Research Centre for Optimal Health

Martin, S., Tyrrell, J., Thomas, E.L., Bown, M.J., Wood, A.R., Beaumont, R.N., Tsoi, L.C., Stuart, P.E., Elder, J.T., Law, P., Houlston, R., Kabrhel, C., Papadimitriou, N., Gunter, M.J., Bull, C.J., Bell, J.A., Vincent, E.E., Sattar, N., Dunlop, M.G., Tomlinson, I.P.M., Bell, J.D., Frayling, T. and Yaghootkar, H. 2022. Disease consequences of higher adiposity uncoupled from its adverse metabolic effects using Mendelian randomisation. eLife. 11 e72452. https://doi.org/10.7554/elife.72452

Wesolowska-Andersen, A., Brorsson, C.A., Bizzotto, R., Mari, A., Tura, A., Koivula, R., Mahajan, A., Viñuela, A., Fernandez Tajes, J, Sharma, S., Haid, M., Prehn, C., Artati, A., Hong, M-G, Musholt, P.B, Kurbasic, A., Masi, F., Tsirigos, K, Pedersen, H., Gudmundsdottir, V., Thomas, C., Banasik, K., Jennison, C., Jones, A., Kennedy, G., Bell, J.D., Thomas, E.L., Frost, G., Thomsen, H., Allin, K., Hansen, T.H., Vestergaard, H., Hansen, T., Rutters, F., Elders, P., t'Hart, L., Bonnefond, A., Canouil, M., Brage, S., Kokkola, T., Heggie, A., McEvoy, D., Hattersley, A., McDonald, T., Teare, H., Ridderstrale, M., Walker, M., Forgie, I., Giordano, G.N., Froguel, P., Pavo, I., Ruetten, H., Pedersen, O., Dermitzakis, E., Franks, P.W., Schwenk, J.M., Adamski, J., Pearson, E., McCarthy, M.I., Brunak, S. and IMI DIRECT Consortium 2022. Four groups of type 2 diabetes contribute to the etiological and clinical heterogeneity in newly diagnosed individuals: An IMI DIRECT study. Cell Reports Medicine. 3 (1) 100477. https://doi.org/10.1016/j.xcrm.2021.100477

Martin, Susan, Sorokin, Elena P, Thomas, E Louise, Sattar, Naveed, Cule, Madeleine, Bell, Jimmy D and Yaghootkar, H. 2022. Estimating the Effect of Liver and Pancreas Volume and Fat Content on Risk of Diabetes: A Mendelian Randomization Study. Diabetes Care. 45 (2), pp. 460-468. https://doi.org/10.2337/dc21-1262

Nunn, A., Guy, G., Botchway, S.W. and Bell, J.D. 2021. SARS-CoV-2 and EBV; the cost of a second mitochondrial "whammy"? Immunity & Ageing. 18 (1), pp. 40-44. https://doi.org/10.1186/s12979-021-00252-x

Osimo, E.F., Sweeney, M., de Marvao, A., Berry, A., Statton, B., Perry, B.I., Pillinger, T., Whitehurst, T., Cook, S.A., O’Regan, D.P., Thomas, E.L. and Howes, O.D. 2021. Adipose tissue dysfunction, inflammation, and insulin resistance alternative pathways to cardiac remodelling in schizophrenia. A multimodal, case-control study. Translational Psychiatry. 11 614. https://doi.org/10.1038/s41398-021-01741-9

Booker, A., Scotti, F., Mou, L., Huang, C., Werckerle, C., Maake, C. and Heinrich, M. 2021. Treating Chronic Wounds Using Photoactive Metabolites: Data Mining the Chinese Pharmacopoeia for Potential Lead Species. Planta Medica. 87, pp. 1-13. https://doi.org/10.1055/a-1578-8778

Thanaj, M., Basty, N., Liu, Y., Cule, M., Sorokin, E., Thomas, E.L., Bell, J.D. and Whitcher, B. 2021. Mass Univariate Regression Analysis for Three-Dimensional Liver Image-Derived Phenotypes. Annual Conference on Medical Image Understanding and Analysis. University of Oxford 12 - 14 Jul 2021 Springer. https://doi.org/10.1007/978-3-030-80432-9_13

Martin, S., Cule, M, Basty, N., Tyrrell, J., Beaumont, R.N., Wood, A.R., Frayling, T., Sorokin, E., Whitcher, B., Liu, Y., Bell, J.D., Thomas, E.L. and Yaghootkar, H. 2021. Genetic evidence for different adiposity phenotypes and their opposing influence on ectopic fat and risk of cardiometabolic disease. Diabetes. 70 (8), pp. 1843-1856. https://doi.org/10.2337/db21-0129

Heinrich, M., Jiang, H., Scotti, F., Booker, A., Walt, H., Weckerle, C. and Maake, C. 2021. Medicinal plants from the Himalayan region as potential novel antimicrobial and anti-inflammatory skin treatments. Journal of Pharmacy and Pharmacology. 73 (7), p. 956–967. https://doi.org/10.1093/jpp/rgab039

Woodley, S., Mould, R., Sahuri Arisoylu, M., Kalampouka, I., Booker, A. and Bell, J.D. 2021. Mitochondrial Function as a Potential Tool for Assessing Function, Quality and Adulteration in Medicinal Herbal Teas. Frontiers in Pharmacology. 12 660938. https://doi.org/10.3389/fphar.2021.660938

Sahuri Arisoylu, M., Mould, R., Shinjyo, N., Bligh, S.W.A., Nunn, A., Guy, G., Thomas, E.L. and Bell, J.D. 2021. Acetate induces growth arrest in colon cancer cells through modulation of mitochondrial function. Frontiers in Nutrition: Nutrition and Metabolism. 8 588466. https://doi.org/10.3389/fnut.2021.588466

Ichim, M.C. and Booker, A. 2021. Chemical Authentication of Botanical Ingredients: A Review of Commercial Herbal Products. Frontiers in Pharmacology. 12 666850. https://doi.org/10.3389/fphar.2021.666850

Mould, R., Botchway, S, Parkinson, J., Thomas, E.L., Guy, G., Bell, J.D. and Nunn, A. 2021. Cannabidiol modulates mitochondrial redox and dynamics in MCF7 cancer cells: a study using fluorescence lifetime imaging microscopy of NAD(P)H. Frontiers in Molecular Biosciences. 8 630107. https://doi.org/10.3389/fmolb.2021.630107

Bizzotto, R., Jennison, C., Jones, A., Kurbasic, A., Kennedy, G., Bell, J.D., Thomas, E.L., Frost, G., Eriksen, R., Koivula, R., Brage, S., Kaye, J., Hattersley, A., Heggie, A., McEvoy, D., Hart, L.M., Beulens, J.W., Elders, P., Musholt, P.B., Ridderstråle, M., Hansen, T., Allin, K., Hansen, T., Vestergaard, H., Lundgaard, A.T., Thomsen, H.S., Masi, F., Tsirigos, K.D., Brunak, S., Viñuela, A., Mahajan, A., McDonald, T.J., Kokkola, T., Forgie, I., Giordano, G.N., Pavo, I., Ruetten, H., Dermitzakis, E., McCarthy, M., Pedersen, O., Schwenk, J., Adamski, J., Franks, P., Walker, M., Pearson, E. and Mari, A. 2021. Processes Underlying Glycemic Deterioration in Type 2 Diabetes: An IMI DIRECT Study. Diabetes Care. 44 (2), pp. 511-518. https://doi.org/10.2337/dc20-1567

Nunn, A.V.W., Guy, G.W., Brysch, W., Botchway, S.W., Frasch, W., Calabrese, E.J. and Bell, J.D. 2020. SARS-CoV-2 and mitochondrial health: implications of lifestyle and ageing. Immunity & Ageing. 17 33 (2020). https://doi.org/10.1186/s12979-020-00204-x

Fitzpatrick, J., Basty, N., Cule, M., Liu, Y., Bell, J.D., Thomas, E.L. and Whitcher, B. 2020. Large‑scale analysis of iliopsoas muscle volumes in the UK Biobank. Scientific Reports. 10 20215. https://doi.org/10.1038/s41598-020-77351-0

Machann, J., Stefan, N., Wagner, R., Fritsche, A., Bell, J.D., Whitcher, B., Häring, H.U., Birkenfeld, A., Nikolaou, K., Schick, F. and Thomas, E.L. 2020. Normalized indices derived from visceral adipose mass assessed by MRI and their correlation with markers for insulin resistance and prediabetes. Nutrients. 12 (7) 2064. https://doi.org/10.3390/nu12072064

Atabaki-Pasdar, N., Ohlsson, M., Viñuela, A., Frau, F., Pomares-Millan, H., Haid, M., Jones, A., Thomas, E.L., Koivula, R., Kurbasic, A., Mutie, P., Fitipaldi, H., Fernandez, J., Dawed, A., Giordano, G., Forgie, I., McDonald, T., Rutters, F., Cederberg, H., Chabanova, E., Dale, M., Masi, F., Thomas, C., Allin, K., Hansen, T., Heggie, A., Hong, M., Elders, P., Kennedy, G., Kokkola, T., Pedersen, H., Mahajan, A., McEvoy, D., Pattou, F., Raverdy, V., Häussler, R., Sharma, S., Thomsen, H., Vangipurapu, J., Vestergaard, H., ‘t Hart, L., Adamski, J., Musholt, P., Brage, S., Brunak, S., Dermitzakis, E., Frost, G., Hansen, T., Laakso, M., Pedersen, O., Ridderstråle, M., Ruetten, H., Hattersley, A., Walker, M., Beulens, J., Mari, A., Schwenk, J., Gupta, R., McCarthy, M., Pearson, E., Bell, J.D., Pavo, I. and Franks, P. 2020. Predicting and elucidating the etiology of fatty liver disease: A machine learning modeling and validation study in the IMI DIRECT cohorts. PLoS Medicine. 17 (6) e1003149. https://doi.org/10.1371/journal.pmed.1003149

Eriksen, R., Perez, I.G., Posma, J.M., Haid, M., Sharma, S., Thomas, E.L., Koivula, R.W., Bizzotto, R., Mari, A., Giordano, G.N., Pavo, I., Schwenk, J., De Masi, F., Tsirigos, K., Brunak, S., Vinuela, A., Mahajan, A., McDonald, T.J., Kokkola, T., Teare, H.J.A., Hansen, T.H., Fernandez, J., Jones, A., Jennison, C., Walker, M., McCarthy, M., Pedersen, O., Reutten, H., Forgie, I., Bell, J.D., Pearson, E., Franks, P.W., Adamski, J., Holmes, E. and Frost, G.S. 2020. Dietary metabolite profiling brings new insight into the relationship between nutrition and metabolic risk: An IMI Direct study. EBioMedicine. 58 102932. https://doi.org/10.1016/j.ebiom.2020.102932

Alenaini, Wareed, Parkinson, J., McCarthy, John P., Goldstone, Anthony P., Wilman, Henry R., Banerjee, Rajarshi, Yaghootkar, Hanieh, Bell, Jimmy D. and Thomas, E.L. 2020. Ethnic Differences in Body Fat Deposition and Liver Fat Content in Two UK-Based Cohorts. Obesity (Silver Spring, Md.). 28 (11), pp. 2142-2152. https://doi.org/10.1002/oby.22948

Aldraimli, M., Soria, D., Parkinson, J., Thomas, E.L., Bell, J.D., Dwek, M. and Chaussalet, T.J. 2020. Machine Learning Prediction of Susceptibility to Visceral Fat Associated Diseases. Health and Technology. 10, pp. 925-944. https://doi.org/10.1007/s12553-020-00446-1

Littlejohns, T., Holliday, J., Gibson, L., Garratt, S., Oesingmann, N., Alfaro-Almagro, F., Bell, J.D., Boultwood, C., Collins, R., Conroy, M., Crabtree, N., Doherty, N., Frangi, A., Harvey, N., Leeson, P., Miller, K., Neubauer, S., Petersen, S., Sellors, J., Sheard, S., Smith, S., Sudlow, C., Matthews, P. and Allen, N. 2020. The UK Biobank imaging enhancement of 100,000 participants: rationale, data collection, management and future directions. Nature Communications . 11 2624. https://doi.org/10.1038/s41467-020-15948-9

Whyte, M.B, Shojaee-Moradie, F., Sharaf, S.E., Cuthbertson, D.J., Kemp, G.J., Barrett, M., Jackson, N.C., Herring, R.A, Wright, J., Thomas, E.L., Bell, J.D. and Umpleby, A.M. 2020. HDL-apoA-I kinetics in response to 16 weeks exercise training in men with non-alcoholic fatty liver disease (NAFLD). American Journal of Physiology - Endocrinology and Metabolism. 318 (6), pp. E839-E847. https://doi.org/10.1152/ajpendo.00019.2020

Dikariyanto, V., Smith, L., Francis, L., Robertson, M., Kusaslan, E., O’Callaghan-Latham, M., Palanche, C., D’Annibale, M., Christodoulou, D., Basty, N., Whitcher, B., Shuaib, H., Charles-Edwards, G., Chowienczyk, P.J., Ellis, P. R., Berry, S.E. and Hall, W. 2020. Snacking on whole almonds for 6 weeks improves endothelial function and lowers LDL cholesterol but does not affect liver fat and other cardiometabolic risk factors in healthy adults: the ATTIS study, a randomized controlled trial. American Journal of Clinical Nutrition. 111 (6), p. 1178–1189. https://doi.org/10.1093/ajcn/nqaa100

Yaghootkar, H., Bell, J.D., Whitcher, B. and Thomas, E.L. 2020. Ethnic differences in adiposity and diabetes risk – insights from genetic studies. Journal of Internal Medicine. 288 (3), pp. 271-283. https://doi.org/10.1111/joim.13082

Basty, N., Liu, Y., Cule, M., Thomas, E.L., Bell, J.D. and Whitcher, B. 2020. Automated Measurement of Pancreatic Fat and Iron Concentration Using Multi-Echo and T1-Weghted MRI Data. International Symposium on Biomedical Imaging 2020. Iowa City, USA 03 - 07 Apr 2020 IEEE . https://doi.org/10.1109/ISBI45749.2020.9098650

Parisinos, C.A., Wilman, H., Thomas, E.L., Kelly, M., Nicholls, R.C., McGonigle, J., Neubauer, S., Hingorani, A.D., Patel, R.S., Hemingway, H., Bell, J.D., Banerjee, R and Yaghootkar, H. 2020. Genome-wide and Mendelian randomisation studies of liver MRI yield insights into the pathogenesis of steatohepatitis. Journal of Hepatology. 73, pp. 241-51. https://doi.org/10.1016/j.jhep.2020.03.032

Koivula, R.W., Atabaki-Pasdar, N, Giordano, G.N., White, T., Adamski, J., Bell, J.D., Beulens, J, Brage, S, Brunak, S., De Masi, F., Dermitzakis, E.T., Forgie, I.M., Frost, G.S., Hansen, T., Hansen, T.H., Hattersley, A., Kokkola, T., Kurbasic, A., Laakso, M., Mari, A., McDonald T.J., Pedersen, O., Rutters, F., Schwenk, J.M, Teare, H.J.A., Thomas, E.L., Vinuela, A., Mahajan, A., McCarthy, M.I., Ruetten, H., Walker, M., Pearson, E., Pavo, I. and Franks, P.W. 2020. The role of physical activity in metabolic homeostasis before and after the onset of type 2 diabetes: an IMI DIRECT study. Diabetologia. https://doi.org/10.1007/s00125-019-05083-6

Fitzgerald, M., Heinrich, M. and Booker, A. 2020. Medicinal plant analysis: A historical and regional discussion of Chinese publication trends and emergent complex techniques. Frontiers in Pharmacology. 10 1480. https://doi.org/10.3389/fphar.2019.01480

Evangelou, E., Gao, H., Chu, C., Ntritsos, G., Blakeley, P., Butts, A., Pazoki, R., Suzuki, H., Koskeridis, F., Yiorkas, A., Karaman, I., Elliott, J., Luo, Q., Aeschbacher, S., Bartz, T., Baumeister, S., Braund, P., Brown, M., Brody, J., Clarke, T., Dimou, N., Faul, J., Homuth, G., Jackson, A., Kentistou, K., Joshi, P., Lemaitre, R., Lind, P., Lyytikäinen, L., Mangino, M., Milaneschi, Y., Nelson, C., Nolte, I., Perälä, M., Polasek, O., Porteous, D., Ratliff, S., Smith, J., Stančáková, A., Teumer, A., Tuominen, S., Thériault, S., Vangipurapu, J., Whitfield, J., Wood, A., Yao, J., Yu, B., Zhao, W., Arking, D., Auvinen, J., Liu, C., Männikkö, M., Risch, L., Rotter, J., Snieder, H., Veijola, J., Blakemore, A., Boehnke, M., Campbell, H., Conen, D., Eriksson, J., Grabe, H., Guo, X., van der Harst, P., Hartman, C., Hayward, C., Heath, A., Jarvelin, M., Kähönen, M., Kardia, S., Kühne, M., Kuusisto, J., Laakso, M., Lahti, J., Lehtimäki, T., McIntosh, A., Mohlke, K., Morrison, A., Martin, N., Oldehinkel, A., Penninx, B., Psaty, B., Raitakari, O., Rudan, I., Samani, N., Scott, L., Spector, T., Verweij, N., Weir, D., Wilson, J., Levy, D., Tzoulaki, I., Bell, J.D., Matthews, P., Rothenfluh, A., Desrivières, S., Schumann, G. and Elliott, P. 2019. New alcohol-related genes suggest shared genetic mechanisms with neuropsychiatric disorders. Nature Human Behaviour. 3 (9), pp. 950-961. https://doi.org/10.1038/S41562-019-0653-Z

Kosgodage, U., Matewele, P., Awamaria, B., Kraev, I., Warde, P., Mastroianni, G., Nunn, A., Guy, G.W., Bell, J.D., Inal, J.M. and Lange, S. 2019. Cannabidiol is a Novel Modulator of Bacterial Membrane Vesicles. Frontiers in Cellular and Infection Microbiology. 9 324. https://doi.org/10.3389/fcimb.2019.00324

Frommenwiler, D., Booker, A., Vila, R., Heinrich, M., Reich, E. and Cañiguerala, S. 2019. Comprehensive HPTLC fingerprinting as a tool for a simplified analysis of purity of ginkgo products. Journal of Ethnopharmacology. 243, p. 112084 112084. https://doi.org/10.1016/j.jep.2019.112084

Aldraimli, M., Soria, D., Parkinson, J., Whitcher, B., Thomas, E.L., Bell, J.D., Chaussalet, T.J. and Dwek, M. 2019. Machine Learning Classification of Females Susceptibility to Visceral Fat Associated Diseases. MEDICON 2019: XV Mediterranean Conference on Medical and Biological Engineering and Computing. Coimbra, Portugal 26 - 28 Sep 2019 Springer. https://doi.org/10.1007/978-3-030-31635-8_81

Wilman, H.R., Parisinos, C.A., Atabaki-Pasdar, N., Kelly, M., Thomas, E.L., Neubauer, S., Mahajan, A., Hingorani, A.D., Patel, R.S., Hemingway, H., Franks, P.W., Bell, J.D., Banerjee, R. and Yaghootkar, H. 2019. Genetic studies of abdominal MRI data identify genes regulating hepcidin as major determinants of liver iron concentration. Journal of Hepatology. 71 (3), pp. 594-602. https://doi.org/10.1016/j.jhep.2019.05.032

Mani, B.K., Puzziferri, N., He, Z., Rodriguez, J.A., Osborne-Lawrence, S., Metzger, N.P., Chhina, N., Gaylinn, B.D., Thorner, M.O., Thomas, E.L., Bell, J.D., Williams, K.W., Goldstone, A.P. and Zigman, J.M. 2019. LEAP2 changes with body mass and food intake in humans and mice. Journal of Clinical Investigation. 129 (9), pp. 3909-3923. https://doi.org/10.1172/JCI125332

Hakim, O., Bello, O., Bonadonna, O.C., Mohandas, C., Shojaee-Moradie, F., Jackson, N., Boselli, L., Whitcher, B., Shuaib, H., Alberti, K.G.M.M., Peacock, J.L., Umpleby, A.M., Charles-Edwards, E., Amiel, S.A. and Goff, L.M. 2019. Ethnic differences in intrahepatic lipid and its association with hepatic insulin sensitivity and insulin clearance between men of Black and White ethnicity with early type 2 diabetes. Diabetes, Obesity and Metabolism. 21 (9), pp. 2163-2168. https://doi.org/10.1111/dom.13771

Linge, J., Whitcher, B., Borga, M. and Dahlqvist Leinhard, O. 2019. Sub‐phenotyping Metabolic Disorders Using Body Composition: An Individualized, Nonparametric Approach Utilizing Large Data Sets. Obesity. 27 (7), pp. 1190-1199. https://doi.org/10.1002/oby.22510

Chatzinasiou, L., Booker, A., MacLennan, E., Mackonochie, M. and Heinrich, M. 2019. Turmeric (Curcuma longa L.) products: What quality differences exist? Journal of Herbal Medicine. 17-18, p. 100281 100281. https://doi.org/10.1016/j.hermed.2019.100281

Bachtiar, V., Kelly, M.D., Wilman, H.R., Jacob, J., Newbould, R., Kelly, C.J., Gyngell, M.L., Groves, K.E., McKay, A., Herlihy, A.H., Fernandes, C.C., Halberstadt, M., Maguire, M., Jayaratne, N., Linden, S., Neubauer, S. and Banerjee, R. 2019. Repeatability and reproducibility of multiparametric magnetic resonance imaging of the liver. PLoS ONE. 14 (4) e0214921. https://doi.org/10.1371/journal.pone.0214921

Koivula, R.W., Forgie, I.M., Kurbasic, A., Viñuela, A., Heggie, A., Giordano, G.N., Hansen, T.H., Hudson, M., Koopman, A.D., Rutters, F., Siloaho, M., Allin, K.H., Brage, S., Brorsson, C.A., Dawed, A.Y., De Masi, F., Groves, C.J., Kokkola, T., Mahajan, A., Perry, M.H., Rauh, S.P., Ridderstråle, M., Teare, H.J.A., Thomas, E.L., Tura, A., Vestergaard, H., White, T., Adamski, J., Bell, J.D., Beulens, J., Brunak, S., Dermitzakis, E.T., Froguel, P., Frost, G., Gupta, R., Hansen, T., Hattersley, A., Jablonka, B., Kaye, J., Laakso, M., McDonald, T.J., Pedersen, O., Schwenk, J.M., Pavo, I., Mari, A., McCarthy, M.I., Ruetten, H., Walker, M., Pearson, E. and Franks, P.W. 2019. Discovery of biomarkers for glycaemic deterioration before and after the onset of type 2 diabetes: descriptive characteristics of the epidemiological studies within the IMI DIRECT Consortium. Diabetologia. 62 (9), pp. 1601-1615. https://doi.org/10.1007/s00125-019-4906-1