The effect of smoking nicotine tobacco versus smoking deprivation on motion sickness

Golding, J.F., Prosyanikova, O., Flynn, M. and Gresty, M.A. 2011. The effect of smoking nicotine tobacco versus smoking deprivation on motion sickness. Autonomic Neuroscience: Basic and Clinical. 160 (1-2), pp. 53-58. https://doi.org/10.1016/j.autneu.2010.09.009

TitleThe effect of smoking nicotine tobacco versus smoking deprivation on motion sickness
AuthorsGolding, J.F., Prosyanikova, O., Flynn, M. and Gresty, M.A.
Abstract

BACKGROUND: The experienced smoker maintains adequate nicotine levels by 'puff-by-puff self-control' which also avoids symptomatic nauseating effects of nicotine overdose. It is postulated that there is a varying 'dynamic threshold for nausea' into which motion sickness susceptibility provides an objective toxin-free probe. Hypotheses were that: (i) nicotine promotes motion sickness whereas deprivation protects; and (ii) pleasurable effects of nicotine protect against motion sickness whereas adverse effects of withdrawal have the opposite effect.

METHODS: Twenty-six healthy habitual cigarette smokers (mean±SD) 15.3±7.6cigs/day, were exposed to a provocative cross-coupled (coriolis) motion on a turntable, with sequences of 8 head movements every 30s. This continued to the point of moderate nausea. Subjects were tested after either ad-lib normal smoking (SMOKE) or after overnight deprivation (DEPRIV), according to a repeated measures design counter-balanced for order with 1-week interval between tests.

RESULTS: Deprivation from recent smoking was confirmed by objective measures: exhaled carbon monoxide CO was lower (P<0.001) for DEPRIV (8.5±5.6ppm) versus SMOKE (16.0±6.3ppm); resting heart rate was lower (P<0.001) for DEPRIV (67.9±8.4bpm) versus SMOKE (74.3±9.5bpm). Mean±SD sequences of head movements tolerated to achieve moderate nausea were more (P=0.014) for DEPRIV (21.3±9.9) versus SMOKE (18.3±8.5).

DISCUSSION: Tolerance to motion sickness was aided by short-term smoking deprivation, supporting Hypothesis (i) but not Hypothesis (ii). The effect was was approximately equivalent to half of the effect of an anti-motion sickness drug. Temporary nicotine withdrawal peri-operatively may explain why smokers have reduced risk for postoperative nausea and vomiting (PONV).

JournalAutonomic Neuroscience: Basic and Clinical
Journal citation160 (1-2), pp. 53-58
ISSN1566-0702
Year24 Feb 2011
PublisherElsevier
Digital Object Identifier (DOI)https://doi.org/10.1016/j.autneu.2010.09.009
Publication dates
Published24 Feb 2011

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Bijveld, M.M.C., Bronstein, A.M., Golding, J.F. and Gresty, M.A. 2008. Nauseogenicity of off-vertical axis rotation vs. equivalent visual motion. Aviation, Space, and Environmental Medicine. 79 (7), pp. 661-665. https://doi.org/10.3357/ASEM.2241.2008

Cognitive impairment by spatial disorientation
Gresty, M.A., Golding, J.F., Le, H. and Nightingale, K. 2008. Cognitive impairment by spatial disorientation. Aviation, Space, and Environmental Medicine. 79 (2), pp. 105-111. https://doi.org/10.3357/ASEM.2143.2008

[18F]2-fluoro-2-deoxy-D-glucose positron emission tomography (FDG PET) as a diagnostic tool for neurofibromatosis 1 (NF1) associated malignant peripheral nerve sheath tumours (MPNSTs): a long-term clinical study
Ferner, R.E., Golding, J.F., Smith, M., Calonje, E., Jan, W., Sanjayanathan, V. and O'Doherty, M. 2008. [18F]2-fluoro-2-deoxy-D-glucose positron emission tomography (FDG PET) as a diagnostic tool for neurofibromatosis 1 (NF1) associated malignant peripheral nerve sheath tumours (MPNSTs): a long-term clinical study. Annals of Oncology. 19 (2), pp. 390-394. https://doi.org/10.1093/annonc/mdm450

Cognitive performance in light current users and ex-users of ecstasy (MDMA) and controls
Golding, J.F., Groome, D.H., Rycroft, N. and Denton, Z. 2007. Cognitive performance in light current users and ex-users of ecstasy (MDMA) and controls. American Journal of Drug and Alcohol Abuse. 33 (2), pp. 301-307. https://doi.org/10.1080/00952990601175052

Genetic influences on motion sickness susceptibility in adult women: a classical twin study
Reavley, C.M., Golding, J.F., Cherkas, L.F., Spector, T.D. and MacGregor, A.J. 2006. Genetic influences on motion sickness susceptibility in adult women: a classical twin study. Aviation, Space, and Environmental Medicine. 77 (11), pp. 1148-1152.

Motion sickness susceptibility
Golding, J.F. 2006. Motion sickness susceptibility. Autonomic Neuroscience. 129 (1-2), pp. 67-76. https://doi.org/10.1016/j.autneu.2006.07.019

Increasing cognitive load with increasing balance challenge: recipe for catastrophe
Barra, J., Bray, A., Vishal, S., Golding, J.F. and Gresty, M.A. 2006. Increasing cognitive load with increasing balance challenge: recipe for catastrophe. Experimental Brain Research. 174 (4), pp. 734-745. https://doi.org/10.1007/s00221-006-0519-2

P36.42 Identification of a pre-attentive visual discrimination response
Flynn, M., Liasis, A., Gardner, M. and Towell, A. 2006. P36.42 Identification of a pre-attentive visual discrimination response. Clinical Neurophysiology. 117 (Supplement 1), p. 194. https://doi.org/10.1016/j.clinph.2006.06.651

Tachypnea and hypocapnia are induced by 'buffeting' in vehicles
Green, D.A., Bray, A., Golding, J.F., Bronstein, A.M. and Gresty, M.A. 2006. Tachypnea and hypocapnia are induced by 'buffeting' in vehicles. Clinical Autonomic Research. 16 (4), pp. 281-285. https://doi.org/10.1007/s10286-006-0360-5

Predicting individual differences in motion sickness susceptibility by questionnaire
Golding, J.F. 2006. Predicting individual differences in motion sickness susceptibility by questionnaire. Personality and Individual Differences. 41 (2), pp. 237-248. https://doi.org/10.1016/j.paid.2006.01.012

Motion sickness susceptibility fluctuates through the menstrual cycle
Golding, J.F., Kadzere, P. and Gresty, M.A. 2005. Motion sickness susceptibility fluctuates through the menstrual cycle. Aviation, Space, and Environmental Medicine. 76 (10), pp. 970-973.

Can tamoxifen relieve motion sickness?
Gianni, M.C., Golding, J.F. and Goldhirsch, A. 2005. Can tamoxifen relieve motion sickness? Annals of Oncology. 16 (10), pp. 1713-1714. https://doi.org/10.1093/annonc/mdi304

Motion sickness
Golding, J.F. and Gresty, M.A. 2005. Motion sickness. Current Opinion in Neurology. 18 (1), pp. 29-34.

The brain-sex theory of occupational choice: a counterexample
Esgate, A. and Flynn, M. 2005. The brain-sex theory of occupational choice: a counterexample. Perceptual and Motor Skills. 100 (1), pp. 25-37.

Effect of a novel motion desensitization training regime and controlled breathing on habituation to motion sickness
Yen Pik Sang, F., Billar, J., Gresty, M.A. and Golding, J.F. 2005. Effect of a novel motion desensitization training regime and controlled breathing on habituation to motion sickness. Perceptual and Motor Skills. 18 (1), pp. 29-34.

Perceived control, locus of control and preparatory information: effects on the perception of an acute pain stimulus
Williams, D., Golding, J.F., Phillips, K. and Towell, A. 2004. Perceived control, locus of control and preparatory information: effects on the perception of an acute pain stimulus. Personality and Individual Differences. 36 (7), pp. 1681-1691. https://doi.org/10.1016/j.paid.2003.07.009

We are most aware of our place in the world when about to fall
Bray, A., Subanandan, A., Isableu, B., Ohlmann, T., Golding, J.F. and Gresty, M.A. 2004. We are most aware of our place in the world when about to fall. Current Biology. 14 (15), pp. R609-R610. https://doi.org/10.1016/j.cub.2004.07.040

Suppression of sickness by controlled breathing during mildly nauseogenic motion
Yen Pik Sang, F., Golding, J.F. and Gresty, M.A. 2003. Suppression of sickness by controlled breathing during mildly nauseogenic motion. Aviation, Space, and Environmental Medicine. 74 (9), pp. 998-1002.

Effect of breathing supplemental oxygen on motion sickness in healthy adults
Ziavra, N., Yen Pik Sang, F., Golding, J.F., Bronstein, A.M. and Gresty, M.A. 2003. Effect of breathing supplemental oxygen on motion sickness in healthy adults. Mayo Clinic Proceedings. 78 (5), pp. 574-578.

Behavioral methods of alleviating motion sickness: effectiveness of controlled breathing and a music audiotape
Yen Pik Sang, F., Billar, J., Golding, J.F. and Gresty, M.A. 2003. Behavioral methods of alleviating motion sickness: effectiveness of controlled breathing and a music audiotape. Journal of Travel Medicine. 10 (2), pp. 108-112.

Impairment of spatial cognitive function with preservation of verbal performance during spatial disorientation
Gresty, M.A., Waters, S., Bray, A., Bunday, K. and Golding, J.F. 2003. Impairment of spatial cognitive function with preservation of verbal performance during spatial disorientation. Current Biology. 13 (21), pp. R829-R830. https://doi.org/10.1016/j.cub.2003.10.013

Motion sickness and tilts of the inertial force environment: active suspension systems vs. active passengers
Golding, J.F., Bles, W., Bos, E., Haynes, T. and Gresty, M.A. 2003. Motion sickness and tilts of the inertial force environment: active suspension systems vs. active passengers. Aviation, Space, and Environmental Medicine. 74 (3), pp. 220-227.

Attentional demands of continuously monitoring orientation using vestibular information
Yardley, L., Papo, D., Bronstein, A.M., Gresty, M.A., Gardner, M., Lavie, N. and Luxon, L. 2002. Attentional demands of continuously monitoring orientation using vestibular information. Neuropsychologia. 40 (4), pp. 373-383. https://doi.org/10.1016/S0028-3932(01)00113-0

A motion sickness maximum around the 0.2 Hz frequency range of horizontal translational oscillation
Golding, J.F., Mueller, A.G. and Gresty, M.A. 2001. A motion sickness maximum around the 0.2 Hz frequency range of horizontal translational oscillation. Aviation, Space, and Environmental Medicine. 72 (3), pp. 188-192.

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