IgG Seroconversion and Pathophysiology in Severe Acute Respiratory Syndrome Coronavirus 2 Infection

Staines, Henry M., Kirwan, Daniela E., Clark, David J., Adams, Emily R., Augustin, Yolanda, Byrne, Rachel L., Cocozza, Michael, Cubas-Atienzar, Ana I., Cuevas, Luis E., Cusinato, Martina, Davies, Benedict M.O., Davis, Mark, Davis, Paul, Duvoix, Annelyse, Eckersley, Nicholas M., Forton, Daniel, Fraser, Alice J., Garrod, Gala, Hadcocks, Linda, Hu, Qinxue, Johnson, Michael, Kay, Grant A, Klekotko, Kesja, Lewis, Zawditu, Macallan, Derek C., Mensah-Kane, Josephine, Menzies, Stefanie, Monahan, Irene, Moore, Catherine M., Nebe-von-Caron, Gerhard, Owen, Sophie I., Sainter, Chris, Sall, Amadou A., Schouten, James, Williams, Christopher T., Wilkins, John, Woolston, Kevin, Fitchett, Joseph R.A., Krishna, Sanjeev and Planche, Tim 2021. IgG Seroconversion and Pathophysiology in Severe Acute Respiratory Syndrome Coronavirus 2 Infection. Emerging Infectious Diseases. 27 (1), pp. 85-91. https://doi.org/10.3201/eid2701.203074

TitleIgG Seroconversion and Pathophysiology in Severe Acute Respiratory Syndrome Coronavirus 2 Infection
TypeJournal article
AuthorsStaines, Henry M., Kirwan, Daniela E., Clark, David J., Adams, Emily R., Augustin, Yolanda, Byrne, Rachel L., Cocozza, Michael, Cubas-Atienzar, Ana I., Cuevas, Luis E., Cusinato, Martina, Davies, Benedict M.O., Davis, Mark, Davis, Paul, Duvoix, Annelyse, Eckersley, Nicholas M., Forton, Daniel, Fraser, Alice J., Garrod, Gala, Hadcocks, Linda, Hu, Qinxue, Johnson, Michael, Kay, Grant A, Klekotko, Kesja, Lewis, Zawditu, Macallan, Derek C., Mensah-Kane, Josephine, Menzies, Stefanie, Monahan, Irene, Moore, Catherine M., Nebe-von-Caron, Gerhard, Owen, Sophie I., Sainter, Chris, Sall, Amadou A., Schouten, James, Williams, Christopher T., Wilkins, John, Woolston, Kevin, Fitchett, Joseph R.A., Krishna, Sanjeev and Planche, Tim
Abstract

We investigated the dynamics of seroconversion in severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection. During March 29–May 22, 2020, we collected serum samples and associated clinical data from 177 persons in London, UK, who had SARS-CoV-2 infection. We measured IgG against SARS-CoV-2 and compared antibody levels with patient outcomes, demographic information, and laboratory characteristics. We found that 2.0%–8.5% of persons did not seroconvert 3–6 weeks after infection. Persons who seroconverted were older, were more likely to have concurrent conditions, and had higher levels of inflammatory markers. Non-White persons had higher antibody concentrations than those who identified as White; these concentrations did not decline during follow-up. Serologic assay results correlated with disease outcome, race, and other risk factors for severe SARS-CoV-2 infection. Serologic assays can be used in surveillance to clarify the duration and protective nature of humoral responses to SARS-CoV-2 infection.

JournalEmerging Infectious Diseases
Journal citation27 (1), pp. 85-91
ISSN1080-6040
Year2021
PublisherCenters for Disease Control and Prevention
Digital Object Identifier (DOI)https://doi.org/10.3201/eid2701.203074
Web address (URL)https://europepmc.org/articles/PMC7774532
Publication dates
Published30 Nov 2020
Published in print2021

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