Motion sickness susceptibility fluctuates through the menstrual cycle

Golding, J.F., Kadzere, P. and Gresty, M.A. 2005. Motion sickness susceptibility fluctuates through the menstrual cycle. Aviation, Space, and Environmental Medicine. 76 (10), pp. 970-973.

TitleMotion sickness susceptibility fluctuates through the menstrual cycle
AuthorsGolding, J.F., Kadzere, P. and Gresty, M.A.
Abstract

Background: Motion sickness is a common and potentially debilitating condition that characteristically occurs in situations of conflicting sensory input. While the precise stimuli that give rise to this trait are increasingly well characterized, the underlying determinants of individual susceptibility to motion sickness remain unclear. This study uses a classical twin design to assess the influence of genetic and environmental factors. Methods: A postal survey was conducted in an age-matched sample of 3652 monozygotic (MZ) and dizygotic (DZ) adult female twins selected from the TwinsUK Registry. Study participants were asked to complete items from a validated questionnaire relating to their lifetime susceptibility to motion sickness. The relative contribution of genetic and environmental factors to motion sickness susceptibility was assessed using variance components analysis. Results: The response rate to the questionnaire was 78%. Approximately 40% of respondents reported at least moderate susceptibility to motion sickness. The pattern of responses among twins indicated a significant genetic contribution with heritability for a motion sickness factor score estimated as 57% (95% CI: 51%, 63%). The heritability of recalled motion sickness was at its highest in childhood (70% [59%, 80%]) and declined through puberty and the early adult years. Discussion and Conclusions: The findings highlight the importance of genetic factors in determining an individual's underlying propensity to motion sickness and should stimulate the search for specific susceptibility genes.

KeywordsHeritability, epidemiology
JournalAviation, Space, and Environmental Medicine
Journal citation76 (10), pp. 970-973
ISSN0095-6562
YearOct 2005
Web address (URL)http://www.ingentaconnect.com/content/asma/asem/2005/00000076/00000010/art00009
Publication dates
PublishedOct 2005

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Golding, J.F. and Gresty, M.A. 2005. Motion sickness. Current Opinion in Neurology. 18 (1), pp. 29-34.

Effect of a novel motion desensitization training regime and controlled breathing on habituation to motion sickness
Yen Pik Sang, F., Billar, J., Gresty, M.A. and Golding, J.F. 2005. Effect of a novel motion desensitization training regime and controlled breathing on habituation to motion sickness. Perceptual and Motor Skills. 18 (1), pp. 29-34.

Perceived control, locus of control and preparatory information: effects on the perception of an acute pain stimulus
Williams, D., Golding, J.F., Phillips, K. and Towell, A. 2004. Perceived control, locus of control and preparatory information: effects on the perception of an acute pain stimulus. Personality and Individual Differences. 36 (7), pp. 1681-1691. https://doi.org/10.1016/j.paid.2003.07.009

We are most aware of our place in the world when about to fall
Bray, A., Subanandan, A., Isableu, B., Ohlmann, T., Golding, J.F. and Gresty, M.A. 2004. We are most aware of our place in the world when about to fall. Current Biology. 14 (15), pp. R609-R610. https://doi.org/10.1016/j.cub.2004.07.040

Suppression of sickness by controlled breathing during mildly nauseogenic motion
Yen Pik Sang, F., Golding, J.F. and Gresty, M.A. 2003. Suppression of sickness by controlled breathing during mildly nauseogenic motion. Aviation, Space, and Environmental Medicine. 74 (9), pp. 998-1002.

Effect of breathing supplemental oxygen on motion sickness in healthy adults
Ziavra, N., Yen Pik Sang, F., Golding, J.F., Bronstein, A.M. and Gresty, M.A. 2003. Effect of breathing supplemental oxygen on motion sickness in healthy adults. Mayo Clinic Proceedings. 78 (5), pp. 574-578.

Behavioral methods of alleviating motion sickness: effectiveness of controlled breathing and a music audiotape
Yen Pik Sang, F., Billar, J., Golding, J.F. and Gresty, M.A. 2003. Behavioral methods of alleviating motion sickness: effectiveness of controlled breathing and a music audiotape. Journal of Travel Medicine. 10 (2), pp. 108-112.

Impairment of spatial cognitive function with preservation of verbal performance during spatial disorientation
Gresty, M.A., Waters, S., Bray, A., Bunday, K. and Golding, J.F. 2003. Impairment of spatial cognitive function with preservation of verbal performance during spatial disorientation. Current Biology. 13 (21), pp. R829-R830. https://doi.org/10.1016/j.cub.2003.10.013

Motion sickness and tilts of the inertial force environment: active suspension systems vs. active passengers
Golding, J.F., Bles, W., Bos, E., Haynes, T. and Gresty, M.A. 2003. Motion sickness and tilts of the inertial force environment: active suspension systems vs. active passengers. Aviation, Space, and Environmental Medicine. 74 (3), pp. 220-227.

Attentional demands of continuously monitoring orientation using vestibular information
Yardley, L., Papo, D., Bronstein, A.M., Gresty, M.A., Gardner, M., Lavie, N. and Luxon, L. 2002. Attentional demands of continuously monitoring orientation using vestibular information. Neuropsychologia. 40 (4), pp. 373-383. https://doi.org/10.1016/S0028-3932(01)00113-0

A motion sickness maximum around the 0.2 Hz frequency range of horizontal translational oscillation
Golding, J.F., Mueller, A.G. and Gresty, M.A. 2001. A motion sickness maximum around the 0.2 Hz frequency range of horizontal translational oscillation. Aviation, Space, and Environmental Medicine. 72 (3), pp. 188-192.

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