Cancer

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Heparan sulfates are critical regulators of the inhibitory megakaryocyte-platelet receptor G6b-B

Journal article

Vögtle, T., Sharma, S., Mori, J., Nagy, Z., Semeniak, D., Scandola, C., Geer, M., Smith, C., Lane, J., Pollack, S., Lassila, R., Jouppila, A., Barr, A.J., Ogg, D., Howard, T., McMiken, H., Warwicker, J., Geh, C., Rowlinson, R., Abbott, W., Eckly, A., Schulze, H., Wright, G., Mazharian, A., Fütterer, K., Rajesh, S., Douglas, M. and Senis, Y. 2019. Heparan sulfates are critical regulators of the inhibitory megakaryocyte-platelet receptor G6b-B. eLife. 2019;8 (e46840). doi:10.7554/eLife.46840

Machine Learning Classification of Females Susceptibility to Visceral Fat Associated Diseases

Conference paper

Aldraimli, M., Soria, D., Parkinson, J., Whitcher, B., Thomas, E.L., Bell, J.D., Chaussalet, T.J. and Dwek, M. 2019. Machine Learning Classification of Females Susceptibility to Visceral Fat Associated Diseases. The 15th Mediterranean Conference on Medical and Biological Engineering and Computing. Coimbra, Portugal 26 - 28 Sep 2019 Springer.

JoVE Methods Collection Highlights: Protein-Protein Interactions

Journal article

Barr, A.J. and Overduin, M. 2019. JoVE Methods Collection Highlights: Protein-Protein Interactions. Journal of Visualized Experiments. 148, p. e59816. doi:10.3791/59816

Intact Sample Analysis

Book chapter

Warford, A. and Volpi, E. 2019. Intact Sample Analysis. in: Warford, A. and Presneau, Nadège (ed.) Molecular Diagnostics Oxford University Press.

Quantitative analysis of Human Endogenous Retrovirus-K transcripts in postmortem premotor cortex fails to confirm elevated expression of HERV-K RNA in amyotrophic lateral sclerosis

Journal article

Garson, J.A., Usher, L., Al-Chalabi, A., Huggett, J., Day, E.F. and McCormick, A.L. 2019. Quantitative analysis of Human Endogenous Retrovirus-K transcripts in postmortem premotor cortex fails to confirm elevated expression of HERV-K RNA in amyotrophic lateral sclerosis. Acta Neuropathologica Communications. 7 (45). doi:10.1186/s40478-019-0698-2

Genome-wide association and transcriptome studies identify target genes and risk loci for breast cancer

Journal article

Dwek, M. and Presneau, Nadège 2019. Genome-wide association and transcriptome studies identify target genes and risk loci for breast cancer. Nature Communications . doi:10.1038/s41467-018-08053-5

Polygenic Risk Scores for Prediction of Breast Cancer and Breast Cancer Subtypes

Journal article

Dwek, M. and Presneau, Nadège 2019. Polygenic Risk Scores for Prediction of Breast Cancer and Breast Cancer Subtypes. American Journal of Human Genetics. 104 (1), pp. 21-34. doi:10.1016/j.ajhg.2018.11.002

Serum IgA1 shows increased levels of a2,6-linked sialic acid in breast cancer

Journal article

Lomax-Browne, H.J., Robertson, C.E., Antonopoulos, A., Leathem, A.J.C., Haslam, S.M., Dell, A. and Dwek, M. 2019. Serum IgA1 shows increased levels of a2,6-linked sialic acid in breast cancer. Interface Focus. 9 (2), p. 20180079. doi:10.1098/rsfs.2018.0079

Genome-wide association and transcriptome studies identify target genes and risk loci for breast cancer

Journal article

Dwek, M. 2019. Genome-wide association and transcriptome studies identify target genes and risk loci for breast cancer. Nature Communications . 10, p. 1741. doi:10.1038/s41467-018-08053-5

Shared heritability and functional enrichment across six solid cancers

Journal article

Dwek, M. 2019. Shared heritability and functional enrichment across six solid cancers. Nature Communications . 10, p. Article number: 431. doi:10.1038/s41467-018-08054-4

Associations of obesity and circulating insulin and glucose with breast cancer risk: a Mendelian randomization analysis

Journal article

Dwek, M. 2019. Associations of obesity and circulating insulin and glucose with breast cancer risk: a Mendelian randomization analysis . International Journal of Epidemiology. 48 (3), pp. 795-806. doi:10.1093/ije/dyy201

Melanocortin‐3 receptor responseis influenced by the melanocortin receptoraccessory protein‐1

Conference item

Berruien, N., Le Tissier, P., Murray, J.F. and Smith, C.L. 2018. Melanocortin‐3 receptor responseis influenced by the melanocortin receptoraccessory protein‐1. Pharmacology 2018. Queen Elizabeth II conference centre London 18 - 20 Dec 2018 Wiley-Blackwell. doi:10.1111/bph.14681

Acquired DNA damage in adolescent obesity – a promoter and predictor of cancer?

Conference poster

Usman, M. and Volpi, E. 2018. Acquired DNA damage in adolescent obesity – a promoter and predictor of cancer? European Association for Cancer Research 25th Congress. Amsterdam 01 Jul 2018 European Society for Medical Oncology (ESMO). doi:10.1136/esmoopen-2018-EACR25.63

A transcriptome-wide association study of 229,000 women identifies new candidate susceptibility genes for breast cancer

Article

Dwek, M. 2018. A transcriptome-wide association study of 229,000 women identifies new candidate susceptibility genes for breast cancer. Nature Genetics. doi:10.1038/s41588-018-0132-x

Glycosylation and Disease

Article

Dwek, M. and Markiv, A. 2018. Glycosylation and Disease. eLS. doi:10.1002/9780470015902.a0002151.pub3

Targeting Receptor-Type Protein Tyrosine Phosphatases with Biotherapeutics: Is Outside-in Better than Inside-Out?

Article

Senis, Y. A. and Barr, A.J. 2018. Targeting Receptor-Type Protein Tyrosine Phosphatases with Biotherapeutics: Is Outside-in Better than Inside-Out? Molecules. 23 (3), pp. 569-585. doi:10.3390/molecules23030569

Prostate-specific PTen deletion in mice activates inflammatory microRNA expression pathways in the epithelium early in hyperplasia development

Article

Dart, D.A., Uysal Onganer, P. and Jiang, W.G. 2017. Prostate-specific PTen deletion in mice activates inflammatory microRNA expression pathways in the epithelium early in hyperplasia development. Oncogenesis. 14 (6), p. 400. doi:10.1038/s41389-017-0007-5

Evaluation of oxidative DNA damage, genome instability and accelerated genomic ageing in childhood obesity

Conference poster

Usman, M. and Volpi, E. 2017. Evaluation of oxidative DNA damage, genome instability and accelerated genomic ageing in childhood obesity. The Human Genome in Healthcare - The Genetics Society. The Royal Society 23 - 24 Nov 2017

In situ hybridization: key concepts and applications

Book chapter

Warford, A. and Volpi, E. 2017. In situ hybridization: key concepts and applications. in: Orchard, G.R. and Nation, B. (ed.) Histopathology Oxford Oxford University Press. pp. 298-317

Identification of ten variants associated with risk of estrogen-receptor-negative breast cancer

Article

Dwek, M. and Presneau, Nadège 2017. Identification of ten variants associated with risk of estrogen-receptor-negative breast cancer. Nature Genetics. 49, pp. 1767-1778. doi:10.1038/ng.3785

Association analysis identifies 65 new breast cancer risk loci

Article

Dwek, M. and Presneau, Nadège 2017. Association analysis identifies 65 new breast cancer risk loci. Nature. doi:10.1038/nature24284

Fluorescence in situ Hybridization (FISH): challenges and opportunities in the post-genomic era

Conference paper

Volpi, E. 2017. Fluorescence in situ Hybridization (FISH): challenges and opportunities in the post-genomic era. Applications of in situ hybridisation in research and disease. Cancer Research UK Cambridge Institute, Cambridge 17 - 18 May 2017

Whole genome analysis of a schistosomiasis-transmitting freshwater snail

Article

Adema, C.M., Hillier, L.W., Jones, C.S., Loker, E.S., Knight, M., Minx, P., Oliveira, G., Raghavan, N., Shedlock, A., Rodrigues do Amaral, L., Arican-Goktas, H.D., Assis, A.G., Baba, E.H., Baron, O.L., Bayne, C.J., Bickham-Wright, U., Biggar, K.K., Blouin, M., Bonning, B.C., Botka, C., Bridger, J.M., Buckley, K.M., Buddenborg, S.K., Caldeira, R.L., Carleton, J., Carvalho, O.S., Castillo, M.G., Chalmers, I.W., Christensens, M., Clifton, S., Cosseau, C., Coustau, C., Cripps, R.M., Cuesta-Astroz, Y., Cummins, S.F., di Stephano, L., Dinguirard, N., Duval, D., Emrich, S., Feschotte, C., Feyereisen, R., FitzGerald, P., Fronick, C., Fulton, L., Galinier, R., Gave, S.G., Geusz, M., Geyer, K.K., Giraldo-Calderón, G.I., Gomes, M.D.S., Gordy, M.A., Gourbal, B., Grunau, C., Hanington, P.C., Hoffmann, K.F., Hughes, D., Humphries, J., Jackson, D.J., Jannotti-Passos, L.K., Jeremias, W.D.J., Jobling, S., Kamel, B., Kapusta, A., Kaur, S., Koene, J.M., Kohn, A.B., Lawson, D., Lawton, S.P., Liang, D., Limpanont, Y., Liu, S., Lockyer, A.E., Lovato, T.L., Ludolf, F., Magrini, V., McManus, D.P., Medina, M., Misra, M., Mitta, G., Mkoji, G.M., Montague, M.J., Montelongo, C., Moroz, L.L., Munoz-Torres, M.C., Niazi, U., Noble, L.R., Oliveira,, F.S., Pais, F.B., Papenfuss, A.T., Peace, R., Pena, J.J., Pila, E.A., Quelais, T., Raney, B.J., Rast, J.P., Rollinson, D., Rosse, I.C., Rotgans, B., Routledge, E.J., Ryan, K.M., Scholte, L.L.S., Storey, K.B., Swain, M., Tennessen, J.A., Tomlinson, C., Trujillo, D.L., Volpi, E., Walker, A.J., Wang, T., Wannaporn, I., Warren, W.C., Wu, X.J., Yoshino, T.P., Yusuf, M., Zhang, S.M., Zhao, M. and Wilson, R.K. 2017. Whole genome analysis of a schistosomiasis-transmitting freshwater snail. Nature Communications. 8, p. 15451. doi:10.1038/ncomms15451

Cellular glycosylation affects Herceptin binding and sensitivity of breast cancer cells to doxorubicin and growth factors

Article

Peiris, D., Spector, A.F., Lomax-Browne, H., Azimi, T., Ramesh, B., Loizidou, M., Welch, H. and Dwek, M. 2017. Cellular glycosylation affects Herceptin binding and sensitivity of breast cancer cells to doxorubicin and growth factors. Scientific Reports. 7, p. Article number: 43006. doi:10.1038/srep43006

Genome instability in childhood obesity: A conceptual framework for an assessment, intervention and monitoring programme of inflammation and DNA damage in paediatric obesity

Article

Usman, M., Tewfik, I. and Volpi, E. 2017. Genome instability in childhood obesity: A conceptual framework for an assessment, intervention and monitoring programme of inflammation and DNA damage in paediatric obesity. International Journal of Food, Nutrition and Public Health. 9 (1), pp. 1-12.

Formamide-free Fluorescence in situ Hybridization (FISH)

Book chapter

Volpi, E. 2017. Formamide-free Fluorescence in situ Hybridization (FISH). in: Liehr, T. (ed.) Fluorescence in situ Hybridization (FISH) - Application Guide Berlin Springer.

The interaction of Wnt-11 and signalling cascades in prostate cancer

Article

Koushyar, S., Grant, G.H. and Uysal Onganer, P. 2016. The interaction of Wnt-11 and signalling cascades in prostate cancer. Tumor Biology. 37 (10), pp. 13049-13057. doi:10.1007/s13277-016-5263-z

Cadherin-5: a biomarker for metastatic breast cancer with optimum efficacy in oestrogen receptor-positive breast cancers with vascular invasion

Article

Fry, S., Robertson, C.E., Swann, R. and Dwek, M. 2016. Cadherin-5: a biomarker for metastatic breast cancer with optimum efficacy in oestrogen receptor-positive breast cancers with vascular invasion. British Journal of Cancer. 114, pp. 1019-1026. doi:10.1038/bjc.2016.66

Efficacy of DOPE/DC-cholesterol liposomes and GCPQ micelles as AZD6244 nanocarriers in a 3D colorectal cancer in vitro model

Article

López-Dávila, V., Magdeldin, T., Welch, H., Dwek, M., Uchegbu, I. and Loizidou, M. 2016. Efficacy of DOPE/DC-cholesterol liposomes and GCPQ micelles as AZD6244 nanocarriers in a 3D colorectal cancer in vitro model. Nanomedicine. 11 (4), pp. 331-344. doi:10.2217/nnm.15.206

Language impairment in a case of a complex chromosomal rearrangement with a breakpoint downstream of FOXP2

Article

Moralli, D., Nudel, R., Chan, M.T.M., Green, C.M., Volpi, E., Benítez-Burraco, A., Newbury, D.F. and García-Bellido, P. 2015. Language impairment in a case of a complex chromosomal rearrangement with a breakpoint downstream of FOXP2 . Molecular Cytogenetics. 8 (36). doi:10.1186/s13039-015-0148-1

Antibody validation of immunohistochemistry for biomarker discovery: Recommendations of a consortium of academic and pharmaceutical based histopathology researchers

Article

Howat, W.J., Lewis, A., Jones, P., Kampf, C., Pontén, F., F, van der Loos, C.M., Gray, N., Womack, C. and Warford, A. 2014. Antibody validation of immunohistochemistry for biomarker discovery: Recommendations of a consortium of academic and pharmaceutical based histopathology researchers. Methods. 70 (1), pp. 34-38. doi:10.1016/j.ymeth.2014.01.018

Antigen retrieval, blocking, detection and visualisation systems in immunohistochemistry: A review and practical evaluation of tyramide and rolling circle amplification systems.

Article

Warford, A., Akbar, H. and Riberio, D. 2014. Antigen retrieval, blocking, detection and visualisation systems in immunohistochemistry: A review and practical evaluation of tyramide and rolling circle amplification systems. Methods. 70 (1), p. 28–33. doi:10.1016/j.ymeth.2014.03.001


People

Barr, Alastair

Senior Lecturer


Presneau, Nadege

Senior Lecturer


Robertson, Claire

Senior Lecturer


Uysal Onganer, Pinar

Senior Lecturer