Impaired crossed facilitation of the corticospinal pathway after cervical spinal cord injury

Bunday, K.L. and Perez, M.A. 2012. Impaired crossed facilitation of the corticospinal pathway after cervical spinal cord injury. Journal of Neurophysiology. https://doi.org/10.1152/jn.00850.2011

TitleImpaired crossed facilitation of the corticospinal pathway after cervical spinal cord injury
TypeJournal article
AuthorsBunday, K.L. and Perez, M.A.
Abstract

In uninjured humans, it is well established that voluntary contraction of muscles on one side of the body can facilitate transmission in the contralateral corticospinal pathway. This crossed facilitatory effect may favor interlimb coordination and motor performance. Whether this aspect of corticospinal function is preserved after chronic spinal cord injury (SCI) is unknown. Here, using transcranial magnetic stimulation, we show in patients with chronic cervical SCI (C5–C8) that the size of motor evoked potentials (MEPs) in a resting intrinsic hand muscle remained unchanged during increasing levels of voluntary contraction with a contralateral distal or proximal arm muscle. In contrast, MEP size in a resting hand muscle was increased during the same motor tasks in healthy control subjects. The magnitude of voluntary electromyography was negatively correlated with MEP size after chronic cervical SCI and positively correlated in healthy control subjects. To examine the mechanisms contributing to MEP crossed facilitation we examined short-interval intracortical inhibition (SICI), interhemispheric inhibition (IHI), and motoneuronal behavior by testing F waves and cervicomedullary MEPs (CMEPs). During strong voluntary contractions SICI was unchanged after cervical SCI and decreased in healthy control subjects compared with rest. F-wave amplitude and persistence and CMEP size remained unchanged after cervical SCI and increased in healthy control subjects compared with rest. In addition, during strong voluntary contractions IHI was unchanged in cervical SCI compared with rest. Our results indicate that GABAergic intracortical circuits, interhemispheric glutamatergic projections between motor cortices, and excitability of index finger motoneurons are neural mechanisms underlying, at least in part, the lack of crossed corticospinal facilitation observed after SCI. Our data point to the spinal motoneurons as a critical site for modulating corticospinal transmission after chronic cervical SCI.

JournalJournal of Neurophysiology
ISSN0022-3077
1522-1598
Year2012
PublisherAmerican Physiological Society
Digital Object Identifier (DOI)https://doi.org/10.1152/jn.00850.2011
PubMed ID22357796
Web address (URL)http://europepmc.org/abstract/med/22357796
Publication dates
Published15 May 2012

Related outputs

The Immediate and Short-Term Effects of Transcutaneous Spinal Cord Stimulation and Peripheral Nerve Stimulation on Corticospinal Excitability
Al’joboori, Yazi, Hannah, Ricci, Lenham, Francesca, Borgas, Pia, Kremers, Charlotte J. P., Bunday, Karen L., Rothwell, John and Duffell, Lynsey D. 2021. The Immediate and Short-Term Effects of Transcutaneous Spinal Cord Stimulation and Peripheral Nerve Stimulation on Corticospinal Excitability. Frontiers in Neuroscience. 15, p. 749042. https://doi.org/10.3389/fnins.2021.749042

Putative propriospinal modulation of premotor and motor cortical output during grasping
Bunday, K.L., Poh, Z., Azzopardi, S. and Davare, M. 2018. Putative propriospinal modulation of premotor and motor cortical output during grasping. Society for Neuroscience. San Diego, USA 03 - 07 Nov 2018

Potentiating paired corticospinal-motoneuronal plasticity after spinal cord injury.
Bunday, K.L., Urbin, M.A. and Perez, M.A. 2018. Potentiating paired corticospinal-motoneuronal plasticity after spinal cord injury. Brain Stimulation. 11, pp. 1083-1092. https://doi.org/10.1016/j.brs.2018.05.006

Grasp-specific motor resonance is influenced by the visibility of the observed actor.
Bunday, K.L., Lemon, R.N., Kilner, J.M., Davare, M. and Orban, G.A. 2016. Grasp-specific motor resonance is influenced by the visibility of the observed actor. Cortex. 84, pp. 43-54. https://doi.org/10.1016/j.cortex.2016.09.002

A Causal Role for Primary Motor Cortex in Perception of Observed Actions.
Palmer, C.E., Bunday, K.L., Davare, M. and Kilner, J.M. 2016. A Causal Role for Primary Motor Cortex in Perception of Observed Actions. Journal of Cognitive Neuroscience. 28 (12), pp. 2021-2029. https://doi.org/10.1162/jocn_a_01015

Locomotor adaptation is modulated by observing the actions of others
Patel, M., Roberts, R.E, Risyaz, M.U., Buckwell, D., Bunday, K.L., Ahmad, H., Kaski, D., Arshad, Q. and Bronstein, A.M. 2015. Locomotor adaptation is modulated by observing the actions of others. Journal of Neurophysiology. 114 (3), pp. 1538-1544. https://doi.org/10.1152/jn.00446.2015

Subcortical control of precision grip after human spinal cord injury.
Bunday, K.L., Tazoe, T., Rothwell, J.C. and Perez, M.A. 2014. Subcortical control of precision grip after human spinal cord injury. Journal of Neuroscience. 21 (34), p. 7341–7350. https://doi.org/10.1523/jneurosci.0390-14.2014

Selective effects of baclofen on use-dependent modulation of GABAB inhibition after tetraplegia
Barry, M.D., Bunday, K.L., Chen, R. and Perez, M.A. 2013. Selective effects of baclofen on use-dependent modulation of GABAB inhibition after tetraplegia. Journal of Neuroscience. 33 (31), pp. 12898-12907. https://doi.org/10.1523/jneurosci.1552-13.2013

Aberrant crossed corticospinal facilitation in muscles distant from a spinal cord injury.
Bunday, K.L., Oudega, M. and Perez, M.A. 2013. Aberrant crossed corticospinal facilitation in muscles distant from a spinal cord injury. PLoS ONE. 8 (10) e76747. https://doi.org/10.1371/journal.pone.0076747

Motor recovery after spinal cord injury enhanced by strengthening corticospinal synaptic transmission.
Bunday, K.L. and Perez, M.A. 2012. Motor recovery after spinal cord injury enhanced by strengthening corticospinal synaptic transmission. Current Biology. 22 (24), pp. P2355-2361. https://doi.org/10.1016/j.cub.2012.10.046

What does autonomic arousal tell us about locomotor learning?
Green, D.A., Bunday, K.L., Bowen, J., Carter, T. and Bronstein, A.M. 2010. What does autonomic arousal tell us about locomotor learning? Neuroscience. 170 (1), pp. 42-53. https://doi.org/10.1016/j.neuroscience.2010.06.079

What the "broken escalator" phenomenon teaches us about balance.
Bronstein, A.M., Bunday, K.L. and Reynolds, R. 2009. What the "broken escalator" phenomenon teaches us about balance. Annals of the New York Academy of Sciences. 1164 (1), pp. 82-88. https://doi.org/10.1111/j.1749-6632.2009.03870.x

Locomotor adaptation and aftereffects in patients with reduced somatosensory input due to peripheral neuropathy.
Bunday, K.L. and Bronstein, A.M. 2009. Locomotor adaptation and aftereffects in patients with reduced somatosensory input due to peripheral neuropathy. Journal of Neurophysiology. 102 (6), pp. 3119-3128. https://doi.org/10.1152/jn.00304.2009

Visuo-vestibular influences on the moving platform locomotor aftereffect.
Bunday, K.L. and Bronstein, A.M. 2008. Visuo-vestibular influences on the moving platform locomotor aftereffect. Journal of Neurophysiology. 99 (3), pp. 1354-1365. https://doi.org/10.1152/jn.01214.2007

The effect of trial number on the emergence of the 'broken escalator' locomotor aftereffect.
Bunday, K.L., Reynolds, R.F., Kaski, D., Rao, M., Salman, S. and Bronstein, A.M. 2006. The effect of trial number on the emergence of the 'broken escalator' locomotor aftereffect. Experimental Brain Research. https://doi.org/10.1007/s00221-006-0446-2

Permalink - https://westminsterresearch.westminster.ac.uk/item/v92q1/impaired-crossed-facilitation-of-the-corticospinal-pathway-after-cervical-spinal-cord-injury


Share this

Usage statistics

60 total views
0 total downloads
These values cover views and downloads from WestminsterResearch and are for the period from September 2nd 2018, when this repository was created.