In the Realm of Psychoneuroimmunology: The Role of Celecoxib as an Add-On Treatment for Bipolar Mania

Al-Alawi, M., Al Sinawi, H. and Rashid, R. 2018. In the Realm of Psychoneuroimmunology: The Role of Celecoxib as an Add-On Treatment for Bipolar Mania. Complex Psychiatry. 4, pp. 164-167. https://doi.org/10.1159/000494700

TitleIn the Realm of Psychoneuroimmunology: The Role of Celecoxib as an Add-On Treatment for Bipolar Mania
TypeJournal article
AuthorsAl-Alawi, M., Al Sinawi, H. and Rashid, R.
Abstract

Bipolar affective disorder (BPAD) is a chronic debilitating psychiatric illness seriously affecting the quality of patients’ life. The available treatment is effective in about half of those suffering from the illness. The neurobiological basis of the disorder is not fully unraveled. With such lacunae, attempts have been made to decipher the underlying neuroimmunological process of the illness as is the case with other mental disorders. As a result, some inflammatory processes have been implicated in the etiology of BPAD, as described in this communication. Subsequently, the role of anti-inflammatory agents such as celecoxib was investigated by treating different phases of BPAD. Given the promising outcomes of several trials and reviews, celecoxib has gained momentum and has been recommended as an adjunctive treatment by some guidelines for treating resistant BPAD cases. This brief communication highlights some of the caveats in the randomized trials using celecoxib as an add-on treatment in bipolar mania specifically, which need to be addressed in future work.

JournalComplex Psychiatry
Journal citation4, pp. 164-167
ISSN2673-3005
2673-298X
Year2018
PublisherKarger
Digital Object Identifier (DOI)https://doi.org/10.1159/000494700
Web address (URL)https://doi.org/10.1159/000494700
Publication dates
Published08 Nov 2018

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