Abstract | The therapeutic plant, Withania somnifera, commonly known as "Ashwagandha" or "Indian ginseng", has been used for over 3,000 years in Indian Systems of Medicine for the treatment of various ailments. Known for promoting youthful vigor and enhancing muscle strength, endurance, and overall health, this plant contains over 50 chemical constituents with diverse biological implications. With preclinical studies demonstrating a broad range of pharmacologic properties, including anti-microbial, anti-inflammatory, anti-tumor, anti-stress, neuroprotective, and cardioprotective, Withania somnifera is a promising drug candidate for treating various clinical conditions, especially those related to the nervous system [1-4]. In this Research Topic, a comprehensive overview of the molecular targets of withanolides and the mechanistic basis of their action in various pathophysiological states has been presented. The collection of research in this issue highlights the therapeutic potential of Withania somnifera in cancer, neurodegenerative diseases, inflammatory and respiratory disorders. |
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