Using Salivary Biomarkers for Stress Assessment in Offshore Saturation Diving: A Pilot Study.

Monnoyer, Roxane, Lautridou, Jacky, Deb, Sanjoy, Hjelde, Astrid and Eftedal, Ingrid 2021. Using Salivary Biomarkers for Stress Assessment in Offshore Saturation Diving: A Pilot Study. Frontiers in Physiology. 12, p. 791525 791525. https://doi.org/10.3389/fphys.2021.791525

TitleUsing Salivary Biomarkers for Stress Assessment in Offshore Saturation Diving: A Pilot Study.
TypeJournal article
AuthorsMonnoyer, Roxane, Lautridou, Jacky, Deb, Sanjoy, Hjelde, Astrid and Eftedal, Ingrid
AbstractHealth monitoring during offshore saturation diving is complicated due to restricted access to the divers, the desire to keep invasive procedures to a minimum, and limited opportunity for laboratory work onboard dive support vessels (DSV). In this pilot study, we examined whether measuring salivary biomarkrers in samples collected by the divers themselves might be a feasible approach to environmental stress assessment. Nine saturation divers were trained in the passive drool method for saliva collection and proceeded to collect samples at nine time points before, during, and after an offshore commercial saturation diving campaign. Samples collected within the hyperbaric living chambers were decompressed and stored frozen at -20°C onboard the DSV until they were shipped to land for analysis. Passive drool samples were collected without loss and assayed for a selection of salivary biomarkers: secretory immunoglobulin A (SIgA), C-reactive protein (CRP), tumor necrosis factor (TNF)-α, interleukins IL-6, IL-8, IL-1β, as well as cortisol and alpha-amylase. During the bottom phase of the hyperbaric saturation, SIgA, CRP, TNF-α, IL-8 and IL-1β increased significantly, whereas IL-6, cortisol and alpha-amylase were unchanged. All markers returned to pre-dive levels after the divers were decompressed back to surface pressure. We conclude that salivary biomarker analysis may be a feasible approach to stress assessment in offshore saturation diving. The results of our pilot test are consonant with an activation of the sympathetic nervous system related to systemic inflammation during hyperbaric and hyperoxic saturation. [Abstract copyright: Copyright © 2021 Monnoyer, Lautridou, Deb, Hjelde and Eftedal.]
Keywordsphysiological stress
cytokine
saliva
hyperbaric heliox saturation
inflammation
biomarkers
hyperbaric hyperoxia
Article number791525
JournalFrontiers in Physiology
Journal citation12, p. 791525
ISSN1664-042X
Year2021
PublisherFrontiers
Publisher's version
License
CC BY 4.0
File Access Level
Open (open metadata and files)
Digital Object Identifier (DOI)https://doi.org/10.3389/fphys.2021.791525
PubMed ID34916964
Publication dates
Published online30 Nov 2021

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