Research Centre for Optimal Health

Basty, N., Thanaj, M., Cule, M., Sorokin, E., Liu, Y., Thomas, E.L., Bell, J.D. and Whitcher, B. 2023. Artifact-Free Fat-Water Separation in Dixon MRI using Deep Learning. Journal of Big Data. 10 4. https://doi.org/10.1186/s40537-022-00677-1

Allesøe, Rosa Lundbye, Lundgaard, A., Hernández Medina, R., Aguayo-Orozco, Alejandro, Johansen, J., Nissen, Jakob Nybo, Brorsson, Caroline, Mazzoni, Gianluca, Niu, L., Biel, J., Brasas, Valentas, Webel, Henry, Benros, M., Pedersen, A., Chmura, Piotr Jaroslaw, Jacobsen, U., Mari, Andrea, Koivula, R., Mahajan, Anubha, Vinuela, A., Tajes, Juan Fernandez, Sharma, Sapna, Haid, M., Hong, M., Musholt, Petra B, De Masi, Federico, Vogt, Josef, Pedersen, Helle Krogh, Gudmundsdottir, Valborg, Jones, Angus, Kennedy, G., Bell, Jimmy, Thomas, E.L., Frost, G., Thomsen, Henrik, Hansen, Elizaveta, Hansen, T., Vestergaard, Henrik, Muilwijk, Mirthe, Blom, Marieke T, 't Hart, Leen M, Pattou, Francois, Raverdy, Violeta, Brage, Soren, Kokkola, Tarja, Heggie, Alison, McEvoy, Donna, Mourby, Miranda, Kaye, J., Hattersley, A., McDonald, Timothy, Ridderstråle, M., Walker, Mark, Forgie, Ian, Giordano, Giuseppe N, Pavo, Imre, Ruetten, Hartmut, Pedersen, O., Hansen, T., Dermitzakis, Emmanouil, Franks, Paul W, Schwenk, J., Adamski, Jerzy, McCarthy, Mark I, Pearson, Ewan, Banasik, Karina, Rasmussen, S., Brunak, S. and IMI DIRECT Consortium 2023. Discovery of drug-omics associations in type 2 diabetes with generative deep-learning models. Nature Biotechnology. 41, pp. 399-408. https://doi.org/10.1038/s41587-022-01520-x

Nunn, A., Guy, G.W., Brysch, W and Bell, J.D. 2022. Understanding Long COVID; Mitochondrial Health and Adaptation—Old Pathways, New Problems. Biomedicines. 10 (12) 3113. https://doi.org//10.3390/biomedicines10123113

Ichim, M. C., Scotti, F. and Booker, A. 2022. Quality evaluation of commercial herbal products using chemical methods. Critical Reviews in Food Science and Nutrition. Advanced online publication. https://doi.org/10.1080/10408398.2022.2140120

Mould, R., Thomas, E.L., Guy, G., Nunn, A. and Bell, J.D. 2022. Cell-Cell Death Communication by Signals Passing Through Non-Aqueous Environments: A Reply . Results in Chemistry. 4 100538. https://doi.org/10.1016/j.rechem.2022.100538

O’Donovan, S.D., Erdős, B., Jacobs, D.M., Wanders, A.J., Thomas, E.L., Bell, J.D., Rundle, M., Frost, G., Arts, I.C.W., Afman, L.A. and van Riel, A.A.W. 2022. The Mixed Meal Model: quantifying the contribution of 1 triglycerides to metabolic resilience. iScience. 25 (11) 105206. https://doi.org/10.1016/j.isci.2022.105206

Asaturyan, A.H., Basty, N., Thanaj, M., Whitcher, B., Thomas, E.L. and Bell, J.D. 2022. Improving the accuracy of fatty liver index to reflect liver fat content with predictive regression modelling. PLoS ONE. 17 (9) e0273171. https://doi.org/10.1371/journal.pone.0273171

Nunn, A.V.W., Guy, G.W. and Bell, J.D. 2022. Bioelectric Fields at the Beginnings of Life. Bioelectriciy. 4 (4), pp. 237-247. https://doi.org/10.1089/bioe.2022.0012

Booker, A., Heinrich, P.M. and Tsou, W.H. 2022. Chinese and Western Herbal Medicines for the Topical Treatment of Psoriasis - a critical review of Efficacy and Safety. Journal of Herbal Medicine. 34. https://doi.org/10.1016/j.hermed.2022.100579

Fiamoncini, J, Donado-Pestana, C.M., Duarte, G.B.S., Rundle, M, Thomas, E.L., Kiselova-Kaneva, Y., Gundersen, T.E., Bunzel, D., Trezzi, J.P., Kulling, S.E., Hiller, K., Sonntag, D., Ivanova, D., Brennan, L., Wopereis, S., van Ommen, B., Frost, G., Bell, J.D., Drevon, C.A. and Daniel, H. 2022. Plasma metabolic signatures of healthy overweight subjects challenged with an oral glucose tolerance test. Frontiers in Nutrition: Nutrition and Metabolism. https://doi.org/10.3389/fnut.2022.898782

Gu, J., Scotti, F., Reich, E., Kirchhoff, R., Booker, A. and Heinrich, P.M. 2022. Chrysanthemum species used as food and medicine: Understanding quality differences on the global market. South African Journal of Botany. 148, pp. 123-134. https://doi.org/10.1016/j.sajb.2022.04.009

Sorokin, E., Basty, N., Whitcher, B., Liu, Y., Bell, J.D., Cohen, R.L., Cule, M. and Thomas, E.L. 2022. Analysis of MRI-derived spleen iron in the UK Biobank identifies genetic variation linked to iron homeostasis and hemolysis. American Journal of Human Genetics. 109 (6), pp. P1092-1104. https://doi.org/10.1016/j.ajhg.2022.04.013

Sheridan, D.A., Shawa, I.T., Thomas, E.L., Felmlee, D.J., Bridge, S.H., Neely, D., Cobbold, J.F., Holmes, E., Bassendine, M.F. and Taylor-Robinson, S.D. 2022. Infection with the hepatitis C virus causes viral genotype-specific differences in cholesterol metabolism and hepatic steatosis. Scientific Reports. 12 5562. https://doi.org/10.1038/s41598-022-09588-w

Osimo, E., Brugger, S., Thomas, E.L. and Howes, O. 2022. A cross-sectional MR study of body fat volumes and distribution in chronic schizophrenia. Schizophrenia. 8 24. https://doi.org/10.1038/s41537-022-00233-z

Whitcher, B., Thanaj, M., Cule, M., Liu, Y., Basty, N., Sorokin, E., Bell, J.D. and Thomas, E.L. 2022. Precision MRI Phenotyping Enables Detection of Small Changes in Body Composition for Longitudinal Cohorts. Scientific Reports. 12 3748. https://doi.org/10.1038/s41598-022-07556-y

Nunn, A.V.W., Guy, G.W. and Bell, J.D. 2022. Thermodynamics and Inflammation: Insights into Quantum Biology and Ageing. Quantum Reports. 4, pp. 47-74. https://doi.org/10.3390/quantum4010005

Martin, S., Tyrrell, J., Thomas, E.L., Bown, M.J., Wood, A.R., Beaumont, R.N., Tsoi, L.C., Stuart, P.E., Elder, J.T., Law, P., Houlston, R., Kabrhel, C., Papadimitriou, N., Gunter, M.J., Bull, C.J., Bell, J.A., Vincent, E.E., Sattar, N., Dunlop, M.G., Tomlinson, I.P.M., Bell, J.D., Frayling, T. and Yaghootkar, H. 2022. Disease consequences of higher adiposity uncoupled from its adverse metabolic effects using Mendelian randomisation. eLife. 11 e72452. https://doi.org/10.7554/elife.72452

Wesolowska-Andersen, A., Brorsson, C.A., Bizzotto, R., Mari, A., Tura, A., Koivula, R., Mahajan, A., Viñuela, A., Fernandez Tajes, J, Sharma, S., Haid, M., Prehn, C., Artati, A., Hong, M-G, Musholt, P.B, Kurbasic, A., Masi, F., Tsirigos, K, Pedersen, H., Gudmundsdottir, V., Thomas, C., Banasik, K., Jennison, C., Jones, A., Kennedy, G., Bell, J.D., Thomas, E.L., Frost, G., Thomsen, H., Allin, K., Hansen, T.H., Vestergaard, H., Hansen, T., Rutters, F., Elders, P., t'Hart, L., Bonnefond, A., Canouil, M., Brage, S., Kokkola, T., Heggie, A., McEvoy, D., Hattersley, A., McDonald, T., Teare, H., Ridderstrale, M., Walker, M., Forgie, I., Giordano, G.N., Froguel, P., Pavo, I., Ruetten, H., Pedersen, O., Dermitzakis, E., Franks, P.W., Schwenk, J.M., Adamski, J., Pearson, E., McCarthy, M.I., Brunak, S. and IMI DIRECT Consortium 2022. Four groups of type 2 diabetes contribute to the etiological and clinical heterogeneity in newly diagnosed individuals: An IMI DIRECT study. Cell Reports Medicine. 3 (1) 100477. https://doi.org/10.1016/j.xcrm.2021.100477

Martin, Susan, Sorokin, Elena P, Thomas, E Louise, Sattar, Naveed, Cule, Madeleine, Bell, Jimmy D and Yaghootkar, H. 2022. Estimating the Effect of Liver and Pancreas Volume and Fat Content on Risk of Diabetes: A Mendelian Randomization Study. Diabetes Care. 45 (2), pp. 460-468. https://doi.org/10.2337/dc21-1262

Nunn, A., Guy, G., Botchway, S.W. and Bell, J.D. 2021. SARS-CoV-2 and EBV; the cost of a second mitochondrial "whammy"? Immunity & Ageing. 18 (1), pp. 40-44. https://doi.org/10.1186/s12979-021-00252-x

Osimo, E.F., Sweeney, M., de Marvao, A., Berry, A., Statton, B., Perry, B.I., Pillinger, T., Whitehurst, T., Cook, S.A., O’Regan, D.P., Thomas, E.L. and Howes, O.D. 2021. Adipose tissue dysfunction, inflammation, and insulin resistance alternative pathways to cardiac remodelling in schizophrenia. A multimodal, case-control study. Translational Psychiatry. 11 614. https://doi.org/10.1038/s41398-021-01741-9

Booker, A., Scotti, F., Mou, L., Huang, C., Werckerle, C., Maake, C. and Heinrich, M. 2021. Treating Chronic Wounds Using Photoactive Metabolites: Data Mining the Chinese Pharmacopoeia for Potential Lead Species. Planta Medica. 87, pp. 1-13. https://doi.org/10.1055/a-1578-8778

Thanaj, M., Basty, N., Liu, Y., Cule, M., Sorokin, E., Thomas, E.L., Bell, J.D. and Whitcher, B. 2021. Mass Univariate Regression Analysis for Three-Dimensional Liver Image-Derived Phenotypes. Annual Conference on Medical Image Understanding and Analysis. University of Oxford 12 - 14 Jul 2021 Springer. https://doi.org/10.1007/978-3-030-80432-9_13

Martin, S., Cule, M, Basty, N., Tyrrell, J., Beaumont, R.N., Wood, A.R., Frayling, T., Sorokin, E., Whitcher, B., Liu, Y., Bell, J.D., Thomas, E.L. and Yaghootkar, H. 2021. Genetic evidence for different adiposity phenotypes and their opposing influence on ectopic fat and risk of cardiometabolic disease. Diabetes. 70 (8), pp. 1843-1856. https://doi.org/10.2337/db21-0129

Heinrich, M., Jiang, H., Scotti, F., Booker, A., Walt, H., Weckerle, C. and Maake, C. 2021. Medicinal plants from the Himalayan region as potential novel antimicrobial and anti-inflammatory skin treatments. Journal of Pharmacy and Pharmacology. 73 (7), p. 956–967. https://doi.org/10.1093/jpp/rgab039

Woodley, S., Mould, R., Sahuri Arisoylu, M., Kalampouka, I., Booker, A. and Bell, J.D. 2021. Mitochondrial Function as a Potential Tool for Assessing Function, Quality and Adulteration in Medicinal Herbal Teas. Frontiers in Pharmacology. 12 660938. https://doi.org/10.3389/fphar.2021.660938

Sahuri Arisoylu, M., Mould, R., Shinjyo, N., Bligh, S.W.A., Nunn, A., Guy, G., Thomas, E.L. and Bell, J.D. 2021. Acetate induces growth arrest in colon cancer cells through modulation of mitochondrial function. Frontiers in Nutrition: Nutrition and Metabolism. 8 588466. https://doi.org/10.3389/fnut.2021.588466

Ichim, M.C. and Booker, A. 2021. Chemical Authentication of Botanical Ingredients: A Review of Commercial Herbal Products. Frontiers in Pharmacology. 12 666850. https://doi.org/10.3389/fphar.2021.666850

Mould, R., Botchway, S, Parkinson, J., Thomas, E.L., Guy, G., Bell, J.D. and Nunn, A. 2021. Cannabidiol modulates mitochondrial redox and dynamics in MCF7 cancer cells: a study using fluorescence lifetime imaging microscopy of NAD(P)H. Frontiers in Molecular Biosciences. 8 630107. https://doi.org/10.3389/fmolb.2021.630107

Bizzotto, R., Jennison, C., Jones, A., Kurbasic, A., Kennedy, G., Bell, J.D., Thomas, E.L., Frost, G., Eriksen, R., Koivula, R., Brage, S., Kaye, J., Hattersley, A., Heggie, A., McEvoy, D., Hart, L.M., Beulens, J.W., Elders, P., Musholt, P.B., Ridderstråle, M., Hansen, T., Allin, K., Hansen, T., Vestergaard, H., Lundgaard, A.T., Thomsen, H.S., Masi, F., Tsirigos, K.D., Brunak, S., Viñuela, A., Mahajan, A., McDonald, T.J., Kokkola, T., Forgie, I., Giordano, G.N., Pavo, I., Ruetten, H., Dermitzakis, E., McCarthy, M., Pedersen, O., Schwenk, J., Adamski, J., Franks, P., Walker, M., Pearson, E. and Mari, A. 2021. Processes Underlying Glycemic Deterioration in Type 2 Diabetes: An IMI DIRECT Study. Diabetes Care. 44 (2), pp. 511-518. https://doi.org/10.2337/dc20-1567

Nunn, A.V.W., Guy, G.W., Brysch, W., Botchway, S.W., Frasch, W., Calabrese, E.J. and Bell, J.D. 2020. SARS-CoV-2 and mitochondrial health: implications of lifestyle and ageing. Immunity & Ageing. 17 33 (2020). https://doi.org/10.1186/s12979-020-00204-x

Fitzpatrick, J., Basty, N., Cule, M., Liu, Y., Bell, J.D., Thomas, E.L. and Whitcher, B. 2020. Large‑scale analysis of iliopsoas muscle volumes in the UK Biobank. Scientific Reports. 10 20215. https://doi.org/10.1038/s41598-020-77351-0

Machann, J., Stefan, N., Wagner, R., Fritsche, A., Bell, J.D., Whitcher, B., Häring, H.U., Birkenfeld, A., Nikolaou, K., Schick, F. and Thomas, E.L. 2020. Normalized indices derived from visceral adipose mass assessed by MRI and their correlation with markers for insulin resistance and prediabetes. Nutrients. 12 (7) 2064. https://doi.org/10.3390/nu12072064

Atabaki-Pasdar, N., Ohlsson, M., Viñuela, A., Frau, F., Pomares-Millan, H., Haid, M., Jones, A., Thomas, E.L., Koivula, R., Kurbasic, A., Mutie, P., Fitipaldi, H., Fernandez, J., Dawed, A., Giordano, G., Forgie, I., McDonald, T., Rutters, F., Cederberg, H., Chabanova, E., Dale, M., Masi, F., Thomas, C., Allin, K., Hansen, T., Heggie, A., Hong, M., Elders, P., Kennedy, G., Kokkola, T., Pedersen, H., Mahajan, A., McEvoy, D., Pattou, F., Raverdy, V., Häussler, R., Sharma, S., Thomsen, H., Vangipurapu, J., Vestergaard, H., ‘t Hart, L., Adamski, J., Musholt, P., Brage, S., Brunak, S., Dermitzakis, E., Frost, G., Hansen, T., Laakso, M., Pedersen, O., Ridderstråle, M., Ruetten, H., Hattersley, A., Walker, M., Beulens, J., Mari, A., Schwenk, J., Gupta, R., McCarthy, M., Pearson, E., Bell, J.D., Pavo, I. and Franks, P. 2020. Predicting and elucidating the etiology of fatty liver disease: A machine learning modeling and validation study in the IMI DIRECT cohorts. PLoS Medicine. 17 (6) e1003149. https://doi.org/10.1371/journal.pmed.1003149

Eriksen, R., Perez, I.G., Posma, J.M., Haid, M., Sharma, S., Thomas, E.L., Koivula, R.W., Bizzotto, R., Mari, A., Giordano, G.N., Pavo, I., Schwenk, J., De Masi, F., Tsirigos, K., Brunak, S., Vinuela, A., Mahajan, A., McDonald, T.J., Kokkola, T., Teare, H.J.A., Hansen, T.H., Fernandez, J., Jones, A., Jennison, C., Walker, M., McCarthy, M., Pedersen, O., Reutten, H., Forgie, I., Bell, J.D., Pearson, E., Franks, P.W., Adamski, J., Holmes, E. and Frost, G.S. 2020. Dietary metabolite profiling brings new insight into the relationship between nutrition and metabolic risk: An IMI Direct study. EBioMedicine. 58 102932. https://doi.org/10.1016/j.ebiom.2020.102932

Alenaini, Wareed, Parkinson, J., McCarthy, John P., Goldstone, Anthony P., Wilman, Henry R., Banerjee, Rajarshi, Yaghootkar, Hanieh, Bell, Jimmy D. and Thomas, E.L. 2020. Ethnic Differences in Body Fat Deposition and Liver Fat Content in Two UK-Based Cohorts. Obesity (Silver Spring, Md.). 28 (11), pp. 2142-2152. https://doi.org/10.1002/oby.22948

Aldraimli, M., Soria, D., Parkinson, J., Thomas, E.L., Bell, J.D., Dwek, M. and Chaussalet, T.J. 2020. Machine Learning Prediction of Susceptibility to Visceral Fat Associated Diseases. Health and Technology. 10, pp. 925-944. https://doi.org/10.1007/s12553-020-00446-1

Littlejohns, T., Holliday, J., Gibson, L., Garratt, S., Oesingmann, N., Alfaro-Almagro, F., Bell, J.D., Boultwood, C., Collins, R., Conroy, M., Crabtree, N., Doherty, N., Frangi, A., Harvey, N., Leeson, P., Miller, K., Neubauer, S., Petersen, S., Sellors, J., Sheard, S., Smith, S., Sudlow, C., Matthews, P. and Allen, N. 2020. The UK Biobank imaging enhancement of 100,000 participants: rationale, data collection, management and future directions. Nature Communications . 11 2624. https://doi.org/10.1038/s41467-020-15948-9

Whyte, M.B, Shojaee-Moradie, F., Sharaf, S.E., Cuthbertson, D.J., Kemp, G.J., Barrett, M., Jackson, N.C., Herring, R.A, Wright, J., Thomas, E.L., Bell, J.D. and Umpleby, A.M. 2020. HDL-apoA-I kinetics in response to 16 weeks exercise training in men with non-alcoholic fatty liver disease (NAFLD). American Journal of Physiology - Endocrinology and Metabolism. 318 (6), pp. E839-E847. https://doi.org/10.1152/ajpendo.00019.2020

Dikariyanto, V., Smith, L., Francis, L., Robertson, M., Kusaslan, E., O’Callaghan-Latham, M., Palanche, C., D’Annibale, M., Christodoulou, D., Basty, N., Whitcher, B., Shuaib, H., Charles-Edwards, G., Chowienczyk, P.J., Ellis, P. R., Berry, S.E. and Hall, W. 2020. Snacking on whole almonds for 6 weeks improves endothelial function and lowers LDL cholesterol but does not affect liver fat and other cardiometabolic risk factors in healthy adults: the ATTIS study, a randomized controlled trial. American Journal of Clinical Nutrition. 111 (6), p. 1178–1189. https://doi.org/10.1093/ajcn/nqaa100