Tissue Architecture and Regeneration Research Group

Group leaderProf Sigrun Lange
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Clinical potential of oligonucleotide-based therapeutics in the respiratory system

Article

Moschos, S.A., Usher, L. and Lindsay, M.A. 2017. Clinical potential of oligonucleotide-based therapeutics in the respiratory system. Pharmacology and Therapeutics. 169, pp. 83-103. https://doi.org/10.1016/j.pharmthera.2016.10.009

Biomarkers in Cardiovascular Disease (Biomarkers in Disease: Methods, Discoveries and Applications)

Book

Patel, V.B and Preedy, V.R. (ed.) 2016. Biomarkers in Cardiovascular Disease (Biomarkers in Disease: Methods, Discoveries and Applications). Springer.

L-Arginine in Clinical Nutrition (Nutrition and Health)

Book

Patel, V., Preedy, V.R. and Rajendram, R. (ed.) 2016. L-Arginine in Clinical Nutrition (Nutrition and Health). Humana Press.

Biomarkers in Kidney Disease (Biomarkers in Disease: Methods, Discoveries and Applications)

Book

Patel, V.B. and Preedy, V.R. (ed.) 2016. Biomarkers in Kidney Disease (Biomarkers in Disease: Methods, Discoveries and Applications) . Springer.

Iron enhances hepatic fibrogenesis through TGF-β activation

Article

Mehta, K., Briones-Orta, M., Manka P., Coombes, J.D., Williams, R., Patel, V.B. and Syn, W-K. 2016. Iron enhances hepatic fibrogenesis through TGF-β activation. Hepatology. 64 (1 suppl), p. 360A. https://doi.org/10.1002/hep.28797

Comprehensive Guide to Post-Traumatic Stress Disorders

Book

Martin, C.R., Preedy, V.R. and Patel, V.B. (ed.) 2016. Comprehensive Guide to Post-Traumatic Stress Disorders. Springer.

Effect of age and pregnancy on the expression of melanocortin receptors 4 and 5 in the mouse female reproductive axis

Conference poster

Smith, C.L., Nuri A. Berruien, N., Murray, J.F. and Le Tissier, P.R. 2016. Effect of age and pregnancy on the expression of melanocortin receptors 4 and 5 in the mouse female reproductive axis. BPS Pharmacology 2016. London, UK 12 - 14 Dec 2016 British Pharmacological Society.

The restorative role of annexin A1 at the blood–brain barrier

Article

McArthur, S., Azevedo Loila, R, Maggioli, E, Errede, M, Virgintino, D and Solito, E 2016. The restorative role of annexin A1 at the blood–brain barrier. Fluids & Barriers of the CNS. 13, pp. 17-33. https://doi.org/10.1186/s12987-016-0043-0

Counteractive effects of antenatal glucocorticoid treatment on D1 receptor modulation of spatial working memory

Article

Virdee, K., Kentrop, J., Jupp, B., Venus, B., Hensman, D., McArthur, S., Wilkinson, J., Robbins, T.W., Gillies, G.E. and Dalley, J.W. 2016. Counteractive effects of antenatal glucocorticoid treatment on D1 receptor modulation of spatial working memory. Psychopharmacology. 233 (21), pp. 3751-3761. https://doi.org/10.1007/s00213-016-4405-8

PF7.09 Non-phagocytic epithelial cells take up microvesicles by micropinocytosis

Conference poster

Lange, S., Kosgodage, U. and Inal, J.M. 2016. PF7.09 Non-phagocytic epithelial cells take up microvesicles by micropinocytosis. The Fifth International Meeting of ISEV, ISEV 2016. Rotterdam, Netherlands 04 - 07 May 2016 Co-Action Publishing.

PW1.04. Inhibitors of microvesicle release with the potential to enhance effectivity of cancer chemotherapy

Conference poster

Lange, S., Kosgodage, U. and Inal, J.M. 2016. PW1.04. Inhibitors of microvesicle release with the potential to enhance effectivity of cancer chemotherapy. The Fifth International Meeting of ISEV, ISEV 2016. Rotterdam, Netherlands 04 - 07 May 2016 Co-Action Publishing. https://doi.org/10.3402/jev.v5.31552

Characterization of hepcidin response to holotransferrin in novel recombinant TfR1 HepG2 cells

Journal article

Mehta, K., Busbridge, Mark, Renshaw, D., Evans, R.W., Farnaud, S. and Patel, V. 2016. Characterization of hepcidin response to holotransferrin in novel recombinant TfR1 HepG2 cells. Blood Cells, Molecules, and Diseases. 61, pp. 37-45. https://doi.org/10.1016/j.bcmd.2016.06.008

Repeat-measures longitudinal study evaluating behavioural and gastrointestinal symptoms in children with autism before, during and after visceral osteopathic technique (VOT)

Article

Bramati-Castellarin, I., Patel, V. and Drysdale, I.P. 2016. Repeat-measures longitudinal study evaluating behavioural and gastrointestinal symptoms in children with autism before, during and after visceral osteopathic technique (VOT). Journal of Bodywork and Movement Therapies. 20 (3), pp. 461-470. https://doi.org/10.1016/j.jbmt.2016.01.001

Activation of melanocortin receptors MC1 and MC5 attenuates retinal damage in experimental diabetic retinopathy

Journal article

Rossi, S., Maisto, R., Gesualdo, C., Trotta, M.C., Ferraraccio, F., Kaneva, M.K., Getting, S.J., Surace, E., Testa, F., Simonelli, F., Grieco, P., Merlino, F., Perretti, M., D'Amico, M. and Di Filippo, C. 2016. Activation of melanocortin receptors MC1 and MC5 attenuates retinal damage in experimental diabetic retinopathy. Mediators of inflammation. 2016 7368389. https://doi.org/10.1155/2016/7368389

An investigation into the impact of peer- and self-marking in a first year biochemistry module

Conference paper

Smith, C.L. 2016. An investigation into the impact of peer- and self-marking in a first year biochemistry module. Inspire to succeed: Transforming teaching and learning in STEM. East Midlands Conference Centre, Nottingham on 28 and 29 January 2016 28 Jan 2016

Kroppenstedtia pulmonis sp. nov. and Kroppenstedtia sanguinis sp. nov., isolated from human patients

Article

Bell, M.E., Lasker, B.A., Klenk, H.-P., Hoyles, L., Spröer, C., Schumann, P. and Brown, J.M. 2016. Kroppenstedtia pulmonis sp. nov. and Kroppenstedtia sanguinis sp. nov., isolated from human patients. Antonie van Leeuwenhoek Journal of Microbiology. 109 (5), pp. 603-610. https://doi.org/10.1007/s10482-016-0663-z

General Methods in Biomarker Research and their Applications (Biomarkers in Disease: Methods, Discoveries and Applications)

Book

Preedy, V.R. and Patel, V.B (ed.) 2015. General Methods in Biomarker Research and their Applications (Biomarkers in Disease: Methods, Discoveries and Applications). Pharmaceutical Society of Korea, co-published with Springer.

Biomarkers in Health and Disease: Further Knowledge

Book chapter

Rajendram, R., Rajendram, R., Patel, V.B. and Preedy, V.R. 2015. Biomarkers in Health and Disease: Further Knowledge. in: Preedy, V.R. and Patel, V.B. (ed.) General Methods in Biomarker Research and their Applications Netherlands Springer. pp. 1311-1316

General Methods in Biomarker Research and their Applications, volume 2

Book

Preedy, V.R. and Patel, V.B. (ed.) 2015. General Methods in Biomarker Research and their Applications, volume 2. Springer.

General Methods in Biomarker Research and their Applications, volume 1

Book

Preedy, V.R. and Patel, V.B. (ed.) 2015. General Methods in Biomarker Research and their Applications, volume 1. Springer.

Regional Increase in the Expression of the BCAT Proteins in Alzheimer's Disease Brain: Implications in Glutamate Toxicity

Journal article

Hull, J., Patel, V.B., El Hindy, M., Hezwani, M., Love, S., Kehoe, P.G., Chalmers, C. and Conway, M.E. 2015. Regional Increase in the Expression of the BCAT Proteins in Alzheimer's Disease Brain: Implications in Glutamate Toxicity. Journal of Alzheimer's Disease. 45 (3), pp. 891-905. https://doi.org/10.3233/JAD-142970

New insights into the role of the branched-chain aminotransferase proteins in the human brain

Article

Hull, J., Patel, V.B., Hutson, S.M. and Conway, M.E. 2015. New insights into the role of the branched-chain aminotransferase proteins in the human brain. Journal of Neuroscience Research. 93, pp. 987-998. https://doi.org/10.1002/jnr.23558

Characterisation of hepcidin response to holotransferrin treatment in CHO TRVb-1 cells

Article

Mehta, K., Greenwell, P., Renshaw, D., Busbridge, Mark, Garcia, M, Farnaud, S. and Patel, V. B. 2015. Characterisation of hepcidin response to holotransferrin treatment in CHO TRVb-1 cells. Blood Cells, Molecules, and Diseases. 55 (2), pp. 110-118. https://doi.org/10.1016/j.bcmd.2015.05.002

Urocortin – From Parkinson’s disease to the skeleton

Journal article

Lawrence, K.M., Jackson, T.R, Jamieson, D., Stevens, A., Owens, G., Sayan, B.S, Locke, I.C. and Townsend, P.A. 2015. Urocortin – From Parkinson’s disease to the skeleton. International Journal of Biochemistry & Cell Biology. 30, pp. 130-138. https://doi.org/10.1016/j.biocel.2014.12.005

Estrogen protects the blood–brain barrier from inflammation-induced disruption and increased lymphocyte trafficking

Journal article

Maggioli, E., McArthur, S., Mauro, C., Kieswich, J., Kusters, D.H.M., Reutelingsperger, C.P.M., Yaqoob, M.M. and Solito, E. 2015. Estrogen protects the blood–brain barrier from inflammation-induced disruption and increased lymphocyte trafficking. Brain Behavior & Immunity. 51, p. 212–222. https://doi.org/10.1016/j.bbi.2015.08.020

Quantifying diet-induced metabolic changes of the human gut microbiome

Journal article

Shoaie, S., Ghaffari, P., Kovatcheva-Datchary, P., Mardinoglu, A., Sen, P., Pujos-Guillot, E., de Wouters, T., Juste, C., Rizkalla, S.W., Chilloux, J., Hoyles, L., Nicholson, J.K., ANR MICRO-Obes Consortium, Dumas, M.-E., Clément, K., Bäckhed, F., Nielsen, J., Tomas de Wouters and Doré, J. 2015. Quantifying diet-induced metabolic changes of the human gut microbiome. Cell Metabolism. 22 (2), pp. 320-331. https://doi.org/10.1016/j.cmet.2015.07.001

Both MC1 and MC3 Receptors Provide Protection From Cerebral Ischemia-Reperfusion-Induced Neutrophil Recruitment.

Journal article

Holloway, P.M., Durrenberger, P.F., Trutschl, M., Cvek, U., Cooper, D., Orr, A.W., Perretti, M., Getting, S.J. and Gavins, F.N. 2015. Both MC1 and MC3 Receptors Provide Protection From Cerebral Ischemia-Reperfusion-Induced Neutrophil Recruitment. Arteriosclerosis, Thrombosis and Vascular biology . 35 (9), pp. 1936-44. https://doi.org/10.1161/ATVBAHA.115.305348

Definition of a Novel Pathway Centered on Lysophosphatidic Acid To Recruit Monocytes during the Resolution Phase of Tissue Inflammation.

Journal article

McArthur, S., Gobbetti, T., Kusters, D.H.M., Reutelingsperger, C.P.M., Flower, R.J. and Perretti, M. 2015. Definition of a Novel Pathway Centered on Lysophosphatidic Acid To Recruit Monocytes during the Resolution Phase of Tissue Inflammation. Journal of Immunology. 195 (3), pp. 1139-1151. https://doi.org/10.4049/jimmunol.1500733

In Vitro Assessment of the Synergy between Polymyxin B (PMB) and Polymyxin B Nonapeptide (PMBN) and Antibiotics on Biofilms from Diabetic Foot Infections

Conference poster

Gyamfi-Brobbey, George, Greenwell, P. and Kimmitt, P.T. 2015. In Vitro Assessment of the Synergy between Polymyxin B (PMB) and Polymyxin B Nonapeptide (PMBN) and Antibiotics on Biofilms from Diabetic Foot Infections. American Society for Microbiology. New Orleans 31 May 2015

F. necrophorum Ecotin Inhibits Human Plasma Kallikrein and Human Neutrophil Elastase

Conference poster

Wright Katie Greenwell Pamela, Greenwell, P. and Kimmitt, P.T. 2015. F. necrophorum Ecotin Inhibits Human Plasma Kallikrein and Human Neutrophil Elastase. American Society for Microbiology. New Orleans 31 May 2015

Sex-specific disruption of murine midbrain astrocytic and dopaminergic developmental trajectories following antenatal GC treatment

Article

McArthur, S., Pienaar, I.S., Siddiqi, S.M., Gillies, G.E. and Mazhar-Siddiqi, S. 2015. Sex-specific disruption of murine midbrain astrocytic and dopaminergic developmental trajectories following antenatal GC treatment. Brain Stucture & Function. https://doi.org/10.1007/s00429-015-1049-0

Presence and characterisation of ecotin in F. necrophorum

Conference poster

Wright Katie Greenwell Pamela, Kimmitt, P.T. and Greenwell, P. 2015. Presence and characterisation of ecotin in F. necrophorum. Society for General Microbiology. Birmingham 30 Mar 2015

Comparison of virulence genes found in draft genomes of F. necrophorum

Conference poster

Wright Katie Greenwell Pamela, Kimmitt, P.T. and Greenwell, P. 2015. Comparison of virulence genes found in draft genomes of F. necrophorum. Society for General Microbiology. Birmingham, UK 30 Mar 2015

Inhibition of thiol isomerase activity diminishes endothelial activation of plasminogen, but not of protein C

Journal article

Smith, C.L., Shah, C.M., Kamaludin, N. and Gordge, M.P. 2015. Inhibition of thiol isomerase activity diminishes endothelial activation of plasminogen, but not of protein C. Thrombosis Research. 135 (4), p. 748–753. https://doi.org/10.1016/j.thromres.2015.01.034

Glutamine in Clinical Nutrition (Nutrition and Health)

Book

Rajendram, R., Preedy, V.R. and Patel, V. (ed.) 2015. Glutamine in Clinical Nutrition (Nutrition and Health) . Humana Press.

Diet and nutrition in critical care

Book

Rajendram, R., Preedy, V.R. and Patel, V. (ed.) 2015. Diet and nutrition in critical care. Springer.

Biomarkers in Cancer

Book

Preedy, V.R. and Patel, V. (ed.) 2015. Biomarkers in Cancer. Springer.

Anatomy, embryology, and cell families

Book chapter

Locke, I.C. and Murray, J.F. 2014. Anatomy, embryology, and cell families. in: Orchard, G. and Nation, B. (ed.) Cell Structure & Function Oxford, UK Oxford University Press. pp. 82-110

Functional Studies On Receptor-Type Protein Tyrosine Phosphatases Of The R3 Subgroup Using Bimolecular Fluorescence Complementation (BiFC) Assays

Conference poster

Dorofejeva, O., Dwek, M. and Barr, A.J. 2014. Functional Studies On Receptor-Type Protein Tyrosine Phosphatases Of The R3 Subgroup Using Bimolecular Fluorescence Complementation (BiFC) Assays . Pharmacology 2014. London 16 Dec 2014 British Pharmacological Society.

Melanocortin peptides protect chondrocytes from mechanically induced cartilage injury

Journal article

Kaneva, M., Kerrigan, M.J.P., Grieco, P., Curley, G.P., Locke, I.C. and Getting, S.J. 2014. Melanocortin peptides protect chondrocytes from mechanically induced cartilage injury. Biochemical Pharmacology. 92 (2), pp. 336-347. https://doi.org/10.1016/j.bcp.2014.08.019


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Biggs, Christopher

Senior Lecturer


Curley, Paul

Senior Lecturer


Porakishvili, Nina

Principal Lecturer