Adulteration and Poor Quality of Ginkgo biloba Supplements

Booker, A., Frommenwiler, D., Reich, E., Horsfield, S. and Heinrich, M. 2016. Adulteration and Poor Quality of Ginkgo biloba Supplements. Journal of Herbal Medicine. 6 (2), pp. 79-87. doi:10.1016/j.hermed.2016.04.003

TitleAdulteration and Poor Quality of Ginkgo biloba Supplements
AuthorsBooker, A., Frommenwiler, D., Reich, E., Horsfield, S. and Heinrich, M.
Abstract

Adulteration of Ginkgo products sold as unregistered supplements within the very large market of Ginkgo products (reputedly £650 million annually) through the post-extraction addition of cheaper (e.g. buckwheat derived) rutin is suspected to allow sub-standard products to appear satisfactory to third parties, e.g. secondary buyers along the value chain or any regulatory authorities. This study was therefore carried out to identify products that did not conform to their label specification and may have been actively adulterated to enable access to the global markets.

500 MHz Bruker NMR spectroscopy instrumentation combined with Topspin version 3.2 and a CAMAG HPTLC system (HPTLC Association for the analysis of Ginkgo biloba leaf) were used to generate NMR spectra (focusing on the 6–8 ppm region for analysis) and chromatograms, respectively.

Out of the 35 samples of Ginkgo biloba analysed, 33 were found to contain elevated levels of rutin and/or quercetin, or low levels of Ginkgo metabolites when compared with the reference samples. Samples with disproportional levels of rutin or quercetin compared with other gingko metabolites are likely to be adulterated, either by accident or intentionally, and those samples with low or non-existent gingko metabolite content may have been produced using poor extraction techniques. Only two of the investigated samples were found to match with the High-Performance Thin-Layer Chromatography (HPTLC) fingerprint of the selected reference material. All others deviated significantly. One product contained a 5-hydroxytryptophan derivative, which is not a natural constituent of Ginkgo biloba.

Overall, these examples either suggest a poor extraction technique or deliberate adulteration along the value chain. Investigating the ratio of different flavonoids e.g. quercetin and kaempferol using NMR spectroscopy and HPTLC will provide further evidence as to the degree and kind of adulteration of Gingko supplements. From a consumer perspective the equivalence in identity and overall quality of the products needs to be guaranteed for supplements too and not only for products produced according to a quality standard or pharmacopoeial monograph.

JournalJournal of Herbal Medicine
Journal citation6 (2), pp. 79-87
ISSN2210-8033
Year2016
PublisherElsevier
Accepted author manuscript1-s2.0-S2210803316300239-main.pdf
Digital Object Identifier (DOI)doi:10.1016/j.hermed.2016.04.003
Publication dates
Published13 Apr 2016
Published in print01 Jun 2016

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