Tissue Architecture and Regeneration Research Group

Group leaderDr Sigrun Lange
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Putative Roles for Peptidylarginine Deiminases in COVID-19

Journal article

Arisan, E.D., Uysal Onganer, P. and Lange, S. 2020. Putative Roles for Peptidylarginine Deiminases in COVID-19. International Journal of Molecular Sciences. 21 (13), p. 4662 4662. doi:10.3390/ijms21134662

Extracellular Vesicles and Post-translational Protein Deimination Signatures in Haemolymph of the American Lobster (Homarus americanus)

Journal article

Bowden, T.J., Kraev, I. and Lange, S. 2020. Extracellular Vesicles and Post-translational Protein Deimination Signatures in Haemolymph of the American Lobster (Homarus americanus) . Fish and Shellfish Immunology. FSIM-D-20-00642.

Reversal of beta-Amyloid-Induced Microglial Toxicity In Vitro by Activation of Fpr2/3

Journal article

Getting, S.J., McArthur, S., Wickstead, E. and Biggs, C.S. 2020. Reversal of beta-Amyloid-Induced Microglial Toxicity In Vitro by Activation of Fpr2/3. Oxidative Medicine and Cellular Longevity. Volume 2020, p. Article ID 2139192 2139192. doi:10.1155/2020/2139192

Patient-specific Alzheimer-like pathology in trisomy 21 cerebral organoids reveals BACE2 as a gene-dose-sensitive AD-suppressor in human brain

Journal article

Volpi, E. 2020. Patient-specific Alzheimer-like pathology in trisomy 21 cerebral organoids reveals BACE2 as a gene-dose-sensitive AD-suppressor in human brain. Molecular Psychiatry.

Data‐driven integration of hippocampal CA1 synaptic physiology in silico

Journal article

Ecker, A., Romani, A., Sáray, S., Káli,S., Migliore, M., Falck, J., Lange, S., Mercer, A., Thomson, A.M., Muller, M., Reimann, M.W. and Ramaswamy, S. 2020. Data‐driven integration of hippocampal CA1 synaptic physiology in silico. Hippocampus. doi:10.1002/hipo.23220

The Prediction of miRNAs in SARS-CoV-2 Genomes: hsa-miR Databases Identify 7 Key miRs Linked to Host Responses and Virus Pathogenicity-Related KEGG Pathways Significant for Comorbidities

Journal article

Arisan, E.D., Dart, A., Grant, G.H., Arisan, S., Cuhadaroglu, S., Lange, S. and Uysal Onganer, P. 2020. The Prediction of miRNAs in SARS-CoV-2 Genomes: hsa-miR Databases Identify 7 Key miRs Linked to Host Responses and Virus Pathogenicity-Related KEGG Pathways Significant for Comorbidities. MDPI Viruses. 12 (6), p. 614 614. doi:10.3390/v12060614

Evaluation of WGS-subtyping methods for epidemiological surveillance of foodborne salmonellosis

Journal article

Mohammed, M. and Thapa, S. 2020. Evaluation of WGS-subtyping methods for epidemiological surveillance of foodborne salmonellosis. One Health Outlook. doi:10.21203/rs.2.23039/v2

Post-Translational Protein Deimination Signatures in Serum and Serum-Extracellular Vesicles of Bos taurus Reveal Immune, Anti-Pathogenic, Anti-Viral, Metabolic and Cancer-Related Pathways for Deimination

Journal article

Criscitiello, M.F., Kraev, I. and Lange, S. 2020. Post-Translational Protein Deimination Signatures in Serum and Serum-Extracellular Vesicles of Bos taurus Reveal Immune, Anti-Pathogenic, Anti-Viral, Metabolic and Cancer-Related Pathways for Deimination. International Journal of Molecular Sciences. 21 (8), p. 2861. doi:10.3390/ijms21082861

Protein Deimination Signatures in Plasma and Plasma-EVs and Protein Deimination in the Brain Vasculature in a Rat Model of Pre-Motor Parkinson’s Disease

Journal article

Sancandi, M., Uysal Onganer, P., Kraev, I., Mercer, A. and Lange, S. 2020. Protein Deimination Signatures in Plasma and Plasma-EVs and Protein Deimination in the Brain Vasculature in a Rat Model of Pre-Motor Parkinson’s Disease. International Journal of Molecular Sciences. 21 (8), p. 2743 2743. doi:10.3390/ijms21082743

Post-translational Protein Deimination Signatures and Extracellular Vesicles (EVs) in the Atlantic Horseshoe Crab (Limulus polyphemus)

Journal article

Bowden, T.J., Kraev, I. and Lange, S. (In press). Post-translational Protein Deimination Signatures and Extracellular Vesicles (EVs) in the Atlantic Horseshoe Crab (Limulus polyphemus) . Developmental and Comparative Immunology. 110 103714. doi:10.1016/j.dci.2020.103714

Deimination Protein Profiles in Alligator mississippiensis Reveal Plasma and Extracellular Vesicle- specific Signatures Relating to Immunity, Metabolic Function and Gene Regulation

Journal article

Criscitiello, M.F., Kraev, I., Petersen, L.H. and Lange, S. 2020. Deimination Protein Profiles in Alligator mississippiensis Reveal Plasma and Extracellular Vesicle- specific Signatures Relating to Immunity, Metabolic Function and Gene Regulation. Frontiers in Immunology. 11, p. 651 651. doi:10.3389/fimmu.2020.00651

Hepcidin secretion was not directly proportional to intracellular iron-loading in recombinant-TfR1 HepG2 cells: short communication

Journal article

Mehta, K., Busbridge Mark, Patel, V.B. and Farnaud, S. 2020. Hepcidin secretion was not directly proportional to intracellular iron-loading in recombinant-TfR1 HepG2 cells: short communication. Molecular and Cellular Biochemistry. 468 (1-2), pp. 121-128. doi:10.1007/s11010-020-03716-8

Deiminated Proteins and Extracellular Vesicles as Novel Biomarkers in Pinnipeds: Grey seal (Halichoerus gryptus) and Harbour seal (Phoca vitulina)

Journal article

Magnadóttir, B., Uysal Onganer, P., Kraev, I., Svansson, V., Skírnisson, K. and Lange, S. 2020. Deiminated Proteins and Extracellular Vesicles as Novel Biomarkers in Pinnipeds: Grey seal (Halichoerus gryptus) and Harbour seal (Phoca vitulina). Biochimie . 171-172, pp. 79-90. doi:10.1016/j.biochi.2020.02.017

Peptidylarginine Deiminase Isozyme-Specific PAD2, PAD3 and PAD4 Inhibitors Differentially Modulate Extracellular Vesicle Signatures and Cell Invasion in Two Glioblastoma Multiforme Cell Lines

Journal article

Uysal Onganer, P., MacLatchy, A., Mahmoud, R., Kraev, I., Thompson, P.R., Inal, J.M. and Lange, S. 2020. Peptidylarginine Deiminase Isozyme-Specific PAD2, PAD3 and PAD4 Inhibitors Differentially Modulate Extracellular Vesicle Signatures and Cell Invasion in Two Glioblastoma Multiforme Cell Lines. International Journal of Molecular Sciences. 21 (4), p. 1495 1495. doi:10.3390/ijms21041495

Deiminated Proteins and Extracellular Vesicles - Novel Serum Biomarkers in Whales and Orca

Journal article

Magnadóttir, B., Uysal Onganer, P., Kraev, I., Svansson, V., Hayes, P.M. and Lange, S. 2020. Deiminated Proteins and Extracellular Vesicles - Novel Serum Biomarkers in Whales and Orca. Comparative Biochemistry and Physiology - Part D: Genomics and Proteomics. 34, p. 100676 100676. doi:10.1016/j.cbd.2020.100676

Novel anti-inflammatory and chondroprotective effects of the human melanocortin MC1 receptor agonist BMS-470539 dihydrochloride and human melanocortin MC3 receptor agonist PG-990 on lipopolysaccharide activated chondrocytes

Journal article

Can, V., Locke, I.C., Kaneva, M., Kerrigan, M.J.P., Merlino, F., De Pascale, C., Grieco, P. and Getting, S.J. 2020. Novel anti-inflammatory and chondroprotective effects of the human melanocortin MC1 receptor agonist BMS-470539 dihydrochloride and human melanocortin MC3 receptor agonist PG-990 on lipopolysaccharide activated chondrocytes. European Journal of Pharmacology. 872 172971. doi:10.1016/j.ejphar.2020.172971

High omega arachidonic acid/docosahexaenoic acid ratio induces mitochondrial dysfunction and altered lipid metabolism in human hepatoma cells

Journal article

Ghazali, R., Mehta, K., Bligh, S.W.A., Tewfik, I., Clemens, D.L. and Patel, V.B. 2020. High omega arachidonic acid/docosahexaenoic acid ratio induces mitochondrial dysfunction and altered lipid metabolism in human hepatoma cells. World Journal of Hepatology. 12 (3), pp. 84-98. doi:10.4254/wjh.v12.i3.84

Protein Deimination and Extracellular Vesicle Profiles in Antarctic Seabirds

Journal article

Phillips, R.A., Kraev, I. and Lange, S. 2020. Protein Deimination and Extracellular Vesicle Profiles in Antarctic Seabirds. MDPI Biology. 9 (1), p. 15 10.3390/biology9010015 . doi:10.3390/biology9010015

Plasma mEV levels in Ghanain malaria patients with low parasitaemia are higher than those of healthy controls, raising the potential for parasite markers in mEVs as diagnostic targets

Journal article

Antwi-Baffour, S., Malibha-Pinchbeck, M., Stratton, D., Jorfi, S., Lange, S. and Inal, J.M. 2019. Plasma mEV levels in Ghanain malaria patients with low parasitaemia are higher than those of healthy controls, raising the potential for parasite markers in mEVs as diagnostic targets. Journal of Extracellular Vesicles. 9, 2020 (issue 1), p. 1697124 1697124 . doi:10.1080/20013078.2019.1697124

Extracellular Vesicles, Deiminated Protein Cargo and microRNAs are Novel Serum Biomarkers for Environmental Rearing Temperature in Atlantic Cod (Gadus morhua L.)

Journal article

Magnadóttir, B., Uysal Onganer, P., Kraev, I., Dodds, A.W., Gudmundsdottir, S. and Lange, S. 2019. Extracellular Vesicles, Deiminated Protein Cargo and microRNAs are Novel Serum Biomarkers for Environmental Rearing Temperature in Atlantic Cod (Gadus morhua L.) . Aquaculture Reports. 16, p. 100245 100245. doi:10.1016/j.aqrep.2019.100245

Deiminated Proteins in Extracellular Vesicles and Serum of Llama (Lama glama) - Novel Insights into Camelid Immunity

Journal article

Criscitiello, M.F., Kraev, I. and Lange, S. 2019. Deiminated Proteins in Extracellular Vesicles and Serum of Llama (Lama glama) - Novel Insights into Camelid Immunity. Molecular Immunology. 117, pp. 37-53 MIMM_5890. doi:10.1016/j.molimm.2019.10.017

Post-translational Deimination of Immunological and Metabolic Protein Markers in Plasma and Extracellular Vesicles of Naked Mole-Rat (Heterocephalus glaber)

Journal article

Pamenter, M.E., Uysal Onganer, P., Huynh, K.W., Kraev, I. and Lange, S. 2019. Post-translational Deimination of Immunological and Metabolic Protein Markers in Plasma and Extracellular Vesicles of Naked Mole-Rat (Heterocephalus glaber). International Journal of Molecular Sciences. 20 (21), p. 5378 5378. doi:10.3390/ijms20215378

Curcumin: novel treatment in neonatal hypoxic-ischaemic brain injury

Journal article

Rocha-Ferreira, E., Sisa, C., Bright, S., Fautz, T., Harris, M., Contreras Riquelme, I., Agwu, C., Kurulday, T., Mistry, B., Hill, D., Lange, S. and Hristova, M. 2019. Curcumin: novel treatment in neonatal hypoxic-ischaemic brain injury. Frontiers in Physiology. 10, p. 1351 1351. doi:10.3389/fphys.2019.01351

Cannabidiol is a Novel Modulator of Bacterial Membrane Vesicles

Journal article

Kosgodage, U., Matewele, P., Awamaria, B., Kraev, I., Warde, P., Mastroianni, G., Nunn, A., Guy, G.W., Bell, J.D., Inal, J.M. and Lange, S. 2019. Cannabidiol is a Novel Modulator of Bacterial Membrane Vesicles. Frontiers in Cellular and Infection Microbiology. 9, p. 324 324. doi:10.3389/fcimb.2019.00324

Complement component C4-like protein in Atlantic cod (Gadus morhua L.) - Detection in ontogeny and identification of post-translational deimination in serum and extracellular vesicles

Journal article

Lange, S., Kraev, I., Magnadottir, B. and Dodds, A.W. 2019. Complement component C4-like protein in Atlantic cod (Gadus morhua L.) - Detection in ontogeny and identification of post-translational deimination in serum and extracellular vesicles. Developmental and Comparative Immunology. 101, p. 103437 103437. doi:10.1016/j.dci.2019.103437

Deiminated Proteins in Extracellular Vesicles and Plasma of Nurse Shark (Ginglymostoma cirratum) - Novel Insights into Shark Immunity

Journal article

Criscitiello, M.F., Kraev, I. and Lange, S. 2019. Deiminated Proteins in Extracellular Vesicles and Plasma of Nurse Shark (Ginglymostoma cirratum) - Novel Insights into Shark Immunity. Fish and Shellfish Immunology. 92, pp. 249-255 YFSIM_6208. doi:10.1016/j.fsi.2019.06.012

Peptidylarginine Deiminase Inhibitors Reduce Bacterial Membrane Vesicle Release and Sensitise Bacteria to Antibiotic Treatment

Journal article

Kosgodage, U., Matewele, P., Mastroianni, G., Kraev, I., Brotherton, D., Awamaria, B., Nicholas, A.P., Lange, S. and Inal, J.M. 2019. Peptidylarginine Deiminase Inhibitors Reduce Bacterial Membrane Vesicle Release and Sensitise Bacteria to Antibiotic Treatment. Frontiers in Cellular and Infection Microbiology. 9, p. 227 227. doi:10.3389/fcimb.2019.00227

Extracellular Vesicles from Cod (Gadus morhua L.) Mucus contain Innate Immune Factors and Deiminated Protein Cargo

Journal article

Magnadóttir, B., Kraev, I., Gudmundsdottir, S., Dodds, A.W. and Lange, S. 2019. Extracellular Vesicles from Cod (Gadus morhua L.) Mucus contain Innate Immune Factors and Deiminated Protein Cargo. Developmental and Comparative Immunology. p. 103397 103397. doi:10.1016/j.dci.2019.103397

Peptidylarginine Deiminase inhibition abolishes the production of large extracellular vesicles from Giardia intestinalis, affecting host-pathogen interactions by hindering adhesion to host cells

Journal article

Gavinho, B., Rossi, I., Evans-Osses, E., Lange, S. and Ramirez, M.I. 2019. Peptidylarginine Deiminase inhibition abolishes the production of large extracellular vesicles from Giardia intestinalis, affecting host-pathogen interactions by hindering adhesion to host cells. Advanced online publication. doi:10.1101/586438

Intact Sample Analysis

Book chapter

Warford, A. and Volpi, E. 2019. Intact Sample Analysis. in: Warford, A. and Presneau, Nadège (ed.) Molecular Diagnostics Oxford University Press.

Techniques for the study of apoptosis in bone

Book chapter

Mann, V. and Noble, B. 2019. Techniques for the study of apoptosis in bone. in: Idris, A.I. (ed.) Bone research protocols Springer. pp. 451-465

Quantitative analysis of Human Endogenous Retrovirus-K transcripts in postmortem premotor cortex fails to confirm elevated expression of HERV-K RNA in amyotrophic lateral sclerosis

Journal article

Garson, J.A., Usher, L., Al-Chalabi, A., Huggett, J., Day, E.F. and McCormick, A.L. 2019. Quantitative analysis of Human Endogenous Retrovirus-K transcripts in postmortem premotor cortex fails to confirm elevated expression of HERV-K RNA in amyotrophic lateral sclerosis. Acta Neuropathologica Communications. 7 (45) 45. doi:10.1186/s40478-019-0698-2

Mesenchymal Stromal Cell derived Extracellular Vesicles reduce Hypoxia-Ischaemia Induced Perinatal Brain Injury

Journal article

Sisa, C., Kholia, S., Naylor, J., Herrera Sanchez, M.B., Bruno, S., Deregibus, M.C., Camussi, G., Inal, J.M., Lange, S. and Hristova, M. 2019. Mesenchymal Stromal Cell derived Extracellular Vesicles reduce Hypoxia-Ischaemia Induced Perinatal Brain Injury. Frontiers in Physiology. 10, p. 282 282. doi:10.3389/fphys.2019.00282

Peptidylarginine Deiminases Post-translationally deiminate Prohibitin and modulate Extracellular Vesicle Release and microRNAs in Glioblastoma Multiforme

Journal article

Kosgodage, U., Uysal Onganer, P., Maclatchy, A., Kraev, I., Chatterton, N.P., Nicholas, A.P., Inal, J.M. and Lange, S. 2018. Peptidylarginine Deiminases Post-translationally deiminate Prohibitin and modulate Extracellular Vesicle Release and microRNAs in Glioblastoma Multiforme . International Journal of Molecular Sciences. 20 (1), p. 103 103. doi:10.3390/ijms20010103

A novel ladder-like lectin relates to sites of mucosal immunity in Atlantic Halibut (Hippoglossus hippoglossus L.)

Journal article

Magnadóttir, B., Gudmundsdottir, S. and Lange, S. 2018. A novel ladder-like lectin relates to sites of mucosal immunity in Atlantic Halibut (Hippoglossus hippoglossus L.) . Fish & Shellfish Immunology. 87, pp. 9-12. doi:10.1016/j.fsi.2018.12.034

Cannabidiol Affects Extracellular Vesicle Release, miR21 and miR126, and Reduces Prohibitin Protein in Glioblastoma Multiforme Cells

Journal article

Kosgodage, U., Uysal Onganer, P., Maclatchy, A., Mould, R., Nunn, A.V.W., Guy, G.W., Kraev, I., Chatterton, N.P., Thomas, E.L., Inal, J.M., Bell, J.D. and Lange, S. 2018. Cannabidiol Affects Extracellular Vesicle Release, miR21 and miR126, and Reduces Prohibitin Protein in Glioblastoma Multiforme Cells. Translational Oncology. 12 (3), pp. 513-522. doi:10.1016/j.tranon.2018.12.004

Peptidylarginine deiminase and deiminated proteins are detected throughout early halibut ontogeny - Complement components C3 and C4 are post-translationally deiminated in halibut (Hippoglossus hippoglossus L.)

Journal article

Magnadóttir, B., Bragason, B.T., Bricknell, I.R., Bowden, T., Nicholas, A.P., Hristova, M., Gudmundsdottir, S., Dodds, A.W. and Lange, S. 2018. Peptidylarginine deiminase and deiminated proteins are detected throughout early halibut ontogeny - Complement components C3 and C4 are post-translationally deiminated in halibut (Hippoglossus hippoglossus L.). Developmental and Comparative Immunology. 92, pp. 1-19. doi:10.1016/j.dci.2018.10.016

Spatiotemporal dynamics of PDGFRβ expression in pericytes and glial scar formation in penetrating brain injuries in adults

Journal article

Reeves, C., Jardim, A.P., Sisodiya, S.M., Thom, M. and Liu, J. 2019. Spatiotemporal dynamics of PDGFRβ expression in pericytes and glial scar formation in penetrating brain injuries in adults. Neuropathology and Applied Neurobiology. 45 (6), pp. 609-627 NAN-2018-0107.R1. doi:10.1111/nan.12539

The biochemical basis of disease

Journal article

Barr, A.J. 2018. The biochemical basis of disease. Essays in Biochemistry. 62 (5), pp. 619-642 https://doi.org/10.1042/EBC20170054. doi:10.1042/EBC20170054

The physiological variability of channel density in hippocampal CA1 pyramidal cells and interneurons explored using a unified data-driven modeling workflow

Journal article

Migliore, R., Lupascu, C.A., Bologna, L.L., Romani, R., Courcol, J-D., Antonel, S., Van Geit, W.A.H., Thompson, A.M., Mercer, A., Lange, S., Falck, J., Rossert, C.A., Shi, Y., Hagens, O., Pezzoli, M., Freund, T.F., Muller, E.B., Kali, S., Schurmann, F., Markram, H. and Migliore, M. 2018. The physiological variability of channel density in hippocampal CA1 pyramidal cells and interneurons explored using a unified data-driven modeling workflow. PLOS Computational Biology. doi:10.1371/journal.pcbi.1006423


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Barr, Alastair

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Coleman, Sarah

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Smith, Caroline

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Uysal Onganer, Pinar

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