Title | Human monoclonal antibodies that neutralize anthrax toxin by inhibiting heptamer assembly |
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Authors | Wang, F., Ruther, P., Jiang, I., Sawada-Hirai, R., Sun, S.M., Nedellec, R., Morrow, P.R. and Kang, A.S. |
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Abstract | A panel of human anti-anthrax protective antigen IgG1 monoclonal antibodies were evaluated to determine the mechanism of toxin neutralization. AVP-22G12, AVP-1C6 and AVP-21D9 bound to the protective antigen with picomolar affinities to distinct non-overlapping linear epitopes. Two of the antibodies neutralized the anthrax toxin by completely inhibiting the protective antigen oligomer assembly process in vitro. |
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Keywords | Human monoclonal antibodies, bacillus anthracis, protective antigen |
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Journal | Human Antibodies |
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Journal citation | 13 (4), pp. 105-110 |
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ISSN | 1093-2607 |
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Year | 2004 |
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Web address (URL) | http://iospress.metapress.com/openurl.asp?genre=article&issn=1093-2607&volume=13&issue=4&spage=105 |
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Publication dates |
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Published | 2004 |
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File | |
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