Metalloprotein design using genetic code expansion

Combining experiment and energy landscapes to explore anaerobic heme breakdown in multifunctional hemoproteins
Alasdair D. Keith, Elizabeth B. Sawyer, Desmond Choy, Yuhang Xie, George Biggs, Oskar James Klein, Paul D. Brear, David Wales and Paul Barker 2024. Combining experiment and energy landscapes to explore anaerobic heme breakdown in multifunctional hemoproteins. Physical Chemistry Chemical Physics. 26, pp. 695-712. https://doi.org/10.1039/d3cp03897a

Ribosome profiling enhances understanding of mycobacterial translation
Sawyer, E.B. and Cortes, T. 2022. Ribosome profiling enhances understanding of mycobacterial translation. Frontiers in Microbiology. 13 976550. https://doi.org/10.3389/fmicb.2022.976550

A snapshot of translation in Mycobacterium tuberculosis during exponential growth and nutrient starvation revealed by ribosome profiling
Sawyer, E.B., Phelan, J.E., Clark, T.G. and Cortes, T. 2021. A snapshot of translation in Mycobacterium tuberculosis during exponential growth and nutrient starvation revealed by ribosome profiling. Cell Reports. 34 (5) 108695. https://doi.org/10.1016/j.celrep.2021.108695

Structural effects of the highly protective V127 polymorphism on human prion protein.
Hosszu LLP, Conners R, Sangar D, Batchelor M, Sawyer EB, Fisher S, Cliff MJ, Hounslow AM, McAuley K, Leo Brady R, Jackson GS, Bieschke J, Waltho JP and Collinge J 2020. Structural effects of the highly protective V127 polymorphism on human prion protein. Communications Biology. 3 402. https://doi.org/10.1038/s42003-020-01126-6

Translational regulation in mycobacteria and its implications for pathogenicity
Sawyer, E.B., Grabowska, A. and Cortes, T. 2018. Translational regulation in mycobacteria and its implications for pathogenicity. Nucleic Acids Research. 46 (14), pp. 6950-6961. https://doi.org/10.1093/nar/gky574

Preclinical detection of infectivity and disease-specific PrP in blood throughout the incubation period of prion disease
Sawyer, E.B., Edgeworth, J.A., Thomas, C., Collinge, J. and Jackson, G.S. 2015. Preclinical detection of infectivity and disease-specific PrP in blood throughout the incubation period of prion disease. Scientific Reports. 5 17742. https://doi.org/10.1038/srep17742

Self-assembly of amyloid fibrils that display active enzymes
Zhou, X.-M., Entwistle, A., Zhang, H., Jackson, A.P., Mason, T.O., Shimanovich, U., Knowles, T.P.J., Smith, A.T., Sawyer, E.B. and Perrett, S. 2014. Self-assembly of amyloid fibrils that display active enzymes. ChemCatChem. 6 (7), pp. 1961-1968. https://doi.org/10.1002/cctc.201402125

Self-assembling nanomaterials: Monitoring the formation of amyloid fibrils, with a focus on small-angle x-ray scattering
Sawyer, E.B. and Gras, S.L. 2013. Self-assembling nanomaterials: Monitoring the formation of amyloid fibrils, with a focus on small-angle x-ray scattering. in: Gerrard, J.A. (ed.) Protein Nanotechnology Humana Press.