Title | Green tea polyphenols in cardiometabolic health: A critical appraisal on Phytogenomics towards personalized green tea |
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Type | Journal article |
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Authors | Rajan, Logesh, Radhakrishnan, Arun, Alagarsamy, Keshav Narayan, Srivastava, Abhay, Dhingra, Sanjiv, Booker, Anthony, Rolfe, Viven, Palaniswamy, Dhanabal and Mohankumar, Suresh Kumar |
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Abstract | Cardiovascular disease is a chronic multifactorial health complication that is either directly or indirectly associated with pathophysiological mechanisms, including pro-oxidation, pro-inflammation, vascular and endothelial dysfunction, impaired platelet function, thrombosis, and others. The therapeutic options to circumvent cardiovascular complications include several phytomedicines, including green tea polyphenols. However, while many experimental and clinical studies report distinct mechanisms by which the polyphenols of green tea elicit a beneficial role in cardiometabolic health, the translation and applications of green tea polyphenols in clinics have yet to gain their optimal use on the broader population. This review critically appraises the various reported mechanisms of green tea polyphenols in modulating cardio-metabolic health and associated phyto-genomic challenges. Further, our review highlights the probability of gene polymorphic associated therapeutic variations in individuals using green tea for cardio-metabolic effects and the necessity to personalize green tea for clinical use, thereby improvising the risk-benefit ratio. |
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Article number | 100296 |
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Journal | PharmaNutrition |
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Journal citation | 20 |
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ISSN | 2213-4344 |
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Year | 2022 |
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Publisher | Elsevier |
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Accepted author manuscript | License CC BY-NC-ND 4.0 File Access Level Open (open metadata and files) |
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Digital Object Identifier (DOI) | https://doi.org/10.1016/j.phanu.2022.100296 |
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Publication dates |
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Published online | 16 Mar 2022 |
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Published in print | Jun 2022 |
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Page range | 100296 |
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