Skip to content Outputs by Type Journal article
2024
Loose Coupling between the Voltage Sensor and the Activation Gate in Mammalian HCN Channels Suggests a Gating Mechanism Wu, X, Cunningham, K.P., Bruening-Wright, A, Pandey, S and Larsson, H. P. 2024. Loose Coupling between the Voltage Sensor and the Activation Gate in Mammalian HCN Channels Suggests a Gating Mechanism. International Journal of Molecular Sciences. 25 (8) 4309. https://doi.org/10.3390/ijms25084309
2023
Similar voltage-sensor movement in spHCN channels can cause closing, opening, or inactivation Xiaoan Wu, Kevin P. Cunningham, Rosamary Ramentol, Marta E. Perez and H. Peter Larsson 2023. Similar voltage-sensor movement in spHCN channels can cause closing, opening, or inactivation. Journal of General Physiology. 155 (5) e202213170. https://doi.org/10.1085/jgp.202213170
2021
The Prostacyclin Analogue, Treprostinil, Used in the Treatment of Pulmonary Arterial Hypertension, is a Potent Antagonist of TREK-1 and TREK-2 Potassium Channels Cunningham, K., Clapp. L.H., Mathie, A. and Veale, E.L. 2021. The Prostacyclin Analogue, Treprostinil, Used in the Treatment of Pulmonary Arterial Hypertension, is a Potent Antagonist of TREK-1 and TREK-2 Potassium Channels. Frontiers in Pharmacology. 12 705421. https://doi.org/10.3389/fphar.2021.705421
2021
Two-Pore Domain Potassium Channels as Drug Targets: Anesthesia and Beyond. Mathie, A., Veale, E.L., Cunningham, K.P., Holden, R.G. and Wright, P.D. 2021. Two-Pore Domain Potassium Channels as Drug Targets: Anesthesia and Beyond. Annual Review of Pharmacology and Toxicology. 61, pp. 401-420. https://doi.org/10.1146/annurev-pharmtox-030920-111536
2020
Effects of the ventilatory stimulant, doxapram on human TASK‐3 (KCNK9, K2P9.1) channels and TASK‐1 (KCNK3, K2P3.1) channels Kevin P. Cunningham, D. Euan MacIntyre, Alistair Mathie and Emma L. Veale 2020. Effects of the ventilatory stimulant, doxapram on human TASK‐3 (KCNK9, K2P9.1) channels and TASK‐1 (KCNK3, K2P3.1) channels. Acta Physiologica. 228 (2) e13361. https://doi.org/10.1111/apha.13361
2019
Characterization and regulation of wild‐type and mutant TASK‐1 two pore domain potassium channels indicated in pulmonary arterial hypertension Cunningham, K.P., Holden, R.G., Escribano‐Subias, P.M., Cogolludo, A., Veale, E.L. and Mathie, A. 2019. Characterization and regulation of wild‐type and mutant TASK‐1 two pore domain potassium channels indicated in pulmonary arterial hypertension. Journal of Physiology. 597 (4), pp. 1087-1101. https://doi.org/10.1113/jp277275 Other
2024
Preprint: Loose Coupling between the Voltage Sensor and the Activation Gate in Mammalian HCN Channels Suggests a Gating Mechanism Xiaoan Wu, Kevin P. Cunningham, Andrew Bruening-Wright, Shilpi Pandey and H. Peter Larsson 2024. Preprint: Loose Coupling between the Voltage Sensor and the Activation Gate in Mammalian HCN Channels Suggests a Gating Mechanism. Preprints.org. https://doi.org/10.20944/preprints202403.0499.v1
2024
Preprint: Binding of PUFA stabilizes a conductive state of the selectivity filter in IKs channels Alessia Golluscio, Jodene Eldstrom, Jessica J. Jowais, Marta E. Perez-Rodriguez, Kevin P. Cunningham, Alicia de la Cruz, Xiaoan Wu, David Fedida and H. Peter Larsson 2024. Preprint: Binding of PUFA stabilizes a conductive state of the selectivity filter in IKs channels. arXiv. https://doi.org/10.1101/2024.01.11.575247
2022
Preprint: Artemisinin inhibits innate immune cell chemotaxis, cytokine production and NET release Morad, H., Luqman, S., Pinto, L., Cunningham, K.P., Vilar, B., Clayton, G., Shankar-Hari, M. and McNaughton, P.A. 2022. Preprint: Artemisinin inhibits innate immune cell chemotaxis, cytokine production and NET release. https://doi.org/10.21203/rs.3.rs-1335980/v1