Pumped up: reflections on PfATP6 as the target for artemisinins

Characterisation of two snake toxin-targeting human monoclonal immunoglobulin G antibodies expressed in tobacco plants
Catherine M. Moore, Anne Ljungars, Matthew J. Paul, Camilla Holst Dahl, Shirin Ahmadi, Anna Christina Adams, Lise Marie Grav, Sanne Schoffelen, Bjørn Gunnar Voldborg, Andreas Hougaard Laustsen and Julian K-C Ma 2023. Characterisation of two snake toxin-targeting human monoclonal immunoglobulin G antibodies expressed in tobacco plants. Toxicon. 232 107225. https://doi.org/10.1016/j.toxicon.2023.107225

A Novel Microfluidic Dielectrophoresis Technology to Enable Rapid Diagnosis of Mycobacteria tuberculosis in Clinical Samples
Catherine M. Moore, Jasvir Dhillon, Rebecca Flynn, Krzysztof Gizynski, Candice Adams, George Morgan, David McGurk, Eduardo Boada, Shireen Shabestary, Jonathan Peat, Jonathan O'Halloran, Neil G. Stoker, Philip D. Butcher, Heather Murton and Moore, C. 2023. A Novel Microfluidic Dielectrophoresis Technology to Enable Rapid Diagnosis of Mycobacteria tuberculosis in Clinical Samples. Journal of Molecular Diagnostics. 25 (7), pp. 513-523. https://doi.org/10.1016/j.jmoldx.2023.04.005

An efficient and novel technology for the extraction of parasite genomic DNA from whole blood or culture
Clark, David J., Moore, Catherine M., Flanagan, Marc, Bocxlaer, Katrien Van, Piperaki, Evangelia-Theophano, Yardley, Vanessa, Croft, Simon L., Tyson, John, Whitehouse, Sam P., O'Halloran, Jonathan, Krishna, Sanjeev and Staines, Henry M. 2022. An efficient and novel technology for the extraction of parasite genomic DNA from whole blood or culture. BioTechniques. 68 (2), pp. 79-84. https://doi.org/10.2144/btn-2019-0086

Selective Inhibition of Plasmodium falciparum ATPase 6 by Artemisinins and Identification of New Classes of Inhibitors after Expression in Yeast
Moore, Catherine M., Wang, Jigang, Lin, Qingsong, Ferreira, Pedro, Avery, Mitchell A, Elokely, Khaled, Staines, Henry M and Krishna, Sanjeev 2022. Selective Inhibition of Plasmodium falciparum ATPase 6 by Artemisinins and Identification of New Classes of Inhibitors after Expression in Yeast. Antimicrobial Agents and Chemotherapy. 66 (5) e02079-21. https://doi.org/10.1128/aac.02079-21

IgG Seroconversion and Pathophysiology in Severe Acute Respiratory Syndrome Coronavirus 2 Infection
Staines, Henry M., Kirwan, Daniela E., Clark, David J., Adams, Emily R., Augustin, Yolanda, Byrne, Rachel L., Cocozza, Michael, Cubas-Atienzar, Ana I., Cuevas, Luis E., Cusinato, Martina, Davies, Benedict M.O., Davis, Mark, Davis, Paul, Duvoix, Annelyse, Eckersley, Nicholas M., Forton, Daniel, Fraser, Alice J., Garrod, Gala, Hadcocks, Linda, Hu, Qinxue, Johnson, Michael, Kay, Grant A, Klekotko, Kesja, Lewis, Zawditu, Macallan, Derek C., Mensah-Kane, Josephine, Menzies, Stefanie, Monahan, Irene, Moore, Catherine M., Nebe-von-Caron, Gerhard, Owen, Sophie I., Sainter, Chris, Sall, Amadou A., Schouten, James, Williams, Christopher T., Wilkins, John, Woolston, Kevin, Fitchett, Joseph R.A., Krishna, Sanjeev and Planche, Tim 2021. IgG Seroconversion and Pathophysiology in Severe Acute Respiratory Syndrome Coronavirus 2 Infection. Emerging Infectious Diseases. 27 (1), pp. 85-91. https://doi.org/10.3201/eid2701.203074

Characterisation of a highly potent and near pan-neutralising anti-HIV monoclonal antibody expressed in tobacco plants
Moore, Catherine M., Grandits, Melanie, Grünwald-Gruber, Clemens, Altmann, Friedrich, Kotouckova, Maria, Teh, Audrey Y-H and Ma, Julian K-C 2021. Characterisation of a highly potent and near pan-neutralising anti-HIV monoclonal antibody expressed in tobacco plants. Retrovirology. 18 17. https://doi.org/10.1186/s12977-021-00560-6

Preprint: Selective inhibition of PfATP6 by artemisinins and identification of new classes of inhibitors after expression in yeast
Catherine M. Moore, Jigang Wang, Qingsong Lin, Pedro Ferreira, Mitchell A. Avery, Khaled Elokely, Henry M. Staines and Sanjeev Krishna 2021. Preprint: Selective inhibition of PfATP6 by artemisinins and identification of new classes of inhibitors after expression in yeast. biorxiv.org. https://doi.org/10.1101/2021.10.27.466210

Preprint: Rapid development of COVID-19 rapid diagnostics for low resource settings: accelerating delivery through transparency, responsiveness, and open collaboration
Adams, Emily, Augustin, Yolanda, Byrne, Rachel, Clark, David, Cocozza, Michael, Cubas-Atienzar, Ana, Cuevas, Luis, Cusinato, Martina, Davies, Benedict, Davis, Mark, Davis, Paul, Duvoix, Annelyse, Eckersley, Nicholas, Edwards, Thomas, Fletcher, Tom, Fraser, Alice, Garrod, Gala, Hadcocks, Linda, Hu, Qinxue, Johnson, Michael, Kay, Grant, Keymer, Katherine, Kirwan, Daniela, Klekotko, Kesja, Lewis, Zawditu, Mason, Jenifer, Mensah-Kane, Josie, Menzies, Stefanie, Monahan, Irene, Moore, Catherine, Nebe-von-Caron, Gerhard, Owen, Sophie, Planche, Tim, Sainter, Chris, Schouten, James, Staines, Henry, Turtle, Lance, Williams, Chris, Wilkins, John, Woolston, Kevin, Sall, Amadou Alpha, Fitchett, Joseph and Krishna, Sanjeev 2020. Preprint: Rapid development of COVID-19 rapid diagnostics for low resource settings: accelerating delivery through transparency, responsiveness, and open collaboration. medRxiv. https://doi.org/10.1101/2020.04.29.20082099

Preprint: Dynamics of IgG seroconversion and pathophysiology of COVID-19 infections
Staines, Henry, Kirwan, Daniela, Clark, David, Adams, Emily, Augustin, Yolanda, Byrne, Rachel, Cocozza, Michael, Cubas-Atienzar, Ana, Cuevas, Luis, Cusinato, Martina, Davies, Benedict, Davis, Mark, Davis, Paul, Duvoix, Annelyse, Eckersley, Nicholas, Forton, Daniel, Fraser, Alice, Garrod, Gala, Hadcocks, Linda, Hu, Qinxue, Johnson, Michael, Kay, Grant, Klekotko, Kesja, Lewis, Zawditu, Macallan, Derek, Mensah-Kane, Josephine, Menzies, Stefanie, Monahan, Irene, Moore, Catherine, Nebe-von-Caron, Gerhard, Owen, Sophie, Sainter, Chris, Sall, Amadou, Schouten, James, Williams, Chris, Wilkins, John, Woolston, Kevin, Fitchett, Joseph, Krishna, Sanjeev and Planche, Tim 2020. Preprint: Dynamics of IgG seroconversion and pathophysiology of COVID-19 infections. medRxiv. https://doi.org/10.1101/2020.06.07.20124636

Preprint: Characterisation of a Highly Potent and Near Pan-Neutralising Anti-HIV Monoclonal Antibody Expressed in Tobacco Plants
Catherine Margaret Moore, Melanie Grandits, Clemens Grünwald-Gruber, Friedrich Altmann, Maria Kotouckova, Audrey Y.H. Teh and Julian K.C. Ma 2020. Preprint: Characterisation of a Highly Potent and Near Pan-Neutralising Anti-HIV Monoclonal Antibody Expressed in Tobacco Plants. Research Square. https://doi.org/10.21203/rs.3.rs-104508/v1

LGR5 receptor promotes cell-cell adhesion in stem cells and colon cancer cells via the IQGAP1-Rac1 pathway
Carmon, Kendra S, Gong, Xing, Yi, Jing, Wu, Ling, Thomas, Anthony, Moore, Catherine M., Masuho, Ikuo, Timson, David J, Martemyanov, Kirill A and Liu, Qingyun J 2017. LGR5 receptor promotes cell-cell adhesion in stem cells and colon cancer cells via the IQGAP1-Rac1 pathway. The Journal of Biological Chemistry. 292 (36), pp. P14989-15001. https://doi.org/10.1074/jbc.m117.786798

Mutations in the Plasmodium falciparum chloroquine resistance transporter, PfCRT, enlarge the parasite's food vacuole and alter drug sensitivities
Pulcini, Serena, Staines, Henry M., Lee, Andrew H., Shafik, Sarah H., Bouyer, Guillaume, Moore, Catherine M., Daley, Daniel A., Hoke, Matthew J., Altenhofen, Lindsey M., Painter, Heather J., Mu, Jianbing, Ferguson, David J.P., Llinás, Manuel, Martin, Rowena E., Fidock, David A., Cooper, Roland A. and Krishna, Sanjeev 2015. Mutations in the Plasmodium falciparum chloroquine resistance transporter, PfCRT, enlarge the parasite's food vacuole and alter drug sensitivities. Scientific Reports. 5 14552. https://doi.org/10.1038/srep14552

Citrate synthase from the liver fluke Fasciola hepatica
Zinsser, Veronika L., Moore, Catherine M., Hoey, Elizabeth M., Trudgett, Alan and Timson, David J. 2013. Citrate synthase from the liver fluke Fasciola hepatica. Parasitology research. 112, pp. 2413-2417. https://doi.org/10.1007/s00436-013-3363-x

Differential expression of liver fluke β-tubulin isotypes at selected life cycle stages
Fuchs, Marc-Aurel, Ryan, Louise A., Chambers, Emma L., Moore, Catherine M., Fairweather, Ian, Trudgett, Alan, Timson, David J., Brennan, Gerry P. and Hoey, Elizabeth M. 2013. Differential expression of liver fluke β-tubulin isotypes at selected life cycle stages. International Journal for Parasitology. 43 (14), pp. 1133-1139. https://doi.org/10.1016/j.ijpara.2013.08.007

A novel calmodulin-like protein from the liver fluke, Fasciola hepatica
Russell, Sean L., McFerran, Neil V., Moore, Catherine M., Tsang, Yvonne, Glass, Peter, Hoey, Elizabeth M., Trudgett, Alan and Timson, David J. 2012. A novel calmodulin-like protein from the liver fluke, Fasciola hepatica. Biochimie . 94 (11), pp. 2398-2406. https://doi.org/10.1016/j.biochi.2012.06.015

A plasma membrane Ca(2+)-ATPase (PMCA) from the liver fluke, Fasciola hepatica
Moore, Catherine M., Hoey, Elizabeth M., Trudgett, Alan and Timson, David J. 2012. A plasma membrane Ca(2+)-ATPase (PMCA) from the liver fluke, Fasciola hepatica. International Journal for Parasitology. 42 (9), pp. 851-858. https://doi.org/10.1016/j.ijpara.2012.06.003

Artemisinins act through at least two targets in a yeast model
Moore, Catherine M., Hoey, Elizabeth M., Trudgett, Alan and Timson, David J. 2011. Artemisinins act through at least two targets in a yeast model. FEMS Yeast Research. 11 (2), pp. 233-237. https://doi.org/10.1111/j.1567-1364.2010.00706.x