Research Centre for Optimal Health

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Genome wide association study of MRI liver iron content confirms pathogenic role of hepcidin regulation

Journal article

Wilman, H.R., Parisinos, C.A., Atabaki-Pasdar, N., Kelly, M., Thomas, E.L., Neubauer, S., Mahajan, A., Hingorani, A.D., Patel, R.S., Hemingway, H., Franks, P.W., Bell, J.D., Banerjee, R. and Yaghootkar, H. 2019. Genome wide association study of MRI liver iron content confirms pathogenic role of hepcidin regulation. Journal of Hepatology. Advanced online publication. doi:10.1016/j.jhep.2019.05.032

Discovery of biomarkers for glycaemic deterioration before and after the onset of type 2 diabetes: descriptive characteristics of the epidemiological studies within the IMI DIRECT Consortium

Journal article

Koivula, R.W., Forgie, I.M., Kurbasic, A., Viñuela, A., Heggie, A., Giordano, G.N., Hansen, T.H., Hudson, M., Koopman, A.D., Rutters, F., Siloaho, M., Allin, K.H., Brage, S., Brorsson, C.A., Dawed, A.Y., De Masi, F., Groves, C.J., Kokkola, T., Mahajan, A., Perry, M.H., Rauh, S.P., Ridderstråle, M., Teare, H.J.A., Thomas, E.L., Tura, A., Vestergaard, H., White, T., Adamski, J., Bell, J.D., Beulens, J., Brunak, S., Dermitzakis, E.T., Froguel, P., Frost, G., Gupta, R., Hansen, T., Hattersley, A., Jablonka, B., Kaye, J., Laakso, M., McDonald, T.J., Pedersen, O., Schwenk, J.M., Pavo, I., Mari, A., McCarthy, M.I., Ruetten, H., Walker, M., Pearson, E. and Franks, P.W. 2019. Discovery of biomarkers for glycaemic deterioration before and after the onset of type 2 diabetes: descriptive characteristics of the epidemiological studies within the IMI DIRECT Consortium. Diabetologia. Advanced online publication. doi:10.1007/s00125-019-4906-1

Intraperitoneal delivery of acetate-encapsulated liposomal nanoparticles for neuroprotection of the penumbra in a rat model of ischemic stroke

Journal article

So, P.W., Ekonomou, A., Galley, K., Brody, Leigh, Sahuri-Arisoylu, M., Rattray, I., Cash, D. and Bell, J.D. 2019. Intraperitoneal delivery of acetate-encapsulated liposomal nanoparticles for neuroprotection of the penumbra in a rat model of ischemic stroke. International Journal of Nanomedicine. 2019 (14), p. 1979–1991. doi:10.2147/IJN.S193965

Cannabidiol Affects Extracellular Vesicle Release, miR21 and miR126, and Reduces Prohibitin Protein in Glioblastoma Multiforme Cells

Journal article

Kosgodage, U., Uysal Onganer, P., Maclatchy, A., Mould, R., Nunn, A.V.W., Guy, G.W., Kraev, I., Chatterton, N.P., Thomas, E.L., Inal, J.M., Bell, J.D. and Lange, S. 2019. Cannabidiol Affects Extracellular Vesicle Release, miR21 and miR126, and Reduces Prohibitin Protein in Glioblastoma Multiforme Cells. Translational Oncology. 12 (3), pp. 513-522. doi:10.1016/j.tranon.2018.12.004

Genome-wide and abdominal MRI-imaging data provides evidence that a genetically determined favourable adiposity phenotype is characterized by lower ectopic liver fat and lower risk of type 2 diabetes, heart disease and hypertension

Journal article

Ji, Y., Yiorkas, A.M., Frau, F., Mook-Kanamori, D., Staiger, H., Thomas, E.L., Atabaki-Pasdar, N., Campbell, A., Tyrrell, J., Jones, S.E., Beaumont, R.N., Wood, A.R., Tuke, M.A., Ruth, K.S., Mahajan, A., Murray, A., Freathy, R.M., Weedon, M.N., Hattersley, A.T., Hayward, C., Machann, J., Häring, H.U., Franks, P.W., de Mutsert, R., Pearson, E., Stefan, N., Frayling, T.M., Allebrandt, K.V., Bell, J.D., Blakemore, A.I. and Yaghootkar, H. 2019. Genome-wide and abdominal MRI-imaging data provides evidence that a genetically determined favourable adiposity phenotype is characterized by lower ectopic liver fat and lower risk of type 2 diabetes, heart disease and hypertension. Diabetes. 68 (1), pp. 207-219. doi:10.2337/db18-0708

The effects of dietary supplementation with inulin and inulin-propionate ester on hepatic steatosis in adults with non-alcoholic fatty liver disease

Journal article

Chambers, E.S., Byrne, C.S., Rugyendo, A., Morrison, D.J., Preston, T., Tedford, M.C., Bell, J.D., Thomas, E.L., Akbar, A.N., Riddell, N.E., Sharma, R., Thursz, M.R., Manousou, P. and Frost, G. 2019. The effects of dietary supplementation with inulin and inulin-propionate ester on hepatic steatosis in adults with non-alcoholic fatty liver disease. Diabetes, Obesity and Metabolism. 21 (2), pp. 372-376. doi:10.1111/dom.13500

Reference range of liver corrected T1 values in a population at low risk for fatty liver disease-a UK Biobank sub-study, with an appendix of interesting cases

Journal article

Mojtahed, A., Kelly, C.J., Herlihy, A.H., Kin, S., Wilman, H.R., McKay, A., Kelly, M., Milanesi, M., Neubauer, S,, Thomas, E.L., Bell, J.D., Banerjee, R. and Harisinghani, M. 2019. Reference range of liver corrected T1 values in a population at low risk for fatty liver disease-a UK Biobank sub-study, with an appendix of interesting cases. Abdominal Radiology. 44 (1), pp. 72-84. doi:10.1007/s00261-018-1701-2

Disentangling Immediate Adaptive Introgression from Selection on Standing Introgressed Variation in Humans

Journal article

Jagoda, E., Lawson, D.J., Wall, J.D., Lambert, D., Muller, C., Westaway, M., Leavesley, M., Capellini, T.D., Lahr, M.M., Gerbault, P., Thomas, M.G., Migliano, A.B., Willerslev, E., Metspalu , M. and Pagani, L. 2018. Disentangling Immediate Adaptive Introgression from Selection on Standing Introgressed Variation in Humans. Molecular Biology and Evolution. 35 (3), pp. 623-630. doi:10.1093/molbev/msx314

Study protocol: HepaT1ca - an observational clinical cohort study to quantify liver health in surgical candidates for liver malignancies.

Journal article

Mole, D.J., Fallowfield, J.A., Kendall, T.J., Welsh, F., Semple, S.I., Bachtiar, V., Kelly, M., Wigmore, S.J., Garden, O.J., Wilman, H.R., Banerjee, R., Rees, M. and Brady, M. 2018. Study protocol: HepaT1ca - an observational clinical cohort study to quantify liver health in surgical candidates for liver malignancies. BMC Cancer . 18, p. 890. doi:10.1186/s12885-018-4737-3.

Measurement of liver iron by magnetic resonance imaging in the UK Biobank population

Journal article

McKay, A., Wilman, H., Dennis, A., Kelly, M., Gyngell, M.L., Neubauer, S., Bell, J.D., Banerjee, R. and Thomas, E.L. 2018. Measurement of liver iron by magnetic resonance imaging in the UK Biobank population. PLoS ONE. 13 (12). doi:10.1371/journal.pone.0209340

Non-alcoholic fatty liver disease: relationship with cardiovascular risk markers and clinical endpoints

Journal article

Buckley, A., Thomas, E.L., Lessan, N., Trovato, F.M., Trovato, G.M. and Taylor-Robinson, S.D. 2018. Non-alcoholic fatty liver disease: relationship with cardiovascular risk markers and clinical endpoints. Diabetes Research and Clinical Practice. 144, pp. 144-152. doi:10.1016/j.diabres.2018.08.011

Cannabidiol (CBD) is a Novel Inhibitor for Exosome and Microvesicle (EMV) Release in Cancer

Journal article

Kosgodage, U., Mould, R., Henley, A., Nunn, A.V.W., Guy, G.W., Thomas, E.L., Inal, J.M., Bell, J.D. and Lange, S. 2018. Cannabidiol (CBD) is a Novel Inhibitor for Exosome and Microvesicle (EMV) Release in Cancer. Frontiers in Pharmacology. 9, p. 889. doi:10.3389/fphar.2018.00889

Plasma metabolome analysis identifies distinct human metabotypes in the postprandial state with different susceptibility to weight loss–mediated metabolic improvements

Journal article

Fiamoncini, J., Rundle, M., Gibbons, H., Thomas, E.L., Geillinger-Kästle, K., Bunzel, D., Trezzi, J.P., Kiselova-Kaneva, J., Wopereis, S., Wahrheit, J., Kulling, S.E., Hiller, K., Sonntag, D., Ivanova, D., van Ommen, B, Frost, G., Brennan, L., Bell, J.D. and Daniel, H. 2018. Plasma metabolome analysis identifies distinct human metabotypes in the postprandial state with different susceptibility to weight loss–mediated metabolic improvements. FASEB Journal. 32 (10), p. 5447–5458. doi:10.1096/fj.201800330R

Body Composition Profiling in the UK Biobank Imaging Study

Journal article

Linge, J., Borger Magnus, West, J., Tuthill, T., Miller, M.R., Dumitriu, A., Thomas, E.L., Romu, T., Tunón, P., Bell, J.D. and Leinhard, O.D. 2018. Body Composition Profiling in the UK Biobank Imaging Study. Obesity. 26 (11), pp. 1785-1795. doi:10.1002/oby.22210

Advanced body composition assessment: from body mass index to body composition profiling

Article

Borga, M., West, J., Bell, J.D., Harvey, N.C., Romu, T., Heymsfield, S.B. and Leinhard, O.D. 2018. Advanced body composition assessment: from body mass index to body composition profiling. Journal of Investigative Medicine. 66 (5), pp. 887-895. doi:10.1136/jim-2018-000722

Rifaximin in Non-Alcoholic Steatohepatitis: An Open-Label Pilot Study

Article

Cobbold, J.F.L., Atkinson, S., Marchesi, J.R., Smith, A., Wai, S.N., Stove, J., Shojaee-Moradie, F., Jackson, N.C., Umpleby, A.M., Fitzpatrick, J., Thomas, E.L., Bell, J.D., Holmes, E., Taylor-Robinson, S.D., Goldin, R.D., Yee, M.S., Anstee, Q.M. and Thursz, M.R. 2018. Rifaximin in Non-Alcoholic Steatohepatitis: An Open-Label Pilot Study. Hepatology Research. 48 (1), pp. 69-77. doi:10.1111/hepr.12904

Impact of liver fat on the differential partitioning of hepatic triacylglycerol into VLDL subclasses on high and low sugar diets

Article

Umpleby, A.M., Shoajee-Moradie, F., Fielding, F., Li, X., Marino, A., Alsini, N, Isherwood, C, Jackson, N.C., Ahmad, A., Stolinski, M., Lovegrove, J.A., Johnsen, S., Mendis, A., Wright, J., Wilinska, M.E., Hovorka, R., Bell, J.D., Thomas, E.L., Frost, G.S. and Griffin, B.A. 2017. Impact of liver fat on the differential partitioning of hepatic triacylglycerol into VLDL subclasses on high and low sugar diets. Clinical Science. 131 (21), pp. 2561-2573. doi:10.1042/CS20171208

Cationic lipid-based nanoparticles mediate functional delivery of acetate to tumor cells in vivo leading to significant anticancer effects

Article

Brody, L.P., Sahuri Arisoylu, M., Parkinson, J.R., Parkes, H.G., So, P-W, Hajji, N, Thomas, E.L., Frost, G.S., Miller, A.D. and Bell, J.D. 2017. Cationic lipid-based nanoparticles mediate functional delivery of acetate to tumor cells in vivo leading to significant anticancer effects. International Journal of Nanomedicine. 12, pp. 6677-6685. doi:10.2147/IJN.S135968

The Hormesis of Thinking: A Deeper Quantum Thermodynamic Perspective?

Article

Nunn, A.V.W., Guy, G.W. and Bell, J.D. 2017. The Hormesis of Thinking: A Deeper Quantum Thermodynamic Perspective? International Journal of Neurorehabilitation. 4 (3), p. 272. doi:10.4172/2376-0281.1000272

Thyroid Hormone Receptor Beta in the Ventromedial Hypothalamus Is Essential for the Physiological Regulation of Food Intake and Body Weight

Article

Hameed, S., Patterson, M., Dhillo, W.S., Rahman, S.A., Ma, Y., Holton, C., Gogakos, A., Yeo, G.S.H., Lam, B.Y.H., Polex-Wolf, J., Fenske, W., Bell, J.D., Anastasovska, J., Samarut, J., Bloom, S.R., Bassett, J.H.D., Williams, G.R. and Gardiner, J.V. 2017. Thyroid Hormone Receptor Beta in the Ventromedial Hypothalamus Is Essential for the Physiological Regulation of Food Intake and Body Weight. Cell Reports. 19 (11), pp. 2202-2219. doi:10.1016/j.celrep.2017.05.066

Psoas major cross-sectional area: A potential marker of cardiorespiratory fitness

Article

Fitzpatrick, J., Chambers, E.S., Parkinson, J.R.C., Frost, G., Bell, J.D. and Thomas, E.L. 2017. Psoas major cross-sectional area: A potential marker of cardiorespiratory fitness. International Journal of Clinical and Experimental Physiology. 4 (1), pp. 15-20. doi:10.4103/ijcep.ijcep_6_17

Metabolic dysfunction following weight cycling in male mice

Article

Schofield, S.E., Parkinson, J., Henley, A., Sahuri Arisoylu, M., Sanchez-Canon, G.J. and Bell, J.D. 2017. Metabolic dysfunction following weight cycling in male mice. International Journal of Obesity. 41 (3), pp. 402-411. doi:10.1038/ijo.2016.193

Characterisation of liver fat in the UK Biobank cohort

Article

Wilman, H., Kelly, M., Garratt, S., Matthews, P., Milanesi, M., Herlihy, A.H., Gyngell, M, Neubauer, S, Bell, J.D., Banerjee, R and Thomas, E.L. 2017. Characterisation of liver fat in the UK Biobank cohort. PLoS ONE. 12 (2), p. e0172921. doi:10.1371/journal.pone.0172921

Genomic analyses inform on migration events during the peopling of Eurasia

Journal article

Gerbault, P. 2016. Genomic analyses inform on migration events during the peopling of Eurasia. Nature. 538 (7624), pp. 238-242. doi:10.1038/nature19792

Feasibility of MR-Based Body Composition Analysis in Large Scale Population Studies

Article

West, J., Leinhard, O.D., Romu, T., Collins, R., Garratt, S., Bell, J.D., Borga, M. and Thomas, E.L. 2016. Feasibility of MR-Based Body Composition Analysis in Large Scale Population Studies. PLoS ONE. 11 (9). doi:10.1371/journal.pone.0163332

The Quantum Mitochondrion and Optimal Health

Article

Bell, J.D., Nunn, A.V.W. and Guy, G.W. 2016. The Quantum Mitochondrion and Optimal Health. Biochemical Society Transactions. 44 (4), pp. 1101-1110. doi:10.1042/BST20160096

Link between increased gut hormones signaling satiety and reduced food reward following gastric bypass surgery for obesity

Article

Goldstone, A.P., Miras, A.D., Scholtz, S., Jackson, S., Neff, K.J., Pénicaud, L., Geoghegan, J., Chhina, N., Durighel, G., Bell, J.D., Meillon, S. and le Roux, C.W. 2016. Link between increased gut hormones signaling satiety and reduced food reward following gastric bypass surgery for obesity. Journal of Clinical Endocrinology and Metabolism. 101 (2), pp. 599-609. doi:10.1210/jc.2015-2665

Synergy between histone deacetylase inhibitors and DNA- damaging agents is mediated by histone deacetylase 2 in colorectal cancer

Article

Alzoubi, S., Brody, L., Rahman, S., Mahul-Mellier, A.L., Mercado, N., Ito, K., El-Bahrawy, M., Silver, A., Boobis, A., Bell, J.D. and Hajji, N. 2016. Synergy between histone deacetylase inhibitors and DNA- damaging agents is mediated by histone deacetylase 2 in colorectal cancer. Oncotarget . 7 (28), pp. 44505-44521. doi:10.18632/oncotarget.9887

Exercise Training Reduces Liver Fat and Increases Rates of VLDL Clearance, but not VLDL Production in NAFLD

Article

Shojaee-Moradie, F., Cuthbertson, D.J., Barrett, M., Jackson, N.C., Herring, R, Thomas, E.L., Bell, J.D., Kemp, G.J., Wright, J. and Umpleby, A.M. 2016. Exercise Training Reduces Liver Fat and Increases Rates of VLDL Clearance, but not VLDL Production in NAFLD. Journal of Clinical Endocrinology and Metabolism. 101 (11), pp. 4219-4228. doi:10.1210/jc.2016-2353

Efficacy and Safety of Cannabidiol and Tetrahydrocannabivarin on Glycemic and Lipid Parameters in Patients With Type 2 Diabetes: A Randomized, Double-Blind, Placebo-Controlled, Parallel Group Pilot Study

Article

Jadoon, K.A., Ratcliffe, S.H., Barrett, D.A., Thomas, E.L., Stott, C., Bell, J.D., O’Sullivan S.E. and Tan, G.D. 2016. Efficacy and Safety of Cannabidiol and Tetrahydrocannabivarin on Glycemic and Lipid Parameters in Patients With Type 2 Diabetes: A Randomized, Double-Blind, Placebo-Controlled, Parallel Group Pilot Study. Diabetes Care. 39 (10), pp. 1777-1786. doi:10.2337/dc16-0650

Differential effects of two fermentable carbohydrates on central appetite regulation and body composition

Journal article

Arora, T., Loo, R.L., Anastasovska, J., Gibson, G.R., Tuohy, K., Kumar Sharma, R., Swann Jonathan, Deaville, E.R., Sleeth Michelle, L., Thomas, E.L., Holmes, E., Bell, J.D. and Frost, G.S. 2012. Differential effects of two fermentable carbohydrates on central appetite regulation and body composition. PLoS ONE. 7 (8), p. e43263. doi:10.1371/journal.pone.0043263

Improved Glycaemia correlates with liver fat reduction in obese, type 2 diabetes, patients given glucagon-like peptide-1 (GLP-1) receptor agonists

Journal article

Cuthbertson, D.J., Irwin, A., Gardner, C.J., Daousi, C., Purewal, T, Furlong, N, Goenka, N, Thomas, E.L., Adams, V.L., Pushpakom, SP, Pirmohamed, M and Kemp, G.J. 2012. Improved Glycaemia correlates with liver fat reduction in obese, type 2 diabetes, patients given glucagon-like peptide-1 (GLP-1) receptor agonists. PLoS ONE. 7 (12), p. e50117. doi:10.1371/journal.pone.0050117

Prediction of specific absorption rate in mother and fetus associated with MRI examinations during pregnancy

Journal article

Hand, J.W., Li, Y., Thomas, E.L., Rutherford, M.A. and Hajnal, J.V. 2006. Prediction of specific absorption rate in mother and fetus associated with MRI examinations during pregnancy. Magnetic Resonance in Medicine. 55 (4), pp. 883-93. doi:10.1002/mrm.20824

In vivo and in vitro hepatic phosphorus-31 magnetic resonance spectroscopy and electron microscopy in chronic ductopenic rejection of human liver allografts

Journal article

Taylor-Robinson, S.D., Sargentoni, J., Bell, J.D., Thomas, E.L., Marcus, C.D., Changani, K.K., Saeed, N., Hodgson, H., Davidson, B.R., Burroughs, A.K., Rolles, K., Foster, C.S. and Cox, I.J. 1998. In vivo and in vitro hepatic phosphorus-31 magnetic resonance spectroscopy and electron microscopy in chronic ductopenic rejection of human liver allografts. Gut. 42 (5), pp. 735-43. doi:10.1136/gut.42.5.735


People


Bell, Jimmy

Professor


Kalampouka, Ifigeneia

KEEP - Research Fellow


Mould, Rhys

Research Fellow


Parkinson, James

Research Fellow


Sahuri Arisoylu, Meliz

Research Fellow


Thomas, Louise

Senior Lecturer


Whitcher, Brandon

Senior Imaging Scientist