of novel therapeutics for tuberculosis.

JournalNucleic Acids Research
Journal citation46 (14), pp. 6950-6961
ISSN0305-1048
1362-4962
Year2018
PublisherOxford University Press
Publisher's version
License
CC BY-NC 4.0
File Access Level
Open (open metadata and files)
Digital Object Identifier (DOI)https://doi.org/10.1093/nar/gky574
Publication dates
Published21 Aug 2018

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