Pathophysiology and treatment of motion sickness
Golding, J.F. and Gresty, M.A. 2015. Pathophysiology and treatment of motion sickness. Current Opinion in Neurology. 28, pp. 83-88. https://doi.org/10.1097/WCO.0000000000000163
Golding, J.F. and Gresty, M.A. 2015. Pathophysiology and treatment of motion sickness. Current Opinion in Neurology. 28, pp. 83-88. https://doi.org/10.1097/WCO.0000000000000163
Title | Pathophysiology and treatment of motion sickness |
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Authors | Golding, J.F. |
Gresty, M.A. | |
Abstract | Purpose of review Motion sickness remains bothersome in conventional transport and is an emerging hazard in visual information technologies. Treatment remains unsatisfactory but advances in brain imaging, neurophysiology, and neuropharmacology may provide insights into more effective drug and behavioural management. We review these major developments. Recent findings Recent progress has been in identifying brain mechanisms and loci associated with motion sickness and nausea per se. The techniques have included conventional neurophysiology, pathway mapping, and functional MRI, implicating multiple brain regions including cortex, brainstem, and cerebellum. Understanding of the environmental and behavioural conditions provocative of and protective against motion sickness and how vestibular disease may sensitize to motion sickness has increased. The problem of nauseogenic information technology has emerged as a target for research, motivated by its ubiquitous applications. Increased understanding of the neurophysiology and brain regions associated with motion sickness may provide for more effective medication in the future. However, the polysymptomatic nature of motion sickness, high interindividual variability, and the extensive brain regions involved may preclude a single, decisive treatment. Summary Motion sickness is an emerging hazard in information technologies. Adaptation remains the most effective countermeasure together with established medications, notably scopolamine and antihistamines. Neuropharmacological investigations may provide more effective medication in the foreseeable future. |
Keywords | motion sickness |
neurophysiology | |
vestibular | |
virtual reality | |
Journal | Current Opinion in Neurology |
Journal citation | 28, pp. 83-88 |
Year | 2015 |
Digital Object Identifier (DOI) | https://doi.org/10.1097/WCO.0000000000000163 |
Web address (URL) | http://dx.doi.org/10.1097/WCO.0000000000000163 |
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[18F]2-fluoro-2-deoxy-D-glucose positron emission tomography (FDG PET) as a diagnostic tool for neurofibromatosis 1 (NF1) associated malignant peripheral nerve sheath tumours (MPNSTs): a long-term clinical study
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Motion sickness susceptibility
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Increasing cognitive load with increasing balance challenge: recipe for catastrophe
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Golding, J.F., Kadzere, P. and Gresty, M.A. 2005. Motion sickness susceptibility fluctuates through the menstrual cycle. Aviation, Space, and Environmental Medicine. 76 (10), pp. 970-973.
Can tamoxifen relieve motion sickness?
Gianni, M.C., Golding, J.F. and Goldhirsch, A. 2005. Can tamoxifen relieve motion sickness? Annals of Oncology. 16 (10), pp. 1713-1714. https://doi.org/10.1093/annonc/mdi304
Motion sickness
Golding, J.F. and Gresty, M.A. 2005. Motion sickness. Current Opinion in Neurology. 18 (1), pp. 29-34.
Effect of a novel motion desensitization training regime and controlled breathing on habituation to motion sickness
Yen Pik Sang, F., Billar, J., Gresty, M.A. and Golding, J.F. 2005. Effect of a novel motion desensitization training regime and controlled breathing on habituation to motion sickness. Perceptual and Motor Skills. 18 (1), pp. 29-34.
Perceived control, locus of control and preparatory information: effects on the perception of an acute pain stimulus
Williams, D., Golding, J.F., Phillips, K. and Towell, A. 2004. Perceived control, locus of control and preparatory information: effects on the perception of an acute pain stimulus. Personality and Individual Differences. 36 (7), pp. 1681-1691. https://doi.org/10.1016/j.paid.2003.07.009
We are most aware of our place in the world when about to fall
Bray, A., Subanandan, A., Isableu, B., Ohlmann, T., Golding, J.F. and Gresty, M.A. 2004. We are most aware of our place in the world when about to fall. Current Biology. 14 (15), pp. R609-R610. https://doi.org/10.1016/j.cub.2004.07.040
Suppression of sickness by controlled breathing during mildly nauseogenic motion
Yen Pik Sang, F., Golding, J.F. and Gresty, M.A. 2003. Suppression of sickness by controlled breathing during mildly nauseogenic motion. Aviation, Space, and Environmental Medicine. 74 (9), pp. 998-1002.
Effect of breathing supplemental oxygen on motion sickness in healthy adults
Ziavra, N., Yen Pik Sang, F., Golding, J.F., Bronstein, A.M. and Gresty, M.A. 2003. Effect of breathing supplemental oxygen on motion sickness in healthy adults. Mayo Clinic Proceedings. 78 (5), pp. 574-578.
Behavioral methods of alleviating motion sickness: effectiveness of controlled breathing and a music audiotape
Yen Pik Sang, F., Billar, J., Golding, J.F. and Gresty, M.A. 2003. Behavioral methods of alleviating motion sickness: effectiveness of controlled breathing and a music audiotape. Journal of Travel Medicine. 10 (2), pp. 108-112.
Impairment of spatial cognitive function with preservation of verbal performance during spatial disorientation
Gresty, M.A., Waters, S., Bray, A., Bunday, K. and Golding, J.F. 2003. Impairment of spatial cognitive function with preservation of verbal performance during spatial disorientation. Current Biology. 13 (21), pp. R829-R830. https://doi.org/10.1016/j.cub.2003.10.013
Motion sickness and tilts of the inertial force environment: active suspension systems vs. active passengers
Golding, J.F., Bles, W., Bos, E., Haynes, T. and Gresty, M.A. 2003. Motion sickness and tilts of the inertial force environment: active suspension systems vs. active passengers. Aviation, Space, and Environmental Medicine. 74 (3), pp. 220-227.
Attentional demands of continuously monitoring orientation using vestibular information
Yardley, L., Papo, D., Bronstein, A.M., Gresty, M.A., Gardner, M., Lavie, N. and Luxon, L. 2002. Attentional demands of continuously monitoring orientation using vestibular information. Neuropsychologia. 40 (4), pp. 373-383. https://doi.org/10.1016/S0028-3932(01)00113-0
A motion sickness maximum around the 0.2 Hz frequency range of horizontal translational oscillation
Golding, J.F., Mueller, A.G. and Gresty, M.A. 2001. A motion sickness maximum around the 0.2 Hz frequency range of horizontal translational oscillation. Aviation, Space, and Environmental Medicine. 72 (3), pp. 188-192.
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