Preprint: Dynamics of IgG seroconversion and pathophysiology of COVID-19 infections

Staines, Henry, Kirwan, Daniela, Clark, David, Adams, Emily, Augustin, Yolanda, Byrne, Rachel, Cocozza, Michael, Cubas-Atienzar, Ana, Cuevas, Luis, Cusinato, Martina, Davies, Benedict, Davis, Mark, Davis, Paul, Duvoix, Annelyse, Eckersley, Nicholas, Forton, Daniel, Fraser, Alice, Garrod, Gala, Hadcocks, Linda, Hu, Qinxue, Johnson, Michael, Kay, Grant, Klekotko, Kesja, Lewis, Zawditu, Macallan, Derek, Mensah-Kane, Josephine, Menzies, Stefanie, Monahan, Irene, Moore, Catherine, Nebe-von-Caron, Gerhard, Owen, Sophie, Sainter, Chris, Sall, Amadou, Schouten, James, Williams, Chris, Wilkins, John, Woolston, Kevin, Fitchett, Joseph, Krishna, Sanjeev and Planche, Tim 2020. Preprint: Dynamics of IgG seroconversion and pathophysiology of COVID-19 infections. medRxiv. https://doi.org/10.1101/2020.06.07.20124636

TitlePreprint: Dynamics of IgG seroconversion and pathophysiology of COVID-19 infections
AuthorsStaines, Henry, Kirwan, Daniela, Clark, David, Adams, Emily, Augustin, Yolanda, Byrne, Rachel, Cocozza, Michael, Cubas-Atienzar, Ana, Cuevas, Luis, Cusinato, Martina, Davies, Benedict, Davis, Mark, Davis, Paul, Duvoix, Annelyse, Eckersley, Nicholas, Forton, Daniel, Fraser, Alice, Garrod, Gala, Hadcocks, Linda, Hu, Qinxue, Johnson, Michael, Kay, Grant, Klekotko, Kesja, Lewis, Zawditu, Macallan, Derek, Mensah-Kane, Josephine, Menzies, Stefanie, Monahan, Irene, Moore, Catherine, Nebe-von-Caron, Gerhard, Owen, Sophie, Sainter, Chris, Sall, Amadou, Schouten, James, Williams, Chris, Wilkins, John, Woolston, Kevin, Fitchett, Joseph, Krishna, Sanjeev and Planche, Tim
Description

We report dynamics of seroconversion to SARS-CoV-2 infections detected by IgG ELISA in 177 individuals diagnosed by RT-PCR. Longitudinal analysis identifies 2-8.5% of individuals who do not seroconvert even weeks after infection. They are younger than seroconverters who have increased co-morbidity and higher inflammatory markers such as C-Reactive Protein. Higher antibody responses are associated with non-white ethnicity. Antibody responses do not decline during follow up almost to 2 months. Serological assays increase understanding of disease severity. Their application in regular surveillance will clarify the duration and protective nature of humoral responses to SARS-CoV-2.

Year2020
Output mediaPreprint made available on MedRxiv
PublishermedRxiv
Publication dates
Published online09 Jun 2020
Digital Object Identifier (DOI)https://doi.org/10.1101/2020.06.07.20124636
Web address (URL)https://europepmc.org/article/PPR/PPR173356

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