Treating Chronic Wounds Using Photoactive Metabolites: Data Mining the Chinese Pharmacopoeia for Potential Lead Species

Booker, A., Scotti, F., Mou, L., Huang, C., Werckerle, C., Maake, C. and Heinrich, M. 2021. Treating Chronic Wounds Using Photoactive Metabolites: Data Mining the Chinese Pharmacopoeia for Potential Lead Species. Planta Medica. 87, pp. 1-13. https://doi.org/10.1055/a-1578-8778

TitleTreating Chronic Wounds Using Photoactive Metabolites: Data Mining the Chinese Pharmacopoeia for Potential Lead Species
TypeJournal article
AuthorsBooker, A., Scotti, F., Mou, L., Huang, C., Werckerle, C., Maake, C. and Heinrich, M.
Abstract

Efficient wound treatment that addresses associated infec-
tions and inflammation remains one of the big unmet needs,
especially in low- and middle-income countries. One strategy
for securing better healthcare can be using medicinal plants if sufficient evidence on their safety and therapeutic benefits can be ascertained. A unique novel opportunity could be photo-enhanced wound treatment with a combination of light-sensitive plant preparations and local exposure to daylight.
Data mining strategies using existing resources offer an excellent basis for developing such an approach with many potential plant candidates. In the present analysis, we researched the 535 botanical drugs included in the Chinese pharmacopeia and identified 183 medicinal plant species, 82 for treating open wounds caused by trauma and 101 for inflammatory skin conditions. After further screening for reports on the presence of known photoactive compounds, we determined a core group of 10 scientifically lesser-known botanical species that may potentially be developed into more widely used topical preparations for photodynamic treatment of infected wounds. Our predictive approach may contribute to developing a more evidence-based use of herbal medicines.

Keywordsherbal medicines
photodynamic therapy
wound treatment
Chinese pharmacopeia
traditional medicines
JournalPlanta Medica
Journal citation87, pp. 1-13
ISSN0032‑0943
Year2021
PublisherThieme
Publisher's version
License
CC BY 4.0
File Access Level
Open (open metadata and files)
Digital Object Identifier (DOI)https://doi.org/10.1055/a-1578-8778
PubMed ID34528222
Publication dates
Published15 Sep 2021

Related outputs

Echinacea Reduces Antibiotics by Preventing Respiratory Infections: A Meta-Analysis (ERA-PRIMA)
Gancitano, G., Mucci, N., Stange, R., Ogal, M., Vimalanathan, S., Sreya, M., Booker, A., Hadj-Cherif, B., Albrich, W., Woelkart-Ardjomand, K., Kreft, S., Vanden Berghe, W., Hoexter, G., Schapowal, A. and Johnston, S.L. 2024. Echinacea Reduces Antibiotics by Preventing Respiratory Infections: A Meta-Analysis (ERA-PRIMA). Antibiotics. 13 (4) 364. Advanced online publication. https://doi.org/10.3390/antibiotics13040364

Editorial: Investigating the molecular targets and therapeutic potential of Withania somnifera (Ashwagandha) in various pathophysiological conditions
Dar, N.J., Bhat, S.A., Rehman, M.U. and Booker, A. 2023. Editorial: Investigating the molecular targets and therapeutic potential of Withania somnifera (Ashwagandha) in various pathophysiological conditions. Frontiers in Pharmacology. 14 1187334. https://doi.org/10.3389/fphar.2023.1187334

Licorice Root Ameliorates Drug Induced Mitochondrial Stress in MCF7 and MCF10A Cells
Woodley, S, Butt, J, Mould, R, Kalampouka, I, Booker, A and Bell, J 2022. Licorice Root Ameliorates Drug Induced Mitochondrial Stress in MCF7 and MCF10A Cells. Planta Medica. 88 (15), p. 1513. https://doi.org/10.1055/s-0042-1759190

Quality evaluation of commercial herbal products using chemical methods
Ichim, M. C., Scotti, F. and Booker, A. 2022. Quality evaluation of commercial herbal products using chemical methods. Critical Reviews in Food Science and Nutrition. Advanced online publication. https://doi.org/10.1080/10408398.2022.2140120

Chinese and Western Herbal Medicines for the Topical Treatment of Psoriasis - a critical review of Efficacy and Safety
Booker, A., Heinrich, P.M. and Tsou, W.H. 2022. Chinese and Western Herbal Medicines for the Topical Treatment of Psoriasis - a critical review of Efficacy and Safety. Journal of Herbal Medicine. 34. https://doi.org/10.1016/j.hermed.2022.100579

Chrysanthemum species used as food and medicine: Understanding quality differences on the global market
Gu, J., Scotti, F., Reich, E., Kirchhoff, R., Booker, A. and Heinrich, P.M. 2022. Chrysanthemum species used as food and medicine: Understanding quality differences on the global market. South African Journal of Botany. 148, pp. 123-134. https://doi.org/10.1016/j.sajb.2022.04.009

Green tea polyphenols in cardiometabolic health: A critical appraisal on Phytogenomics towards personalized green tea
Rajan, Logesh, Radhakrishnan, Arun, Alagarsamy, Keshav Narayan, Srivastava, Abhay, Dhingra, Sanjiv, Booker, Anthony, Rolfe, Viven, Palaniswamy, Dhanabal and Mohankumar, Suresh Kumar 2022. Green tea polyphenols in cardiometabolic health: A critical appraisal on Phytogenomics towards personalized green tea. PharmaNutrition. 20 100296. https://doi.org/10.1016/j.phanu.2022.100296

Emergent quality issues in Chinese medicinal plants: Investigation of their contemporary occurrence and historical persistence through questionnaires and interviews of key informants.
Fitzgerald, M., Heinrich, M. and Booker, A. 2021. Emergent quality issues in Chinese medicinal plants: Investigation of their contemporary occurrence and historical persistence through questionnaires and interviews of key informants. Planta Medica. 87 (15), pp. 1283-1284. https://doi.org/10.1055/s-0041-1736891

Quality differences of genus Chrysanthemum used as food and medicine from the global market
Gu, Jingyi, Reich, Eike, Kirchhof, Rainer, Scotti, Francesca, Booker, Anthony and Heinrich, Michael 2021. Quality differences of genus Chrysanthemum used as food and medicine from the global market. Planta Medica. 87 (15), pp. 1301-1302. https://doi.org/10.1055/s-0041-1736948

Simultaneous identification of common synthetic adulterants in slimming aids and sexual enhancers herbal supplements by High-performance Thin Layer Chromatography
Jalil, Banaz, Prieto, Jose M., Booker, Anthony and Heinrich, Michael 2021. Simultaneous identification of common synthetic adulterants in slimming aids and sexual enhancers herbal supplements by High-performance Thin Layer Chromatography. Planta Medica. 87 (15) 1243. https://doi.org/10.1055/s-0041-1736759

Medicinal plants from the Himalayan region as potential novel antimicrobial and anti-inflammatory skin treatments
Heinrich, M., Jiang, H., Scotti, F., Booker, A., Walt, H., Weckerle, C. and Maake, C. 2021. Medicinal plants from the Himalayan region as potential novel antimicrobial and anti-inflammatory skin treatments. Journal of Pharmacy and Pharmacology. 73 (7), p. 956–967. https://doi.org/10.1093/jpp/rgab039

Mitochondrial Function as a Potential Tool for Assessing Function, Quality and Adulteration in Medicinal Herbal Teas
Woodley, S., Mould, R., Sahuri Arisoylu, M., Kalampouka, I., Booker, A. and Bell, J.D. 2021. Mitochondrial Function as a Potential Tool for Assessing Function, Quality and Adulteration in Medicinal Herbal Teas. Frontiers in Pharmacology. 12 660938. https://doi.org/10.3389/fphar.2021.660938

Chemical Authentication of Botanical Ingredients: A Review of Commercial Herbal Products
Ichim, M.C. and Booker, A. 2021. Chemical Authentication of Botanical Ingredients: A Review of Commercial Herbal Products. Frontiers in Pharmacology. 12 666850. https://doi.org/10.3389/fphar.2021.666850

Medicinal plant analysis: A historical and regional discussion of Chinese publication trends and emergent complex techniques
Fitzgerald, M., Heinrich, M. and Booker, A. 2020. Medicinal plant analysis: A historical and regional discussion of Chinese publication trends and emergent complex techniques. Frontiers in Pharmacology. 10 1480. https://doi.org/10.3389/fphar.2019.01480

Comprehensive HPTLC fingerprinting as a tool for a simplified analysis of purity of ginkgo products
Frommenwiler, D., Booker, A., Vila, R., Heinrich, M., Reich, E. and Cañiguerala, S. 2019. Comprehensive HPTLC fingerprinting as a tool for a simplified analysis of purity of ginkgo products. Journal of Ethnopharmacology. 243, p. 112084 112084. https://doi.org/10.1016/j.jep.2019.112084

Turmeric (Curcuma longa L.) products: What quality differences exist?
Chatzinasiou, L., Booker, A., MacLennan, E., Mackonochie, M. and Heinrich, M. 2019. Turmeric (Curcuma longa L.) products: What quality differences exist? Journal of Herbal Medicine. 17-18, p. 100281 100281. https://doi.org/10.1016/j.hermed.2019.100281

Unblocking high-value botanical value chains: Is there a role for blockchain systems?
Booker, A., Heinrich, M., Scotti, F., Fitzgerald, M., Kum, K.Y. and Lobel, K. 2019. Unblocking high-value botanical value chains: Is there a role for blockchain systems? Frontiers in Pharmacology. 10 396. https://doi.org/10.3389/fphar.2019.00396

Quality Control of Hypericum perforatum L. Analytical challenges and recent progress
Agapouda, A., Booker, A., Kiss, T., Hohmann, J., Heinrich, M. and Csupor, D. 2019. Quality Control of Hypericum perforatum L. Analytical challenges and recent progress. Journal of Pharmacy and Pharmacology. 71 (1), pp. 15-37. https://doi.org/10.1111/jphp.12711

Complexity in Chinese herbal medicine supply chains
Booker, A., Fitzgerald, M., Heinrich, P.M. and Scheid, V. 2018. Complexity in Chinese herbal medicine supply chains. 66th International Congress and Annual Meeting of the Society for Medicinal Plant and Natural Product Research (GA) jointly with the 11th Shanghai TCM conference. Shanghai, PRC 26 - 29 Aug 2018

Domestication Study of Senecio nutans Sch.Bip. (Asteraceae): its Economic Potential and Sustainable Management
Lira, A., Crossley, L., Parra, C., Echiburú, C., Booker, A. and Heinrich, M. 2018. Domestication Study of Senecio nutans Sch.Bip. (Asteraceae): its Economic Potential and Sustainable Management. 66th International Congress and Annual Meeting of the Society for Medicinal Plant and Natural Product Research (GA) jointly with the 11th Shanghai TCM conference. Shanghai, PRC 26 - 29 Aug 2018

St. John’s Wort (Hypericum perforatum) products – How variable is the primary material?
Scotti, F., Lobel, K., Booker, A. and Heinrich, M. 2018. St. John’s Wort (Hypericum perforatum) products – How variable is the primary material? Frontiers in Plant Science. 9 1973. https://doi.org/10.3389/fpls.2018.01973

St John’s wort (Hypericum perforatum) products – an assessment of their authenticity and quality
Booker, A., Agapouda, A., Frommenwiler, D.A., Scotti, F., Reich, E. and Heinrich, P.M. 2018. St John’s wort (Hypericum perforatum) products – an assessment of their authenticity and quality. Phytomedicine. 40, pp. 158-164 PHYMED52314. https://doi.org/10.1016/j.phymed.2017.12.012

Book Review: Chinese Medicinal Plants, Herbal Drugs and Substitutes, an identification guide
Booker, A. 2018. Book Review: Chinese Medicinal Plants, Herbal Drugs and Substitutes, an identification guide. Journal of Ethnopharmacology. 213, p. 198. https://doi.org/10.1016/j.jep.2017.11.017

Useful Plants - Medicines
Booker, A., Allkin, B., Patmore, K., Black, N., Canteiro, C., Dauncy, E., Edwards, S., Forest, F., Giovannini, P., Howes, M.J., Hudson, A., Irving, J., Leon, C., Milliken, W., Lughadha, E.N., Schippmann, U. and Simmonds, M.S.J. 2017. Useful Plants - Medicines. in: Willis, K.J. (ed.) The State of the World's Plants. Report London, UK The Board of Trustees of the Royal Botanic Gardens, Kew. pp. 22-29

Collectors of Rhodiola species on the Sichuan-Tibetan and Sichuan-Shaanxi borders
Booker, A., Springer, L. and Heinrich, M. 2016. Collectors of Rhodiola species on the Sichuan-Tibetan and Sichuan-Shaanxi borders. The 16th International Congress on Ethnopharmacology. Yulin, China 15 - 18 May 2016 International Society for Ethnopharmacology.

Comparison of different Rhodiola species using NMR- metabolomics, HPTLC and DNA barcoding techniques
Booker, A., Zhai, L., Gkouva, C., Li, S., Frommenwiler, D., Reich, E., Howard, C., Sgamma, T., Williams, S., Slater, A. and Heinrich, M. 2016. Comparison of different Rhodiola species using NMR- metabolomics, HPTLC and DNA barcoding techniques. 9th Joint Natural Products Conference. Copenhagen, Denmark 24 - 27 Jul 2016 Georg Thieme Verlag. https://doi.org/10.1055/s-0036-1597026

Value Chains of Botanical and Herbal Medicinal Products: A European Perspective
Booker, A. and Heinrich, M. 2016. Value Chains of Botanical and Herbal Medicinal Products: A European Perspective. HerbalGram. 112, pp. 40-45.

From traditional resource to global commodities: a comparison of Rhodiola species using NMR spectroscopy - metabolomics and HPTLC
Booker, A., Zhai, L., Gkouva, C., Li, S. and Heinrich, M. 2016. From traditional resource to global commodities: a comparison of Rhodiola species using NMR spectroscopy - metabolomics and HPTLC. Frontiers in Pharmacology. 7 254. https://doi.org/10.3389/fphar.2016.00254

Adulteration and Poor Quality of Ginkgo biloba Supplements
Booker, A., Frommenwiler, D., Reich, E., Horsfield, S. and Heinrich, M. 2016. Adulteration and Poor Quality of Ginkgo biloba Supplements. Journal of Herbal Medicine. 6 (2), pp. 79-87. https://doi.org/10.1016/j.hermed.2016.04.003

Chinese Medicine: Contentions and Global Complexities
Booker, A. 2015. Chinese Medicine: Contentions and Global Complexities. in: Heinrich, M. and Jäger, A.K. (ed.) Ethnopharmacology New York, United States Wiley. pp. 293-302

Permalink - https://westminsterresearch.westminster.ac.uk/item/v6y42/treating-chronic-wounds-using-photoactive-metabolites-data-mining-the-chinese-pharmacopoeia-for-potential-lead-species


Restricted files

Accepted author manuscript

Under embargo indefinitely

Publisher's version

Under embargo indefinitely

Share this

Usage statistics

83 total views
1 total downloads
These values cover views and downloads from WestminsterResearch and are for the period from September 2nd 2018, when this repository was created.