McCartney, A.L., Hoyles, L., Jiménez-Pranteda, M.L., Chilloux, J. and Dumas, M.-E. 2015. Reduction of trimethylamine N-oxide to trimethylamine by the human gut microbiota: supporting evidence for ‘metabolic retroversion’. Exploring Human Host-Microbiome Interactions in Health and Disease. Cambridge, UK 29 Jun 2015
| Title | Reduction of trimethylamine N-oxide to trimethylamine by the human gut microbiota: supporting evidence for ‘metabolic retroversion’ |
|---|---|
| Authors | McCartney, A.L., Hoyles, L., Jiménez-Pranteda, M.L., Chilloux, J. and Dumas, M.-E. |
| Type | Conference poster |
| Abstract | Dietary sources of methylamines such as choline, trimethylamine (TMA), trimethylamine N-oxide (TMAO), phosphatidylcholine (PC) and carnitine are present in a number of foodstuffs, including meat, fish, nuts and eggs. It is recognized that the gut microbiota is able to convert choline to TMA in a fermentation-like process. Similarly, PC and carnitine are converted to TMA by the gut microbiota. It has been suggested that TMAO is subject to ‘metabolic retroversion’ in the gut (i.e. it is reduced to TMA by the gut microbiota, with this TMA being oxidized to produce TMAO in the liver). Sixty-six strains of human faecal and caecal bacteria were screened on solid and liquid media for their ability to utilize trimethylamine N-oxide (TMAO), with metabolites in spent media profiled by Proton Nuclear Magnetic Resonance (1H NMR) spectroscopy. Enterobacteriaceae produced mostly TMA from TMAO, with caecal/small intestinal isolates of Escherichia coli producing more TMA than their faecal counterparts. Lactic acid bacteria (enterococci, streptococci, bifidobacteria) produced increased amounts of lactate when grown in the presence of TMAO, but did not produce large amounts of TMA from TMAO. The presence of TMAO in media increased the growth rate of Enterobacteriaceae; while it did not affect the growth rate of lactic acid bacteria, TMAO increased the biomass of these bacteria. The positive influence of TMAO on Enterobacteriaceae was confirmed in anaerobic, stirred, pH-controlled batch culture fermentation systems inoculated with human faeces, where this was the only bacterial population whose growth was significantly stimulated by the presence of TMAO in the medium. We hypothesize that dietary TMAO is used as an alternative electron acceptor by the gut microbiota in the small intestine/proximal colon, and contributes to microbial population dynamics upon its utilization and retroversion to TMA, prior to absorption and secondary conversion to TMAO by hepatic flavin-containing monooxygenases. Our findings support the idea that oral TMAO supplementation is a physiologically-stable microbiota-mediated strategy to deliver TMA at the gut barrier. |
| Year | 2015 |
| Conference | Exploring Human Host-Microbiome Interactions in Health and Disease |
| Accepted author manuscript |
Kroppenstedtia pulmonis sp. nov. and Kroppenstedtia sanguinis sp. nov., isolated from human patients
Bell, M.E., Lasker, B.A., Klenk, H.-P., Hoyles, L., Spröer, C., Schumann, P. and Brown, J.M. 2016. Kroppenstedtia pulmonis sp. nov. and Kroppenstedtia sanguinis sp. nov., isolated from human patients. Antonie van Leeuwenhoek Journal of Microbiology. 109 (5), pp. 603-610. https://doi.org/10.1007/s10482-016-0663-z
Akkermansia muciniphila and improved metabolic health during a dietary intervention in obesity: relationship with gut microbiome richness and ecology
Dao, M.C., Everard, A., Aron-Wisnewsky, J., Sokolovska Nataliya, Prifti, E., Kayser, B., Levenez, F., Chilloux, J., Hoyles, L., MICRO-Obes Consortium, Dumas, M.-E., Doré, J., Clément, K., Sokolvska, N., Verger, E.O., Rizkalla, S.W. and Cani, P.D. 2016. Akkermansia muciniphila and improved metabolic health during a dietary intervention in obesity: relationship with gut microbiome richness and ecology. Gut. 65 (3), pp. 426-436. https://doi.org/10.1136/gutjnl-2014-308778
Quantifying diet-induced metabolic changes of the human gut microbiome
Shoaie, S., Ghaffari, P., Kovatcheva-Datchary, P., Mardinoglu, A., Sen, P., Pujos-Guillot, E., de Wouters, T., Juste, C., Rizkalla, S.W., Chilloux, J., Hoyles, L., Nicholson, J.K., ANR MICRO-Obes Consortium, Dumas, M.-E., Clément, K., Bäckhed, F., Nielsen, J., Tomas de Wouters and Doré, J. 2015. Quantifying diet-induced metabolic changes of the human gut microbiome. Cell Metabolism. 22 (2), pp. 320-331. https://doi.org/10.1016/j.cmet.2015.07.001
Klebsiella pneumoniae subsp. pneumoniae–bacteriophage combination from the caecal effluent of a healthy woman
Hoyles, L., Murphy, J., Neve, H., Heller, K., Turton, J.F., Mahony, J., Sanderson, J.D., Hudspith, B., Gibson, G.R., McCartney, A.L. and van Sinderen, D. 2015. Klebsiella pneumoniae subsp. pneumoniae–bacteriophage combination from the caecal effluent of a healthy woman. PeerJ. 3, p. e1061 e1061. https://doi.org/10.7717/peerj.1061
P145 La trimethylamine, métabolite du microbiote intestinal, inhibe la voie inflammatoire des Toll-Like Receptor (TLRs) via une inhibition directe d’une enzyme clé de la transduction du signal
Chilloux, J., Fearnside, J., Barton, R., Fuchs, J., Rothwell, A., Hoyles, L., Gerard, C., Calderari, S., Boulange, C., Patel, S., Scott, J., Glen, R., Gauguier, D., Gooderham, N., Nicholson, J.K., Dumas, M.-E. and Gaugier, D. 2015. P145 La trimethylamine, métabolite du microbiote intestinal, inhibe la voie inflammatoire des Toll-Like Receptor (TLRs) via une inhibition directe d’une enzyme clé de la transduction du signal. Congrès annuel de la SFD et de la SFD Paramédical. Bordeaux, France 24 Mar 2015 Elsevier. https://doi.org/10.1016/S1262-3636(15)30258-5
IMP: Imperial Metagenomics Pipeline for high-throughput sequence data
Hoyles, L., Abbott, J.C., Holmes, E., Dumas, M.-E., Butcher, S.A. and Nicholson, J.K. 2015. IMP: Imperial Metagenomics Pipeline for high-throughput sequence data. Exploring Human Host-Microbiome Interactions in Health and Disease. Cambridge, UK 29 Jun 2015
Klebsiella pneumoniae subsp. pneumoniae–bacteriophage combination from the caecal effluent of a healthy woman
Hoyles, L., Murphy, J., Neve, H., Mahony, J., Gibson, G.R., McCartney, A.L., van Sinderen, D., Turton, J.F. and Sanderson, J.D. 2015. Klebsiella pneumoniae subsp. pneumoniae–bacteriophage combination from the caecal effluent of a healthy woman. 8th International Yakult Symposium: Probiotics, a protective approach to health – an expert insight into the latest research. Berlin 23 Apr 2015
Dynamics and diversity of the 'Atopobium cluster' in the human faecal microbiota, and phenotypic characterization of 'Atopobium cluster' isolates
Thorasin, T., Hoyles, L. and McCartney, A.L. 2015. Dynamics and diversity of the 'Atopobium cluster' in the human faecal microbiota, and phenotypic characterization of 'Atopobium cluster' isolates. Microbiology. 161 (3), pp. 565-579. https://doi.org/10.1099/mic.0.000016
In vitro examination of the effect of orlistat on the ability of the faecal microbiota to utilize dietary lipids
Hoyles, L. 2009. In vitro examination of the effect of orlistat on the ability of the faecal microbiota to utilize dietary lipids. PhD thesis University of Reading Food and Nutritional Biosciences
Practical Microbiology for Secondary Schools: A Resource for Key Stages 3, 4 and Post-16 and the Equivalent Scottish Qualifications
Fry, P., Grainger, J., Hurst, J. and Hoyles, L. 2002. Practical Microbiology for Secondary Schools: A Resource for Key Stages 3, 4 and Post-16 and the Equivalent Scottish Qualifications. Reading Society for General Microbiology.
Characterization of Actinomyces isolates from infected root canals of teeth: description of Actinomyces radicidentis sp. nov.
Collins, M., Hoyles, L., Kalfas, S., Sundquist, G., Monsen, T., Nikolaitchouk, N. and Falsen, E. 2000. Characterization of Actinomyces isolates from infected root canals of teeth: description of Actinomyces radicidentis sp. nov. Journal of Clinical Microbiology. 38 (9), pp. 3399-3403.
Phenotypic and phylogenetic characterization of a new Corynebacterium species from dogs: description of Corynebacterium auriscanis sp. nov.
Collins, M., Hoyles, L., Lawson, P., Falsen, E., Robson, R. and Foster, G. 1999. Phenotypic and phylogenetic characterization of a new Corynebacterium species from dogs: description of Corynebacterium auriscanis sp. nov. Journal of Clinical Microbiology. 37 (11), pp. 3443-3447.
Facklamia
Hoyles, L. 2014. Facklamia. in: Holzapfel, W.H. and Wood, B.J.B. (ed.) Lactic Acid Bacteria: Biodiversity and Taxonomy Wiley. pp. 91-98
Characterization of virus-like particles associated with the human faecal and caecal microbiota
Hoyles, L., McCartney, A.L., Neve, H., Gibson, G.R., Sanderson, J.D., Heller, K. and van Sinderen, D. 2014. Characterization of virus-like particles associated with the human faecal and caecal microbiota. Research in Microbiology. 165 (10), pp. 803-812. https://doi.org/10.1016/j.resmic.2014.10.006
Microbiota and metabolome associated with the human caecum
Hoyles, L. 2013. Microbiota and metabolome associated with the human caecum. Exploring Human Host–Microbiome Interactions in Health and Disease. Fitzwilliam College, Cambridge, UK 08 Jul 2013
The microbial–mammalian metabolic and signalling axis in cardiometabolic diseases
Dumas, M.E., Chilloux, J., Hoyles, L., Gooderham, N. and Nicholson, J.K. 2013. The microbial–mammalian metabolic and signalling axis in cardiometabolic diseases. Cell Symposium: Microbiome and Host Health. Lisbon, Portugal 12 May 2013
Kroppenstedtia sanguinis sp. nov., and Kroppenstedtia pulmonis sp. nov., thermoactinomycetes isolated from human clinical sources
Lasker, B.A., Bell, M.E., Klenk, H.-P., Hoyles, L. and Brown, J.M. 2013. Kroppenstedtia sanguinis sp. nov., and Kroppenstedtia pulmonis sp. nov., thermoactinomycetes isolated from human clinical sources. International Conference on the Biology of Nocardiae. Toluca, Mexico 23 Apr 2013
An assessment of the prebiotic potential of single and blended substrates in anaerobic in vitro batch culture fermentations using canine faecal samples as inocula
Inness, V.L., Khoo, C., Hoyles, L., Gibson, G.R. and McCartney, A.L. 2013. An assessment of the prebiotic potential of single and blended substrates in anaerobic in vitro batch culture fermentations using canine faecal samples as inocula. International Journal of Probiotics and Prebiotics. 8 (4), pp. 133-144.
Coriobacteriaceae: could gut bacteria be implicated in lipid metabolism?
Thorasin, T., Maria L Jiménez-Pranteda, M.L., Hoyles, L., McCartney, A.L. and Jiménez-Pranteda, M.L. 2013. Coriobacteriaceae: could gut bacteria be implicated in lipid metabolism? Gut Microbiota for Health, 2nd World Summit. Madrid, Spain 26 Feb 2013
The microbial–mammalian metabolic and signalling axis in cardiometabolic diseases
Dumas, M.-E., Chilloux, J., Hoyles, L., Gooderham, N. and Nicholson, J.K. 2013. The microbial–mammalian metabolic and signalling axis in cardiometabolic diseases. Cell Symposium: Microbiome and Host Health. Lisbon, Portugal 12 May 2013
Microbiota and metabolome associated with the human caecum
Hoyles, L. 2013. Microbiota and metabolome associated with the human caecum. Exploring Human Host–Microbiome Interactions in Health and Disease. Fitzwilliam College, Cambridge, UK 08 Jul 2013
An assessment of the prebiotic potential of single and blended substrates in anaerobic in vitro batch culture fermentations using canine faecal samples as inocula
Inness, V.L., Khoo, C., Gross, K.L., Hoyles, L., Gibson, G.R. and McCartney, A.L. 2013. An assessment of the prebiotic potential of single and blended substrates in anaerobic in vitro batch culture fermentations using canine faecal samples as inocula. Int J Probiotics Prebiotics. 8, pp. 133-144.
Use of denaturing gradient gel electrophoresis to detect Actinobacteria associated with the human faecal microbiota
Hoyles, L., Clear, J.A. and McCartney, A.L. 2013. Use of denaturing gradient gel electrophoresis to detect Actinobacteria associated with the human faecal microbiota. Anaerobe. 22, pp. 90-96. https://doi.org/10.1016/j.anaerobe.2013.06.001
Corynebacterium uterequi sp. nov., a non-lipophilic bacterium isolated from urogenital samples from horses
Hoyles, L., Ortman, K., Cardew, S., Foster, G., Rogerson, F. and Falsen, E. 2013. Corynebacterium uterequi sp. nov., a non-lipophilic bacterium isolated from urogenital samples from horses. Veterinary Microbiology. 165 (3-4), pp. 469-474. https://doi.org/10.1016/j.vetmic.2013.03.025
Biodiversity of lactococcal bacteriophages isolated from 3 Gouda-type cheese producing plants
Murphy, J., Royer, B., Mahony, J., Hoyles, L., Heller, K., Neve, H., Bonestroo, M., Nauta, A., van Sinderen, D. and Banestroo, M. 2013. Biodiversity of lactococcal bacteriophages isolated from 3 Gouda-type cheese producing plants. Journal of Dairy Science. 96 (8), pp. 4945-4957. https://doi.org/10.3168/jds.2013-6748
Colonic bacterial metabolites and host health
Russell, W., Hoyles, L., Flint H, J. and Dumas M-E 2013. Colonic bacterial metabolites and host health. Current Opinion in Microbiology. 16 (3), pp. 246-254. https://doi.org/10.1016/j.mib.2013.07.002
Investigation of the impact of feeding Lactobacillus plantarum CRL 1815 encapsulated in microbially derived polymers on the rat faecal microbiota
Jiménez-Pranteda, M.L., Aguilera, M., McCartney, A.L., Hoyles, L., Jiménez-Valera, M., Náder-Macías, M.E., Ramos-Cormenzana, A. and Monteoliva-Sánchez, M. 2012. Investigation of the impact of feeding Lactobacillus plantarum CRL 1815 encapsulated in microbially derived polymers on the rat faecal microbiota. Journal of Applied Microbiology. 113 (2), pp. 399-410. https://doi.org/10.1111/j.1365-2672.2012.05343.x
Investigations of the human faecal Coriobacteriaceae population
McCartney, A.L., Thorasin, T. and Hoyles, L. 2012. Investigations of the human faecal Coriobacteriaceae population. Exploring Human Host–Microbiome Interactions in Health and Disease. Cambridge, UK 08 May 2012
Genus IV. Mobiluncus
Hoyles, L. and McCartney, A.L. 2012. Genus IV. Mobiluncus. in: Whitman, W., Goodfellow, M., Kämpfer, P., Busse, H.J., Trujillo, M.E., Ludwig, W., Suzuki, K.I. and Parte, A. (ed.) Bergey’s Manual of Systematic Bacteriology. Volume Five The Actinobacteria, Part A and B Springer.
Isolation of Actinomyces hyovaginalis from sheep and comparison with isolates obtained from pigs
Foster, G., Wragg, P., Koylass, M.S., Whatmore, A.M. and Hoyles, L. 2012. Isolation of Actinomyces hyovaginalis from sheep and comparison with isolates obtained from pigs. Veterinary Microbiology. 157 (3-4), pp. 471-475. https://doi.org/10.1016/j.vetmic.2012.01.003
Recognition of greater diversity of Bacillus species and related bacteria in human faeces
Hoyles, L., Honda, H., Logan, N.A., Halket, G., La Ragione, R.M. and McCartney, A.L. 2012. Recognition of greater diversity of Bacillus species and related bacteria in human faeces. Research in Microbiology. 163 (1), pp. 3-13. https://doi.org/10.1016/j.resmic.2011.10.004
Investigations of the human faecal Coriobacteriaceae population
Thorasin, T., Hoyles, L. and McCartney, A.L. 2011. Investigations of the human faecal Coriobacteriaceae population. International Scientific Conference on Nutraceuticals and Functional Foods – FF2011. Kosice, Slovakia 25 Oct 2011
Isolation of a Klebsiella bacterium–bacteriophage combination from human caecum effluent
Hoyles, L., McCartney, A.L. and van Sinderen, D. 2011. Isolation of a Klebsiella bacterium–bacteriophage combination from human caecum effluent. SGM Autumn Conference. University of York, UK 05 Sep 2011
Investigation of bacteriophage diversity associated with the human gastrointestinal microbiota
Hoyles, L., Neve, H., McCartney, A.L. and van Sinderen, D. 2011. Investigation of bacteriophage diversity associated with the human gastrointestinal microbiota. SGM Irish Division: Microbial Viruses: Genomics, Evolution and Applications in Ecology, Biotechnology and Medicine. University of Belfast, UK 19 Apr 2011
Use of static batch culture systems to investigate the fermentation effects of selected oligosaccharides and fibres by the canine faecal microbiota
Inness, V.L., Khoo, C., Gross, K.L., Hoyles, L., Gibson, G.R. and McCartney, A.L. 2011. Use of static batch culture systems to investigate the fermentation effects of selected oligosaccharides and fibres by the canine faecal microbiota. International Journal of Probiotics and Prebiotics. 6 (1), pp. 57-64.
Impact of GanedenBC30 (Bacillus coagulans GBI-30, 6086) on population dynamics of the human gut microbiota in a continuous culture fermentation system
Honda, H., Hoyles, L., Gibson, G.R. and Farmer, S. 2011. Impact of GanedenBC30 (Bacillus coagulans GBI-30, 6086) on population dynamics of the human gut microbiota in a continuous culture fermentation system. International Journal of Probiotics and Prebiotics. 6 (1), pp. 65-72.
Investigation of bacteriophage diversity associated with the human gastrointestinal microbiota
Hoyles, L., Neve, H., McCartney, A.L. and van Sinderen, D. 2011. Investigation of bacteriophage diversity associated with the human gastrointestinal microbiota. SGM Irish Division: Microbial Viruses: Genomics, Evolution and Applications in Ecology, Biotechnology and Medicine. University of Belfast, UK 19 Apr 2011
Isolation of a Klebsiella bacterium–bacteriophage combination from human caecum effluent
Hoyles, L., McCartney, A.L. and van Sinderen, D. 2011. Isolation of a Klebsiella bacterium–bacteriophage combination from human caecum effluent. SGM Autumn Conference. University of York, UK 05 Sep 2011
Pilot study investigating the Coriobacteriaceae population of the human gastrointestinal microbiota
Thorasin, T., Hoyles, L. and McCartney, A.L. 2011. Pilot study investigating the Coriobacteriaceae population of the human gastrointestinal microbiota. International Scientific Conference on Nutraceuticals and Functional Foods – FF2011. Kosice, Slovakia 25 Oct 2011
Use of static batch culture systems to investigate the fermentation effects of selected oligosaccharides and fibres by the canine faecal microbiota
Inness, V.L., Khoo, C., Gross, K.L., Hoyles, L., Gibson, G.R. and McCartney, A.L. 2011. Use of static batch culture systems to investigate the fermentation effects of selected oligosaccharides and fibres by the canine faecal microbiota. International Journal of Probiotics and Prebiotics. 6, pp. 57-64.
In vitro fermentation of rice bran combined with Lactobacillus acidophilus 14 150B or Bifidobacterium longum 05 by the canine faecal microbiota
Ogué Bon, E., Khoo, C., Hoyles, L., McCartney, A.L., Gibson, G.R. and Rastall, R.A. 2011. In vitro fermentation of rice bran combined with Lactobacillus acidophilus 14 150B or Bifidobacterium longum 05 by the canine faecal microbiota. FEMS Microbiology Ecology. 75 (3), pp. 365-376. https://doi.org/10.1111/j.1574-6941.2010.01014.x
Investigation of bacteriophage diversity associated with the human gastrointestinal microbiota
Hoyles, L., Neve, H., McCartney, A.L. and van Sinderen, D. 2010. Investigation of bacteriophage diversity associated with the human gastrointestinal microbiota. Globe Forum. Dublin, Ireland 18 Nov 2010
Examination of faecal Bifidobacterium populations in breast- and formula-fed infants during the first 18 months of life
Roger, L.C., Costabile, A., Hoyles, L., Holland, D.T. and McCartney, A.L. 2010. Examination of faecal Bifidobacterium populations in breast- and formula-fed infants during the first 18 months of life. Rowett–INRA 2010: Gut Microbiology: New Insights into Gut Microbial Ecosystems. Aberdeen, UK 23 Jun 2010 Society for General Microbiology. https://doi.org/10.1099/mic.0.043224-0
In vitro investigations into the effect of orlistat, an anti-obesity therapy, on the human fecal microbiota
Hoyles, L., Daggy, B.P., McKain, N., Wallace, R.J., Gibson, G.R. and McCartney, A.L. 2010. In vitro investigations into the effect of orlistat, an anti-obesity therapy, on the human fecal microbiota. Rowett–INRA 2010: Gut Microbiology: New Insights into Gut Microbial Ecosystems. Aberdeen, UK 23 Jun 2010
Gastrointestinal tract: intestinal fatty acid metabolism and implications for health
Hoyles, L. and Wallace, R.J. 2010. Gastrointestinal tract: intestinal fatty acid metabolism and implications for health. in: Timmis, K.N. (ed.) Handbook of Hydrocarbon and Lipid Microbiology Springer.
Gastrointestinal Tract: Fat Metabolism in the Colon
Hoyles, L. and Wallace, R.J. 2010. Gastrointestinal Tract: Fat Metabolism in the Colon. in: Timmis, K.N. (ed.) Handbook of Hydrocarbon and Lipid Microbiology Springer.
Effects of a novel galactooligosaccharide on the faecal microbiota of healthy and inflammatory bowel disease cats during a randomized, double-blind, cross-over feeding study
Abecia, L., Hoyles, L., Khoo, C., Frantz, N. and McCartney, A.L. 2010. Effects of a novel galactooligosaccharide on the faecal microbiota of healthy and inflammatory bowel disease cats during a randomized, double-blind, cross-over feeding study. International Journal of Probiotics and Prebiotics. 5 (2), pp. 61-68.
Investigation of bacteriophage diversity associated with the human gastrointestinal microbiota
Hoyles, L., Neve, H., McCartney, A.L. and van Sinderen, D. 2010. Investigation of bacteriophage diversity associated with the human gastrointestinal microbiota. Globe Forum. Dublin, Ireland 18 Nov 2010
Gastrointestinal tract: intestinal fatty acid metabolism and implications for health
Hoyles, L. and Wallace R, J. 2010. Gastrointestinal tract: intestinal fatty acid metabolism and implications for health. in: T McGenity K N Timmis J R van der Meer and V de Lorenzo (ed.) Handbook of Hydrocarbon and Lipid Microbiology, vol. 4, part 7, Human-Animal-Plant Health and Physiology Consequences of Microbial Interactions with Hydrocarbons and Lipids New York Springer. pp. 3119-3132
Evaluation of the inclusion of a mixture of organic acids or lactulose in the feed of pigs experimentally challenged with Salmonella Typhimurium
Martín-Peláez, S., Costabile, A., Hoyles, L., Rastall R, A., Gibson, G.R., La Ragione, R.M., Woodward, M.J., Mateu, E. and Martín-Orúe, S.M. 2010. Evaluation of the inclusion of a mixture of organic acids or lactulose in the feed of pigs experimentally challenged with Salmonella Typhimurium. Veterinary Microbiology. 142 (3-4), pp. 337-345. https://doi.org/10.1016/j.vetmic.2009.09.061
Prebiotic effects: metabolic and health benefits
Roberfroid, M., Gibson, G.R., Hoyles, L., McCartney A, L., Rastall, R., Rowland, I., Wolvers, D., Watzl, B., Szajewska, H., Stahl, B., Guarner, F., Respondek, F., Whelan, K., Coxam, V., Davicco M-J, Léotoing, L., Wittrant, Y., Delzenne, N.M., Cani, P.D., Neyrinck, A.M. and Meheust, A. 2010. Prebiotic effects: metabolic and health benefits. British Journal of Nutrition. 104 (Suppl 2), pp. S1-S63. https://doi.org/10.1017/S0007114510003363
Characterization of Bacillus and related species isolated from human faeces
Honda, H., Hoyles, L., Logan, N.A., Halket, G., La Ragione, R.M. and McCartney, A.L. 2009. Characterization of Bacillus and related species isolated from human faeces. 5th International Yakult Symposium: the Gut and More; Probiotic Influences Beyond the Gut. Amsterdam, Netherlands 18 Jun 2009
In vitro investigations into the effect of orlistat, an anti-obesity therapy, on the human fecal microbiota
Hoyles, L., Daggy, B.P., McKain, N., Wallace, R.J., Gibson, G.R. and McCartney, A.L. 2009. In vitro investigations into the effect of orlistat, an anti-obesity therapy, on the human fecal microbiota. American Society for Microbiology, 109th General Meeting. Philadelphia, USA 17 May 2009
In vitro examination of the effect of orlistat on the ability of the faecal microbiota to utilize dietary lipids
Hoyles, L. 2009. In vitro examination of the effect of orlistat on the ability of the faecal microbiota to utilize dietary lipids. PhD thesis University of Reading Food and Nutritional Biosciences
What do we mean when we refer to Bacteroidetes populations in the human gastrointestinal microbiota?
Hoyles, L. and McCartney, A.L. 2009. What do we mean when we refer to Bacteroidetes populations in the human gastrointestinal microbiota? FEMS Microbiology Letters. 299 (2), pp. 175-183. https://doi.org/10.1111/j.1574-6968.2009.01741.x
Isolation of Bacillus clausii, Bacillus licheniformis and other bacilli from human faecal samples
Hoyles, L., Honda, H., Logan, N.A., Halket, G., La Ragione, R.M. and McCartney, A.L. 2008. Isolation of Bacillus clausii, Bacillus licheniformis and other bacilli from human faecal samples. INRA–Rowett 2008: Gut Microbiome: Functionality, Interaction with the Host and Impact on the Environment. Clermont-Ferrand, France 18 Jun 2008
Detection of Actinobacteria associated with the human faecal microbiota
Hoyles, L., Clear, J.A., Gibson, G.R. and McCartney, A.L. 2007. Detection of Actinobacteria associated with the human faecal microbiota. 14th International Symposium on the Biology of Actinomycetes. The Sage, Newcastle 26 Aug 2007
Survivability of a probiotic Lactobacillus casei in the gastrointestinal tract of healthy human volunteers and its impact on the faecal microflora
Tuohy, K.M., Pinart-Gilberga, M., Jones, M., Hoyles, L., McCartney, A.L. and Gibson, G.R. 2007. Survivability of a probiotic Lactobacillus casei in the gastrointestinal tract of healthy human volunteers and its impact on the faecal microflora. Journal of Applied Microbiology. 102 (4), pp. 1026-1032. https://doi.org/10.1111/j.1365-2672.2006.03154.x
Diet, immunity and functional foods
Hoyles, L. and Vulevic, J. 2007. Diet, immunity and functional foods. Advances in Experimental Medicine and Biology. 635, pp. 79-92. https://doi.org/10.1007/978-0-387-09550-9_7
In vitro investigations of the effects of orlistat on the human faecal microbiota
Hoyles, L., Daggy, B.P., Gibson, G.R. and McCartney, A.L. 2006. In vitro investigations of the effects of orlistat on the human faecal microbiota. SGM Annual Meeting. University of Warwick, UK 03 Apr 2006
'List of Changes in Taxonomic Opinion': making use of the new lists
Euzéby, J.P., Hoyles, L., Kämpfer, P., Oren, A., Saddler, G.S., Trüper, H.G. and Tindall, B.J. 2004. 'List of Changes in Taxonomic Opinion': making use of the new lists. International Journal of Systematic and Evolutionary Microbiology. 54 (5), pp. 1429-1430. https://doi.org/10.1099/ijs.0.63375-0
Corynebacterium caspium sp. nov., from a Caspian seal (Phoca caspica)
Collins M, D., Hoyles, L., Foster, G. and Falsen, E. 2004. Corynebacterium caspium sp. nov., from a Caspian seal (Phoca caspica). International Journal of Systematic and Evolutionary Microbiology. 54 (3), pp. 925-928. https://doi.org/10.1099/ijs.0.02950-0
Jeotgalicoccus pinnipedialis sp. nov., from a southern elephant seal (Mirounga leonina)
Hoyles, L., Collins M, D., Foster, G., Falsen, E. and Schumann, P. 2004. Jeotgalicoccus pinnipedialis sp. nov., from a southern elephant seal (Mirounga leonina). International Journal of Systematic and Evolutionary Microbiology. 54 (3), pp. 745-748. https://doi.org/10.1099/ijs.0.02833-0
Transfer of members of the genus Falcivibrio to the genus Mobiluncus, and emended description of the genus Mobiluncus
Hoyles, L., Collins, M.D., Falsen, E., Nikolaitchouk, N. and McCartney, A.L. 2004. Transfer of members of the genus Falcivibrio to the genus Mobiluncus, and emended description of the genus Mobiluncus. Systematic and Applied Microbiology. 27 (1), pp. 72-83. https://doi.org/10.1078/0723-2020-00260
Practical Microbiology for Secondary Schools: A Resource for Key Stages 3, 4 and Post-16 and the Equivalent Scottish Qualifications
Fry, P., Grainger, J., Hurst, J., Hoyles, L. and Noble, S. Fry, P., Grainger, J. and Hurst, J. (ed.) 2002. Practical Microbiology for Secondary Schools: A Resource for Key Stages 3, 4 and Post-16 and the Equivalent Scottish Qualifications. Reading Society for General Microbiology.
Actinomyces coleocanis sp. nov., from the vagina of a dog
Hoyles, L., Falsen, E., Foster, G. and Collins M, D. 2002. Actinomyces coleocanis sp. nov., from the vagina of a dog. International Journal of Systematic and Evolutionary Microbiology. 52 (4), pp. 1201-1203. https://doi.org/10.1099/ijs.0.01934-0
Bifidobacterium scardovii sp. nov., from human sources
Hoyles, L., Inganas, E., Falsen, E., Drancourt, M., Weiss, N., McCartney, A.L. and Collins, M.D. 2002. Bifidobacterium scardovii sp. nov., from human sources. International Journal of Systematic and Evolutionary Microbiology. 52 (3), pp. 995-999. https://doi.org/10.1099/ijs.0.02065-0
Arcanobacterium hippocoleae sp. nov., from the vagina of a horse
Hoyles, L., Falsen, E., Foster, G., Rogerson, F. and Collins M, D. 2002. Arcanobacterium hippocoleae sp. nov., from the vagina of a horse. International Journal of Systematic and Evolutionary Microbiology. 52 (2), pp. 617-619. https://doi.org/10.1099/ijs.0.01950-0
Arthrobacter nasiphocae sp. nov., from the common seal (Phoca vitulina)
Collins M, D., Hoyles, L., Foster, G., Falsen, E. and Weiss, N. 2002. Arthrobacter nasiphocae sp. nov., from the common seal (Phoca vitulina). International Journal of Systematic and Evolutionary Microbiology. 52, pp. 569-571. https://doi.org/10.1099/ijs.0.01932-0
Characterization of some strains from human clinical sources which resemble "Leptotrichia sanguinegens": description of Sneathia sanguinegens sp. nov., gen. nov.
Collins M, D., Hoyles, L., Tornqvist, E., von Essen, R. and Falsen, E. 2001. Characterization of some strains from human clinical sources which resemble "Leptotrichia sanguinegens": description of Sneathia sanguinegens sp. nov., gen. nov. Systematic and Applied Microbiology. 24 (3), pp. 358-361. https://doi.org/10.1078/0723-2020-00047
Facklamia miroungae sp. nov., from a juvenile southern elephant seal (Mirounga leonina)
Hoyles, L., Foster, G., Falsen, E., Thomson L, F. and Collins M, D. 2001. Facklamia miroungae sp. nov., from a juvenile southern elephant seal (Mirounga leonina). International Journal of Systematic and Evolutionary Microbiology. 51 (4), pp. 1401-1403. https://doi.org/10.1099/00207713-51-4-1401
Corynebacterium testudinoris sp. nov., from a tortoise, and Corynebacterium felinum sp. nov., from a Scottish wild cat
Collins M, D., Hoyles, L., Hutson R, A., Foster, G. and Falsen, E. 2001. Corynebacterium testudinoris sp. nov., from a tortoise, and Corynebacterium felinum sp. nov., from a Scottish wild cat. International Journal of Systematic and Evolutionary Microbiology. 51 (4), pp. 1349-1352. https://doi.org/10.1099/00207713-51-4-1349
Actinomyces suimastitidis sp. nov., isolated from pig mastitis
Hoyles, L., Falsen, E., Holmstrom, G., Persson, A., Sjoden, B. and Collins, M.D. 2001. Actinomyces suimastitidis sp. nov., isolated from pig mastitis. International Journal of Systematic and Evolutionary Microbiology. 51 (4), pp. 1323-1326. https://doi.org/10.1099/00207713-51-4-1323
Corynebacterium capitovis sp. nov., from a sheep
Collins, M.D., Hoyles, L., Foster, G., Sjoden, B. and Falsen, E. 2001. Corynebacterium capitovis sp. nov., from a sheep. International Journal of Systematic and Evolutionary Microbiology. 51 (3), pp. 857-860. https://doi.org/10.1099/00207713-51-3-857
Streptococcus ovis sp. nov., isolated from sheep
Collins M, D., Hutson R, A., Hoyles, L., Falsen, E., Nikolaitchouk, N. and Foster, G. 2001. Streptococcus ovis sp. nov., isolated from sheep. International Journal of Systematic and Evolutionary Microbiology. 51 (3), pp. 1147-1150. https://doi.org/10.1099/00207713-51-3-1147
Actinomyces catuli sp. nov., from dogs
Hoyles, L., Falsen, E., Pascual, C., Sjoden, B., Foster, G., Henderson, D. and Collins, M.D. 2001. Actinomyces catuli sp. nov., from dogs. International Journal of Systematic and Evolutionary Microbiology. 51 (2), pp. 679-682. https://doi.org/10.1099/00207713-51-2-679
Arcanobacterium/Corynebacterium-like bacterial isolates from sheep
Foster, G., Ritchie, C., Cowie, R.A., Rusbridge, S.M., Collins, M.D. and Hoyles, L. 2001. Arcanobacterium/Corynebacterium-like bacterial isolates from sheep. Veterinary Record. 148 (9), p. 284.
Actinomyces marimammalium sp. nov., from marine mammals
Hoyles, L., Pascual, C., Falsen, E., Foster, G., Grainger, J.M. and Collins, M.D. 2001. Actinomyces marimammalium sp. nov., from marine mammals. International Journal of Systematic and Evolutionary Microbiology. 51 (1), pp. 151-156. https://doi.org/10.1099/00207713-51-1-151
Characterization of a Gemella-like organism isolated from an abscess of a rabbit: description of Gemella cunicula sp. nov.
Hoyles, L., Foster, G., Falsen, E. and Collins M, D. 2000. Characterization of a Gemella-like organism isolated from an abscess of a rabbit: description of Gemella cunicula sp. nov. International Journal of Systematic and Evolutionary Microbiology. 50 (6), pp. 2037-2041. https://doi.org/10.1099/00207713-50-6-2037
Characterization of Actinomyces isolates from infected root canals of teeth: description of Actinomyces radicidentis sp. nov.
Collins M, D., Hoyles, L., Kalfas, S., Sundquist, G., Monsen, T., Nikolaitchouk, N. and Falsen, E. 2000. Characterization of Actinomyces isolates from infected root canals of teeth: description of Actinomyces radicidentis sp. nov. Journal of Clinical Microbiology. 38 (9), pp. 3399-3403.
Characterization of Actinomyces isolates from samples from the human urogenital tract: description of Actinomyces urogenitalis sp. nov.
Nikolaitchouk, N., Hoyles, L., Falsen, E., Grainger J, M. and Collins M, D. 2000. Characterization of Actinomyces isolates from samples from the human urogenital tract: description of Actinomyces urogenitalis sp. nov. International Journal of Systematic and Evolutionary Microbiology. 50 (4), pp. 1649-1654. https://doi.org/10.1099/00207713-50-4-1649
Actinomyces canis sp. nov., isolated from dogs
Hoyles, L., Falsen, E., Foster, G., Pascual, C., Greko, C. and Collins, M.D. 2000. Actinomyces canis sp. nov., isolated from dogs. International Journal of Systematic and Evolutionary Microbiology. 50 (4), pp. 1547-1551. https://doi.org/10.1099/00207713-50-4-1547
Vagococcus fessus sp. nov., isolated from a seal and a harbour porpoise
Hoyles, L., Lawson P, A., Foster, G., Falsen, E., Ohlen, M., Grainger J, M. and Collins M, D. 2000. Vagococcus fessus sp. nov., isolated from a seal and a harbour porpoise. International Journal of Systematic and Evolutionary Microbiology. 50 (3), pp. 1151-1154. https://doi.org/10.1099/00207713-50-3-1151
Phenotypic and phylogenetic characterization of a new Corynebacterium species from dogs: description of Corynebacterium auriscanis sp. nov.
Collins M, D., Hoyles, L., Lawson P, A., Falsen, E., Robson R, L. and Foster, G. 1999. Phenotypic and phylogenetic characterization of a new Corynebacterium species from dogs: description of Corynebacterium auriscanis sp. nov. Journal of Clinical Microbiology. 37 (11), pp. 3443-3447.
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