Sawyer, E.B., Edgeworth, J.A., Thomas, C., Collinge, J. and Jackson, G.S. 2015. Preclinical detection of infectivity and disease-specific PrP in blood throughout the incubation period of prion disease. Scientific Reports. 5 17742. https://doi.org/10.1038/srep17742
| Title | Preclinical detection of infectivity and disease-specific PrP in blood throughout the incubation period of prion disease |
|---|---|
| Type | Journal article |
| Authors | Sawyer, E.B., Edgeworth, J.A., Thomas, C., Collinge, J. and Jackson, G.S. |
| Abstract | Variant Creutzfeldt-Jakob disease (vCJD) is a fatal neurodegenerative disorder characterised by accumulation of pathological isoforms of the prion protein, PrP. Although cases of clinical vCJD are rare, there is evidence there may be tens of thousands of infectious carriers in the United Kingdom alone. This raises concern about the potential for perpetuation of infection via medical procedures, in particular transfusion of contaminated blood products. Accurate biochemical detection of prion infection is crucial to mitigate risk and we have previously reported a blood assay for vCJD. This assay is sensitive for abnormal PrP conformers at the earliest stages of preclinical prion disease in mice and precedes the maximum infectious titre in blood. Not only does this support the possibility of screening asymptomatic individuals, it will also facilitate the elucidation of the complex relationship that exists between the ensemble of abnormal PrP conformers present in blood and the relationship to infectivity. |
| Article number | 17742 |
| Journal | Scientific Reports |
| Journal citation | 5 |
| ISSN | 2045-2322 |
| Year | 2015 |
| Publisher | Nature Publishing Group |
| Publisher's version | License CC BY 4.0 File Access Level Open (open metadata and files) |
| Digital Object Identifier (DOI) | https://doi.org/10.1038/srep17742 |
| Web address (URL) | http://www.scopus.com/inward/record.url?eid=2-s2.0-84949256542&partnerID=MN8TOARS |
| Publication dates | |
| Published | 03 Dec 2015 |