Pathogenicity of Misfolded and Dimeric HLA-B27 Molecules

Antoniou, A.N., Lenart, I. and Guiliano, D.B. 2011. Pathogenicity of Misfolded and Dimeric HLA-B27 Molecules. International Journal of Rheumatology. 2011 Article ID 486856. https://doi.org/10.1155/2011/486856

TitlePathogenicity of Misfolded and Dimeric HLA-B27 Molecules
TypeJournal article
AuthorsAntoniou, A.N., Lenart, I. and Guiliano, D.B.
Abstract

The association between HLA-B27 and the group of autoimmune inflammatory arthritic diseases, the spondyloarthropathies (SpAs) which include ankylosing spondylitis (AS) and Reactive Arthritis (ReA), has been well established and remains the strongest association between any HLA molecule and autoimmune disease. The mechanism behind this striking association remains elusive; however animal model and biochemical data suggest that HLA-B27 misfolding may be key to understanding its association with the SpAs. Recent investigations have focused on the unusual biochemical structures of HLA-B27 and their potential role in SpA pathogenesis. Here we discuss how these unusual biochemical structures may participate in cellular events leading to chronic inflammation and thus disease progression.

Article numberArticle ID 486856
JournalInternational Journal of Rheumatology
Journal citation2011
ISSN1687-9260
1687-9279
Year2011
PublisherHindawi
Publisher's version
License
CC BY 3.0
File Access Level
Open (open metadata and files)
Digital Object Identifier (DOI)https://doi.org/10.1155/2011/486856
Web address (URL)http://dx.doi.org/10.1155/2011/486856
Publication dates
Published30 Mar 2011

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