Pharmaceutical development of a medicinal product containing an isocitrate lyase inhibitor

Preclinical safety and burn wound healing activity of “Novostron”, a novel topical iodine-based therapeutic
Ibragimova, N., Aitynova, A., Turganbay, S., Lyu, M., Ilin, A., Gapurkhaeva, T., Ponomareva, G., Vassilyeva, K., Issayeva, D., Azembayev, A., Mombekov, S., Rsaliyev, A., Sikhayeva, N., Abduraimov, Y. and Raheem, S. 2025. Preclinical safety and burn wound healing activity of “Novostron”, a novel topical iodine-based therapeutic. PLoS ONE. 20 (12) e0338837. https://doi.org/10.1371/journal.pone.0338837

Evaluation of the Therapeutic Efficacy of the Newly Formulated Drug “Novostron” as an Experimental Basis for Clinical Trials
Nailya Ibragimova, Aisulu Kabdraisova, Marina Lyu, Zhanar Iskakbayeva, Arkadiy Krasnoshtanov, Yuliya Tin, Sakhipov Yermek, Seitzhan Turganbay, Roza Karzhaubayeva, Aleksander Ivanovich Ilin, Amirkan Azembayev, Serzhan Mombekov and Saki Raheem 2025. Evaluation of the Therapeutic Efficacy of the Newly Formulated Drug “Novostron” as an Experimental Basis for Clinical Trials. ACS Omega. 10 (33), pp. 36946-36959. https://doi.org/10.1021/acsomega.4c11017

Novel 3-Aminoimidazole[1,2-α]Pyridine/Pyrazine Analogues: Synthesis and Biological Evaluation as Anticancer Agents
Al-Qadi, I, Hanania, M, Soliman, S.M, Hassan, N.I, Zaharim, W.N, Raheem, S. and Al-Maharik, N 2025. Novel 3-Aminoimidazole[1,2-α]Pyridine/Pyrazine Analogues: Synthesis and Biological Evaluation as Anticancer Agents. Journal of Molecular Structure. 1340 142549. https://doi.org/10.1016/j.molstruc.2025.142549

Result of reclamation of man-made dumps from phosphorite deposits in the semi-desert zone of Kazakhstan
Raheem, S. 2025. Result of reclamation of man-made dumps from phosphorite deposits in the semi-desert zone of Kazakhstan. PLoS ONE. 20 (2) e0317500. https://doi.org/10.1371/journal.pone.0317500

Synthesis and biological activities of 3-aminoimidazo[1,2-α]pyridine compounds
Isra Al-Qadi, Michel Hanania, Ismail Warad, Nisreen Al-Hajj, Rand Hazzam, Yousef Salama, Saki Raheem and Nawaf Al-Maharik 2025. Synthesis and biological activities of 3-aminoimidazo[1,2-α]pyridine compounds. BMC Chemistry. 19 (1) 48. https://doi.org/10.1186/s13065-025-01412-6

Combined Effect of Depressor Additive and Heat Treatment on the Rheological Properties of Highly Paraffinic Oils
Laura Boranbayeva, Galina Boiko, Alexander Didukh, Raushan Sarmurzina, Zhanserik Ilmaliyev, Nina Lubchenko, Assel Kozhamzharova, Serzhan Mombekov and Saki Raheem 2025. Combined Effect of Depressor Additive and Heat Treatment on the Rheological Properties of Highly Paraffinic Oils. ACS Omega. 10 (8), pp. 7783-7794. https://doi.org/10.1021/acsomega.4c08126

Synthesis, Molecular Docking and Heme Detoxification of Pyrano[2,3-c]pyrazole-aminoquinoline Hybrids as Potential Antimalarial Agents
Lekkala Ravindar, Ng Yan hong, Khairul Azreena Bakar, Ahmad Fadhlurrahman bin Ahmad hidayat, Shevin Rizal Feroz, Saki Raheem, Siti Aishah Hasbullah and Nurul Izzaty Hassan 2024. Synthesis, Molecular Docking and Heme Detoxification of Pyrano[2,3-c]pyrazole-aminoquinoline Hybrids as Potential Antimalarial Agents. Sains Malaysiana. 53 (8), pp. 1953-1968. https://doi.org/10.17576/jsm-2024-5308-18

Pyridine and Pyrimidine hybrids as privileged scaffolds in antimalarial drug discovery: A recent development
Lekkala Ravindar, Siti Aishah Hasbullah, K.P. Rakesh, Saki Raheem, Norzila Ismail, Lau Yee Ling and Nurul Izzaty Hassan 2024. Pyridine and Pyrimidine hybrids as privileged scaffolds in antimalarial drug discovery: A recent development. Bioorganic and Medicinal Chemistry Letters. 114 129992. https://doi.org/10.1016/j.bmcl.2024.129992

Food safety issues associated with sesame seed value chains: Current status and future perspectives
Anyogu, A., Somorin, Y., Oladipo, A.O. and Raheem, S. 2024. Food safety issues associated with sesame seed value chains: Current status and future perspectives. Heliyon. 10 (16) e36347. https://doi.org/10.1016/j.heliyon.2024.e36347

Prevalence of yaws and syphilis in the Ashanti region of Ghana and occurrence of H. ducreyi, herpes simplex virus 1 and herpes simplex virus 2 in skin lesions associated with treponematoses
Agyekum Boaitey, Y., Alex Owusu-Ofori,, Amarachukwu Anyogu, Farhang Aghakhanian, Natasha Arora, Jonathan B. Parr, Philipp P. Bosshard, Saki Raheem and Pascale Gerbault 2024. Prevalence of yaws and syphilis in the Ashanti region of Ghana and occurrence of H. ducreyi, herpes simplex virus 1 and herpes simplex virus 2 in skin lesions associated with treponematoses. PLoS ONE. 19 (5) e0295088. https://doi.org/10.1371/journal.pone.0295088

Exploring diverse frontiers: Advancements of bioactive 4-aminoquinoline-based molecular hybrids in targeted therapeutics and beyond
Ravindar, L., Hasbullah, S.A., Rakesh, K.P., Raheem, S., Agustar, H.K., Ismail, N., Ling, L.Y. and Hassan, N.I. 2023. Exploring diverse frontiers: Advancements of bioactive 4-aminoquinoline-based molecular hybrids in targeted therapeutics and beyond. European Journal of Medicinal Chemistry. 264 116043. https://doi.org/10.1016/j.ejmech.2023.116043

Fatty acid metabolism of Mycobacterium tuberculosis: a double-edged sword
Gaspar Quinonez, C., Lee, J.J., Lim, J., Odell, M., Lawson, C.P., Anyogu, A., Raheem, S. and Eoh, H. 2022. Fatty acid metabolism of Mycobacterium tuberculosis: a double-edged sword. mBio. 13 (1) e03559-21. https://doi.org/10.15698/mic2022.05.777

The Role of Fatty Acid Metabolism in Drug Tolerance of Mycobacterium tuberculosis
Gaspar Quinonez, C., Lee, J.J., Lim, J., Odell, M., Lawson, C.P., Anyogu, A., Raheem, S. and Eoh, H. 2022. The Role of Fatty Acid Metabolism in Drug Tolerance of Mycobacterium tuberculosis. mBio. 13 (1), pp. e03559-21. https://doi.org/10.1128/mbio.03559-21

Glutamate mediated metabolic neutralization mitigates propionate toxicity in intracellular Mycobacterium tuberculosis
Lee, J.J., Lim, J., Gao, S., Lawson, C.P., Odell, M., Raheem, S., Woo, J., Kang, S-H., Kang, S-S., Jeon, B-Y. and Eoh, H. 2018. Glutamate mediated metabolic neutralization mitigates propionate toxicity in intracellular Mycobacterium tuberculosis. Scientific Reports. 8 8506. https://doi.org/10.1038/s41598-018-26950-z

Signatures of anthocyanin metabolites identified in humans inhibit biomarkers of vascular inflammation in human endothelial cells
Warner, E.F., Smith, M.J., Zhang, Q., Raheem, S., O’Hagan, D., O'Connell, M.A. and Kay, C.D. 2017. Signatures of anthocyanin metabolites identified in humans inhibit biomarkers of vascular inflammation in human endothelial cells. Molecular Nutrition & Food Research. 61 (9) 1700053. https://doi.org/10.1002/mnfr.201700053

Influence of LAR and VAR on Para-Aminopyridine Antimalarials Targetting Haematin in Chloroquine-Resistance
Warhurst, D., Craig, J.C. and Raheem, S. 2016. Influence of LAR and VAR on Para-Aminopyridine Antimalarials Targetting Haematin in Chloroquine-Resistance. PLoS ONE. 11 (8) e0160091. https://doi.org/10.1371/journal.pone.0160091

Common Phenolic Metabolites of Flavonoids, but Not Their Unmetabolized Precursors, Reduce the Secretion of Vascular Cellular Adhesion Molecules by Human Endothelial Cells
Warner, E.F., Zhang, Q., Raheem, S., O’Hagan, D., O’Connell, M.A. and Kay, C.D. 2016. Common Phenolic Metabolites of Flavonoids, but Not Their Unmetabolized Precursors, Reduce the Secretion of Vascular Cellular Adhesion Molecules by Human Endothelial Cells. Journal of Nutrition. 146 (3), pp. 465-473. https://doi.org/10.3945/jn.115.217943

Effects of Fluconazole on the Metabolomic Profile of Candida albicans
Katragkou, A., Alexander, E.L., Eoh, H., Raheem, S., Roilides, E. and Walsh, T.J. 2016. Effects of Fluconazole on the Metabolomic Profile of Candida albicans. Journal of Antimicrobial Chemotherapy. 71 (3), pp. 635-640. https://doi.org/10.1093/jac/dkv381

Flavonoid metabolites reduce tumor necrosis factor-α secretion to a greater extent than their precursor compounds in human THP-1 monocytes.
di Gesso, J.L., Kerr, J.S., Zhang, Q., Raheem, S., Yalamanchili, S.K., O’Hagan, D., Kay, C.D. and O'Connell, M.A. 2015. Flavonoid metabolites reduce tumor necrosis factor-α secretion to a greater extent than their precursor compounds in human THP-1 monocytes. Molecular Nutrition & Food Research. 59 (6), pp. 1143-1154. https://doi.org/10.1002/mnfr.201400799

Anthocyanins and their physiologically relevant metabolites alter the expression of IL-6 and VCAM-1 in CD40L and oxidized LDL challenged vascular endothelial cells
Amin, H.P., Czank, C., Raheem, S., Zhang, Q., Botting, N.P., Cassidy, A. and Kay, C.D. 2015. Anthocyanins and their physiologically relevant metabolites alter the expression of IL-6 and VCAM-1 in CD40L and oxidized LDL challenged vascular endothelial cells. Molecular Nutrition & Food Research. 59 (6), pp. 1095-1106. https://doi.org/10.1002/mnfr.201400803

Methods for Isolating, Identifying, and Quantifying Anthocyanin Metabolites in Clinical Samples
de Ferrars, R.M., Czank, C., Saha, S., Needs, P.W., Zhang, Q., Raheem, S., Botting, N.P., Kroon, P.A. and Kay, C.D. 2014. Methods for Isolating, Identifying, and Quantifying Anthocyanin Metabolites in Clinical Samples. Analytical Chemistry. 86 (20), pp. 10052-10058. https://doi.org/10.1021/ac500565a

Flavonoid metabolism: the synthesis of phenolic glucuronides and sulfates as candidate metabolites for bioactivity studies of dietary flavonoids
Zhang, Q., Raheem, S., Botting, N.P., Slawin, A.M.Z., Kay, C.D. and O’Hagan, D. 2012. Flavonoid metabolism: the synthesis of phenolic glucuronides and sulfates as candidate metabolites for bioactivity studies of dietary flavonoids. Tetrahedron. 68, pp. 4194-4201. https://doi.org/10.1016/j.tet.2012.03.100

Total synthesis of 3,5-O-dicaffeoylquinic acid and its derivatives
Raheem, S., Botting, Nigel P., Williamson, G. and Barron, D. 2011. Total synthesis of 3,5-O-dicaffeoylquinic acid and its derivatives. Tetrahedron Letters. 52 (52), p. 7175. https://doi.org/10.1016/j.tetlet.2011.10.127