Quality Control of Hypericum perforatum L. Analytical challenges and recent progress

Agapouda, A., Booker, A., Kiss, T., Hohmann, J., Heinrich, M. and Csupor, D. 2019. Quality Control of Hypericum perforatum L. Analytical challenges and recent progress. Journal of Pharmacy and Pharmacology. 71 (1), pp. 15-37. doi:10.1111/jphp.12711

TitleQuality Control of Hypericum perforatum L. Analytical challenges and recent progress
TypeJournal article
AuthorsAgapouda, A., Booker, A., Kiss, T., Hohmann, J., Heinrich, M. and Csupor, D.
Abstract

Objectives
The most widely applied qualitative and quantitative analytical methods in the quality control of Hypericum perforatum extracts will be reviewed, including routine analytical tools and most modern approaches.

Key findings
Biologically active components of H. perforatum are chemically diverse, therefore different chromatographic and detection methods are required for the comprehensive analysis of St. John’s wort extracts. Naphthodianthrones, phloroglucinols and flavonoids are the most widely analysed metabolites of this plant. For routine quality control, detection of major compounds belonging to these groups seem to be sufficient, however closer characterisation requires the detection of minor compounds as well.

Conclusions
TLC and HPTLC are basic methods in the routine analysis, whereas HPLC-DAD is the most widely applied method for quantitative analysis due to its versatility. LC-MS is gaining importance in pharmacokinetic studies due to its sensitivity. Modern approaches, such as DNA barcoding, NIRS and NMR metabolomics may offer new possibilities for the more detailed characterization of secondary metabolite profile of Hypericum perforatum extracts.

KeywordsHypericum perforatum, St. John’s wort, HPLC, TLC, NMR metabolomics, DNA barcoding
JournalJournal of Pharmacy and Pharmacology
Journal citation71 (1), pp. 15-37
ISSN0022-3573
Year2019
PublisherWiley
Accepted author manuscriptQuality Control of Hypericum Perforatum.pdf
Digital Object Identifier (DOI)doi:10.1111/jphp.12711
Publication dates
Published online07 Mar 2017
Published in printJan 2019

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