Exploring diverse frontiers: Advancements of bioactive 4-aminoquinoline-based molecular hybrids in targeted therapeutics and beyond

Ravindar, L., Hasbullah, S.A., Rakesh, K.P., Raheem, S., Agustar, H.K., Ismail, N., Ling, L.Y. and Hassan, N.I. 2023. Exploring diverse frontiers: Advancements of bioactive 4-aminoquinoline-based molecular hybrids in targeted therapeutics and beyond. European Journal of Medicinal Chemistry. 264 116043. https://doi.org/10.1016/j.ejmech.2023.116043

TitleExploring diverse frontiers: Advancements of bioactive 4-aminoquinoline-based molecular hybrids in targeted therapeutics and beyond
TypeJournal article
AuthorsRavindar, L., Hasbullah, S.A., Rakesh, K.P., Raheem, S., Agustar, H.K., Ismail, N., Ling, L.Y. and Hassan, N.I.
Abstract

Amongst heterocyclic compounds, quinoline and its derivatives are advantaged scaffolds that appear as a significant assembly motif for developing new drug entities. Aminoquinoline moiety has gained significant attention among researchers in the 21stcentury. Considering the biological and pharmaceutical importance of aminoquinoline derivatives, herein, we review the recent developments (since 2019) in various biological activities of the 4-aminoquinoline scaffold hybridized with diverse heterocyclic moieties such as quinoline, pyridine, pyrimidine, triazine, dioxine, piperazine, pyrazoline, piperidine, imidazole, indole, oxadiazole, carbazole, dioxole, thiazole, benzothiazole, pyrazole, phthalimide, adamantane, benzochromene, and pyridinone. Moreover, by gaining knowledge about SARs, structural insights, and molecular targets, this review may help medicinal chemists design cost-effective, selective, safe, and more potent 4-aminoquinoline hybrids for diverse biological activities.

Article number116043
JournalEuropean Journal of Medicinal Chemistry
Journal citation264
ISSN0223-5234
Year2023
PublisherElsevier
Accepted author manuscript
License
CC BY-NC-ND 4.0
File Access Level
Open (open metadata and files)
Digital Object Identifier (DOI)https://doi.org/10.1016/j.ejmech.2023.116043
PubMed ID38118392
Web address (URL)https://www.sciencedirect.com/science/article/pii/S0223523423010103?via%3Dihub
Publication dates
Published online14 Dec 2023
ProjectChiral resolution and optimization of novel multi-stage active antimalarials that disrupt hemoglobin uptake and Na+ homeostasis in malaria parasites
FunderRoyal Society

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