Dissociated cerebellar contributions to feedforward gait adaptation

Bunday, Karen L., Ellmers, T., Wimalaratna, M. Rashmi, Nadarajah, Luxme and Bronstein, Adolfo M. 2024. Dissociated cerebellar contributions to feedforward gait adaptation. Experimental Brain Research. 242, pp. 1583-1593. https://doi.org/10.1007/s00221-024-06840-9

TitleDissociated cerebellar contributions to feedforward gait adaptation
TypeJournal article
AuthorsBunday, Karen L., Ellmers, T., Wimalaratna, M. Rashmi, Nadarajah, Luxme and Bronstein, Adolfo M.
AbstractThe cerebellum is important for motor adaptation. Lesions to the vestibulo-cerebellum selectively cause gait ataxia. Here we investigate how such damage affects locomotor adaptation when performing the 'broken escalator' paradigm. Following an auditory cue, participants were required to step from the fixed surface onto a moving platform (akin to an airport travellator). The experiment included three conditions: 10 stationary (BEFORE), 15 moving (MOVING) and 10 stationary (AFTER) trials. We assessed both behavioural (gait approach velocity and trunk sway after stepping onto the moving platform) and neuromuscular outcomes (lower leg muscle activity, EMG). Unlike controls, cerebellar patients showed reduced after-effects (AFTER trials) with respect to gait approach velocity and leg EMG activity. However, patients with cerebellar damage maintain the ability to learn the trunk movement required to maximise stability after stepping onto the moving platform (i.e., reactive postural behaviours). Importantly, our findings reveal that these patients could even initiate these behaviours in a feedforward manner, leading to an after-effect. These findings reveal that the cerebellum is crucial for feedforward locomotor control, but that adaptive locomotor behaviours learned via feedback (i.e., reactive) mechanisms may be preserved following cerebellum damage. [Abstract copyright: © 2024. The Author(s).]
KeywordsGait
Locomotion
After-effect
Cerebellum
Cerebellar
Adaptation
Downbeat nystagmus
Ataxia
JournalExperimental Brain Research
Journal citation242, pp. 1583-1593
ISSN1432-1106
Year2024
PublisherSpringer Nature
Publisher's version
License
CC BY 4.0
File Access Level
Open (open metadata and files)
Digital Object Identifier (DOI)https://doi.org/10.1007/s00221-024-06840-9
PubMed ID38760469
Publication dates
Published online17 May 2024
Project100229/Z/12/Z
MRC
FunderWellcome Trust
MRC

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