Effect of nanoparticulate bioactive glass particles on bioactivity and cytocompatibility of poly(3-hydroxybutyrate) composites

Misra, S.K., Ansari, T.I., Mohn, D., Valappil, S.P., Brunner, T.J., Stark, W.J., Roy, I., Knowles, J.C., Sibbons, P.D., Valsami-Jones, E., Boccaccini, A.R. and Salih, V. 2010. Effect of nanoparticulate bioactive glass particles on bioactivity and cytocompatibility of poly(3-hydroxybutyrate) composites. Journal of the Royal Society Interface. 7 (44), pp. 453-465. https://doi.org/10.1098/rsif.2009.0255

TitleEffect of nanoparticulate bioactive glass particles on bioactivity and cytocompatibility of poly(3-hydroxybutyrate) composites
AuthorsMisra, S.K., Ansari, T.I., Mohn, D., Valappil, S.P., Brunner, T.J., Stark, W.J., Roy, I., Knowles, J.C., Sibbons, P.D., Valsami-Jones, E., Boccaccini, A.R. and Salih, V.
Abstract

This work investigated the effect of adding nanoparticulate (29 nm) bioactive glass particles on the bioactivity, degradation and in vitro cytocompatibility of poly(3-hydroxybutyrate) (P(3HB)) composites/nano-sized bioactive glass (n-BG). Two different concentrations (10 and 20 wt %) of nanoscale bioactive glass particles of 45S5 Bioglass composition were used to prepare composite films. Several techniques (Raman spectroscopy, scanning electron microscopy, atomic force microscopy, energy dispersive X-ray) were used to monitor their surface and bioreactivity over a 45-day period of immersion in simulated body fluid (SBF). All results suggested the P(3HB)/n-BG composites to be highly bioactive, confirmed by the formation of hydroxyapatite on material surfaces upon immersion in SBF. The weight loss and water uptake were found to increase on increasing bioactive glass content. Cytocompatibility study (cell proliferation, cell attachment, alkaline phosphatase activity and osteocalcin production) using human MG-63 osteoblast-like cells in osteogenic and non-osteogenic medium showed that the composite substrates are suitable for cell attachment, proliferation and differentiation.

JournalJournal of the Royal Society Interface
Journal citation7 (44), pp. 453-465
ISSN1742-5689
YearMar 2010
PublisherRoyal Society
Digital Object Identifier (DOI)https://doi.org/10.1098/rsif.2009.0255
Publication dates
PublishedMar 2010

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Akaraonye, E., Safarikova, M., Keshavarz, T. and Roy, I. 2010. Enhanced and economical production of poly(3-hydroxybutyrate), a biodegradable polymer and its applications. 12th International Symposium on Biodegradable Polyesters. Stuttgart, Germany.

Multi-functional P(3HB) microsphere/45S5 Bioglass((R))-based composite scaffolds for bone tissue engineering
Francis, L., Meng, D., Knowles, J.C., Roy, I. and Boccaccini, A.R. 2010. Multi-functional P(3HB) microsphere/45S5 Bioglass((R))-based composite scaffolds for bone tissue engineering. Acta Biomaterialia. 6 (7), pp. 2773-2786. https://doi.org/10.1016/j.actbio.2009.12.054

In vitro production of polyhydroxyalkanoates: achievements and applications
Thomson, N., Roy, I., Summers, D. and Sivaniah, E. 2010. In vitro production of polyhydroxyalkanoates: achievements and applications. Journal of Chemical Technology and Biotechnology. 85 (6), pp. 760-767. https://doi.org/10.1002/jctb.2299

Polyhydroxyalkanoates: bioplastics with a green agenda
Keshavarz, T. and Roy, I. 2010. Polyhydroxyalkanoates: bioplastics with a green agenda. Current Opinion in Microbiology. 13 (3), pp. 321-326. https://doi.org/10.1016/j.mib.2010.02.006

Production of polyhydroxyalkanoates: the future green materials of choice
Akaraonye, E., Keshavarz, T. and Roy, I. 2010. Production of polyhydroxyalkanoates: the future green materials of choice. Journal of Chemical Technology and Biotechnology. 85 (6), pp. 732-743. https://doi.org/10.1002/jctb.2392

Poly(3-hydroxybutyrate) multifunctional composite scaffolds for tissue engineering applications
Misra, S.K., Ansari, T.I., Valappil, S.P., Mohn, D., Philip, S.E., Stark, W.J., Roy, I., Knowles, J.C., Salih, V. and Boccaccini, A.R. 2010. Poly(3-hydroxybutyrate) multifunctional composite scaffolds for tissue engineering applications. Biomaterials. 31 (10), pp. 2806-2815. https://doi.org/10.1016/j.biomaterials.2009.12.045

Characterization of carbon nanotube (MWCNT) containing P(3HB)/bioactive glass composites for tissue engineering applications
Misra, S.K., Ohashi, F., Valappil, S.P., Knowles, J.C., Roy, I., Ravi, S., Silva, P., Salih, V. and Boccaccini, A.R. 2010. Characterization of carbon nanotube (MWCNT) containing P(3HB)/bioactive glass composites for tissue engineering applications. Acta Biomaterialia. 6 (3), pp. 735-742. https://doi.org/10.1016/j.actbio.2009.09.023

Polyhydroxyalkanoates, the emerging new green polymers of choice
Rai, R. and Roy, I. 2010. Polyhydroxyalkanoates, the emerging new green polymers of choice. in: Biodegradable polymers and green chemistry Royal Society of Chemistry. pp. 79-97

River sediment sampling and analysis for selected heavy metals: establishing a practical protocol
Mokwe-Ozonzeadi, N.U., McEldowney, S., Foster, I. and Valsami-Jones, E. 2010. River sediment sampling and analysis for selected heavy metals: establishing a practical protocol. Society of environmental toxicology and chemistry UK annual meeting 2010: ‘environmental pollution in a changing world’. 13-14th Sept 2010

Microbial production of biodegradable polymers and their role in cardiac stent development
Basnett, P. and Roy, I. 2010. Microbial production of biodegradable polymers and their role in cardiac stent development. in: Mendez-Vilas, A. (ed.) Current research, technology and education topics in applied microbiology and microbial biotechnology Formatex Research Center.

Biodegradable polymers and their role in coronary stent development
Basnett, P. and Roy, I. 2010. Biodegradable polymers and their role in coronary stent development. in: Current research in technology and education topics in applied microbiology and microbial biotechnology Formatex Research Center.

Fabrication of a novel poly(3-hydroxyoctanoate) / nanoscale bioactive glass composite film with potential as a multifunctional wound dressing
Rai, R., Boccaccini, A.R., Knowles, J.C., Locke, I.C., Gordge, M.P., McCormick, A., Salih, V., Mordon, N., Keshavarz, T. and Roy, I. 2010. Fabrication of a novel poly(3-hydroxyoctanoate) / nanoscale bioactive glass composite film with potential as a multifunctional wound dressing. 5th international conference on times of polymers (TOP) and composites. Ischia, Italy 20–23 June 2010 https://doi.org/10.1063/1.3455552

The influence of tetracycline loading on the surface morphology and biocompatibility of films made from P(3HB) microspheres
Francis, L., Meng, D., Locke, I.C., Mordon, N., Salih, V., Knowles, J.C., Boccaccini, A.R. and Roy, I. 2010. The influence of tetracycline loading on the surface morphology and biocompatibility of films made from P(3HB) microspheres. Advanced Engineering Materials. 12 (7), pp. B260-B268. https://doi.org/10.1002/adem.201080020

Electrospun nanofibrous biodegradable polyester coatings on Bioglass®-based glass-ceramics for tissue engineering
Bretcanu, O., Misra, S.K., Yunos, D.M., Boccaccini, A.R., Roy, I., Kowalczyk, T., Blonski, S. and Kowalewski, T.A. 2009. Electrospun nanofibrous biodegradable polyester coatings on Bioglass®-based glass-ceramics for tissue engineering. Materials Chemistry and Physics. 118 (2-3), pp. 420-426. https://doi.org/10.1016/jmatchemphys.2009.08.01

Quantitative PCR study on the mode of action of oligosaccharide elicitors on penicillin G production by Penicillium chrysogenum
Nair, R.R., Roy, I., Bucke, C. and Keshavarz, T. 2009. Quantitative PCR study on the mode of action of oligosaccharide elicitors on penicillin G production by Penicillium chrysogenum. Journal of Applied Microbiology. 107 (4), pp. 1131-1139. https://doi.org/10.1111/j.1365-2672.2009.04293.x

Effect of impeller speed and pH on the production of Poly(3-hydroxybutyrate) using Bacillus cereus SPV
Philip, S.E., Sengupta, S., Keshavarz, T. and Roy, I. 2009. Effect of impeller speed and pH on the production of Poly(3-hydroxybutyrate) using Bacillus cereus SPV. Biomacromolecules. 10 (4), pp. 691-699. https://doi.org/10.1021/bm801395p

Incorporation of vitamin E in poly(3hydroxybutyrate)/Bioglass composite films: effect on surface properties and cell attachment
Misra, S.K., Philip, S.E., Chrzanowski, W., Nazhat, S.N., Roy, I., Knowles, J.C., Salih, V. and Boccaccini, A.R. 2009. Incorporation of vitamin E in poly(3hydroxybutyrate)/Bioglass composite films: effect on surface properties and cell attachment. Journal of the Royal Society Interface. 6 (33), pp. 401-409. https://doi.org/10.1098/rsif.2008.0278

In vitro biocompatibility of 45S5 Bioglass®-derived glass-ceramic scaffolds coated with poly(3-hydroxybutyrate)
Bretcanu, O., Misra, S.K., Roy, I., Renghini, C., Fiori, F., Boccaccini, A.R. and Salih, V. 2009. In vitro biocompatibility of 45S5 Bioglass®-derived glass-ceramic scaffolds coated with poly(3-hydroxybutyrate). Journal of Tissue Engineering and Regenerative Medicine. 3 (2), pp. 139-148. https://doi.org/10.1002/term.150

Polyhydroxyalkanoate synthases-enzymes involved in biodegradable polymer synthesis
Roy, I., Philip, S.E. and Keshavarz, T. 2009. Polyhydroxyalkanoate synthases-enzymes involved in biodegradable polymer synthesis. COST Action 868: Biotechnical Functionalisation of Renewable Polymeric Materials : Meeting on "Biotechnology and Biopolymers in Textile, Packaging, Cosmetics and Medical Applications". Istanbul, Turkey 19 - 20 Feb 2009

Microbial PHA biosynthesis and its biomedical applications
Roy, I., Philip, S.E., Francis, L., Rai, R., Keshavarz, T., Misra, S.K., Decheng, M. and Boccaccini, A.R. 2009. Microbial PHA biosynthesis and its biomedical applications. in: Proceedings of Euromat 2009, Glasgow, 7 - 10 September 2009 Euromat.

A class IV PHA synthase from Bacillus cereus SPV
Philip, S.E. and Roy, I. 2009. A class IV PHA synthase from Bacillus cereus SPV. in: Kiekens, P., Nierstrasz, V. and Lenting, H.B.M. (ed.) Proceedings of the international conference on textile and polymer biotechnology 6th Het Pand, Ghent, Belgium 23-25 September 2009 Ghent University. Department of Textiles Ghent.

P(3HB) production by Bacillus cereus SPV using sucrose as a carbon source
Akaraonye, E., Keshavarz, T. and Roy, I. 2009. P(3HB) production by Bacillus cereus SPV using sucrose as a carbon source. in: Kiekens, P., Nierstrasz, V. and Lenting, H.B.M. (ed.) Proceedings of the international conference on textile and polymer biotechnology 6th Het Pand, Ghent, Belgium 23-25 September 2009 Ghent University. Department of Textiles Ghent.

Elicitation effects of oligosaccharides on the transcriptional level of bacitracin ABC transporter genes in Bacillus licheniformis
Murphy, T., Roy, I., Harrop, A., Dixon, K. and Keshavarz, T. 2008. Elicitation effects of oligosaccharides on the transcriptional level of bacitracin ABC transporter genes in Bacillus licheniformis. Biotechnology Letters. 30 (9), pp. 1665-1670. https://doi.org/10.1007/s10529-008-9743-0

Polyhydroxyalkanoate biosynthesis in Bacillus cereus SPV under varied limiting conditions and an insight into the biosynthetic genes involved
Valappil, S.P., Rai, R., Bucke, C. and Roy, I. 2008. Polyhydroxyalkanoate biosynthesis in Bacillus cereus SPV under varied limiting conditions and an insight into the biosynthetic genes involved. Journal of Applied Microbiology. 104 (6), pp. 1624-1635. https://doi.org/10.1111/j.1365-2672.2007.03678.x

Comparison of nanoscale and microscale bioactive glass on the properties of P(3HB)/Bioglass® composites
Misra, S.K., Mohn, D., Brunner, T.J., Stark, W.J., Philip, S.E., Roy, I., Salih, V., Knowles, J.C. and Boccaccini, A.R. 2008. Comparison of nanoscale and microscale bioactive glass on the properties of P(3HB)/Bioglass® composites. Biomaterials. 29 (12), pp. 1750-1761. https://doi.org/10.1016/j.biomaterials.2007.12.040

Metabolite profiles of interacting mycelial fronts differ for pairings of the wood decay basidiomycete fungus, Stereum hirsutum with its competitors Coprinus micaceus and Coprinus disseminatus
Peiris, D., Dunn, W.B., Brown, M., Kell, D.B., Roy, I. and Hedger, J.N. 2008. Metabolite profiles of interacting mycelial fronts differ for pairings of the wood decay basidiomycete fungus, Stereum hirsutum with its competitors Coprinus micaceus and Coprinus disseminatus. Metabolomics. 4 (1), pp. 52-62. https://doi.org/10.1007/s11306-007-0100-4

Optimisation of β-glucuronidase production from a newly isolated Ganoderma applanatum
Chouiter, R., Roy, I. and Bucke, C. 2008. Optimisation of β-glucuronidase production from a newly isolated Ganoderma applanatum. Journal of Molecular Catalysis B: Enzymatic. 50 (2-4), pp. 114-120. https://doi.org/10.1016/j.molcatb.2007.09.015

Microbial biosynthesis of PHAs and its applications
Roy, I., Philip, S.E., Francis, L., Rai, R., Valappil, S.P., Markiv, A., Keshavarz, T., Misra, S.K., Decheng, M. and Boccaccini, A.R. 2008. Microbial biosynthesis of PHAs and its applications. COST Action 868: Biotechnical Functionalisation of Renewable Polymeric Materials: 2008 Annual Workshop (combined Working Group and Management Committee meeting). Varna, Bulgaria 18 -19 Sep 2008

Microbial PHA biosynthesis and its applications
Roy, I., Philip, S.E., Francis, L., Rai, R., Valappil, S.P., Markiv, A., Keshavarz, T., Misra, S.K., Decheng, M. and Boccaccini, A.R. 2008. Microbial PHA biosynthesis and its applications. 11th International Symposium on Biodegradable Polyesters. Massey University in Auckland, New Zealand 23 - 26 Nov 2008

Polyhydroxyalkanoates: a new generation of biotechnologically produced biodegradable polymers
Roy, I. and Philip, S.E. 2008. Polyhydroxyalkanoates: a new generation of biotechnologically produced biodegradable polymers. in: Richter, F.W. (ed.) Biotechnology: research, technology and applications New York Nova Science Publishers. pp. 1-48

Fabrication of a novel
Roy, I. and Philip, S.E. 2008. Fabrication of a novel. in: Richter, F.W. (ed.) Biotechnology: research, technology and applications New York Nova Science Publishers. pp. 1-48

Production of medium chain length polyhydroxyalkanoates using Pseudomonas species
Rai, R., Keshavarz, T. and Roy, I. 2008. Production of medium chain length polyhydroxyalkanoates using Pseudomonas species. 11th International Symposium on Biodegradable Polyesters. Massey University in Auckland, New Zealand 23 - 26 Nov 2008

Polyhydroxyalkanoate synthase in Bacillus cereus SPV, a class IV PHA synthase
Philip, S.E., Odell, M., Keshavarz, T. and Roy, I. 2008. Polyhydroxyalkanoate synthase in Bacillus cereus SPV, a class IV PHA synthase. 11th International Symposium on Biodegradable Polyesters. Massey University in Auckland, New Zealand 23 - 26 Nov 2008

Optimisation studies of multiple elicitor addition in microbial systems: P.Chrysogenum and B.Lichiniformis
Nair, R.R., Murphy, T., Roy, I., Harrop, A., Dixon, K. and Keshavarz, T. 2008. Optimisation studies of multiple elicitor addition in microbial systems: P.Chrysogenum and B.Lichiniformis. in: Marino, G., Bardone, E. and Viglia, A. (ed.) IBIC2008 - 1st International Conference on Industrial Biotechnology AIDIC Servizi S.r.l..

Polyhydroxyalkanoate synthasis using Bacillus cereus SPV
Francis, L., Keshavarz, T. and Roy, I. 2008. Polyhydroxyalkanoate synthasis using Bacillus cereus SPV. COST Action 868: Biotechnical Functionalisation of Renewable Polymeric Materials: 2008 Annual Workshop (combined Working Group and Management Committee meeting). Varna, Bulgaria 18 -19 Sep 2008

The ecotoxicology of nanoparticles and nanomaterials: current status, knowledge gaps, challenges, and future needs
Handy, R.D., Owen, R. and Valsami-Jones, E. 2008. The ecotoxicology of nanoparticles and nanomaterials: current status, knowledge gaps, challenges, and future needs. Ecotoxicology. 17 (5), pp. 315-325. https://doi.org/10.1007/s10646-008-0206-0

Large-scale production and efficient recovery of PHB with desirable material properties, from the newly characterised Bacillus cereus SPV
Valappil, S.P., Misra, S.K., Boccaccini, A.R., Keshavarz, T., Bucke, C. and Roy, I. 2007. Large-scale production and efficient recovery of PHB with desirable material properties, from the newly characterised Bacillus cereus SPV. Journal of Biotechnology. 132 (3), pp. 251-258. https://doi.org/10.1016/j.jbiotec.2007.03.013

Biodegradable polymer coated 45S5 Bioglassderived glass-ceramic scaffolds for bone tissue engineering
Bretcanu, O., Chen, Q., Misra, S.K., Boccaccini, A.R., Roy, I., Verne, E. and Brovarone, C.V. 2007. Biodegradable polymer coated 45S5 Bioglassderived glass-ceramic scaffolds for bone tissue engineering. European Journal of Glass Science and Technology Part A. 48 (5), pp. 227-234.

Effect of oligosaccharide elicitors on bacitracin A production and evidence of transcriptional level control
Keshavarz, T., Murphy, T., Roy, I., Harrop, A. and Dixon, K. 2007. Effect of oligosaccharide elicitors on bacitracin A production and evidence of transcriptional level control. Journal of Biotechnology. 131 (4), pp. 397-403. https://doi.org/10.1016/j.jbiotec.2007.07.943

Fabrication and characterization of biodegradable poly(3-hydroxybutyrate) composite containing Bioglass
Misra, S.K., Nazhat, S.N., Valappil, S.P., Moshrefi-Torbati, M., Wood, R.J.K., Roy, I. and Boccaccini, A.R. 2007. Fabrication and characterization of biodegradable poly(3-hydroxybutyrate) composite containing Bioglass. Biomacromolecules. 8 (7), pp. 2112-2119. https://doi.org/10.1021/bm0701954S1525-7797(07)00195-X

Novel application of oligosaccharides as elicitors for the enhancement of bacitracin A production in cultures of Bacillus licheniformis
Murphy, T., Parra, R., Radman, R., Roy, I., Harrop, A., Dixon, K. and Keshavarz, T. 2007. Novel application of oligosaccharides as elicitors for the enhancement of bacitracin A production in cultures of Bacillus licheniformis. Enzyme and Microbial Technology. 40 (6), pp. 1518-1523. https://doi.org/10.1016/j.enzmictec.2006.10.030

Polyhydroxyalkanoates: biodegradable polymers with a range of applications
Philip, S.E., Keshavarz, T. and Roy, I. 2007. Polyhydroxyalkanoates: biodegradable polymers with a range of applications. Journal of Chemical Technology and Biotechnology. 82 (3), pp. 233-247. https://doi.org/10.1002/jctb.1667

Poly(3- hydroxybutyrate)/Bioglass® composite films containing carbon nanotubes
Misra, S.K., Watts, P.C.P., Valappil, S.P., Silva, S.R.P., Boccaccini, A.R. and Roy, I. 2007. Poly(3- hydroxybutyrate)/Bioglass® composite films containing carbon nanotubes. Nanotechnology. 18 (7), p. 075701. https://doi.org/10.1088/0957-4484/18/7/075701

PHA biosynthesis in Bacillus cereus SPV and its applications
Roy, I., Valappil, S.P., Misra, S.K. and Boccaccini, A.R. 2007. PHA biosynthesis in Bacillus cereus SPV and its applications. COST Action 868: Biotechnical Functionalisation of Renewable Polymeric Materials: first annual workshop. Graz, Austria 12 - 14 Sep 2007

PHA Biosynthesis in Bacillus cereus SPV
Roy, I., Philip, S.E., Rai, R. and Valappil, S.P. 2007. PHA Biosynthesis in Bacillus cereus SPV. International Conference on Biodegradable Polymers: their production, characterisation and application. SCI, London 10 Dec 2007

Production of Polyhydroxyalkanoates from Bacillus cereus SPV under different nutrient limiting conditions
Rai, R., Padinhara, S.V., Keshavarz, T. and Roy, I. 2007. Production of Polyhydroxyalkanoates from Bacillus cereus SPV under different nutrient limiting conditions. COST Action 868: Biotechnical Functionalisation of Renewable Polymeric Materials: first annual workshop. Graz, Austria 12 - 14 Sep 2007

Production of medium chain length polyhydroxyalkanoates using pseudomonas species UOW0417398
Rai, R., Keshavarz, T. and Roy, I. 2007. Production of medium chain length polyhydroxyalkanoates using pseudomonas species UOW0417398. International Conference on Biodegradable Polymers: their production, characterisation and application. SCI, London 10 Dec 2007

Polyhydroxy-alkanoates - the biodegradable polymers
Philip, S.E., Odell, M., Keshavarz, T. and Roy, I. 2007. Polyhydroxy-alkanoates - the biodegradable polymers. International Conference on Biodegradable Polymers: their production, characterisation and application. SCI, London 10 Dec 2007

Biosynthesis of polyhydroxyalkanoates and their applications
Francis, L., Keshavarz, T. and Roy, I. 2007. Biosynthesis of polyhydroxyalkanoates and their applications. International Conference on Biodegradable Polymers: their production, characterisation and application. SCI, London 10 Dec 2007

Polyhydroxyalkanoate (PHA) biosynthesis from structurally unrelated carbon sources by a newly characterized Bacillus spp
Valappil, S.P., Peiris, D., Langley, G.J., Herniman, J.M., Boccaccini, A.R., Bucke, C. and Roy, I. 2007. Polyhydroxyalkanoate (PHA) biosynthesis from structurally unrelated carbon sources by a newly characterized Bacillus spp. Journal of Biotechnology. 127 (3), pp. 475-487. https://doi.org/10.1016/j.jbiotec.2006.07.015

Polyhydroxyalkanoates in Gram-positive bacteria: insights from the genera Bacillus and Streptomyces
Valappil, S.P., Boccaccini, A.R., Bucke, C. and Roy, I. 2007. Polyhydroxyalkanoates in Gram-positive bacteria: insights from the genera Bacillus and Streptomyces. Antonie van Leeuwenhoek. 91 (1), pp. 1-17. https://doi.org/10.1007/s10482-006-9095-5

Biomedical applications of polyhydroxyalkanoates: an overview of animal testing and in vivo responses
Valappil, S.P., Misra, S.K., Boccaccini, A.R. and Roy, I. 2006. Biomedical applications of polyhydroxyalkanoates: an overview of animal testing and in vivo responses. Expert Review of Medical Devices. 3 (6), pp. 853-868. https://doi.org/10.1586/17434440.3.6.853

An experimental investigation of the effect of Bacillus megaterium on apatite dissolution
Hutchens, E., Valsami-Jones, E., Harouiya, N., Chairat, C., Oelkers, E.H. and McEldowney, S. 2006. An experimental investigation of the effect of Bacillus megaterium on apatite dissolution. Geomicrobiology Journal. 23 (3-4), pp. 177-182. https://doi.org/10.1080/01490450600599239

Nanoindentation testing of biodegradabale polymers
Wood, R.J.K., Dan, S., Moshrefi-Torbati, M., Misra, S.K., Valappil, S.P., Boccaccini, A.R. and Roy, I. 2006. Nanoindentation testing of biodegradabale polymers. Proceedings of CAMTEC Workshop. University of Cambridge, Cambridge, UK 11 Apr 2006

PHA biosynthesis in Bacillus cereus SPV and its applications
Roy, I., Valappil, S.P., Misra, S.K. and Boccaccini, A.R. 2006. PHA biosynthesis in Bacillus cereus SPV and its applications. Proceedings of the International Symposium on Biological Polyesters. Minneapolis, USA 27 - 31 Aug 2006

Polyhydroxyalkanoate (PHA)/inorganic phase composites for tissue engineering applications
Misra, S.K., Valappil, S.P., Roy, I. and Boccaccini, A.R. 2006. Polyhydroxyalkanoate (PHA)/inorganic phase composites for tissue engineering applications. Biomacromolecules. 7 (8), pp. 2250-2257. https://doi.org/10.1021/bm060317c

Development of polyhydroxyalkanoates/Bioglass® composite tissue scaffolds for tissue engineering applications
Misra, S.K., Valappil, S.P., Nazhat, S.N., Moshrefi-Torbati, M., Roy, I. and Boccaccini, A.R. 2006. Development of polyhydroxyalkanoates/Bioglass® composite tissue scaffolds for tissue engineering applications. Proceedings of the 20th European Conference on Biomaterials, European Society of Biomaterials. Nantes, FRANCE 27 Sep - 01 Oct 2006

From bacteria to tissue engineering applications-usage of polyhydroxyalkanoates for biomedical applications
Misra, S.K., Nazhat, S.N., Torbati, M.M., Silva, S.R.P., Roy, I. and Boccaccini, A.R. 2006. From bacteria to tissue engineering applications-usage of polyhydroxyalkanoates for biomedical applications. Proceedings of the International Conference on the Design of Biomaterials. Kanpur, India 08 - 11 Dec 2006

Polyhydroxyalkanoate synthases: the enzymes involved in biodegradable polymer synthesis
Valappil, S.P., Philip, S.E., Odell, M., Keshavarz, T. and Roy, I. 2005. Polyhydroxyalkanoate synthases: the enzymes involved in biodegradable polymer synthesis. Proceedings of Frontiers in Chemical Biology: Mechanistic Enzymology and Biocatalysis. Exeter, UK 31 Aug - 02 Sep 2005

Effect of recovery process on the physical and mechanical properties of Polyhydroxybutyrate (PHB) extracted from a newly isolated Bacillus sp.
Valappil, S.P., Misra, S.K., Boccaccini, A.R. and Bucke, C. 2005. Effect of recovery process on the physical and mechanical properties of Polyhydroxybutyrate (PHB) extracted from a newly isolated Bacillus sp. Proceedings of the UKSB annual meeting, Nottingham, UK. Nottingham, UK 2005

Large scale production of P(3HB) from newly isolated Bacillus sp.
Valappil, S.P., Keshavarz, T., Bucke, C. and Roy, I. 2005. Large scale production of P(3HB) from newly isolated Bacillus sp. Proceedings of the 1st International Conference on Environmental Industrial and Applied Microbiology. Badajoz, Spain 15 - 18 Mar 2005

Effect of various carbon sources on the production of PHAs from the newly isolated Bacillus sp.
Valappil, S.P., Bucke, C. and Roy, I. 2005. Effect of various carbon sources on the production of PHAs from the newly isolated Bacillus sp. Proceedings of the International Union of Microbiological Societies Congress, IUMS. San Fransisco, USA 23 - 28 Jul 2005

Towards unravelling the elicitation mechanism in cultures of Penicillium chrysogenin: Chrysogenin elicitation
Nair, R.R., Radman, R., Roy, I., Bucke, C. and Keshavarz, T. 2005. Towards unravelling the elicitation mechanism in cultures of Penicillium chrysogenin: Chrysogenin elicitation. in: Pierucci, S. (ed.) 7th Italian Conference on Chemical and Process Engineering: ICheaP 7, May 15-16, 2005, Giardini Di Naxos, Italy Italy Associazione Italiana Di Ingegneria Chimica.

Natural biodegradable polymers from the Polyhydroxyalkanoate family emerging as a promising material for biomedical applications
Misra, S.K., Boccaccini, A.R., Valappil, S.P. and Roy, I. 2005. Natural biodegradable polymers from the Polyhydroxyalkanoate family emerging as a promising material for biomedical applications. Proceedings of 'a Forecast of the Future for Biomaterials' Professor Larry L. Hench Retirement Symposium. London, UK 29 - 30 Sep 2005

The metabolic role of methymalonyl CoA mutase in Escherichia coli
Kannan, S.M., Dwek, M., Bucke, C. and Roy, I. 2005. The metabolic role of methymalonyl CoA mutase in Escherichia coli. Proceedings of Viteomics: structure and function of vitamins and cofactors. Cambridge, UK 2005

Polysaccharides and polysaccharide-modifying enzymes in Ganoderma species
Chouiter, R., Roy, I. and Bucke, C. 2005. Polysaccharides and polysaccharide-modifying enzymes in Ganoderma species. Proceedings of the 13th European Carbohydrate Symposium. Bratislava, Slovakia 21 - 26 Aug 2005

Polysaccharide-modifying enzymes from Ganoderma species and their applications
Chouiter, R., Roy, I. and Bucke, C. 2005. Polysaccharide-modifying enzymes from Ganoderma species and their applications. Proceedings of the 1st International Conference on Environmental Industrial and Applied Microbiology. Badajoz, Spain 15 - 18 Mar 2005

Phylogenetic relationships between Basidiomycetes believed to be Ganoderma species based on distance analysis of their 5.8S, ITS1 and ITS2 rDNA sequences
Chouiter, R., Roy, I. and Bucke, C. 2005. Phylogenetic relationships between Basidiomycetes believed to be Ganoderma species based on distance analysis of their 5.8S, ITS1 and ITS2 rDNA sequences. Proceedings of the 1st International Conference on Environmental Industrial and Applied Microbiology. Badajoz, Spain 15 - 18 Mar 2005

‘Identification and isolation of polyhydroalkanoates and cloning of PHA biosynthetic genes from Bacillus cereus SPV
Valappil, S.P., Bucke, C. and Roy, I. 2004. ‘Identification and isolation of polyhydroalkanoates and cloning of PHA biosynthetic genes from Bacillus cereus SPV. Proceedings of the International Symposium on Biological Polyesters, ISBP. Beijing, China 22 - 28 Aug 2004

Biosynthesis of polyhydroxyalkanoic acids by Streptomyces coelicolor
Valappil, S.P., Bhatia, Y., Bucke, C. and Roy, I. 2004. Biosynthesis of polyhydroxyalkanoic acids by Streptomyces coelicolor. e-Polymers.

Polyhydroxyalkanoate production by Bacillus cereus SPV
Roy, I. 2004. Polyhydroxyalkanoate production by Bacillus cereus SPV. Proceedings of the International Symposium on Biological Polyesters, ISBP. Beijing, China 22 - 28 Aug 2004

Carbohydrates and carbohydrate active enzymes in Ganoderma applanatum
Budala, S., Bucke, C. and Roy, I. 2004. Carbohydrates and carbohydrate active enzymes in Ganoderma applanatum. Proceedings of the 22nd International Carbohydrate Symposium. Glasgow, UK 23 - 27 Jul 2004

The role of heterotrophic bacteria in feldspar dissolution: an experimental approach
Hutchens, E., Valsami-Jones, E., McEldowney, S., Gaze, W. and McLean, J. 2003. The role of heterotrophic bacteria in feldspar dissolution: an experimental approach. Mineralogical Magazine. 67 (6), pp. 1157-1170. https://doi.org/10.1180/0026461036760155

5-Aminolevulinic acid synthase: mechanism, mutations and medicine
Shoolingin-Jordan, P., Al-Daihan, S., Alexeev, D., Baxter, R.L., Bottomley, S.S., Kahari, I.D., Roy, I., Sarwar, M., Sawyer, L. and Wang, S.F. 2003. 5-Aminolevulinic acid synthase: mechanism, mutations and medicine. Biochimica et Biophysica Acta: Proteins and Proteomics. 1647 (1-2), pp. 361-365. https://doi.org/10.1016/S1570-9639(03)00095-5

Biosynthesis of medium chain length polyhydroxyalakanoic acids by Streptomyces coelicolor
Valappil, S.P., Bucke, C. and Roy, I. 2003. Biosynthesis of medium chain length polyhydroxyalakanoic acids by Streptomyces coelicolor. ICBP 2003. Proceedings of the 1st IUPAC International Conference on Bio-Based Polymers. Saitama, Japan 12 - 14 Nov 2003

The influence of heterotrophic bacteria and fungi on K-feldspar dissolution
Hutchens, E., Valsami-Jones, E. and McEldowney, S. 2003. The influence of heterotrophic bacteria and fungi on K-feldspar dissolution. Geochimica et Cosmochimica Acta. 67 (18, Supp. 1), p. A163.

A possible role of poly-3-hydroxybutyric acid in antibiotic production in Streptomyces
Verma, S., Bhatia, Y., Valappil, S.P. and Roy, I. 2002. A possible role of poly-3-hydroxybutyric acid in antibiotic production in Streptomyces. Archives of Microbiology. 179 (1), pp. 66-69. https://doi.org/10.1007/s00203-002-0500-9

Biosynthesis of polyhydroxyalkanoates by Streptomyces coelicolor
Valappil, S.P., Bucke, C. and Roy, I. 2002. Biosynthesis of polyhydroxyalkanoates by Streptomyces coelicolor. Proceedings of the International Symposium on Biological Polyesters. Munster, Germany 22 - 26 Sep 2002

Production of polyhydroxybutyrate by streptomyces
Verma, S. and Roy, I. 2001. Production of polyhydroxybutyrate by streptomyces. Proceedings of the Gordon Research Conference. Connecticut, USA 2001

Phosphorylation of the periplasmic binding protein in two transport systems for arginine incorporation in Escherichia coli K-12 is unrelated to the function of the transport system
Celis, R.T.F., Leadlay, P.F., Roy, I. and Hansen, A. 1998. Phosphorylation of the periplasmic binding protein in two transport systems for arginine incorporation in Escherichia coli K-12 is unrelated to the function of the transport system. Journal of Bacteriology. 180 (18), pp. 4828-4833.

Metabolic Engineering, a route to the production of novel products
Roy, I. 1998. Metabolic Engineering, a route to the production of novel products. Proceedings of the National Conference on Bioprocessing and R-DNA Technology. Central Drug Research Institute, Lucknow, India 27 - 28 Mar 1998

A Methylmalonyl-CoA mutase in Escherichia coli?
Roy, I. and Leadlay, P.F. 1997. A Methylmalonyl-CoA mutase in Escherichia coli? in: Ahmad, F. (ed.) Advances in gene technology: biomolecular design, form and function Nature Publishing Group.

The masked cysteine residues in methylmalonyl-CoA mutase from Propionibacterium shermanii are essential for catalytic activity
Roy, I. 1996. The masked cysteine residues in methylmalonyl-CoA mutase from Propionibacterium shermanii are essential for catalytic activity. FEBS Letters. 394 (2), pp. 126-128. https://doi.org/10.1016/0014-5793(96)00897-6

Physical map location of the new Escherichia coli gene sbm
Roy, I. and Leadlay, P.F. 1992. Physical map location of the new Escherichia coli gene sbm. Journal of Bacteriology. 174 (17), pp. 5763-5764.

Mechanism and structure of a coenzyme-B12 dependent enzyme
Roy, I., Patchett, M.L., Keep, N.H. and Leadlay, P.F. 1990. Mechanism and structure of a coenzyme-B12 dependent enzyme. Proceedings of the Royal Society of Chemistry Fifth International Symposium on the Mechanisms of Reactions in Solution. University of Kent, UK 02 - 06 Jul 1990

The expression of adenosylcobalamin dependent methylmalonyl-CoA mutase from Propionibacterium shermanii in Escherichia coli
McKie, N., Keep, N.H., Roy, I., Patchett, M.L. and Leadlay, P.F. 1989. The expression of adenosylcobalamin dependent methylmalonyl-CoA mutase from Propionibacterium shermanii in Escherichia coli. Proceedings of the Royal Society of Chemistry International Symposium on the Molecular Mechanisms in Bioorganic Processes. University of Newcastle upon Tyne, UK 17 - 20 Jul 1989

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