Controlled Delivery of Pan-PAD-Inhibitor Cl-Amidine Using Poly(3-Hydroxybutyrate) Microspheres

Monocyte-derived extracellular vesicles, stimulated by Trypanosoma cruzi, enhance cellular invasion in vitro via activated TGF-β1
Ansa-Addo, E.A., Pathak, P., McCrossan, M.V., Volpato Rossi, I., Abdullahi, M., Stratton, D., Lange, S., Ramirez, M.I. and Inal, J.M. 2024. Monocyte-derived extracellular vesicles, stimulated by Trypanosoma cruzi, enhance cellular invasion in vitro via activated TGF-β1. Journal of Extracellular Vesicles. 13 e70014. https://doi.org/10.1002/jev2.70014

Community-based reconstruction and simulation of a full-scale model of the rat hippocampus CA1 region
Romani, A., Antonietti, A., Bella, D., Budd, J., Giacalone, E., Kurban, K., Sáray, S., Abdellah, M., Arnaudon, A., Boci, E., Colangelo, C., Courcol, J-D., Delemontex, T., Ecker, A., Falck, J., Favreau, C., Gevaert, M., Hernando, J.B., Herttuainen, J., Ivaska, G., Kanari. L., Kaufmann, A-K., King, J.G., Kumbhar, P., Lange, S., Lu, H., Lupascu, C.A., Migliore, R., Petitjean, F., Planas, J., Rai, P., Ramaswamy, S., Reimann, M., Riquelme, J.L., Guerrero, N.R., Shi, Y., Sood, V., Sy, M.F., Van Geit, W., Vanherp, L., Freund, T.F., Mercer, A., Muller, E., Schürmann, F., Thomson, A.M., Migliore, M., Káli, S. and Markram, H. 2024. Community-based reconstruction and simulation of a full-scale model of the rat hippocampus CA1 region. PLOS Biology. 22 (11) e3002861. https://doi.org/10.1371/journal.pbio.3002861

Extracellular vesicles and citrullination signatures are novel biomarkers in sturgeon (Acipenser gueldenstaedtii) during chronic stress due to seasonal temperature challenge
Ferreira, A.M., Silva-Álvarez, V., Kraev, I., Uysal Onganer, P. and Lange, S. 2024. Extracellular vesicles and citrullination signatures are novel biomarkers in sturgeon (Acipenser gueldenstaedtii) during chronic stress due to seasonal temperature challenge. Fish and Shellfish Immunology. 154 (8), p. 109974 109974. https://doi.org/10.1016/j.fsi.2024.109974

Brain-Region-Specific Differences in Protein Citrullination/Deimination in a Pre-Motor Parkinson’s Disease Rat Model
Mercer, A., Sancandi, M., Maclatchy, A. and Lange, S. 2024. Brain-Region-Specific Differences in Protein Citrullination/Deimination in a Pre-Motor Parkinson’s Disease Rat Model. International Journal of Molecular Sciences. 25 (20) 11168. https://doi.org/10.3390/ijms252011168

Low Magnetic Field Exposure Alters Prostate Cancer Cell Properties
Lange, S., Inal, J.M., Kraev, I., Dart, D. and Uysal Onganer, P. 2024. Low Magnetic Field Exposure Alters Prostate Cancer Cell Properties. Biology. 13 (9), p. 734 13090734. https://doi.org/10.3390/biology13090734

Preprint: The Brain Region Specific Citrullinome and PAD 1-6 Isozyme Detection in a Pre-motor Parkinson’s Disease Rat Model
Mercer, A., Sancandi, M., Maclatchy, A. and Lange, S. 2024. Preprint: The Brain Region Specific Citrullinome and PAD 1-6 Isozyme Detection in a Pre-motor Parkinson’s Disease Rat Model. Preprints.org. https://doi.org/10.20944/preprints202406.2001.v1

3D Melt-Extrusion Printing of Medium Chain Length Polyhydroxyalkanoates and Their Application as Antibiotic-Free Antibacterial Scaffolds for Bone Regeneration
Marcello, E., Nigmatullin, R., Basnett, Pooja, Maqbool, Muhammad, Prieto, M., Knowles, J.C., Boccaccini, A. and Roy, I. 2024. 3D Melt-Extrusion Printing of Medium Chain Length Polyhydroxyalkanoates and Their Application as Antibiotic-Free Antibacterial Scaffolds for Bone Regeneration. ACS Biomaterials Science & Engineering. https://doi.org/10.1021/acsbiomaterials.4c00624

Minimal information for studies of extracellular vesicles (MISEV2023): From basic to advanced approaches
Joshua A. Welsh, Deborah Goberdhan, Lorraine O'Driscoll, Edit Buzás, Cherie Blenkiron, Bussolati B, Joseph Whitley, Dolores Di Vizio, Tom A. P. Driedonks, Uta Erdbrügger, Juan M Falcon-Perez, Qing‐Ling Fu, Andrew Hill, Metka Lenassi, Sai Kiang Lim, Mỹ G. Mahoney, Sujata Mohanty, Andreas Möller, Rienk Nieuwland, Takahiro Ochiya, Susmita Sahoo, Ana Claudia Torrecilhas, Lei Zheng, Andries Zijlstra, Sarah Abuelreich, Reem Bagabas, Paolo Bergese, Esther M. Bridges, Marco Brucale, Dylan Burger, Randy Carney, Emanuele Cocucci, Rossella Crescitelli, Edveena Hanser, Adrian L. Harris, Norman Haughey, An Hendrix, Alexander R. Ivanov, Tijana Jovanovic‐Talisman, Nicole A. Kruh‐Garcia, Vroniqa Ku'ulei‐Lyn Faustino, Diego Kyburz, Cecilia Lässer, Kathleen M. Lennon, Jan Lötvall, Adam L. Maddox, Elena Martens-Uzunova, Rachel R. Mizenko, Lauren Newman, Andrea Ridolfi, Eva Rohde, Lange, S. and Dina Ahmed 2024. Minimal information for studies of extracellular vesicles (MISEV2023): From basic to advanced approaches. Journal of Extracellular Vesicles. 13 (2) e12404. https://doi.org/10.1002/jev2.12404

A brief insight into the rare diseases in Egypt
Tarek Taha, Dina Ahmed, Zaynab El-Gammal, Gehad Atef Oura, Shimaa E. Elshenawy, Yasmine Gaber, Tarek Elnagdy and Khaled Amer 2023. A brief insight into the rare diseases in Egypt. Journal of Rare Diseases. 2 6. https://doi.org/10.1007/s44162-023-00010-1

Immunopathology of Hematodinium sp. infection of decapod crustaceans
Coates, C., Rowley, A. and Lange, S. 2023. Immunopathology of Hematodinium sp. infection of decapod crustaceans. Developmental and Comparative Immunology. 148 104936. https://doi.org/10.1016/j.dci.2023.104936

The Cavendish Living lab - a multidisciplinary, vertically integrated project focused on sustainability
Basnett, P., Percy, L., Sengupta, D. and Smith, C.L. 2023. The Cavendish Living lab - a multidisciplinary, vertically integrated project focused on sustainability. Westminster Learning and Teaching Symposium 2023: Better Than the Real Thing? Exploring Education Futures at the University of Westminster. University of Westminster 04 Sep 2023

A Coxsackievirus B1-mediated nonlytic Extracellular Vesicle-to-cell mechanism of virus transmission and its possible control through modulation of EV release
Jorfi, S., Ansa-Addo, E.A., Mariniello, K., Warde, P., Bin Senian, A.A., Stratton, D., Bax, B.E., Levene, M., Lange, S. and Inal, J.M. 2023. A Coxsackievirus B1-mediated nonlytic Extracellular Vesicle-to-cell mechanism of virus transmission and its possible control through modulation of EV release. Journal of General Virology. 104 (9) 001884. https://doi.org/10.1099/jgv.0.001884

The Extracellular Vesicle Citrullinome and Signature in a Piglet Model of Neonatal Seizures
Mitra, S., Harvey-Jones, K., Kraev, I., Verma, V., Meehan, C., Mintoft, A., Norris, G., Campbell, E., Tucker, K., Robertson, N.J., Hristova, M. and Lange, S. 2023. The Extracellular Vesicle Citrullinome and Signature in a Piglet Model of Neonatal Seizures. International Journal of Molecular Sciences. 24 (14) 11529. https://doi.org/10.3390/ijms241411529

Extracellular Vesicles in Phylogeny
Lange, S. 2023. Extracellular Vesicles in Phylogeny. International Journal of Molecular Sciences. 24 (13) 10466. https://doi.org/10.3390/ijms241310466

Extracellular vesicle signatures and protein citrullination are modified in shore crabs (Carcinus maenas) infected with Hematodinium sp
Coates, C., Kraev, I., Rowley, A. and Lange, S. 2023. Extracellular vesicle signatures and protein citrullination are modified in shore crabs (Carcinus maenas) infected with Hematodinium sp. Virulence. 14 (1) 2180932. https://doi.org/10.1080/21505594.2023.2180932

Aligned Polyhydroxyalkanoate Blend Electrospun Fibers as Intraluminal Guidance Scaffolds for Peripheral Nerve Repair
Taylor, C., Behbehani, Mehri, Glen, Adam, Basnett, Pooja, Gregory, D., Lukasiewicz, Barbara B., Nigmatullin, R., Claeyssens, F., Roy, Ipsita and Haycock, John W. 2023. Aligned Polyhydroxyalkanoate Blend Electrospun Fibers as Intraluminal Guidance Scaffolds for Peripheral Nerve Repair. ACS Biomaterials Science & Engineering. 9 (3), pp. 1472-1485. https://doi.org/10.1021/acsbiomaterials.2c00964

Enhanced production of biobased, biodegradable, Poly(3-hydroxybutyrate) using an unexplored marine bacterium Pseudohalocynthiibacter aestuariivivens, isolated from highly polluted coastal environment.
Esposito, Fortunato Palma, Vecchiato, Vittoria, Buonocore, Carmine, Tedesco, Pietro, Noble, Brendon, Basnett, Pooja and de Pascale, Donatella 2023. Enhanced production of biobased, biodegradable, Poly(3-hydroxybutyrate) using an unexplored marine bacterium Pseudohalocynthiibacter aestuariivivens, isolated from highly polluted coastal environment. Bioresource Technology. 368, p. 128287. https://doi.org/10.1016/j.biortech.2022.128287

Special Issue "The Exposome in Immune Evolution, Health and Disease"
Lange, S. 2023. Special Issue "The Exposome in Immune Evolution, Health and Disease". Biology.

Differential, Stage Dependent Detection of Peptidylarginine Deiminases and Protein Deimination in Lewy Body Diseases-Findings from a Pilot Study
Mercer, A., Jaunmuktane, Z., Hristova, M. and Lange, S. 2022. Differential, Stage Dependent Detection of Peptidylarginine Deiminases and Protein Deimination in Lewy Body Diseases-Findings from a Pilot Study. International Journal of Molecular Sciences. 23 (21) 13117. https://doi.org/10.3390/ijms232113117

microRNA 1307 Is a Potential Target for SARS-CoV-2 Infection: An <i>in Vitro</i> Model
Arisan, Elif Damla, Dart, D. Alwyn, Grant, Guy H., Dalby, A.R., Kancagi, Derya Dilek, Turan, Raife Dilek, Yurtsever, Bulut, Karakus, Gozde Sir, Ovali, Ercument, Lange, Sigrun and Uysal-Onganer, P. 2022. microRNA 1307 Is a Potential Target for SARS-CoV-2 Infection: An <i>in Vitro</i> Model. ACS Omega. 7 (42), pp. 38003-38014. https://doi.org/10.1021/acsomega.2c05245

Special Issue: “State-of-the-Art Neurobiology in the U.K."
Lange, S. 2022. Special Issue: “State-of-the-Art Neurobiology in the U.K.". MDPI.

Special Topic: "Animal Models of Human Disease"
Lange, S. and Inal, J.M. 2022. Special Topic: "Animal Models of Human Disease". MDPI.

A Pilot Study on Peptidylarginine Deiminases and Protein Deimination in Animal Cancers across Vertebrate Species
Inal, J.M., Hristova, M. and Lange, S. 2022. A Pilot Study on Peptidylarginine Deiminases and Protein Deimination in Animal Cancers across Vertebrate Species. International Journal of Molecular Sciences. 23 (15) e8697. https://doi.org/10.3390/ijms23158697

3D Disease Modelling of Hard and Soft Cancer Using PHA-Based Scaffolds
Tomar, A., Uysal-Onganer, P., Basnett, P., Pati, U. and Roy, I. 2022. 3D Disease Modelling of Hard and Soft Cancer Using PHA-Based Scaffolds. Cancers. 14 (14) e3549. https://doi.org/10.3390/cancers14143549

Acute Hypoxia Alters Extracellular Vesicle Signatures and the Brain Citrullinome of Naked Mole-Rats (Heterocephalus glaber)
D'alessio, S., Cheng, H., Eaton, L., Kraev, I., Pamenter, M.E. and Lange, S. 2022. Acute Hypoxia Alters Extracellular Vesicle Signatures and the Brain Citrullinome of Naked Mole-Rats (Heterocephalus glaber). International Journal of Molecular Sciences. 23 (9) 4683. https://doi.org/10.3390/ijms23094683

microRNA-21 Regulates Stemness in Pancreatic Ductal Adenocarcinoma Cells
Mortoglou, M., Miralles, F., Arisan, E.D., Dart, A., Jurcevic, S., Lange, S. and Uysal Onganer, P. 2022. microRNA-21 Regulates Stemness in Pancreatic Ductal Adenocarcinoma Cells. International Journal of Molecular Sciences. 23 (3) 1275. https://doi.org/10.3390/ijms23031275

Special Issue: “Extracellular Vesicles in Phylogeny”
Lange, S. 2021. Special Issue: “Extracellular Vesicles in Phylogeny”. MDPI.

Special Issue: “Cancers across Phylogeny and Cancer Evolution”
Lange, S. 2021. Special Issue: “Cancers across Phylogeny and Cancer Evolution” . MDPI.

Controlled Delivery of Pan-PAD-Inhibitor Cl-Amidine Using Poly(3-Hydroxybutyrate) Microspheres.
Ahmed, D., Puthussery, Hima, Basnett, Pooja, Knowles, J., Lange, S. and Roy, I. 2021. Controlled Delivery of Pan-PAD-Inhibitor Cl-Amidine Using Poly(3-Hydroxybutyrate) Microspheres. International Journal of Molecular Sciences. 22 (23) 12852. https://doi.org/10.3390/ijms222312852

Preliminary Investigations Into the Effect of Exercise-Induced Muscle Damage on Systemic Extracellular Vesicle Release in Trained Younger and Older Men
Kyriakidou, Y., Cooper, I., Kraev, I., Lange, S. and Elliott, B. 2021. Preliminary Investigations Into the Effect of Exercise-Induced Muscle Damage on Systemic Extracellular Vesicle Release in Trained Younger and Older Men. Frontiers in Physiology. 12 723931. https://doi.org/10.3389/fphys.2021.723931

Silver Nanoparticle-Coated Polyhydroxyalkanoate Based Electrospun Fibers for Wound Dressing Applications.
Kalaoglu-Altan, Ozlem Ipek, Baskan, Havva, Meireman, Timo, Basnett, Pooja, Azimi, Bahareh, Fusco, A., Funel, N., Donnarumma, G., Lazzeri, A., Roy, I., Danti, S. and De Clerck, K. 2021. Silver Nanoparticle-Coated Polyhydroxyalkanoate Based Electrospun Fibers for Wound Dressing Applications. Materials. 14 (17) 4907. https://doi.org/10.3390/ma14174907

Extracellular Vesicle Signatures and Post-Translational Protein Deimination in Purple Sea Urchin ( Strongylocentrotus purpuratus ) Coelomic Fluid—Novel Insights into Echinodermata Biology
D'alessio, S., Buckley, K., Kraev, Igor, Hayes, P.M. and Lange, S. 2021. Extracellular Vesicle Signatures and Post-Translational Protein Deimination in Purple Sea Urchin ( Strongylocentrotus purpuratus ) Coelomic Fluid—Novel Insights into Echinodermata Biology. Biology. 10 (9) 866. https://doi.org/10.3390/biology10090866

Post-translational protein deimination signatures in sea lamprey (Petromyzon marinus) plasma and plasma-extracellular vesicles
Rast, J.P., D'alessio, S., Kraev, I. and Lange, S. 2021. Post-translational protein deimination signatures in sea lamprey (Petromyzon marinus) plasma and plasma-extracellular vesicles. Developmental & Comparative Immunology. 125 (2021) 104225. https://doi.org/10.1016/j.dci.2021.104225

Harnessing Polyhydroxyalkanoates and Pressurized Gyration for Hard and Soft Tissue Engineering
Basnett, P., Matharu, R.K., Taylor, C.S., Illangakoon, U., Dawson, J.I., Kanczler, J.M., Behbehani, M., Humphrey, E., Majid, Q., Lukasiewicz, B., Nigmatullin, R., Haseltine, P., Oreffo, R.O.C., Haycock, J.W., Terracciano, C., Harding, S.E., Edirisinghe, M. and Roy, I. 2021. Harnessing Polyhydroxyalkanoates and Pressurized Gyration for Hard and Soft Tissue Engineering. ACS Applied Materials & Interfaces. 13 (28), p. 32624–32639. https://doi.org/10.1021/acsami.0c19689

Preclinical study of peripheral nerve regeneration using nerve guidance conduits based on polyhydroxyalkanaotes
Lizarraga Valderrama, L., Ronchi, Giulia, Nigmatullin, Rinat, Fregnan, Federica, Basnett, Pooja, Paxinou, Alexandra, Geuna, Stefano and Roy, I. 2021. Preclinical study of peripheral nerve regeneration using nerve guidance conduits based on polyhydroxyalkanaotes. Bioengineering & Translational Medicine. 6 (3) e10223. https://doi.org/10.1002/btm2.10223

Bioresorbable and Mechanically Optimized Nerve Guidance Conduit Based on a Naturally Derived Medium Chain Length Polyhydroxyalkanoate and Poly(ε-Caprolactone) Blend
Mendibil, Xabier, González-Pérez, Francisco, Bazan, Xabier, Díez-Ahedo, Ruth, Quintana, Iban, Rodríguez, Francisco Javier, Basnett, Pooja, Nigmatullin, Rinat, Lukasiewicz, Barbara, Roy, Ipsita, Taylor, Caroline S., Glen, Adam, Claeyssens, F., Haycock, John W., Schaafsma, Wandert, González, Eva, Castro, Begoña, Duffy, Patrick and Merino, S. 2021. Bioresorbable and Mechanically Optimized Nerve Guidance Conduit Based on a Naturally Derived Medium Chain Length Polyhydroxyalkanoate and Poly(ε-Caprolactone) Blend. ACS Biomaterials Science & Engineering. 7 (2), pp. 672-689. https://doi.org/10.1021/acsbiomaterials.0c01476

Antibacterial Composite Materials Based on the Combination of Polyhydroxyalkanoates With Selenium and Strontium Co-substituted Hydroxyapatite for Bone Regeneration
Marcello, Elena, Maqbool, Muhammad, Nigmatullin, Rinat, Cresswell, Mark, Jackson, Philip R., Basnett, Pooja, Knowles, Jonathan C., Boccaccini, Aldo R. and Roy, I. 2021. Antibacterial Composite Materials Based on the Combination of Polyhydroxyalkanoates With Selenium and Strontium Co-substituted Hydroxyapatite for Bone Regeneration. Frontiers in Bioengineering and Biotechnology. 9 647007. https://doi.org/10.3389/fbioe.2021.647007

Post-Translational Protein Deimination Signatures in Plasma and Plasma EVs of Reindeer ( Rangifer tarandus )
D'alessio, S., Thorgeirsdóttir, Stefanía, Kraev, Igor, Skírnisson, Karl and Lange, S. 2021. Post-Translational Protein Deimination Signatures in Plasma and Plasma EVs of Reindeer ( Rangifer tarandus ). Biology. 10 (3) e222. https://doi.org/10.3390/biology10030222

Peptidylarginine Deiminase (PAD) and Post-Translational Protein Deimination—Novel Insights into Alveolata Metabolism, Epigenetic Regulation and Host–Pathogen Interactions
Kristmundsson, Árni, Erlingsdóttir, Ásthildur and Lange, S. 2021. Peptidylarginine Deiminase (PAD) and Post-Translational Protein Deimination—Novel Insights into Alveolata Metabolism, Epigenetic Regulation and Host–Pathogen Interactions. Biology. 10 (3) e177. https://doi.org/10.3390/biology10030177

Editorial: Tissue Remodeling in Health and Disease Caused by Bacteria, Parasites, Fungi, and Viruses
Lange, S. and Ramirez, M.I. 2021. Editorial: Tissue Remodeling in Health and Disease Caused by Bacteria, Parasites, Fungi, and Viruses. Frontiers in Cellular and Infection Microbiology. 11 642311. https://doi.org/10.3389/fcimb.2021.642311

Peptidylarginine Deiminase Inhibitor Application, Using Cl-Amidine, PAD2, PAD3 and PAD4 Isozyme-Specific Inhibitors in Pancreatic Cancer Cells, Reveals Roles for PAD2 and PAD3 in Cancer Invasion and Modulation of Extracellular Vesicle Signatures
Uysal Onganer, P., D'alessio, S., Mortoglou, M., Kraev, I. and Lange, S. 2021. Peptidylarginine Deiminase Inhibitor Application, Using Cl-Amidine, PAD2, PAD3 and PAD4 Isozyme-Specific Inhibitors in Pancreatic Cancer Cells, Reveals Roles for PAD2 and PAD3 in Cancer Invasion and Modulation of Extracellular Vesicle Signatures. International Journal of Molecular Sciences. 22 (3) 1396. https://doi.org/10.3390/ijms22031396

MicroRNAs for Virus Pathogenicity and Host Responses, Identified in SARS-CoV-2 Genomes, May Play Roles in Viral-Host Co-Evolution in Putative Zoonotic Host Species
Lange, S., Arisan, E.D., Grant, G.H. and Uysal Onganer, P. 2021. MicroRNAs for Virus Pathogenicity and Host Responses, Identified in SARS-CoV-2 Genomes, May Play Roles in Viral-Host Co-Evolution in Putative Zoonotic Host Species. MDPI Viruses. 13 (1), p. 117 10.3390/v13010117 . https://doi.org/10.3390/v13010117

The Proteome and Citrullinome of Hippoglossus hippoglossus Extracellular Vesicles—Novel Insights into Roles of the Serum Secretome in Immune, Gene Regulatory and Metabolic Pathways
Magnadóttir, B., Kraev, I., Dodds, A.W. and Lange, S. 2021. The Proteome and Citrullinome of Hippoglossus hippoglossus Extracellular Vesicles—Novel Insights into Roles of the Serum Secretome in Immune, Gene Regulatory and Metabolic Pathways. International Journal of Molecular Sciences. 22 (2) 875. https://doi.org/10.3390/ijms22020875

Peptidylarginine deiminases and extracellular vesicles: prospective drug targets and biomarkers in central nervous system diseases and repair.
Lange, Sigrun 2021. Peptidylarginine deiminases and extracellular vesicles: prospective drug targets and biomarkers in central nervous system diseases and repair. Neural Regeneration Research. 16 (5), pp. 934-938. https://doi.org/10.4103/1673-5374.297058

Patterns in nature - the true art of microscopy
Lange, S. 2020. Patterns in nature - the true art of microscopy. University of Westminster

Cover Image, Volume 30, Issue 11
András Ecker, Armando Romani, Sára Sáray, Szabolcs Káli, Michele Migliore, Joanne Falck, Sigrun Lange, Audrey Mercer, Alex M. Thomson, Eilif Muller, Michael W. Reimann and Srikanth Ramaswamy 2020. Cover Image, Volume 30, Issue 11. Hippocampus. 30 (11), p. C1. https://doi.org/10.1002/hipo.23273

Extracellular Vesicles and Post-Translational Protein Deimination Signatures in Mollusca—The Blue Mussel ( Mytilus edulis ), Soft Shell Clam ( Mya arenaria ), Eastern Oyster ( Crassostrea virginica ) and Atlantic Jacknife Clam ( Ensis leei )
Bowden, Timothy J., Kraev, Igor and Lange, S. 2020. Extracellular Vesicles and Post-Translational Protein Deimination Signatures in Mollusca—The Blue Mussel ( Mytilus edulis ), Soft Shell Clam ( Mya arenaria ), Eastern Oyster ( Crassostrea virginica ) and Atlantic Jacknife Clam ( Ensis leei ). Biology. 9 (12) e416. https://doi.org/10.3390/biology9120416

Natural Biomaterials for Cardiac Tissue Engineering: A Highly Biocompatible Solution
Majid, Qasim A., Fricker, Annabelle T. R., Gregory, David A., Davidenko, Natalia, Hernandez Cruz, Olivia, Jabbour, Richard J., Owen, Thomas J., Basnett, Pooja, Lukasiewicz, Barbara, Stevens, Molly, Best, Serena, Cameron, Ruth, Sinha, Sanjay, Harding, Sian E. and Roy, Ipsita 2020. Natural Biomaterials for Cardiac Tissue Engineering: A Highly Biocompatible Solution. Frontiers in Cardiovascular Medicine. 7 554597. https://doi.org/10.3389/fcvm.2020.554597

Chemical Modification of Bacterial Cellulose for the Development of an Antibacterial Wound Dressing
Orlando, I., Basnett, P., Nigmatullin, R., Wang, W., Knowles, J. and Roy, I. 2020. Chemical Modification of Bacterial Cellulose for the Development of an Antibacterial Wound Dressing. Frontiers in Bioengineering and Biotechnology. 8 557885. https://doi.org/10.3389/fbioe.2020.557885

Electrosprayed Chitin Nanofibril/Electrospun Polyhydroxyalkanoate Fiber Mesh as Functional Nonwoven for Skin Application
Azimi, Bahareh, Thomas, Lily, Fusco, A., Kalaoglu-Altan, Ozlem Ipek, Basnett, P., Cinelli, P., De Clerck, Karen, Roy, I., Donnarumma, G., Coltelli, M., Danti, S. and Lazzeri, A. 2020. Electrosprayed Chitin Nanofibril/Electrospun Polyhydroxyalkanoate Fiber Mesh as Functional Nonwoven for Skin Application. Journal of Functional Biomaterials. 11 (3), p. e62. https://doi.org/10.3390/jfb11030062

Toward a Closed Loop, Integrated Biocompatible Biopolymer Wound Dressing Patch for Detection and Prevention of Chronic Wound Infections
Ward, A., Dubey, P., Basnett, P., Lika, G., Newman, G., Corrigan, D., Russell, C., Kim, J., Chakrabarty, S., Connolly, P. and Roy, I. 2020. Toward a Closed Loop, Integrated Biocompatible Biopolymer Wound Dressing Patch for Detection and Prevention of Chronic Wound Infections. Frontiers in Bioengineering and Biotechnology. 8 1039. https://doi.org/10.3389/fbioe.2020.01039

Cytocompatibility Evaluation of a Novel Series of PEG-Functionalized Lactide-Caprolactone Copolymer Biomaterials for Cardiovascular Applications
Pacharra, S., McMahon, S., Duffy, P., Basnett, P., Yu, W., Seisel, S., Stervbo, U., Babel, N., Roy, I., Viebahn, R., Wang, W. and Salber, J. 2020. Cytocompatibility Evaluation of a Novel Series of PEG-Functionalized Lactide-Caprolactone Copolymer Biomaterials for Cardiovascular Applications. Frontiers in Bioengineering and Biotechnology. 8 991. https://doi.org/10.3389/fbioe.2020.00991

Peptidylarginine Deiminase inhibition abolishes the production of large extracellular vesicles from Giardia intestinalis, affecting host-pathogen interactions by hindering adhesion to host cells
Gavinho, B., Sabatke, B., Rossi, I., Feijoli, V., Macedo, J., Evans-Osses, I., Palmisano, G., Lange, S. and Ramirez, M.I. 2020. Peptidylarginine Deiminase inhibition abolishes the production of large extracellular vesicles from Giardia intestinalis, affecting host-pathogen interactions by hindering adhesion to host cells. Frontiers in Cellular and Infection Microbiology. 10 417. https://doi.org/10.1101/586438

Comparison of the Influence of 45S5 and Cu-Containing 45S5 Bioactive Glass (BG) on the Biological Properties of Novel Polyhydroxyalkanoate (PHA)/BG Composites
Schuhladen, K., Lukasiewicz, B., Basnett, P., Roy, I. and Boccaccini, A.R. 2020. Comparison of the Influence of 45S5 and Cu-Containing 45S5 Bioactive Glass (BG) on the Biological Properties of Novel Polyhydroxyalkanoate (PHA)/BG Composites. Materials. 13 (11) 2607. https://doi.org/10.3390/ma13112607

Antimicrobial Materials with Lime Oil and a Poly (3-hydroxyalkanoate) Produced via Valorisation of Sugar Cane Molasses
Basnett, P., Marcello, E., Lukasiewicz, B., Nigmatullin, R., Paxinou, A., Ahmad, M.A., Gurumayum , B. and Roy, I. 2020. Antimicrobial Materials with Lime Oil and a Poly (3-hydroxyalkanoate) Produced via Valorisation of Sugar Cane Molasses. Journal of Functional Biomaterials. 11 (2) 24. https://doi.org/10.3390/jfb11020024

Extracellular Vesicles and Post-translational Protein Deimination Signatures in Haemolymph of the American Lobster (Homarus americanus)
Bowden, T.J., Kraev, I. and Lange, S. 2020. Extracellular Vesicles and Post-translational Protein Deimination Signatures in Haemolymph of the American Lobster (Homarus americanus) . Fish and Shellfish Immunology. 106, pp. 79-102 FSIM-D-20-00642. https://doi.org/10.1016/j.fsi.2020.06.053

Data‐driven integration of hippocampal CA1 synaptic physiology in silico
Ecker, A., Romani, A., Sáray, S., Káli,S., Migliore, M., Falck, J., Lange, S., Mercer, A., Thomson, A.M., Muller, M., Reimann, M.W. and Ramaswamy, S. 2020. Data‐driven integration of hippocampal CA1 synaptic physiology in silico. Hippocampus. 30 (11), pp. 1129-1145. https://doi.org/10.1002/hipo.23220

The Prediction of miRNAs in SARS-CoV-2 Genomes: hsa-miR Databases Identify 7 Key miRs Linked to Host Responses and Virus Pathogenicity-Related KEGG Pathways Significant for Comorbidities
Arisan, E.D., Dart, A., Grant, G.H., Arisan, S., Cuhadaroglu, S., Lange, S. and Uysal Onganer, P. 2020. The Prediction of miRNAs in SARS-CoV-2 Genomes: hsa-miR Databases Identify 7 Key miRs Linked to Host Responses and Virus Pathogenicity-Related KEGG Pathways Significant for Comorbidities. MDPI Viruses. 12 (6) 614. https://doi.org/10.3390/v12060614

Post-Translational Protein Deimination Signatures in Serum and Serum-Extracellular Vesicles of Bos taurus Reveal Immune, Anti-Pathogenic, Anti-Viral, Metabolic and Cancer-Related Pathways for Deimination
Criscitiello, M.F., Kraev, I. and Lange, S. 2020. Post-Translational Protein Deimination Signatures in Serum and Serum-Extracellular Vesicles of Bos taurus Reveal Immune, Anti-Pathogenic, Anti-Viral, Metabolic and Cancer-Related Pathways for Deimination. International Journal of Molecular Sciences. 21 (8) 2861. https://doi.org/10.3390/ijms21082861

Post-translational Protein Deimination Signatures and Extracellular Vesicles (EVs) in the Atlantic Horseshoe Crab (Limulus polyphemus)
Bowden, T.J., Kraev, I. and Lange, S. 2020. Post-translational Protein Deimination Signatures and Extracellular Vesicles (EVs) in the Atlantic Horseshoe Crab (Limulus polyphemus) . Developmental and Comparative Immunology. 110 103714. https://doi.org/10.1016/j.dci.2020.103714

Deimination Protein Profiles in Alligator mississippiensis Reveal Plasma and Extracellular Vesicle- specific Signatures Relating to Immunity, Metabolic Function and Gene Regulation
Criscitiello, M.F., Kraev, I., Petersen, L.H. and Lange, S. 2020. Deimination Protein Profiles in Alligator mississippiensis Reveal Plasma and Extracellular Vesicle- specific Signatures Relating to Immunity, Metabolic Function and Gene Regulation. Frontiers in Immunology. 11 651. https://doi.org/10.3389/fimmu.2020.00651

Deiminated Proteins and Extracellular Vesicles as Novel Biomarkers in Pinnipeds: Grey seal (Halichoerus gryptus) and Harbour seal (Phoca vitulina)
Magnadóttir, B., Uysal Onganer, P., Kraev, I., Svansson, V., Skírnisson, K. and Lange, S. 2020. Deiminated Proteins and Extracellular Vesicles as Novel Biomarkers in Pinnipeds: Grey seal (Halichoerus gryptus) and Harbour seal (Phoca vitulina). Biochimie . 171-172, pp. 79-90. https://doi.org/10.1016/j.biochi.2020.02.017

Deiminated proteins and extracellular vesicles - Novel serum biomarkers in whales and orca
Magnadóttir, B., Uysal-Onganer, P., Kraev, I., Svansson, V., Hayes, P.M. and Lange, S. 2020. Deiminated proteins and extracellular vesicles - Novel serum biomarkers in whales and orca. Comparative Biochemistry and Physiology - Part D: Genomics and Proteomics. 34, p. 100676 100676. https://doi.org/10.1016/j.cbd.2020.100676

Protein Deimination and Extracellular Vesicle Profiles in Antarctic Seabirds
Phillips, R.A., Kraev, I. and Lange, S. 2020. Protein Deimination and Extracellular Vesicle Profiles in Antarctic Seabirds. MDPI Biology. 9 (1) 15. https://doi.org/10.3390/biology9010015

Plasma mEV levels in Ghanain malaria patients with low parasitaemia are higher than those of healthy controls, raising the potential for parasite markers in mEVs as diagnostic targets
Antwi-Baffour, S., Malibha-Pinchbeck, M., Stratton, D., Jorfi, S., Lange, S. and Inal, J.M. 2020. Plasma mEV levels in Ghanain malaria patients with low parasitaemia are higher than those of healthy controls, raising the potential for parasite markers in mEVs as diagnostic targets. Journal of Extracellular Vesicles. 9, 2020 (issue 1) 1697124 . https://doi.org/10.1080/20013078.2019.1697124

Extracellular Vesicles, Deiminated Protein Cargo and microRNAs are Novel Serum Biomarkers for Environmental Rearing Temperature in Atlantic Cod (Gadus morhua L.)
Magnadóttir, B., Uysal Onganer, P., Kraev, I., Dodds, A.W., Gudmundsdottir, S. and Lange, S. 2020. Extracellular Vesicles, Deiminated Protein Cargo and microRNAs are Novel Serum Biomarkers for Environmental Rearing Temperature in Atlantic Cod (Gadus morhua L.) . Aquaculture Reports. 16 100245. https://doi.org/10.1016/j.aqrep.2019.100245

Deiminated Proteins in Extracellular Vesicles and Serum of Llama (Lama glama) - Novel Insights into Camelid Immunity
Criscitiello, M.F., Kraev, I. and Lange, S. 2020. Deiminated Proteins in Extracellular Vesicles and Serum of Llama (Lama glama) - Novel Insights into Camelid Immunity. Molecular Immunology. 117, pp. 37-53 MIMM_5890. https://doi.org/10.1016/j.molimm.2019.10.017

Peptidylarginine Deiminase Inhibition Abolishes the Production of Large Extracellular Vesicles From Giardia intestinalis, Affecting Host-Pathogen Interactions by Hindering Adhesion to Host Cells
Gavinho, B., Sabatke, B., Feijoli, V., Rossi, I., da Silva, J. M., Evans-Osses, I., Palmisano. G., Lange, S. and Ramirez, M.I. 2020. Peptidylarginine Deiminase Inhibition Abolishes the Production of Large Extracellular Vesicles From Giardia intestinalis, Affecting Host-Pathogen Interactions by Hindering Adhesion to Host Cells. Frontiers in Cellular and Infection Microbiology. 10 417. https://doi.org/10.3389/fcimb.2020.00417

Populated Collagen Hydrogel and Polyhydroxyalkanoate Composites: Novel Matrices for Cartilage Repair and Regeneration?
De Pascale, C., Marcello, E., Getting, S.J., Roy, I. and Locke, I.C. Forthcoming. Populated Collagen Hydrogel and Polyhydroxyalkanoate Composites: Novel Matrices for Cartilage Repair and Regeneration? OARSI World Congress on Osteoarthritis . Toronto, Canada 02 Mar - 05 May 2019

Special Issue: Peptidylarginine Deiminases and Protein Deimination in Health and Disease
Lange, S. and Nicholas, A.P. 2019. Special Issue: Peptidylarginine Deiminases and Protein Deimination in Health and Disease. MDPI.

Picosecond Laser Ablation of Polyhydroxyalkanoates (PHAs): Comparative Study of Neat and Blended Material Response
Ortiz, R, Basnett, P., Roy, I. and Quintana, I. 2019. Picosecond Laser Ablation of Polyhydroxyalkanoates (PHAs): Comparative Study of Neat and Blended Material Response. e-Polymers. 12 (1) 127. https://doi.org/10.3390/polym12010127

Curcumin: novel treatment in neonatal hypoxic-ischaemic brain injury
Rocha-Ferreira, E., Sisa, C., Bright, S., Fautz, T., Harris, M., Contreras Riquelme, I., Agwu, C., Kurulday, T., Mistry, B., Hill, D., Lange, S. and Hristova, M. 2019. Curcumin: novel treatment in neonatal hypoxic-ischaemic brain injury. Frontiers in Physiology. 10 1351. https://doi.org/10.3389/fphys.2019.01351

Cannabidiol is a Novel Modulator of Bacterial Membrane Vesicles
Kosgodage, U., Matewele, P., Awamaria, B., Kraev, I., Warde, P., Mastroianni, G., Nunn, A., Guy, G.W., Bell, J.D., Inal, J.M. and Lange, S. 2019. Cannabidiol is a Novel Modulator of Bacterial Membrane Vesicles. Frontiers in Cellular and Infection Microbiology. 9 324. https://doi.org/10.3389/fcimb.2019.00324

Unidirectional Neuronal Cell growth and Differentiation on Aligned Polyhydroxyalkanoate Blend Microfibres with Varying Diameters
Lizarraga Valderrama, L., Taylor, C.S., Claeyssens, F., Haycock, J.W., Knowles, J.C. and Roy, I. 2019. Unidirectional Neuronal Cell growth and Differentiation on Aligned Polyhydroxyalkanoate Blend Microfibres with Varying Diameters. Journal of Tissue Engineering and Regenerative Medicine. 13 (3), pp. 1581-1594. https://doi.org/10.1002/term.2911

Esterase Cleavable 2D Assemblies of Magnetic Iron Oxide Nanocubes: Exploiting Enzymatic Polymer Disassembling to Improve Magnetic Hyperthermia Heat Losses
Avugadda, S.K., Materia, M.E., Nigmatullin, R., Cabrera, D., Marotta, R., Cabada, T.F., Marcello, E., Nitti, S., Artés-Ibañez, E.J., Basnett, P., Wilhelm, C., Teran, F.J., Roy, I. and Pellegrino, T. 2019. Esterase Cleavable 2D Assemblies of Magnetic Iron Oxide Nanocubes: Exploiting Enzymatic Polymer Disassembling to Improve Magnetic Hyperthermia Heat Losses. Chemistry of Materials. 31 (15), pp. 5450-5463. https://doi.org/10.1021/acs.chemmater.9b00728

Complement component C4-like protein in Atlantic cod (Gadus morhua L.) - Detection in ontogeny and identification of post-translational deimination in serum and extracellular vesicles
Lange, S., Kraev, I., Magnadottir, B. and Dodds, A.W. 2019. Complement component C4-like protein in Atlantic cod (Gadus morhua L.) - Detection in ontogeny and identification of post-translational deimination in serum and extracellular vesicles. Developmental and Comparative Immunology. 101 103437. https://doi.org/10.1016/j.dci.2019.103437

A Sustainable Approach for the Downstream Processing of Bacterial Polyhydroxyalkanoates: State-of-the-art and latest developments
Perez Rivero, C., López-Gómez, J.P. and Roy, I. 2019. A Sustainable Approach for the Downstream Processing of Bacterial Polyhydroxyalkanoates: State-of-the-art and latest developments. Biochemical Engineering Journal. 150, p. 107283 107283. https://doi.org/10.1016/j.bej.2019.107283

Deiminated Proteins in Extracellular Vesicles and Plasma of Nurse Shark (Ginglymostoma cirratum) - Novel Insights into Shark Immunity
Criscitiello, M.F., Kraev, I. and Lange, S. 2019. Deiminated Proteins in Extracellular Vesicles and Plasma of Nurse Shark (Ginglymostoma cirratum) - Novel Insights into Shark Immunity. Fish and Shellfish Immunology. 92, pp. 249-255 YFSIM_6208. https://doi.org/10.1016/j.fsi.2019.06.012

Peptidylarginine Deiminase Inhibitors Reduce Bacterial Membrane Vesicle Release and Sensitise Bacteria to Antibiotic Treatment
Kosgodage, U., Matewele, P., Mastroianni, G., Kraev, I., Brotherton, D., Awamaria, B., Nicholas, A.P., Lange, S. and Inal, J.M. 2019. Peptidylarginine Deiminase Inhibitors Reduce Bacterial Membrane Vesicle Release and Sensitise Bacteria to Antibiotic Treatment. Frontiers in Cellular and Infection Microbiology. 9 227. https://doi.org/10.3389/fcimb.2019.00227

Extracellular Vesicles from Cod (Gadus morhua L.) Mucus contain Innate Immune Factors and Deiminated Protein Cargo
Magnadóttir, B., Kraev, I., Gudmundsdottir, S., Dodds, A.W. and Lange, S. 2019. Extracellular Vesicles from Cod (Gadus morhua L.) Mucus contain Innate Immune Factors and Deiminated Protein Cargo. Developmental and Comparative Immunology. p. 103397 103397. https://doi.org/10.1016/j.dci.2019.103397

Cellulose-based hydrogels for wound healing
Orlando, I. and Roy, I. 2019. Cellulose-based hydrogels for wound healing. in: Mondal, Md. and Ibrahim H. (ed.) Cellulose-Based Superabsorbent Hydrogels Springer. pp. 1131-1148

Mesenchymal Stromal Cell derived Extracellular Vesicles reduce Hypoxia-Ischaemia Induced Perinatal Brain Injury
Sisa, C., Kholia, S., Naylor, J., Herrera Sanchez, M.B., Bruno, S., Deregibus, M.C., Camussi, G., Inal, J.M., Lange, S. and Hristova, M. 2019. Mesenchymal Stromal Cell derived Extracellular Vesicles reduce Hypoxia-Ischaemia Induced Perinatal Brain Injury. Frontiers in Physiology. 10 282. https://doi.org/10.3389/fphys.2019.00282

Biosynthesis of Poly-3-Hydroxybutyrate and its Application in Controlled Drug Delivery
Puthussery, H. 2019. Biosynthesis of Poly-3-Hydroxybutyrate and its Application in Controlled Drug Delivery. PhD thesis University of Westminster School of Life Sciences https://doi.org/10.34737/q9xy6

Peptidylarginine Deiminases Post-translationally deiminate Prohibitin and modulate Extracellular Vesicle Release and microRNAs in Glioblastoma Multiforme
Kosgodage, U., Uysal Onganer, P., Maclatchy, A., Kraev, I., Chatterton, N.P., Nicholas, A.P., Inal, J.M. and Lange, S. 2019. Peptidylarginine Deiminases Post-translationally deiminate Prohibitin and modulate Extracellular Vesicle Release and microRNAs in Glioblastoma Multiforme . International Journal of Molecular Sciences. 20 (1) 103. https://doi.org/10.3390/ijms20010103

A novel ladder-like lectin relates to sites of mucosal immunity in Atlantic Halibut (Hippoglossus hippoglossus L.)
Magnadóttir, B., Gudmundsdottir, S. and Lange, S. 2019. A novel ladder-like lectin relates to sites of mucosal immunity in Atlantic Halibut (Hippoglossus hippoglossus L.) . Fish & Shellfish Immunology. 87, pp. 9-12. https://doi.org/10.1016/j.fsi.2018.12.034

Cannabidiol Affects Extracellular Vesicle Release, miR21 and miR126, and Reduces Prohibitin Protein in Glioblastoma Multiforme Cells
Kosgodage, U., Uysal Onganer, P., Maclatchy, A., Mould, R., Nunn, A.V.W., Guy, G.W., Kraev, I., Chatterton, N.P., Thomas, E.L., Inal, J.M., Bell, J.D. and Lange, S. 2019. Cannabidiol Affects Extracellular Vesicle Release, miR21 and miR126, and Reduces Prohibitin Protein in Glioblastoma Multiforme Cells. Translational Oncology. 12 (3), pp. 513-522. https://doi.org/10.1016/j.tranon.2018.12.004

Peptidylarginine deiminase and deiminated proteins are detected throughout early halibut ontogeny - Complement components C3 and C4 are post-translationally deiminated in halibut (Hippoglossus hippoglossus L.)
Magnadóttir, B., Bragason, B.T., Bricknell, I.R., Bowden, T., Nicholas, A.P., Hristova, M., Gudmundsdottir, S., Dodds, A.W. and Lange, S. 2019. Peptidylarginine deiminase and deiminated proteins are detected throughout early halibut ontogeny - Complement components C3 and C4 are post-translationally deiminated in halibut (Hippoglossus hippoglossus L.). Developmental and Comparative Immunology. 92, pp. 1-19. https://doi.org/10.1016/j.dci.2018.10.016

Biosynthesis and characterization of a novel, biocompatible medium chain length polyhydroxyalkanoate by Pseudomonas mendocina CH50 using coconut oil as the carbon source
Basnett, P., Marcello, E., Lukasiewicz, B., Panchal, B., Nigmatullin, R., Knowles, J.C. and Roy, I. 2018. Biosynthesis and characterization of a novel, biocompatible medium chain length polyhydroxyalkanoate by Pseudomonas mendocina CH50 using coconut oil as the carbon source. Journal of Materials Science: Materials in Medicine. 29, p. 179 179. https://doi.org/10.1007/s10856-018-6183-9

The physiological variability of channel density in hippocampal CA1 pyramidal cells and interneurons explored using a unified data-driven modeling workflow
Migliore, R., Lupascu, C.A., Bologna, L.L., Romani, R., Courcol, J-D., Antonel, S., Van Geit, W.A.H., Thompson, A.M., Mercer, A., Lange, S., Falck, J., Rossert, C.A., Shi, Y., Hagens, O., Pezzoli, M., Freund, T.F., Muller, E.B., Kali, S., Schurmann, F., Markram, H. and Migliore, M. 2018. The physiological variability of channel density in hippocampal CA1 pyramidal cells and interneurons explored using a unified data-driven modeling workflow. PLOS Computational Biology. 14 (9) e1006423. https://doi.org/10.1371/journal.pcbi.1006423

In Vivo Tracking and 1H/19F Magnetic Resonance Imaging of Biodegradable Polyhydroxyalkanoate / Polycaprolactone Blend Scaffolds Seeded with Labeled Cardiac Stem Cells
Constantinides, C., Basnett, P., Lukasiewicz, B., Carnicer, R., Swider, E., Majid, Q.A., Srinivas, M., Carr, C.A. and Roy, I. 2018. In Vivo Tracking and 1H/19F Magnetic Resonance Imaging of Biodegradable Polyhydroxyalkanoate / Polycaprolactone Blend Scaffolds Seeded with Labeled Cardiac Stem Cells. ACS Applied Materials and Interfaces. 10 (30), p. 25056–25068. https://doi.org/10.1021/acsami.8b06096

Cannabidiol (CBD) is a Novel Inhibitor for Exosome and Microvesicle (EMV) Release in Cancer
Kosgodage, U., Mould, R., Henley, A., Nunn, A.V.W., Guy, G.W., Thomas, E.L., Inal, J.M., Bell, J.D. and Lange, S. 2018. Cannabidiol (CBD) is a Novel Inhibitor for Exosome and Microvesicle (EMV) Release in Cancer. Frontiers in Pharmacology. 9 889. https://doi.org/10.3389/fphar.2018.00889

Post-translational Protein Deimination in Cod (Gadus morhua L.) Ontogeny: Novel Roles in Tissue Remodelling and Mucosal Immune Defences?
Magnadóttir, B., Hayes, P.M., Hristova, M., Bragason, B., Nicholas, A.P., Dodds, A.W., Gudmundsdottir, S. and Lange, S. 2018. Post-translational Protein Deimination in Cod (Gadus morhua L.) Ontogeny: Novel Roles in Tissue Remodelling and Mucosal Immune Defences? Developmental and Comparative Immunology. 87, pp. 157-170. https://doi.org/10.1016/j.dci.2018.06.006

Pentraxins CRP-I and CRP-II are post-translationally deiminated and differ in tissue specificity in cod (Gadus morhua L.) ontogeny
Magnadóttir, B., Hayes, P.M., Gisladottir, B., Bragason, B., Hristova, M., Nicholas, A.P., Gudmundsdottir, S. and Lange, S. 2018. Pentraxins CRP-I and CRP-II are post-translationally deiminated and differ in tissue specificity in cod (Gadus morhua L.) ontogeny. Developmental and Comparative Immunology. 87, pp. 1-11. https://doi.org/10.1016/j.dci.2018.05.014

Aligned nanofibres made of poly(3-hydroxybutyrate) grafted to hyaluronan for potential healthcare applications
Huerta-Ángeles, G., Knotková,, K., Knotek, P., Židek, O., Brandejsová, M., Pokorný, M., Vagnerová, H., Roy, I. and Velebný, V. 2018. Aligned nanofibres made of poly(3-hydroxybutyrate) grafted to hyaluronan for potential healthcare applications . Journal of Materials Science: Materials in Medicine . 29 (32), pp. 2-8 32. https://doi.org/10.1007/s10856-018-6045-5

Binary Polyhydroxyalkanoate Systems for Soft Tissue Engineering
Lukasiewicz, B., Basnett, P., Nigmatullin, R., Matharu, R., Knowles, J.C. and Roy, I. 2018. Binary Polyhydroxyalkanoate Systems for Soft Tissue Engineering. Acta Biomaterialia. 71, pp. 225-234. https://doi.org/10.1016/j.actbio.2018.02.027

Poly(3-hydroxyoctanoate), a promising new material for cardiac tissue engineering
Bagdadi, A., Safari, M., Dubey, P., Basnett, P., Sofokleous P., Humphrey E, Locke, I.C., Edirisinghe M., Terracciano C., Boccaccini, A.R., Knowles, J.C., Harding, S. and Roy, I. 2018. Poly(3-hydroxyoctanoate), a promising new material for cardiac tissue engineering. Journal of Tissue Engineering and Regenerative Medicine. 12 (1), pp. E495-E512. https://doi.org/10.1002/term.2318

Science and Principles of Biodegradable and Bioresorbable Medical Polymers
Basnett, P., Ravi, S. and Roy, I. 2017. Science and Principles of Biodegradable and Bioresorbable Medical Polymers. in: Xiang Zhang (ed.) Science and Principles of Biodegradable and Bioresorbable Medical Polymers: Materials and Properties Woodhead Publishing. pp. 257-277

Data-driven computational modeling of CA1 hippocampal principal cells and interneurons
Lange, S., migliore, S. and Lupascu, A.C. 2017. Data-driven computational modeling of CA1 hippocampal principal cells and interneurons. 26th Annual Computational Neuroscience Meeting (CNS*2017). Antwerp, Belgium 15 - 20 Jul 2017 BioMed Central. https://doi.org/10.1186/s12868-017-0372-1

Production of a novel medium chain length Poly(3-hydroxyalkanoate) using unprocessed biodiesel waste and its evaluation as a tissue engineering scaffold
Basnett, P., Lukasiewicz, B., Marcello, E., Kaur, H., Knowles, J.C. and Roy, I. 2017. Production of a novel medium chain length Poly(3-hydroxyalkanoate) using unprocessed biodiesel waste and its evaluation as a tissue engineering scaffold. Microbial Biotechnology. 10 (6), pp. 1384-1399. https://doi.org/10.1111/1751-7915.12782

Treatment of Prostate Cancer Using Deimination Antagonists and Microvesicle Technology
Lange, S., Kholia, S., Kosgodage, U. and Inal, J.M. 2017. Treatment of Prostate Cancer Using Deimination Antagonists and Microvesicle Technology. in: Nicholas, A.P., Bhattacharya, S. and Thompson, P.R. (ed.) Protein Deimination in Human Health and Disease Cham, Switzerland Springer. pp. 413-425

Protein Deimination in Protein Misfolding Disorders - Modelled in Human induced Pluripotent Stem Cells (iPSCs)
Lange, S., Wray, S., Devine, M., Matarin, M. and Hardy, J. 2017. Protein Deimination in Protein Misfolding Disorders - Modelled in Human induced Pluripotent Stem Cells (iPSCs). in: Nicholas, A.P., Battacharya, S.K. and Thompson, P.R. (ed.) Protein Deimination in Human Health and Disease Cham, Switzerland Springer. pp. 227-239

Peptidylarginine Deiminases-Roles in Cancer and Neurodegeneration and Possible Avenues for Therapeutic Intervention via Modulation of Exosome and Microvesicle (EMV) Release?
Lange, S., Gallagher, M, Kholia, S., Kosgodage, U., Hristova, M., Hardy, J. and Inal, J.M. 2017. Peptidylarginine Deiminases-Roles in Cancer and Neurodegeneration and Possible Avenues for Therapeutic Intervention via Modulation of Exosome and Microvesicle (EMV) Release? International Journal of Molecular Sciences. 18 (6) 1196. https://doi.org/10.3390/ijms18061196

Highly elastomeric poly(3-hydroxyoctanoate) based natural polymer composite for enhanced keratinocyte regeneration
Rai, R., Roether, J.A., Knowles, J.C., Mordan, N., Salih, V., Locke, I.C., Gordge, M.P., McCormick, A., Mohn, D., Stark, W.J., Keshavarz, T., Boccaccini, A.R. and Roy, I. 2017. Highly elastomeric poly(3-hydroxyoctanoate) based natural polymer composite for enhanced keratinocyte regeneration. International Journal of Polymeric Materials and Polymeric Biomaterials . 66 (7), pp. 326-335. https://doi.org/10.1080/00914037.2016.1217530

Synthesis of graft copolymers based on hyaluronan and poly(3-hydroxyalkanoates)
Huerta-Angeles, G., Brandejsová, M., Nigmatullin, R., Kopecká, K., Vágnerová, H., Šmejkalová, D., Roy, I. and Velebný, V. 2017. Synthesis of graft copolymers based on hyaluronan and poly(3-hydroxyalkanoates). Carbohydrate Polymers. 171, pp. 220-228. https://doi.org/10.1016/j.carbpol.2017.05.011

Chloramidine/Bisindolylmaleimide-I-Mediated Inhibition of Exosome and Microvesicle Release and Enhanced Efficacy of Cancer Chemotherapy
Kosgodage, U., Trindade R.P., Thompson, P.R., Inal, J.M. and Lange, S. 2017. Chloramidine/Bisindolylmaleimide-I-Mediated Inhibition of Exosome and Microvesicle Release and Enhanced Efficacy of Cancer Chemotherapy. International Journal of Molecular Sciences. 18 (5) 1007. https://doi.org/10.3390/ijms18051007

A Strategy for Dual Biopolymer Production of P(3HB) and γ-PGA
Sukan, A., Roy, I. and Keshavarz, T. 2017. A Strategy for Dual Biopolymer Production of P(3HB) and γ-PGA. Journal of Chemical Technology and Biotechnology. 92 (7), pp. 1548-1557. https://doi.org/10.1002/jctb.5259

The emerging role of exosome and microvesicle- (EMV-) based cancer therapeutics and immunotherapy
Moore, C., Kosgodage, U., Lange, S. and Inal, J.M. 2017. The emerging role of exosome and microvesicle- (EMV-) based cancer therapeutics and immunotherapy. International Journal of Cancer. 141 (3), pp. 428-436. https://doi.org/10.1002/ijc.30672

Data-driven model of the hippocampus using the HBP Brain Simulation Platform
Romani, A., Antille, N., Atenekeng, G., Courcol, J.D., Devresse, A., Dynes, J.A., Gevaert, M., Gonzalo, J.K., Gulyas, A., Kali, S., Kanari, L., Lange, S., Mercer, A., Migliore, M., Muller, E.B., Palacios, J.P., Ramaswamy, S., Reimann, M., Riquelme, R.L., Rössert, C.A., Ying, S., Shillcock, J., Telefont, M., Van Geit, W.A.H., Vanherpe, L., Markram, H. and Thomson, A. 2016. Data-driven model of the hippocampus using the HBP Brain Simulation Platform. 10th FENS Forum of Neuroscience. Copenhagen, Denmark 02 - 06 Jul 2016

Novel P(3HB) Composite Films Containing Bioactive Glass Nanoparticles for Wound Healing Applications
Francis, L., Meng, D., Locke, I.C., Knowles, J.C., Mordan, N., Salih, V., Boccaccini, A.R. and Roy, I. 2016. Novel P(3HB) Composite Films Containing Bioactive Glass Nanoparticles for Wound Healing Applications. Polymer International. 65 (6), pp. 661-674. https://doi.org/10.1002/pi.5108

PF7.09 Non-phagocytic epithelial cells take up microvesicles by micropinocytosis
Lange, S., Kosgodage, U. and Inal, J.M. 2016. PF7.09 Non-phagocytic epithelial cells take up microvesicles by micropinocytosis. The Fifth International Meeting of ISEV, ISEV 2016. Rotterdam, Netherlands 04 - 07 May 2016 Co-Action Publishing.

PW1.04. Inhibitors of microvesicle release with the potential to enhance effectivity of cancer chemotherapy
Lange, S., Kosgodage, U. and Inal, J.M. 2016. PW1.04. Inhibitors of microvesicle release with the potential to enhance effectivity of cancer chemotherapy. The Fifth International Meeting of ISEV, ISEV 2016. Rotterdam, Netherlands 04 - 07 May 2016 Co-Action Publishing. https://doi.org/10.3402/jev.v5.31552

Peptidylarginine deiminases as drug targets in neonatal hypoxic-ischemic encephalopathy
Lange, S. 2016. Peptidylarginine deiminases as drug targets in neonatal hypoxic-ischemic encephalopathy. Frontiers in Neurology. 7 22. https://doi.org/10.3389/fneur.2016.00022

Biomedical applications of polyhydroxyalkanoates
Roy, I., Lizarraga Valderrama, L., Panchal, B. and Boccaccini, A. 2016. Biomedical applications of polyhydroxyalkanoates. in: Reis, R.L. and Neves, N. (ed.) Biomaterials from nature for advanced devices and therapies Oxford Wiley.

Nerve tissue engineering using blends of poly(3-hydroxyalkanoates) for peripheral nerve regeneration
Lizarraga Valderrama, L., Nigmatullin, R., Taylor, C., Haycock, J.W., Claeyssens, F., Knowles, J.C. and Roy, I. 2015. Nerve tissue engineering using blends of poly(3-hydroxyalkanoates) for peripheral nerve regeneration. Engineering in Life Sciences. 15 (6), pp. 612-621. https://doi.org/10.1002/elsc.201400151

Prostate cancer cells stimulated by calcium-mediated activation of protein kinase C undergo a refractory period before re-releasing calcium-bearing microvesicles
Lange, S., Stratton, D., Moore, C., Inal, J., Zheng, L. and Li, Z. 2015. Prostate cancer cells stimulated by calcium-mediated activation of protein kinase C undergo a refractory period before re-releasing calcium-bearing microvesicles. Biochemical and Biophysical Research Communications. 460 (3), pp. 511-517. https://doi.org/10.1016/j.bbrc.2015.03.061

Microvesicles released constitutively from prostate cancer cells differ biochemically and functionally to stimulated microvesicles released through sublytic C5b-9
Lange, S., Stratton, D., Moore, C., Antwi-Baffour, S. and Inal, J. 2015. Microvesicles released constitutively from prostate cancer cells differ biochemically and functionally to stimulated microvesicles released through sublytic C5b-9. Biochemical and Biophysical Research Communications. 460 (3), p. 589–595. https://doi.org/10.1016/j.bbrc.2015.03.074

Data-driven Hippocampus CA1 Modeling in the Human Brain Project
Romani, A., Antille, N., Mercer, A., Dynes, J.A., Falk, J., Gevaert, M., Gonzalo, J.K., Kali, S., Kanari, L., Migliore, M., Lange, S., Muller, E.B., Ramaswamy, S., Reimann, M., Riquelme, R.J.L., Rössert, C.A., Shi, Y., Telefont, M., Van Geit, W.A.H., Markram, H., Thomson, A. and W.A.H. Van Geit 2015. Data-driven Hippocampus CA1 Modeling in the Human Brain Project. Neuroscience 2015. Chicago 17 Oct 2015 Society for Neuroscience.

A novel role for peptidylarginine deiminases in microvesicle release reveals therapeutic potential of PAD inhibition in sensitizing prostate cancer cells to chemotherapy
Kholia, S., Jorfi, S., Thompson, P.R., Causey, C.P., Nicholas, A.P., Inal, J. and Lange, S. 2015. A novel role for peptidylarginine deiminases in microvesicle release reveals therapeutic potential of PAD inhibition in sensitizing prostate cancer cells to chemotherapy. Journal of Extracellular Vesicles. 4 (1) 26192. https://doi.org/10.3402/jev.v4.26192

Inhibition of microvesiculation sensitizes prostate cancer cells to chemotherapy and reduces docetaxel dose required to limit tumor growth in vivo
Jorfi, S., Ansa-Addo, E.A., Kholia, S., Stratton, D., Valley, S., Lange, S. and Inal, J. 2015. Inhibition of microvesiculation sensitizes prostate cancer cells to chemotherapy and reduces docetaxel dose required to limit tumor growth in vivo. Scientific Reports. 5 (13006) 13006. https://doi.org/10.1038/srep13006

Production, chemistry and properties of biopolymers in food science
Puthussery, H., Prasad, R., Gorazda, K. and Roy, I. 2015. Production, chemistry and properties of biopolymers in food science. in: Cirillo, G., Spizzirri, U. and Iemma, F. (ed.) Functional polymers in food science: from technology to biology: volume 1 food packaging London Wiley.

Novel cardiac patch development using biopolymers and biocomposites
Dubey, P., Boccaccini, A. and Roy, I. 2015. Novel cardiac patch development using biopolymers and biocomposites. in: Yang, Y. and Xu, H. (ed.) Lightweight materials from biopolymers and biofibers Washington DC, USA American Chemical Society.

Dual production of biopolymers from bacteria
Sukan, A., Roy, I. and Keshavarz, T. 2015. Dual production of biopolymers from bacteria. Carbohydrate Polymers. 126, pp. 47-51. https://doi.org/10.1016/j.carbpol.2015.03.001

Label-free real-time acoustic sensing of microvesicle release from prostate cancer (PC3) cells using a Quartz Crystal Microbalance
Lange, S., Stratton, D., Kholia, S., Jorfi, S., Antwi-Baffour, S. and Inal, J. 2014. Label-free real-time acoustic sensing of microvesicle release from prostate cancer (PC3) cells using a Quartz Crystal Microbalance. Biochemical and Biophysical Research Communications. 453 (3), p. 619–624. https://doi.org/10.1016/j.bbrc.2014.09.132

Peptidylarginine deiminases (PADs): novel drug targets for prevention of neuronal damage following hypoxic ischemic insult (HI) in neonates
Lange, S., Rocha-Ferreira, E., Thei, L., Mawjee, P., Thompson, P.R., Nicholas, A.P., Hristova, M., Peebles, D. and Raivich, G. 2014. Peptidylarginine deiminases (PADs): novel drug targets for prevention of neuronal damage following hypoxic ischemic insult (HI) in neonates. Journal of Neurochemistry. 130 (4), pp. 555-562. https://doi.org/10.1111/jnc.12744

The Role of Infection and the TNF Family of Cytokines in Neonatal Hypoxic-Ischemic Brain Injury
Rocha-Ferreira, E., Francesch-Domenech, E., Thei, L., Rahim, A., Lange, S., Peebles, D., Hristova, M. and Raivich, G. 2014. The Role of Infection and the TNF Family of Cytokines in Neonatal Hypoxic-Ischemic Brain Injury. Reproductive Sciences. 21 (3 suppl), pp. 108A-109A. https://doi.org/10.1177/1933719114528275

Poly(3-hydroxyoctanoate): a novel natural material for cardiac tissue engineering
Dubey, P., Bagdadi, A., Boccaccini, A., Knowles, J., Stevens, M., Harding, S., Roy, I. and Ravi, S. 2014. Poly(3-hydroxyoctanoate): a novel natural material for cardiac tissue engineering. BHF Regenerative Medicine Centre Joint Annual and SAB meetings. Imperial College, London 31 Jul 2014

Nerve tissue engineering using blends of polyhydroxyalkanoates
Lizarraga Valderrama, L., Percy, L. and Roy, I. 2014. Nerve tissue engineering using blends of polyhydroxyalkanoates. 8th International Conference on Polymer and Fiber Biotechnology. Braga, Portugal 25 May 2014

Production of polyhydroxyalkanoates and their medical applications
Roy, I. 2014. Production of polyhydroxyalkanoates and their medical applications. International Symposium on Biopolymers. Santos, Brazil 30 Sep 2014

Agro-Industrial Waste Materials as Substrates for the Production of Poly(3-Hydroxybutyric Acid)
Sukan, A., Roy, I. and Keshavarz, T. 2014. Agro-Industrial Waste Materials as Substrates for the Production of Poly(3-Hydroxybutyric Acid). Journal of Biomaterials and Nanobiotechnology. 5 (4), pp. 229-240. https://doi.org/10.4236/jbnb.2014.54027

Biosynthesis of polyhydroxyalkanoates, their novel blends and composites for biomedical applications
Basnett, P. 2014. Biosynthesis of polyhydroxyalkanoates, their novel blends and composites for biomedical applications. PhD thesis University of Westminster Faculty of Science and Technology https://doi.org/10.34737/8y9yx

Composite polymer-bioceramic scaffolds with drug delivery capability for bone tissue engineering
Mourino, V., Cattalini, J.P., Roether, J.A., Dubey, P., Roy, I. and Boccaccini, A.R. 2013. Composite polymer-bioceramic scaffolds with drug delivery capability for bone tissue engineering. Expert Opinion on Drug Delivery. 10 (10), pp. 1353-1365. https://doi.org/10.1517/17425247.2013.808183

Evidence for the involvement of intracellular Ca 2+ ions in the elicitation mechanism of Bacillus Licheniformis
Reffatti, P., Roy, I., Odell, M. and Keshavarz, T. 2013. Evidence for the involvement of intracellular Ca 2+ ions in the elicitation mechanism of Bacillus Licheniformis. Journal of Molecular Microbiology and Biotechnology. OnlineFirst. https://doi.org/10.1159/000351515

Pulsed extremely low-frequency magnetic fields stimulate microvesicle release from human monocytic leukaemia cells
Lange, S., Stratton, D. and Inal, J. 2013. Pulsed extremely low-frequency magnetic fields stimulate microvesicle release from human monocytic leukaemia cells. Biochemical and Biophysical Research Communications. 430 (2), pp. 470-475. https://doi.org/10.1016/j.bbrc.2012.12.012

The Role of Deimination as a Response to Trauma and Hypoxic Injury in the Developing CNS
Ferretti, P., Lange, S., U, KP and Raivich, G. 2013. The Role of Deimination as a Response to Trauma and Hypoxic Injury in the Developing CNS. in: Nicholas, A. and Bhattacharya, S. (ed.) Protein Deimination in Human Health and Disease Springer. pp. 281-294

Blood/plasma secretome and microvesicles
Inal, J.M., Kosgodage, U., Azam, S., Stratton, D., Antwi-Baffour, S. and Lange, S. 2013. Blood/plasma secretome and microvesicles. Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids. 1834 (11), pp. 2317-2325. https://doi.org/10.1016/j.bbapap.2013.04.005

Interplay of host–pathogen microvesicles and their role in infectious disease
Inal, J.M., Ansa-Addo, E.A. and Lange, S. 2013. Interplay of host–pathogen microvesicles and their role in infectious disease. Biochemical Society Transactions. 41 (1), pp. 258-262. https://doi.org/10.1042/BST20120257

Inhibition of Protein Deimination Ameliorates Neuronal Damage Caused by Hypoxic Ischemic Insult in the Neonatal Brain
Lange, S., Rocha-Ferreira, E., Hristova, M., Thei, L., Mawjee, P., Thompson, P.R., Nicholas, T. and Raivich, G. 2013. Inhibition of Protein Deimination Ameliorates Neuronal Damage Caused by Hypoxic Ischemic Insult in the Neonatal Brain. British Neuroscience Association Abstracts. 22, pp. P1-B-071.

Advances in PHAs Production
Amache, R., Sukan, A., Safari, M., Roy, I. and Keshavarz, T. 2013. Advances in PHAs Production . Chemical Engineering Transactions. 32, pp. 931-936. https://doi.org/10.3303/CET1332156

Polyhydroxyalkanoates: the natural polymers produced by bacterial fermentation
Panchal, B., Bagdadi, A. and Roy, I. 2013. Polyhydroxyalkanoates: the natural polymers produced by bacterial fermentation. in: Advances in natural polymer Elsevier.

Tetracycline-encapsulated P(3HB) microsphere-coated 45S5 Bioglass®-based scaffolds for bone tissue engineering
Meng, D., Francis, L., Thompson, I.D., Mierke, C., Huebner, H., Amtmann, A., Roy, I. and Boccaccini, A.R. 2013. Tetracycline-encapsulated P(3HB) microsphere-coated 45S5 Bioglass®-based scaffolds for bone tissue engineering. Journal of Materials Science: Materials in Medicine. 24 (12), pp. 2809-2817. https://doi.org/10.1007/s10856-013-5012-4

Aspirin-loaded P(3HO)/P(3HB) blend films: potential materials for biodegradable drug-eluting stents
Basnett, P., Ching, K.Y., Stolz, M., Knowles, J.C., Boccaccini, A.R., Smith, C.L., Locke, I.C. and Roy, I. 2013. Aspirin-loaded P(3HO)/P(3HB) blend films: potential materials for biodegradable drug-eluting stents. Bioinspired, Biomimetic and Nanobiomaterials. 2 (3), pp. 141-153. https://doi.org/10.1680/bbn.13.00009

Novel Poly(3-hydroxyoctanoate)/Poly(3-hydroxybutyrate) blends for medical applications
Basnett, P., Ching, K.Y., Stolz, M., Knowles, J.C., Boccaccini, A.R., Smith, C.L., Locke, I.C., Keshavarz, T. and Roy, I. 2013. Novel Poly(3-hydroxyoctanoate)/Poly(3-hydroxybutyrate) blends for medical applications. Reactive and Functional Polymers. 73 (10), pp. 1340-1348. https://doi.org/10.1016/j.reactfunctpolym.2013.03.019

Poly(3-hydroxybutyrate) production by Bacillus cereus SPV using sugarcane molasses as the main carbon source
Akaraonye, E., Moreno, C., Knowles, J.C., Keshavarz, T. and Roy, I. 2012. Poly(3-hydroxybutyrate) production by Bacillus cereus SPV using sugarcane molasses as the main carbon source. Biotechnology Journal. 7 (2), pp. 293-303. https://doi.org/10.1002/biot.201100122

Microvesicles in Health and Disease
Inal, J.M., Ansa-Addo, E.A., Stratton, D., Kholia, S., Antwi-Baffour, S., Jorfi, S. and Lange, S. 2012. Microvesicles in Health and Disease. Archivum Immunologiae et Therapiae Experimentalis. 60 (2), pp. 107-121. https://doi.org/10.1007/s00005-012-0165-2

TNF gene deletion prevents lipopolysaccharide-mediated sensitisation of the neonatal mouse brain to hypoxic-ischaemic insult
Sahota, A., Kendall, G., Lange, S. and Raivich, G. 2012. TNF gene deletion prevents lipopolysaccharide-mediated sensitisation of the neonatal mouse brain to hypoxic-ischaemic insult. BMC Proceedings. 6 (Suppl 4), p. O9. https://doi.org/10.1186/1753-6561-6-S4-O9

Characterisation of microvesicles released from cells constitutively and upon stimulation
Stratton, D., Antwi-Baffour, S., Williams, G., Grant, R., Lange, S. and Inal, J.M. 2012. Characterisation of microvesicles released from cells constitutively and upon stimulation. Journal of Extracellular Vesicles. 1.

Isolation of microvesicles and exosomes by filtration and estimation of normal reference range in blood plasma
Grant, R., Ansa-Addo, E., Stratton, S., Antwi-Baffour, S., Jorfi, S., Kholia, S., Krige, L., Lange, S. and Inal, J.M. 2012. Isolation of microvesicles and exosomes by filtration and estimation of normal reference range in blood plasma. Journal of Extracellular Vesicles. 1.

The intracellular parasite, Trypanosoma cruzi, utilizes microvesicle release to invade host cells
Inal, J.M., Ansa-Addo, E., Cestari, I., Pathak, P.I., McCrossan, M.V., Lange, S. and Ramirez, M. 2012. The intracellular parasite, Trypanosoma cruzi, utilizes microvesicle release to invade host cells. Journal of Extracellular Vesicles. 1.

Enhanced production of the polyhydroxyalkanoate, P(3HB), from cacillus cereus SPV and its applications in cartilage regeneration
Everest, A., Keshavarz, T. and Roy, I. 2012. Enhanced production of the polyhydroxyalkanoate, P(3HB), from cacillus cereus SPV and its applications in cartilage regeneration. Gordon Research Conference on Biopolymers. Salve Regina University, Newport, Rhode Island, USA 3-8 June 2012

Novel biodegradable and biocompatible poly(3-hydroxyoctanoate)/bacterial cellulose composites
Basnett, P., Knowles, J.C., Pishbin, F., Smith, C.L., Keshavarz, T., Boccaccini, A.R. and Roy, I. 2012. Novel biodegradable and biocompatible poly(3-hydroxyoctanoate)/bacterial cellulose composites. Advanced Engineering Materials. 14 (6), pp. B330-B343. https://doi.org/10.1002/adem.201180076

Poly-3-hydroxyoctanoate P(3HO), a medium chain length polyhydroxyalkanoate homopolymer from Pseudomonas mendocina
Rai, R., Yunos, D.M., Boccaccini, A.R., Knowles, J.C., Barker, I.A., Howdle, S.M., Tredwell, G.D., Keshavarz, T. and Roy, I. 2011. Poly-3-hydroxyoctanoate P(3HO), a medium chain length polyhydroxyalkanoate homopolymer from Pseudomonas mendocina. Biomacromolecules. 12 (6), pp. 2126-2136. https://doi.org/10.1021/bm2001999

Enhanced intracellular Ca(2+) concentrations in Escherichia coli and Bacillus subtilis after addition of oligosaccharide elicitors
Murphy, T., Nilsson, A., Roy, I., Harrop, A., Dixon, K. and Keshavarz, T. 2011. Enhanced intracellular Ca(2+) concentrations in Escherichia coli and Bacillus subtilis after addition of oligosaccharide elicitors. Biotechnology Letters. 33 (5), pp. 985-991. https://doi.org/10.1007/s10529-010-0511-6

Medium chain length polyhydroxyalkanoates, promising new biomedical materials for the future
Rai, R., Keshavarz, T., Roether, J.A., Boccaccini, A.R. and Roy, I. 2011. Medium chain length polyhydroxyalkanoates, promising new biomedical materials for the future. Materials Science and Engineering R: Reports. 72 (3), pp. 29-47. https://doi.org/10.1016/j.mser.2010.11.002

Production of polyhydroxyalkanoates and their medical applications
Roy, I., Akaraonye, E., Francis, L., Rai, R., Basnett, P. and Keshavarz, T. 2011. Production of polyhydroxyalkanoates and their medical applications. 7th International Conference on Polymer and Textile Biotechnology. Milan, Italy 2nd - 4th March 2011

A filtration-based protocol to isolate human plasma membrane-derived vesicles and exosomes from blood plasma
Lange, S., Grant, R., Ansa-Addo, E.A., Stratton, D., Antwi-Baffour, S., Jorfi, S., Kholia, S., Krige, L. and Inal, J. 2011. A filtration-based protocol to isolate human plasma membrane-derived vesicles and exosomes from blood plasma. Journal of Immunological Methods. 371 (1-2), pp. 143-151. https://doi.org/10.1016/j.jim.2011.06.024

Protein deiminases: new players in the developmentally regulated loss of neural regenerative ability
Lange, S., Gogel, S., Yeung K-Y, Nicholas, A.P., Causey, C.P., Thompson, P.R., Greene, N.D.E. and Ferretti, P. 2011. Protein deiminases: new players in the developmentally regulated loss of neural regenerative ability. Developmental Biology. 355 (2), pp. 205-214. https://doi.org/10.1016/j.ydbio.2011.04.015

Imaging internal features of whole, unfixed bacteria
Thomson, N., Channon, K., Mokhtar, N.A., Staniewicz, L., Rai, R., Roy, I., Sato, S., Tsuge, T., Donald, A.M., Summers, D. and Sivaniah, E. 2011. Imaging internal features of whole, unfixed bacteria. Scanning. 33 (2), pp. 59-68. https://doi.org/10.1002/sca.20221

Production of polyhydroxyalkanoates and their biomedical applications
Roy, I., Akaraonye, E., Francis, L., Rai, R., Basnett, P. and Keshavarz, T. 2011. Production of polyhydroxyalkanoates and their biomedical applications. Euro BioMat 2011 - European Symposium on Biomaterials and Related Areas. Jena, Germany

Polyhydroxyalkanoates: the emerging new green polymers of choice
Rai, R. and Roy, I. 2011. Polyhydroxyalkanoates: the emerging new green polymers of choice. in: Sharma, S.K. and Mudhoo, A. (ed.) A handbook of applied biopolymer technology: synthesis, degradation and applications Royal Society of Chemistry.

Using electrophoretic deposition to identify protein charge in biological medium
Meng, D., Francis, L., Roy, I. and Boccaccini, A.R. 2011. Using electrophoretic deposition to identify protein charge in biological medium. Journal of Applied Electrochemistry. 41 (8), pp. 919-923. https://doi.org/10.1007/s10800-011-0317-9

Controlled delivery of gentamicin using poly(3-hydroxybutyrate) microspheres
Francis, L., Meng, D., Knowles, J.C., Keshavarz, T., Boccaccini, A.R. and Roy, I. 2011. Controlled delivery of gentamicin using poly(3-hydroxybutyrate) microspheres. International Journal of Molecular Sciences. 12 (7), pp. 4294-4314. https://doi.org/10.3390/ijms12074294

Polyhydroxyalkanoate (PHA): bacterial cellulose composites for biomedical applications
Basnett, P., Smith, C.L., Boccaccini, A.R., Knowles, J.C., Keshavarz, T. and Roy, I. 2011. Polyhydroxyalkanoate (PHA): bacterial cellulose composites for biomedical applications. 24th European Conference on Biomaterials - Annual Conference of the European Society for Biomaterials. Dublin, Ireland Sept 2011

The homopolymer poly(3-hydroxyoctanoate) as a matrix material for soft tissue engineering
Rai, R., Boccaccini, A.R., Knowles, J.C., Mordon, N., Salih, V., Locke, I.C., Moshrefi-Torbati, M., Keshavarz, T. and Roy, I. 2011. The homopolymer poly(3-hydroxyoctanoate) as a matrix material for soft tissue engineering. Journal of Applied Polymer Science. 122 (6), pp. 3606-3617. https://doi.org/10.1002/app.34772

Impact of linoleic acid supplementation on lovastatin production in Aspergillus terreus cultures
Sorrentino, F., Roy, I. and Keshavarz, T. 2010. Impact of linoleic acid supplementation on lovastatin production in Aspergillus terreus cultures. Applied Microbiology and Biotechnology. 88 (1), pp. 65-73. https://doi.org/10.1007/s00253-010-2722-0

Production of SCL and MCL polyhydroxyalkanoates and their applications
Roy, I., Akaraonye, E., Francis, L., Rai, R. and Boccaccini, A.R. 2010. Production of SCL and MCL polyhydroxyalkanoates and their applications. 12th International Symposium on Biodegradable Polyesters. Stuttgart, Germany.

Multifunctional P(3HB) microsphere/45S Bioglass ®-based composite scaffolds for bone tissue engineering
Francis, L., Meng, D., Boccaccini, A.R. and Roy, I. 2010. Multifunctional P(3HB) microsphere/45S Bioglass ®-based composite scaffolds for bone tissue engineering. 12th International Symposium on Biodegradable Polyesters. Stuttgart, Germany.

In vitro mutagenesis of the type IV polyhydroxyalkanoate synthase from bacillus cereus SPV
Basnett, P., Philip, S.E., Markhiv, A., Vydayanathan, A. and Roy, I. 2010. In vitro mutagenesis of the type IV polyhydroxyalkanoate synthase from bacillus cereus SPV. 12th International Symposium on Biodegradable Polyesters. Stuttgart, Germany.

Enhanced and economical production of poly(3-hydroxybutyrate), a biodegradable polymer and its applications
Akaraonye, E., Safarikova, M., Keshavarz, T. and Roy, I. 2010. Enhanced and economical production of poly(3-hydroxybutyrate), a biodegradable polymer and its applications. 12th International Symposium on Biodegradable Polyesters. Stuttgart, Germany.

Multi-functional P(3HB) microsphere/45S5 Bioglass((R))-based composite scaffolds for bone tissue engineering
Francis, L., Meng, D., Knowles, J.C., Roy, I. and Boccaccini, A.R. 2010. Multi-functional P(3HB) microsphere/45S5 Bioglass((R))-based composite scaffolds for bone tissue engineering. Acta Biomaterialia. 6 (7), pp. 2773-2786. https://doi.org/10.1016/j.actbio.2009.12.054

In vitro production of polyhydroxyalkanoates: achievements and applications
Thomson, N., Roy, I., Summers, D. and Sivaniah, E. 2010. In vitro production of polyhydroxyalkanoates: achievements and applications. Journal of Chemical Technology and Biotechnology. 85 (6), pp. 760-767. https://doi.org/10.1002/jctb.2299

Polyhydroxyalkanoates: bioplastics with a green agenda
Keshavarz, T. and Roy, I. 2010. Polyhydroxyalkanoates: bioplastics with a green agenda. Current Opinion in Microbiology. 13 (3), pp. 321-326. https://doi.org/10.1016/j.mib.2010.02.006

Production of polyhydroxyalkanoates: the future green materials of choice
Akaraonye, E., Keshavarz, T. and Roy, I. 2010. Production of polyhydroxyalkanoates: the future green materials of choice. Journal of Chemical Technology and Biotechnology. 85 (6), pp. 732-743. https://doi.org/10.1002/jctb.2392

Poly(3-hydroxybutyrate) multifunctional composite scaffolds for tissue engineering applications
Misra, S.K., Ansari, T.I., Valappil, S.P., Mohn, D., Philip, S.E., Stark, W.J., Roy, I., Knowles, J.C., Salih, V. and Boccaccini, A.R. 2010. Poly(3-hydroxybutyrate) multifunctional composite scaffolds for tissue engineering applications. Biomaterials. 31 (10), pp. 2806-2815. https://doi.org/10.1016/j.biomaterials.2009.12.045

Characterization of carbon nanotube (MWCNT) containing P(3HB)/bioactive glass composites for tissue engineering applications
Misra, S.K., Ohashi, F., Valappil, S.P., Knowles, J.C., Roy, I., Ravi, S., Silva, P., Salih, V. and Boccaccini, A.R. 2010. Characterization of carbon nanotube (MWCNT) containing P(3HB)/bioactive glass composites for tissue engineering applications. Acta Biomaterialia. 6 (3), pp. 735-742. https://doi.org/10.1016/j.actbio.2009.09.023

Effect of nanoparticulate bioactive glass particles on bioactivity and cytocompatibility of poly(3-hydroxybutyrate) composites
Misra, S.K., Ansari, T.I., Mohn, D., Valappil, S.P., Brunner, T.J., Stark, W.J., Roy, I., Knowles, J.C., Sibbons, P.D., Valsami-Jones, E., Boccaccini, A.R. and Salih, V. 2010. Effect of nanoparticulate bioactive glass particles on bioactivity and cytocompatibility of poly(3-hydroxybutyrate) composites. Journal of the Royal Society Interface. 7 (44), pp. 453-465. https://doi.org/10.1098/rsif.2009.0255

Post-translational regulation of CRMP in developing and regenerating chick spinal cord
Lange, S., Gogel, S., Leung Kit-Y, Greene, N.D.E. and Ferretti, P. 2010. Post-translational regulation of CRMP in developing and regenerating chick spinal cord. Developmental Neurobiology. 70 (6), pp. 456-471. https://doi.org/10.1002/dneu.20789

Human plasma membrane-derived vesicles inhibit the phagocytosis of apoptotic cells: possible role in SLE
Lange, S., Antwi-Baffour, S., Kholia, S., Ansa-Addo, E.A., Stratton, D., Aryee Y, K. and Inal, J. 2010. Human plasma membrane-derived vesicles inhibit the phagocytosis of apoptotic cells: possible role in SLE. Biochemical and Biophysical Research Communications. 398 (2), pp. 278-283. https://doi.org/10.1016/j.bbrc.2010.06.079

Human plasma membrane-derived vesicles halt proliferation and induce differentiation of THP-1 acute monocytic leukemia cells
Lange, S., Ansa-Addo, E.A., McCrossan, M.V. and Inal, J. 2010. Human plasma membrane-derived vesicles halt proliferation and induce differentiation of THP-1 acute monocytic leukemia cells. Journal of Immunology. 185 (9), pp. 5236-5246. https://doi.org/10.4049/jimmunol.1001656

Red cell PMVs, plasma membrane-derived vesicles calling out for standards
Hind, E., Heugh, S., Ansa-Addo, E.A., Antwi-Baffour, S., Lange, S. and Inal, J.M. 2010. Red cell PMVs, plasma membrane-derived vesicles calling out for standards. Biochemical and Biophysical Research Communications. 399 (4), pp. 465-469. https://doi.org/10.1016/j.bbrc.2010.07.095

Spinal cord regeneration: A role for peptidylarginine deiminase (PAD) in secondary injury response
Lange, S. 2010. Spinal cord regeneration: A role for peptidylarginine deiminase (PAD) in secondary injury response. SfN Minisymposium on Deimination in Opthalmic and Neurodegenerative diseases. San Diego Convention Center, California 16 Nov 2010

Spinal cord regeneration: peptidylarginine deiminase (PAD) and epigentic regulation of injury response
Lange, S., Ferretti, P., Goegel, S., Leung, K.T., Nicholas, A.P., Thompson, P.R. and Greene, N.D.E. 2010. Spinal cord regeneration: peptidylarginine deiminase (PAD) and epigentic regulation of injury response. FENS Forum 2010. Amsterdam 04 Jul 2010 Federation of European Neuroscience Societies.

Polyhydroxyalkanoates, the emerging new green polymers of choice
Rai, R. and Roy, I. 2010. Polyhydroxyalkanoates, the emerging new green polymers of choice. in: Biodegradable polymers and green chemistry Royal Society of Chemistry. pp. 79-97

Microbial production of biodegradable polymers and their role in cardiac stent development
Basnett, P. and Roy, I. 2010. Microbial production of biodegradable polymers and their role in cardiac stent development. in: Mendez-Vilas, A. (ed.) Current research, technology and education topics in applied microbiology and microbial biotechnology Formatex Research Center.

Biodegradable polymers and their role in coronary stent development
Basnett, P. and Roy, I. 2010. Biodegradable polymers and their role in coronary stent development. in: Current research in technology and education topics in applied microbiology and microbial biotechnology Formatex Research Center.

Fabrication of a novel poly(3-hydroxyoctanoate) / nanoscale bioactive glass composite film with potential as a multifunctional wound dressing
Rai, R., Boccaccini, A.R., Knowles, J.C., Locke, I.C., Gordge, M.P., McCormick, A., Salih, V., Mordon, N., Keshavarz, T. and Roy, I. 2010. Fabrication of a novel poly(3-hydroxyoctanoate) / nanoscale bioactive glass composite film with potential as a multifunctional wound dressing. 5th international conference on times of polymers (TOP) and composites. Ischia, Italy 20–23 June 2010 https://doi.org/10.1063/1.3455552

The influence of tetracycline loading on the surface morphology and biocompatibility of films made from P(3HB) microspheres
Francis, L., Meng, D., Locke, I.C., Mordon, N., Salih, V., Knowles, J.C., Boccaccini, A.R. and Roy, I. 2010. The influence of tetracycline loading on the surface morphology and biocompatibility of films made from P(3HB) microspheres. Advanced Engineering Materials. 12 (7), pp. B260-B268. https://doi.org/10.1002/adem.201080020

Electrospun nanofibrous biodegradable polyester coatings on Bioglass®-based glass-ceramics for tissue engineering
Bretcanu, O., Misra, S.K., Yunos, D.M., Boccaccini, A.R., Roy, I., Kowalczyk, T., Blonski, S. and Kowalewski, T.A. 2009. Electrospun nanofibrous biodegradable polyester coatings on Bioglass®-based glass-ceramics for tissue engineering. Materials Chemistry and Physics. 118 (2-3), pp. 420-426. https://doi.org/10.1016/jmatchemphys.2009.08.01

Quantitative PCR study on the mode of action of oligosaccharide elicitors on penicillin G production by Penicillium chrysogenum
Nair, R.R., Roy, I., Bucke, C. and Keshavarz, T. 2009. Quantitative PCR study on the mode of action of oligosaccharide elicitors on penicillin G production by Penicillium chrysogenum. Journal of Applied Microbiology. 107 (4), pp. 1131-1139. https://doi.org/10.1111/j.1365-2672.2009.04293.x

Effect of impeller speed and pH on the production of Poly(3-hydroxybutyrate) using Bacillus cereus SPV
Philip, S.E., Sengupta, S., Keshavarz, T. and Roy, I. 2009. Effect of impeller speed and pH on the production of Poly(3-hydroxybutyrate) using Bacillus cereus SPV. Biomacromolecules. 10 (4), pp. 691-699. https://doi.org/10.1021/bm801395p

Incorporation of vitamin E in poly(3hydroxybutyrate)/Bioglass composite films: effect on surface properties and cell attachment
Misra, S.K., Philip, S.E., Chrzanowski, W., Nazhat, S.N., Roy, I., Knowles, J.C., Salih, V. and Boccaccini, A.R. 2009. Incorporation of vitamin E in poly(3hydroxybutyrate)/Bioglass composite films: effect on surface properties and cell attachment. Journal of the Royal Society Interface. 6 (33), pp. 401-409. https://doi.org/10.1098/rsif.2008.0278

In vitro biocompatibility of 45S5 Bioglass®-derived glass-ceramic scaffolds coated with poly(3-hydroxybutyrate)
Bretcanu, O., Misra, S.K., Roy, I., Renghini, C., Fiori, F., Boccaccini, A.R. and Salih, V. 2009. In vitro biocompatibility of 45S5 Bioglass®-derived glass-ceramic scaffolds coated with poly(3-hydroxybutyrate). Journal of Tissue Engineering and Regenerative Medicine. 3 (2), pp. 139-148. https://doi.org/10.1002/term.150

Changes in progenitor populations and ongoing neurogenesis in the regenerating chick spinal cord
Lange, S., Whalley, K., Gogel, S. and Ferretti, P. 2009. Changes in progenitor populations and ongoing neurogenesis in the regenerating chick spinal cord. Developmental Biology. 332 (2), p. 234–245. https://doi.org/10.1016/j.ydbio.2009.05.569

Polyhydroxyalkanoate synthases-enzymes involved in biodegradable polymer synthesis
Roy, I., Philip, S.E. and Keshavarz, T. 2009. Polyhydroxyalkanoate synthases-enzymes involved in biodegradable polymer synthesis. COST Action 868: Biotechnical Functionalisation of Renewable Polymeric Materials : Meeting on "Biotechnology and Biopolymers in Textile, Packaging, Cosmetics and Medical Applications". Istanbul, Turkey 19 - 20 Feb 2009

Microbial PHA biosynthesis and its biomedical applications
Roy, I., Philip, S.E., Francis, L., Rai, R., Keshavarz, T., Misra, S.K., Decheng, M. and Boccaccini, A.R. 2009. Microbial PHA biosynthesis and its biomedical applications. in: Proceedings of Euromat 2009, Glasgow, 7 - 10 September 2009 Euromat.

A class IV PHA synthase from Bacillus cereus SPV
Philip, S.E. and Roy, I. 2009. A class IV PHA synthase from Bacillus cereus SPV. in: Kiekens, P., Nierstrasz, V. and Lenting, H.B.M. (ed.) Proceedings of the international conference on textile and polymer biotechnology 6th Het Pand, Ghent, Belgium 23-25 September 2009 Ghent University. Department of Textiles Ghent.

P(3HB) production by Bacillus cereus SPV using sucrose as a carbon source
Akaraonye, E., Keshavarz, T. and Roy, I. 2009. P(3HB) production by Bacillus cereus SPV using sucrose as a carbon source. in: Kiekens, P., Nierstrasz, V. and Lenting, H.B.M. (ed.) Proceedings of the international conference on textile and polymer biotechnology 6th Het Pand, Ghent, Belgium 23-25 September 2009 Ghent University. Department of Textiles Ghent.

Elicitation effects of oligosaccharides on the transcriptional level of bacitracin ABC transporter genes in Bacillus licheniformis
Murphy, T., Roy, I., Harrop, A., Dixon, K. and Keshavarz, T. 2008. Elicitation effects of oligosaccharides on the transcriptional level of bacitracin ABC transporter genes in Bacillus licheniformis. Biotechnology Letters. 30 (9), pp. 1665-1670. https://doi.org/10.1007/s10529-008-9743-0

Polyhydroxyalkanoate biosynthesis in Bacillus cereus SPV under varied limiting conditions and an insight into the biosynthetic genes involved
Valappil, S.P., Rai, R., Bucke, C. and Roy, I. 2008. Polyhydroxyalkanoate biosynthesis in Bacillus cereus SPV under varied limiting conditions and an insight into the biosynthetic genes involved. Journal of Applied Microbiology. 104 (6), pp. 1624-1635. https://doi.org/10.1111/j.1365-2672.2007.03678.x

Comparison of nanoscale and microscale bioactive glass on the properties of P(3HB)/Bioglass® composites
Misra, S.K., Mohn, D., Brunner, T.J., Stark, W.J., Philip, S.E., Roy, I., Salih, V., Knowles, J.C. and Boccaccini, A.R. 2008. Comparison of nanoscale and microscale bioactive glass on the properties of P(3HB)/Bioglass® composites. Biomaterials. 29 (12), pp. 1750-1761. https://doi.org/10.1016/j.biomaterials.2007.12.040

Metabolite profiles of interacting mycelial fronts differ for pairings of the wood decay basidiomycete fungus, Stereum hirsutum with its competitors Coprinus micaceus and Coprinus disseminatus
Peiris, D., Dunn, W.B., Brown, M., Kell, D.B., Roy, I. and Hedger, J.N. 2008. Metabolite profiles of interacting mycelial fronts differ for pairings of the wood decay basidiomycete fungus, Stereum hirsutum with its competitors Coprinus micaceus and Coprinus disseminatus. Metabolomics. 4 (1), pp. 52-62. https://doi.org/10.1007/s11306-007-0100-4

Optimisation of β-glucuronidase production from a newly isolated Ganoderma applanatum
Chouiter, R., Roy, I. and Bucke, C. 2008. Optimisation of β-glucuronidase production from a newly isolated Ganoderma applanatum. Journal of Molecular Catalysis B: Enzymatic. 50 (2-4), pp. 114-120. https://doi.org/10.1016/j.molcatb.2007.09.015

Microbial biosynthesis of PHAs and its applications
Roy, I., Philip, S.E., Francis, L., Rai, R., Valappil, S.P., Markiv, A., Keshavarz, T., Misra, S.K., Decheng, M. and Boccaccini, A.R. 2008. Microbial biosynthesis of PHAs and its applications. COST Action 868: Biotechnical Functionalisation of Renewable Polymeric Materials: 2008 Annual Workshop (combined Working Group and Management Committee meeting). Varna, Bulgaria 18 -19 Sep 2008

Microbial PHA biosynthesis and its applications
Roy, I., Philip, S.E., Francis, L., Rai, R., Valappil, S.P., Markiv, A., Keshavarz, T., Misra, S.K., Decheng, M. and Boccaccini, A.R. 2008. Microbial PHA biosynthesis and its applications. 11th International Symposium on Biodegradable Polyesters. Massey University in Auckland, New Zealand 23 - 26 Nov 2008

Polyhydroxyalkanoates: a new generation of biotechnologically produced biodegradable polymers
Roy, I. and Philip, S.E. 2008. Polyhydroxyalkanoates: a new generation of biotechnologically produced biodegradable polymers. in: Richter, F.W. (ed.) Biotechnology: research, technology and applications New York Nova Science Publishers. pp. 1-48

Fabrication of a novel
Roy, I. and Philip, S.E. 2008. Fabrication of a novel. in: Richter, F.W. (ed.) Biotechnology: research, technology and applications New York Nova Science Publishers. pp. 1-48

Production of medium chain length polyhydroxyalkanoates using Pseudomonas species
Rai, R., Keshavarz, T. and Roy, I. 2008. Production of medium chain length polyhydroxyalkanoates using Pseudomonas species. 11th International Symposium on Biodegradable Polyesters. Massey University in Auckland, New Zealand 23 - 26 Nov 2008

Polyhydroxyalkanoate synthase in Bacillus cereus SPV, a class IV PHA synthase
Philip, S.E., Odell, M., Keshavarz, T. and Roy, I. 2008. Polyhydroxyalkanoate synthase in Bacillus cereus SPV, a class IV PHA synthase. 11th International Symposium on Biodegradable Polyesters. Massey University in Auckland, New Zealand 23 - 26 Nov 2008

Optimisation studies of multiple elicitor addition in microbial systems: P.Chrysogenum and B.Lichiniformis
Nair, R.R., Murphy, T., Roy, I., Harrop, A., Dixon, K. and Keshavarz, T. 2008. Optimisation studies of multiple elicitor addition in microbial systems: P.Chrysogenum and B.Lichiniformis. in: Marino, G., Bardone, E. and Viglia, A. (ed.) IBIC2008 - 1st International Conference on Industrial Biotechnology AIDIC Servizi S.r.l..

Polyhydroxyalkanoate synthasis using Bacillus cereus SPV
Francis, L., Keshavarz, T. and Roy, I. 2008. Polyhydroxyalkanoate synthasis using Bacillus cereus SPV. COST Action 868: Biotechnical Functionalisation of Renewable Polymeric Materials: 2008 Annual Workshop (combined Working Group and Management Committee meeting). Varna, Bulgaria 18 -19 Sep 2008

Large-scale production and efficient recovery of PHB with desirable material properties, from the newly characterised Bacillus cereus SPV
Valappil, S.P., Misra, S.K., Boccaccini, A.R., Keshavarz, T., Bucke, C. and Roy, I. 2007. Large-scale production and efficient recovery of PHB with desirable material properties, from the newly characterised Bacillus cereus SPV. Journal of Biotechnology. 132 (3), pp. 251-258. https://doi.org/10.1016/j.jbiotec.2007.03.013

Biodegradable polymer coated 45S5 Bioglassderived glass-ceramic scaffolds for bone tissue engineering
Bretcanu, O., Chen, Q., Misra, S.K., Boccaccini, A.R., Roy, I., Verne, E. and Brovarone, C.V. 2007. Biodegradable polymer coated 45S5 Bioglassderived glass-ceramic scaffolds for bone tissue engineering. European Journal of Glass Science and Technology Part A. 48 (5), pp. 227-234.

Effect of oligosaccharide elicitors on bacitracin A production and evidence of transcriptional level control
Keshavarz, T., Murphy, T., Roy, I., Harrop, A. and Dixon, K. 2007. Effect of oligosaccharide elicitors on bacitracin A production and evidence of transcriptional level control. Journal of Biotechnology. 131 (4), pp. 397-403. https://doi.org/10.1016/j.jbiotec.2007.07.943

Fabrication and characterization of biodegradable poly(3-hydroxybutyrate) composite containing Bioglass
Misra, S.K., Nazhat, S.N., Valappil, S.P., Moshrefi-Torbati, M., Wood, R.J.K., Roy, I. and Boccaccini, A.R. 2007. Fabrication and characterization of biodegradable poly(3-hydroxybutyrate) composite containing Bioglass. Biomacromolecules. 8 (7), pp. 2112-2119. https://doi.org/10.1021/bm0701954S1525-7797(07)00195-X

Novel application of oligosaccharides as elicitors for the enhancement of bacitracin A production in cultures of Bacillus licheniformis
Murphy, T., Parra, R., Radman, R., Roy, I., Harrop, A., Dixon, K. and Keshavarz, T. 2007. Novel application of oligosaccharides as elicitors for the enhancement of bacitracin A production in cultures of Bacillus licheniformis. Enzyme and Microbial Technology. 40 (6), pp. 1518-1523. https://doi.org/10.1016/j.enzmictec.2006.10.030

Polyhydroxyalkanoates: biodegradable polymers with a range of applications
Philip, S.E., Keshavarz, T. and Roy, I. 2007. Polyhydroxyalkanoates: biodegradable polymers with a range of applications. Journal of Chemical Technology and Biotechnology. 82 (3), pp. 233-247. https://doi.org/10.1002/jctb.1667

Poly(3- hydroxybutyrate)/Bioglass® composite films containing carbon nanotubes
Misra, S.K., Watts, P.C.P., Valappil, S.P., Silva, S.R.P., Boccaccini, A.R. and Roy, I. 2007. Poly(3- hydroxybutyrate)/Bioglass® composite films containing carbon nanotubes. Nanotechnology. 18 (7), p. 075701. https://doi.org/10.1088/0957-4484/18/7/075701

Proteome changes in developing and injured chick spinal cord
Goegel, S., Lange, S., Greene, N.D.E. and Ferretti, P. 2007. Proteome changes in developing and injured chick spinal cord. Neuron Glia Biology. pp. S122-S122.

Differential gene expression following chick spinal cord injury at permissive and non permissive stages for regeneration
Lange, S., Goegel, S., Greene, N.D.E. and Ferretti, P. 2007. Differential gene expression following chick spinal cord injury at permissive and non permissive stages for regeneration. Neuron Glia Biology. pp. S121-S121.

The complement regulatory receptor CRIT is expressed in the developing kidney
Lange, S., Hui Kwok-M, Schifferli, J. and Inal, J.M. 2007. The complement regulatory receptor CRIT is expressed in the developing kidney. Molecular Immunology. 44 (16), p. 3991. https://doi.org/10.1016/j.molimm.2007.06.213

Complement C2 and CRIT are involved in the terminal differentiation of monocytes
Inal, J.M., Eva, W., Lange, S., Shamshiev, A. and Schifferli, J. 2007. Complement C2 and CRIT are involved in the terminal differentiation of monocytes. Journal of Immunology. 178, p. 83.17.

PHA biosynthesis in Bacillus cereus SPV and its applications
Roy, I., Valappil, S.P., Misra, S.K. and Boccaccini, A.R. 2007. PHA biosynthesis in Bacillus cereus SPV and its applications. COST Action 868: Biotechnical Functionalisation of Renewable Polymeric Materials: first annual workshop. Graz, Austria 12 - 14 Sep 2007

PHA Biosynthesis in Bacillus cereus SPV
Roy, I., Philip, S.E., Rai, R. and Valappil, S.P. 2007. PHA Biosynthesis in Bacillus cereus SPV. International Conference on Biodegradable Polymers: their production, characterisation and application. SCI, London 10 Dec 2007

Production of Polyhydroxyalkanoates from Bacillus cereus SPV under different nutrient limiting conditions
Rai, R., Padinhara, S.V., Keshavarz, T. and Roy, I. 2007. Production of Polyhydroxyalkanoates from Bacillus cereus SPV under different nutrient limiting conditions. COST Action 868: Biotechnical Functionalisation of Renewable Polymeric Materials: first annual workshop. Graz, Austria 12 - 14 Sep 2007

Production of medium chain length polyhydroxyalkanoates using pseudomonas species UOW0417398
Rai, R., Keshavarz, T. and Roy, I. 2007. Production of medium chain length polyhydroxyalkanoates using pseudomonas species UOW0417398. International Conference on Biodegradable Polymers: their production, characterisation and application. SCI, London 10 Dec 2007

Polyhydroxy-alkanoates - the biodegradable polymers
Philip, S.E., Odell, M., Keshavarz, T. and Roy, I. 2007. Polyhydroxy-alkanoates - the biodegradable polymers. International Conference on Biodegradable Polymers: their production, characterisation and application. SCI, London 10 Dec 2007

Biosynthesis of polyhydroxyalkanoates and their applications
Francis, L., Keshavarz, T. and Roy, I. 2007. Biosynthesis of polyhydroxyalkanoates and their applications. International Conference on Biodegradable Polymers: their production, characterisation and application. SCI, London 10 Dec 2007

Polyhydroxyalkanoate (PHA) biosynthesis from structurally unrelated carbon sources by a newly characterized Bacillus spp
Valappil, S.P., Peiris, D., Langley, G.J., Herniman, J.M., Boccaccini, A.R., Bucke, C. and Roy, I. 2007. Polyhydroxyalkanoate (PHA) biosynthesis from structurally unrelated carbon sources by a newly characterized Bacillus spp. Journal of Biotechnology. 127 (3), pp. 475-487. https://doi.org/10.1016/j.jbiotec.2006.07.015

Polyhydroxyalkanoates in Gram-positive bacteria: insights from the genera Bacillus and Streptomyces
Valappil, S.P., Boccaccini, A.R., Bucke, C. and Roy, I. 2007. Polyhydroxyalkanoates in Gram-positive bacteria: insights from the genera Bacillus and Streptomyces. Antonie van Leeuwenhoek. 91 (1), pp. 1-17. https://doi.org/10.1007/s10482-006-9095-5

Biomedical applications of polyhydroxyalkanoates: an overview of animal testing and in vivo responses
Valappil, S.P., Misra, S.K., Boccaccini, A.R. and Roy, I. 2006. Biomedical applications of polyhydroxyalkanoates: an overview of animal testing and in vivo responses. Expert Review of Medical Devices. 3 (6), pp. 853-868. https://doi.org/10.1586/17434440.3.6.853

Immunostimulation of larvae and juveniles of cod, Gadus morhua L.
Lange, S., Magnadóttir, B., Gudmundsdóttir, B.K., Bambir, S.H., Steinarsson, A., Oddgeirsson, M., Bowden, T., Bricknell, I., Dalmo, R.A. and Gudmundsdottir, S. 2006. Immunostimulation of larvae and juveniles of cod, Gadus morhua L. Journal of Fish Diseases. 29 (3), p. 147–155. https://doi.org/10.1111/j.1365-2761.2006.00701.x.

CRIT is expressed on podocytes in normal human kidney and upregulated in membranous nephropathy
Lange, S., Moll, S., Mihatsch M, J., Schifferli, J. and Inal, J. 2006. CRIT is expressed on podocytes in normal human kidney and upregulated in membranous nephropathy. Kidney International. 69 (11), p. 1961–1968. https://doi.org/10.1038/sj.ki.5000379

Complement component C3 transcription in Atlantic halibut (Hippoglossus hippoglossus L.) larvae
Lange, S., Bambir, S.H., Dodds, A.W., Bowden, T., Bricknell, I., Espelid, S. and Magnadóttir, B. 2006. Complement component C3 transcription in Atlantic halibut (Hippoglossus hippoglossus L.) larvae. Fish & Shellfish Immunology. 20 (3), p. 285–294. https://doi.org/10.1016/j.fsi.2005.05.004

Nanoindentation testing of biodegradabale polymers
Wood, R.J.K., Dan, S., Moshrefi-Torbati, M., Misra, S.K., Valappil, S.P., Boccaccini, A.R. and Roy, I. 2006. Nanoindentation testing of biodegradabale polymers. Proceedings of CAMTEC Workshop. University of Cambridge, Cambridge, UK 11 Apr 2006

PHA biosynthesis in Bacillus cereus SPV and its applications
Roy, I., Valappil, S.P., Misra, S.K. and Boccaccini, A.R. 2006. PHA biosynthesis in Bacillus cereus SPV and its applications. Proceedings of the International Symposium on Biological Polyesters. Minneapolis, USA 27 - 31 Aug 2006

Polyhydroxyalkanoate (PHA)/inorganic phase composites for tissue engineering applications
Misra, S.K., Valappil, S.P., Roy, I. and Boccaccini, A.R. 2006. Polyhydroxyalkanoate (PHA)/inorganic phase composites for tissue engineering applications. Biomacromolecules. 7 (8), pp. 2250-2257. https://doi.org/10.1021/bm060317c

Development of polyhydroxyalkanoates/Bioglass® composite tissue scaffolds for tissue engineering applications
Misra, S.K., Valappil, S.P., Nazhat, S.N., Moshrefi-Torbati, M., Roy, I. and Boccaccini, A.R. 2006. Development of polyhydroxyalkanoates/Bioglass® composite tissue scaffolds for tissue engineering applications. Proceedings of the 20th European Conference on Biomaterials, European Society of Biomaterials. Nantes, FRANCE 27 Sep - 01 Oct 2006

From bacteria to tissue engineering applications-usage of polyhydroxyalkanoates for biomedical applications
Misra, S.K., Nazhat, S.N., Torbati, M.M., Silva, S.R.P., Roy, I. and Boccaccini, A.R. 2006. From bacteria to tissue engineering applications-usage of polyhydroxyalkanoates for biomedical applications. Proceedings of the International Conference on the Design of Biomaterials. Kanpur, India 08 - 11 Dec 2006

Complement C2 receptor inhibitor trispanning: a novel human complement inhibitory receptor
Lange, S., Inal, J., Hui Kwok-M, Miot, S., Ramirez, M., Schneider, B. and Krueger, G. 2005. Complement C2 receptor inhibitor trispanning: a novel human complement inhibitory receptor. The Journal of Immunology. 174 (1), pp. 356-366.

The ontogenic transcription of complement component C3 and Apolipoprotein A-I tRNA in Atlantic cod (Gadus morhua L.): a role in development and homeostasis?
Lange, S., Dodds, A.W., Bambir, S.H., Gudmundsdottir, S. and Magnadóttir, B. 2005. The ontogenic transcription of complement component C3 and Apolipoprotein A-I tRNA in Atlantic cod (Gadus morhua L.): a role in development and homeostasis? Developmental & Comparative Immunology. 29 (12), p. 1065–1077. https://doi.org/10.1016/j.dci.2005.03.009

The Complement Systems of Two Teleost Species with Emphasis on Ontogeny
Lange, S. 2005. The Complement Systems of Two Teleost Species with Emphasis on Ontogeny. PhD thesis University of Iceland Faculty of Medicine

Ontogeny of humoral immune parameters in fish
Magnadóttir, B., Lange, S., Gudmundsdottir, S., Bogwald, J. and Dalmo, R.A. 2005. Ontogeny of humoral immune parameters in fish. Fish and Shellfish Immunology. 19 (5), pp. 429-439. https://doi.org/10.1016/j.fsi.2005.03.010

Polyhydroxyalkanoate synthases: the enzymes involved in biodegradable polymer synthesis
Valappil, S.P., Philip, S.E., Odell, M., Keshavarz, T. and Roy, I. 2005. Polyhydroxyalkanoate synthases: the enzymes involved in biodegradable polymer synthesis. Proceedings of Frontiers in Chemical Biology: Mechanistic Enzymology and Biocatalysis. Exeter, UK 31 Aug - 02 Sep 2005

Large scale production of P(3HB) from newly isolated Bacillus sp.
Valappil, S.P., Keshavarz, T., Bucke, C. and Roy, I. 2005. Large scale production of P(3HB) from newly isolated Bacillus sp. Proceedings of the 1st International Conference on Environmental Industrial and Applied Microbiology. Badajoz, Spain 15 - 18 Mar 2005

Effect of various carbon sources on the production of PHAs from the newly isolated Bacillus sp.
Valappil, S.P., Bucke, C. and Roy, I. 2005. Effect of various carbon sources on the production of PHAs from the newly isolated Bacillus sp. Proceedings of the International Union of Microbiological Societies Congress, IUMS. San Fransisco, USA 23 - 28 Jul 2005

Towards unravelling the elicitation mechanism in cultures of Penicillium chrysogenin: Chrysogenin elicitation
Nair, R.R., Radman, R., Roy, I., Bucke, C. and Keshavarz, T. 2005. Towards unravelling the elicitation mechanism in cultures of Penicillium chrysogenin: Chrysogenin elicitation. in: Pierucci, S. (ed.) 7th Italian Conference on Chemical and Process Engineering: ICheaP 7, May 15-16, 2005, Giardini Di Naxos, Italy Italy Associazione Italiana Di Ingegneria Chimica.

Natural biodegradable polymers from the Polyhydroxyalkanoate family emerging as a promising material for biomedical applications
Misra, S.K., Boccaccini, A.R., Valappil, S.P. and Roy, I. 2005. Natural biodegradable polymers from the Polyhydroxyalkanoate family emerging as a promising material for biomedical applications. Proceedings of 'a Forecast of the Future for Biomaterials' Professor Larry L. Hench Retirement Symposium. London, UK 29 - 30 Sep 2005

The metabolic role of methymalonyl CoA mutase in Escherichia coli
Kannan, S.M., Dwek, M., Bucke, C. and Roy, I. 2005. The metabolic role of methymalonyl CoA mutase in Escherichia coli. Proceedings of Viteomics: structure and function of vitamins and cofactors. Cambridge, UK 2005

Polysaccharides and polysaccharide-modifying enzymes in Ganoderma species
Chouiter, R., Roy, I. and Bucke, C. 2005. Polysaccharides and polysaccharide-modifying enzymes in Ganoderma species. Proceedings of the 13th European Carbohydrate Symposium. Bratislava, Slovakia 21 - 26 Aug 2005

Polysaccharide-modifying enzymes from Ganoderma species and their applications
Chouiter, R., Roy, I. and Bucke, C. 2005. Polysaccharide-modifying enzymes from Ganoderma species and their applications. Proceedings of the 1st International Conference on Environmental Industrial and Applied Microbiology. Badajoz, Spain 15 - 18 Mar 2005

Phylogenetic relationships between Basidiomycetes believed to be Ganoderma species based on distance analysis of their 5.8S, ITS1 and ITS2 rDNA sequences
Chouiter, R., Roy, I. and Bucke, C. 2005. Phylogenetic relationships between Basidiomycetes believed to be Ganoderma species based on distance analysis of their 5.8S, ITS1 and ITS2 rDNA sequences. Proceedings of the 1st International Conference on Environmental Industrial and Applied Microbiology. Badajoz, Spain 15 - 18 Mar 2005

The ontogeny of complement component C3 in Atlantic cod (Gadus morhua L.)—an immunohistochemical study
Lange, S., Bambir, S., Dodds, A.W. and Magnadóttir, B. 2004. The ontogeny of complement component C3 in Atlantic cod (Gadus morhua L.)—an immunohistochemical study. Fish & Shellfish Immunology. 16 (3), pp. 359-367. https://doi.org/10.1016/j.fsi.2003.06.001

Is Apolipoprotein A-I a regulating protein for the complement system of cod (Gadus morhua L.)?
Magnadóttir, B. and Lange, S. 2004. Is Apolipoprotein A-I a regulating protein for the complement system of cod (Gadus morhua L.)? Fish and Shellfish Immunology. 16 (2), pp. 265-269. https://doi.org/10.1016/S1050-4648(03)00061-5

Isolation and characterization of complement component C3 from Atlantic cod (Gadus morhua L.) and Atlantic halibut (Hippoglossus hippoglossus L.)
Lange, S., Dodds, A.W. and Magnadóttir, B. 2004. Isolation and characterization of complement component C3 from Atlantic cod (Gadus morhua L.) and Atlantic halibut (Hippoglossus hippoglossus L.). Fish and Shellfish Immunology. 16 (2), pp. 227-239. https://doi.org/10.1016/S1050-4648(03)00081-0

‘Identification and isolation of polyhydroalkanoates and cloning of PHA biosynthetic genes from Bacillus cereus SPV
Valappil, S.P., Bucke, C. and Roy, I. 2004. ‘Identification and isolation of polyhydroalkanoates and cloning of PHA biosynthetic genes from Bacillus cereus SPV. Proceedings of the International Symposium on Biological Polyesters, ISBP. Beijing, China 22 - 28 Aug 2004

Biosynthesis of polyhydroxyalkanoic acids by Streptomyces coelicolor
Valappil, S.P., Bhatia, Y., Bucke, C. and Roy, I. 2004. Biosynthesis of polyhydroxyalkanoic acids by Streptomyces coelicolor. e-Polymers.

Polyhydroxyalkanoate production by Bacillus cereus SPV
Roy, I. 2004. Polyhydroxyalkanoate production by Bacillus cereus SPV. Proceedings of the International Symposium on Biological Polyesters, ISBP. Beijing, China 22 - 28 Aug 2004

Carbohydrates and carbohydrate active enzymes in Ganoderma applanatum
Budala, S., Bucke, C. and Roy, I. 2004. Carbohydrates and carbohydrate active enzymes in Ganoderma applanatum. Proceedings of the 22nd International Carbohydrate Symposium. Glasgow, UK 23 - 27 Jul 2004

5-Aminolevulinic acid synthase: mechanism, mutations and medicine
Shoolingin-Jordan, P., Al-Daihan, S., Alexeev, D., Baxter, R.L., Bottomley, S.S., Kahari, I.D., Roy, I., Sarwar, M., Sawyer, L. and Wang, S.F. 2003. 5-Aminolevulinic acid synthase: mechanism, mutations and medicine. Biochimica et Biophysica Acta: Proteins and Proteomics. 1647 (1-2), pp. 361-365. https://doi.org/10.1016/S1570-9639(03)00095-5

Spontaneous haemolytic activity of Atlantic halibut (Hippoglossus hippoglossus L.) and sea bass (Dicentrarchus labrax) serum
Lange, S. and Magnadóttir, B. 2003. Spontaneous haemolytic activity of Atlantic halibut (Hippoglossus hippoglossus L.) and sea bass (Dicentrarchus labrax) serum. Comparative Biochemistry and Physiology - Part B: Biochemistry & Molecular Biology. 136 (1), pp. 99-106. https://doi.org/10.1016/S1096-4959(03)00173-8

Protection against atypical furunculosis in Atlantic halibut, Hippoglossus hippoglossus (L.); comparison of a commercial furunculosis vaccine and an autogenous vaccine
Gudmundsdottir, S., Lange, S., Magnadóttir, B. and Gudmundsdóttir, B.K. 2003. Protection against atypical furunculosis in Atlantic halibut, Hippoglossus hippoglossus (L.); comparison of a commercial furunculosis vaccine and an autogenous vaccine. Journal of Fish Diseases. 26 (6), pp. 331-338. https://doi.org/10.1046/j.1365-2761.2003.00462.x

Biosynthesis of medium chain length polyhydroxyalakanoic acids by Streptomyces coelicolor
Valappil, S.P., Bucke, C. and Roy, I. 2003. Biosynthesis of medium chain length polyhydroxyalakanoic acids by Streptomyces coelicolor. ICBP 2003. Proceedings of the 1st IUPAC International Conference on Bio-Based Polymers. Saitama, Japan 12 - 14 Nov 2003

A possible role of poly-3-hydroxybutyric acid in antibiotic production in Streptomyces
Verma, S., Bhatia, Y., Valappil, S.P. and Roy, I. 2002. A possible role of poly-3-hydroxybutyric acid in antibiotic production in Streptomyces. Archives of Microbiology. 179 (1), pp. 66-69. https://doi.org/10.1007/s00203-002-0500-9

Biosynthesis of polyhydroxyalkanoates by Streptomyces coelicolor
Valappil, S.P., Bucke, C. and Roy, I. 2002. Biosynthesis of polyhydroxyalkanoates by Streptomyces coelicolor. Proceedings of the International Symposium on Biological Polyesters. Munster, Germany 22 - 26 Sep 2002

Humoral immune parameters of cultured Atlantic halibut (Hippoglossus hippoglossus L.)
Lange, S., Guđmundsdottir, B.K. and Magnadóttir, B. 2001. Humoral immune parameters of cultured Atlantic halibut (Hippoglossus hippoglossus L.). Fish and Shellfish Immunology. 11 (6), pp. 523-535. https://doi.org/10.1006/fsim.2000.0333

Production of polyhydroxybutyrate by streptomyces
Verma, S. and Roy, I. 2001. Production of polyhydroxybutyrate by streptomyces. Proceedings of the Gordon Research Conference. Connecticut, USA 2001

Phosphorylation of the periplasmic binding protein in two transport systems for arginine incorporation in Escherichia coli K-12 is unrelated to the function of the transport system
Celis, R.T.F., Leadlay, P.F., Roy, I. and Hansen, A. 1998. Phosphorylation of the periplasmic binding protein in two transport systems for arginine incorporation in Escherichia coli K-12 is unrelated to the function of the transport system. Journal of Bacteriology. 180 (18), pp. 4828-4833.

Metabolic Engineering, a route to the production of novel products
Roy, I. 1998. Metabolic Engineering, a route to the production of novel products. Proceedings of the National Conference on Bioprocessing and R-DNA Technology. Central Drug Research Institute, Lucknow, India 27 - 28 Mar 1998

A Methylmalonyl-CoA mutase in Escherichia coli?
Roy, I. and Leadlay, P.F. 1997. A Methylmalonyl-CoA mutase in Escherichia coli? in: Ahmad, F. (ed.) Advances in gene technology: biomolecular design, form and function Nature Publishing Group.

The masked cysteine residues in methylmalonyl-CoA mutase from Propionibacterium shermanii are essential for catalytic activity
Roy, I. 1996. The masked cysteine residues in methylmalonyl-CoA mutase from Propionibacterium shermanii are essential for catalytic activity. FEBS Letters. 394 (2), pp. 126-128. https://doi.org/10.1016/0014-5793(96)00897-6

Physical map location of the new Escherichia coli gene sbm
Roy, I. and Leadlay, P.F. 1992. Physical map location of the new Escherichia coli gene sbm. Journal of Bacteriology. 174 (17), pp. 5763-5764.

Mechanism and structure of a coenzyme-B12 dependent enzyme
Roy, I., Patchett, M.L., Keep, N.H. and Leadlay, P.F. 1990. Mechanism and structure of a coenzyme-B12 dependent enzyme. Proceedings of the Royal Society of Chemistry Fifth International Symposium on the Mechanisms of Reactions in Solution. University of Kent, UK 02 - 06 Jul 1990

The expression of adenosylcobalamin dependent methylmalonyl-CoA mutase from Propionibacterium shermanii in Escherichia coli
McKie, N., Keep, N.H., Roy, I., Patchett, M.L. and Leadlay, P.F. 1989. The expression of adenosylcobalamin dependent methylmalonyl-CoA mutase from Propionibacterium shermanii in Escherichia coli. Proceedings of the Royal Society of Chemistry International Symposium on the Molecular Mechanisms in Bioorganic Processes. University of Newcastle upon Tyne, UK 17 - 20 Jul 1989