|Title||Total synthesis of 3,5-O-dicaffeoylquinic acid and its derivatives|
|Authors||Raheem, S., Botting, Nigel P., Williamson, G. and Barron, D.|
We report the first total synthesis of 3,5-O-dicaffeoylquinic acid and its derivatives, 3,5-O-diferuloylqui- nic acid and 3,5-(3,4-dimethoxycinnamyl)quinic acid, in a nine-step sequence. The key step involves Knoevenagel condensations between vanillin, 3,4-dimethoxybenzaldehyde or 4-hydroxy-3-methoxy- benzaldehyde and the dimalonate ester of quinic acid.
|Keywords||Dicaffeoylquinic acids, Natural product synthesis, Knoevenagel condensation, Metabolism references, Plant natural products|
|Journal citation||52 (52), p. 7175|
|Digital Object Identifier (DOI)||https://doi.org/10.1016/j.tetlet.2011.10.127|
|Published online||28 Oct 2011|
|Published in print||28 Dec 2011|