Prof Louise Thomas

Prof Louise Thomas


Analysis of MRI-derived spleen iron in the UK Biobank identifies genetic variation linked to iron homeostasis and hemolysis
Sorokin, E., Basty, N., Whitcher, B., Liu, Y., Bell, J.D., Cohen, R.L., Cule, M. and Thomas, E.L. 2022. Analysis of MRI-derived spleen iron in the UK Biobank identifies genetic variation linked to iron homeostasis and hemolysis. American Journal of Human Genetics. 109 (6), pp. P1092-1104. https://doi.org/10.1016/j.ajhg.2022.04.013

Precision MRI Phenotyping Enables Detection of Small Changes in Body Composition for Longitudinal Cohorts
Whitcher, B., Thanaj, M., Cule, M., Liu, Y., Basty, N., Sorokin, E., Bell, J.D. and Thomas, E.L. 2022. Precision MRI Phenotyping Enables Detection of Small Changes in Body Composition for Longitudinal Cohorts. Scientific Reports. 12 3748. https://doi.org/10.1038/s41598-022-07556-y

Large‑scale analysis of iliopsoas muscle volumes in the UK Biobank
Fitzpatrick, J., Basty, N., Cule, M., Liu, Y., Bell, J.D., Thomas, E.L. and Whitcher, B. 2020. Large‑scale analysis of iliopsoas muscle volumes in the UK Biobank. Scientific Reports. 10 20215. https://doi.org/10.1038/s41598-020-77351-0

Genetic architecture of 11 organ traits derived from abdominal MRI using deep learning.
Liu, Y., Basty, N., Whitcher, B., Bell, J.D., Sorokin, E., van Bruggen, Nick, Thomas, E.L. and Cule, M. 2021. Genetic architecture of 11 organ traits derived from abdominal MRI using deep learning. eLife. 10. https://doi.org/10.7554/elife.65554


2024

Genetic evidence for distinct biological mechanisms that link adiposity to type 2 diabetes: towards precision medicine
Abraham, Angela, Cule, M., Thanaj, M., Basty, N., Hashemloo, M.A., Sorokin, E., Whitcher, B., Burgess, S., Bell, J.D., Sattar, N., Thomas, E.L. and Yaghootkar, H. 2024. Genetic evidence for distinct biological mechanisms that link adiposity to type 2 diabetes: towards precision medicine. Diabetes. 73 (6), pp. 1012-1025. https://doi.org/10.2337/db23-1005

2024

The Association of Cardiometabolic, Diet and Lifestyle Parameters With Plasma Glucagon-like Peptide-1: An IMI DIRECT Study
Eriksen, Rebeca, White, Margaret C., Dawed, Adem Y., Perez, Isabel Garcia, Posma, Joram M., Haid, Mark, Sharma, Sapna, Prehn, Cornelia, Thomas, E. Louise, Koivula, Robert W., Bizzotto, Roberto, Mari, Andrea, Giordano, Giuseppe N., Pavo, Imre, Schwenk, Jochen M., De Masi, Federico, Tsirigos, Konstantinos D., Brunak, Søren, Viñuela, Ana, Mahajan, Anubha, McDonald, Timothy J., Kokkola, Tarja, Rutters, Femke, Beulens, Joline, Muilwijk, Mirthe, Blom, Marieke, Elders, Petra, Hansen, Tue H., Fernandez-Tajes, Juan, Jones, Angus, Jennison, Chris, Walker, Mark, McCarthy, Mark I., Pedersen, Oluf, Ruetten, Hartmut, Forgie, Ian, Holst, Jens J., Thomsen, Henrik S., Ridderstråle, Martin, Bell, Jimmy D., Adamski, Jerzy, Franks, Paul W., Hansen, Torben, Holmes, Elaine, Frost, Gary and Pearson, Ewan R. 2024. The Association of Cardiometabolic, Diet and Lifestyle Parameters With Plasma Glucagon-like Peptide-1: An IMI DIRECT Study. The Journal of Clinical Endocrinology & Metabolism. Advanced online publication. https://doi.org/10.1210/clinem/dgae119

2024

Quantifying the effect of nutritional interventions on metabolic resilience using personalised computational models
O'Donovan, S., Rundle, M., Thomas, E.L., Bell, J.D., Frost, G., Jacobs, D.M., Wanders, A., de Vries, R., Mariman, E.C.M., va Baak, M.A., Sterkman, L., Nieuwdorp, M., Groem, A.K., Arts, I.C.W., van Riel, N. and Afman, L.A. 2024. Quantifying the effect of nutritional interventions on metabolic resilience using personalised computational models. iScience. 27 (4) 109362. https://doi.org/10.1016/j.isci.2024.109362

2024

Ultra Weak Photon Emission - A Brief Review
Mould, R., Mackenzie, A.M., Kalampouka, I., Nunn, A., Thomas, E.L., Bell, J.D. and Botchway, S.W. 2024. Ultra Weak Photon Emission - A Brief Review. Frontiers in Physiology - Biophysics. 15 1348915. https://doi.org/10.3389/fphys.2024.1348915

2024

Precision MRI phenotyping of muscle volume and quality at a population scale
Thanaj, M., Basty, N., Whitcher, B., Sorokin, E., Liu, Y., Srinivasan, R., Cule, M., Thomas, E.L. and Bell, J.D. 2024. Precision MRI phenotyping of muscle volume and quality at a population scale. Frontiers in Physiology. 15 1288657. https://doi.org/10.3389/fphys.2024.1288657

2024

Liver Shape Analysis using Statistical Parametric Maps at Population Scale
Thanaj, M., Basty, N., Cule, M., Sorokin, E., Whitcher, B., Bell, J.D. and Thomas, E.L. 2024. Liver Shape Analysis using Statistical Parametric Maps at Population Scale. BMC Medical Imaging. 24 15. https://doi.org/10.1186/s12880-023-01149-5

2023

Artifact-Free Fat-Water Separation in Dixon MRI using Deep Learning
Basty, N., Thanaj, M., Cule, M., Sorokin, E., Liu, Y., Thomas, E.L., Bell, J.D. and Whitcher, B. 2023. Artifact-Free Fat-Water Separation in Dixon MRI using Deep Learning. Journal of Big Data. 10 4. https://doi.org/10.1186/s40537-022-00677-1

2023

Discovery of drug-omics associations in type 2 diabetes with generative deep-learning models.
Allesøe, Rosa Lundbye, Lundgaard, A., Hernández Medina, R., Aguayo-Orozco, Alejandro, Johansen, J., Nissen, Jakob Nybo, Brorsson, Caroline, Mazzoni, Gianluca, Niu, L., Biel, J., Brasas, Valentas, Webel, Henry, Benros, M., Pedersen, A., Chmura, Piotr Jaroslaw, Jacobsen, U., Mari, Andrea, Koivula, R., Mahajan, Anubha, Vinuela, A., Tajes, Juan Fernandez, Sharma, Sapna, Haid, M., Hong, M., Musholt, Petra B, De Masi, Federico, Vogt, Josef, Pedersen, Helle Krogh, Gudmundsdottir, Valborg, Jones, Angus, Kennedy, G., Bell, Jimmy, Thomas, E.L., Frost, G., Thomsen, Henrik, Hansen, Elizaveta, Hansen, T., Vestergaard, Henrik, Muilwijk, Mirthe, Blom, Marieke T, 't Hart, Leen M, Pattou, Francois, Raverdy, Violeta, Brage, Soren, Kokkola, Tarja, Heggie, Alison, McEvoy, Donna, Mourby, Miranda, Kaye, J., Hattersley, A., McDonald, Timothy, Ridderstråle, M., Walker, Mark, Forgie, Ian, Giordano, Giuseppe N, Pavo, Imre, Ruetten, Hartmut, Pedersen, O., Hansen, T., Dermitzakis, Emmanouil, Franks, Paul W, Schwenk, J., Adamski, Jerzy, McCarthy, Mark I, Pearson, Ewan, Banasik, Karina, Rasmussen, S., Brunak, S. and IMI DIRECT Consortium 2023. Discovery of drug-omics associations in type 2 diabetes with generative deep-learning models. Nature Biotechnology. 41, pp. 399-408. https://doi.org/10.1038/s41587-022-01520-x

2023

Kidney Shape Statistical Analysis: Associations with Disease and Anthropometric Factors
Thanaj, M., Basty, N., Cule, M., Sorokin, E., Whitcher, B., Srinivasan, R., Lennon, R., Bell, J.D. and Thomas, E.L. 2023. Kidney Shape Statistical Analysis: Associations with Disease and Anthropometric Factors. BMC Nephrology. 24 362. https://doi.org/10.1186/s12882-023-03407-8

2023

Non-chemical Signalling Between Mitochondria
Mould, R., Kalampouka, I., Thomas, E.L., Guy, G., Nunn, A. and Bell, J.D. 2023. Non-chemical Signalling Between Mitochondria. Frontiers in Physiology. 14 1268075. https://doi.org/10.3389/fphys.2023.1268075

2023

Diet-induced weight loss and phenotypic flexibility among healthy overweight adults: a randomized trial
Rundle, M., Fiamoncini, J., Thomas, E.L., Wopereis, S., Afman, L.A., Brennan, L., Drevon, C.A., Gundersen, T.E., Daniel, H,, Garcia Perez, I., Posma, J.M., Ivanova, D.G., Bell, J.D., van Ommen, B. and Frost, G. 2023. Diet-induced weight loss and phenotypic flexibility among healthy overweight adults: a randomized trial . American Journal of Clinical Nutrition. 118 (3), pp. 591-604. https://doi.org/10.1016/j.ajcnut.2023.07.002

2023

Abdominal imaging associates body composition with COVID-19 severity
Basty, N., Sorokin, E., Thanaj, M., Srinivasan, R., Whitcher, B., Bell, J.D., Cule, M. and Thomas, E.L. 2023. Abdominal imaging associates body composition with COVID-19 severity. PLoS ONE. 18 (4) e0283506. https://doi.org/10.1371/journal.pone.0283506

2022

Analysis of MRI-derived spleen iron in the UK Biobank identifies genetic variation linked to iron homeostasis and hemolysis
Sorokin, E., Basty, N., Whitcher, B., Liu, Y., Bell, J.D., Cohen, R.L., Cule, M. and Thomas, E.L. 2022. Analysis of MRI-derived spleen iron in the UK Biobank identifies genetic variation linked to iron homeostasis and hemolysis. American Journal of Human Genetics. 109 (6), pp. P1092-1104. https://doi.org/10.1016/j.ajhg.2022.04.013

2022

Precision MRI Phenotyping Enables Detection of Small Changes in Body Composition for Longitudinal Cohorts
Whitcher, B., Thanaj, M., Cule, M., Liu, Y., Basty, N., Sorokin, E., Bell, J.D. and Thomas, E.L. 2022. Precision MRI Phenotyping Enables Detection of Small Changes in Body Composition for Longitudinal Cohorts. Scientific Reports. 12 3748. https://doi.org/10.1038/s41598-022-07556-y

2022

Cell-Cell Death Communication by Signals Passing Through Non-Aqueous Environments: A Reply
Mould, R., Thomas, E.L., Guy, G., Nunn, A. and Bell, J.D. 2022. Cell-Cell Death Communication by Signals Passing Through Non-Aqueous Environments: A Reply . Results in Chemistry. 4 100538. https://doi.org/10.1016/j.rechem.2022.100538

2022

The Mixed Meal Model: quantifying the contribution of 1 triglycerides to metabolic resilience.
O’Donovan, S.D., Erdős, B., Jacobs, D.M., Wanders, A.J., Thomas, E.L., Bell, J.D., Rundle, M., Frost, G., Arts, I.C.W., Afman, L.A. and van Riel, A.A.W. 2022. The Mixed Meal Model: quantifying the contribution of 1 triglycerides to metabolic resilience. iScience. 25 (11) 105206. https://doi.org/10.1016/j.isci.2022.105206

2022

Improving the accuracy of fatty liver index to reflect liver fat content with predictive regression modelling
Asaturyan, A.H., Basty, N., Thanaj, M., Whitcher, B., Thomas, E.L. and Bell, J.D. 2022. Improving the accuracy of fatty liver index to reflect liver fat content with predictive regression modelling. PLoS ONE. 17 (9) e0273171. https://doi.org/10.1371/journal.pone.0273171

2022

Plasma metabolic signatures of healthy overweight subjects challenged with an oral glucose tolerance test
Fiamoncini, J, Donado-Pestana, C.M., Duarte, G.B.S., Rundle, M, Thomas, E.L., Kiselova-Kaneva, Y., Gundersen, T.E., Bunzel, D., Trezzi, J.P., Kulling, S.E., Hiller, K., Sonntag, D., Ivanova, D., Brennan, L., Wopereis, S., van Ommen, B., Frost, G., Bell, J.D., Drevon, C.A. and Daniel, H. 2022. Plasma metabolic signatures of healthy overweight subjects challenged with an oral glucose tolerance test. Frontiers in Nutrition: Nutrition and Metabolism. https://doi.org/10.3389/fnut.2022.898782

2022

Infection with the hepatitis C virus causes viral genotype-specific differences in cholesterol metabolism and hepatic steatosis
Sheridan, D.A., Shawa, I.T., Thomas, E.L., Felmlee, D.J., Bridge, S.H., Neely, D., Cobbold, J.F., Holmes, E., Bassendine, M.F. and Taylor-Robinson, S.D. 2022. Infection with the hepatitis C virus causes viral genotype-specific differences in cholesterol metabolism and hepatic steatosis. Scientific Reports. 12 5562. https://doi.org/10.1038/s41598-022-09588-w

2022

Estimating the Effect of Liver and Pancreas Volume and Fat Content on Risk of Diabetes: A Mendelian Randomization Study
Martin, Susan, Sorokin, Elena P, Thomas, E Louise, Sattar, Naveed, Cule, Madeleine, Bell, Jimmy D and Yaghootkar, H. 2022. Estimating the Effect of Liver and Pancreas Volume and Fat Content on Risk of Diabetes: A Mendelian Randomization Study. Diabetes Care. 45 (2), pp. 460-468. https://doi.org/10.2337/dc21-1262

2022

A cross-sectional MR study of body fat volumes and distribution in chronic schizophrenia
Osimo, E., Brugger, S., Thomas, E.L. and Howes, O. 2022. A cross-sectional MR study of body fat volumes and distribution in chronic schizophrenia. Schizophrenia. 8 24. https://doi.org/10.1038/s41537-022-00233-z

2022

Disease consequences of higher adiposity uncoupled from its adverse metabolic effects using Mendelian randomisation
Martin, S., Tyrrell, J., Thomas, E.L., Bown, M.J., Wood, A.R., Beaumont, R.N., Tsoi, L.C., Stuart, P.E., Elder, J.T., Law, P., Houlston, R., Kabrhel, C., Papadimitriou, N., Gunter, M.J., Bull, C.J., Bell, J.A., Vincent, E.E., Sattar, N., Dunlop, M.G., Tomlinson, I.P.M., Bell, J.D., Frayling, T. and Yaghootkar, H. 2022. Disease consequences of higher adiposity uncoupled from its adverse metabolic effects using Mendelian randomisation. eLife. 11 e72452. https://doi.org/10.7554/elife.72452

2022

Four groups of type 2 diabetes contribute to the etiological and clinical heterogeneity in newly diagnosed individuals: An IMI DIRECT study
Wesolowska-Andersen, A., Brorsson, C.A., Bizzotto, R., Mari, A., Tura, A., Koivula, R., Mahajan, A., Viñuela, A., Fernandez Tajes, J, Sharma, S., Haid, M., Prehn, C., Artati, A., Hong, M-G, Musholt, P.B, Kurbasic, A., Masi, F., Tsirigos, K, Pedersen, H., Gudmundsdottir, V., Thomas, C., Banasik, K., Jennison, C., Jones, A., Kennedy, G., Bell, J.D., Thomas, E.L., Frost, G., Thomsen, H., Allin, K., Hansen, T.H., Vestergaard, H., Hansen, T., Rutters, F., Elders, P., t'Hart, L., Bonnefond, A., Canouil, M., Brage, S., Kokkola, T., Heggie, A., McEvoy, D., Hattersley, A., McDonald, T., Teare, H., Ridderstrale, M., Walker, M., Forgie, I., Giordano, G.N., Froguel, P., Pavo, I., Ruetten, H., Pedersen, O., Dermitzakis, E., Franks, P.W., Schwenk, J.M., Adamski, J., Pearson, E., McCarthy, M.I., Brunak, S. and IMI DIRECT Consortium 2022. Four groups of type 2 diabetes contribute to the etiological and clinical heterogeneity in newly diagnosed individuals: An IMI DIRECT study. Cell Reports Medicine. 3 (1) 100477. https://doi.org/10.1016/j.xcrm.2021.100477

2021

Genetic architecture of 11 organ traits derived from abdominal MRI using deep learning.
Liu, Y., Basty, N., Whitcher, B., Bell, J.D., Sorokin, E., van Bruggen, Nick, Thomas, E.L. and Cule, M. 2021. Genetic architecture of 11 organ traits derived from abdominal MRI using deep learning. eLife. 10. https://doi.org/10.7554/elife.65554

2021

Adipose tissue dysfunction, inflammation, and insulin resistance alternative pathways to cardiac remodelling in schizophrenia. A multimodal, case-control study
Osimo, E.F., Sweeney, M., de Marvao, A., Berry, A., Statton, B., Perry, B.I., Pillinger, T., Whitehurst, T., Cook, S.A., O’Regan, D.P., Thomas, E.L. and Howes, O.D. 2021. Adipose tissue dysfunction, inflammation, and insulin resistance alternative pathways to cardiac remodelling in schizophrenia. A multimodal, case-control study. Translational Psychiatry. 11 614. https://doi.org/10.1038/s41398-021-01741-9

2021

Genetic evidence for different adiposity phenotypes and their opposing influence on ectopic fat and risk of cardiometabolic disease
Martin, S., Cule, M, Basty, N., Tyrrell, J., Beaumont, R.N., Wood, A.R., Frayling, T., Sorokin, E., Whitcher, B., Liu, Y., Bell, J.D., Thomas, E.L. and Yaghootkar, H. 2021. Genetic evidence for different adiposity phenotypes and their opposing influence on ectopic fat and risk of cardiometabolic disease. Diabetes. 70 (8), pp. 1843-1856. https://doi.org/10.2337/db21-0129

2021

Cannabidiol modulates mitochondrial redox and dynamics in MCF7 cancer cells: a study using fluorescence lifetime imaging microscopy of NAD(P)H
Mould, R., Botchway, S, Parkinson, J., Thomas, E.L., Guy, G., Bell, J.D. and Nunn, A. 2021. Cannabidiol modulates mitochondrial redox and dynamics in MCF7 cancer cells: a study using fluorescence lifetime imaging microscopy of NAD(P)H. Frontiers in Molecular Biosciences. 8 630107. https://doi.org/10.3389/fmolb.2021.630107

2021

Acetate induces growth arrest in colon cancer cells through modulation of mitochondrial function
Sahuri Arisoylu, M., Mould, R., Shinjyo, N., Bligh, S.W.A., Nunn, A., Guy, G., Thomas, E.L. and Bell, J.D. 2021. Acetate induces growth arrest in colon cancer cells through modulation of mitochondrial function. Frontiers in Nutrition: Nutrition and Metabolism. 8 588466. https://doi.org/10.3389/fnut.2021.588466

2021

Processes Underlying Glycemic Deterioration in Type 2 Diabetes: An IMI DIRECT Study
Bizzotto, R., Jennison, C., Jones, A., Kurbasic, A., Kennedy, G., Bell, J.D., Thomas, E.L., Frost, G., Eriksen, R., Koivula, R., Brage, S., Kaye, J., Hattersley, A., Heggie, A., McEvoy, D., Hart, L.M., Beulens, J.W., Elders, P., Musholt, P.B., Ridderstråle, M., Hansen, T., Allin, K., Hansen, T., Vestergaard, H., Lundgaard, A.T., Thomsen, H.S., Masi, F., Tsirigos, K.D., Brunak, S., Viñuela, A., Mahajan, A., McDonald, T.J., Kokkola, T., Forgie, I., Giordano, G.N., Pavo, I., Ruetten, H., Dermitzakis, E., McCarthy, M., Pedersen, O., Schwenk, J., Adamski, J., Franks, P., Walker, M., Pearson, E. and Mari, A. 2021. Processes Underlying Glycemic Deterioration in Type 2 Diabetes: An IMI DIRECT Study. Diabetes Care. 44 (2), pp. 511-518. https://doi.org/10.2337/dc20-1567

2020

Large‑scale analysis of iliopsoas muscle volumes in the UK Biobank
Fitzpatrick, J., Basty, N., Cule, M., Liu, Y., Bell, J.D., Thomas, E.L. and Whitcher, B. 2020. Large‑scale analysis of iliopsoas muscle volumes in the UK Biobank. Scientific Reports. 10 20215. https://doi.org/10.1038/s41598-020-77351-0

2020

Ethnic Differences in Body Fat Deposition and Liver Fat Content in Two UK-Based Cohorts
Alenaini, Wareed, Parkinson, J., McCarthy, John P., Goldstone, Anthony P., Wilman, Henry R., Banerjee, Rajarshi, Yaghootkar, Hanieh, Bell, Jimmy D. and Thomas, E.L. 2020. Ethnic Differences in Body Fat Deposition and Liver Fat Content in Two UK-Based Cohorts. Obesity (Silver Spring, Md.). 28 (11), pp. 2142-2152. https://doi.org/10.1002/oby.22948

2020

Normalized indices derived from visceral adipose mass assessed by MRI and their correlation with markers for insulin resistance and prediabetes
Machann, J., Stefan, N., Wagner, R., Fritsche, A., Bell, J.D., Whitcher, B., Häring, H.U., Birkenfeld, A., Nikolaou, K., Schick, F. and Thomas, E.L. 2020. Normalized indices derived from visceral adipose mass assessed by MRI and their correlation with markers for insulin resistance and prediabetes. Nutrients. 12 (7) 2064. https://doi.org/10.3390/nu12072064

2020

Dietary metabolite profiling brings new insight into the relationship between nutrition and metabolic risk: An IMI Direct study
Eriksen, R., Perez, I.G., Posma, J.M., Haid, M., Sharma, S., Thomas, E.L., Koivula, R.W., Bizzotto, R., Mari, A., Giordano, G.N., Pavo, I., Schwenk, J., De Masi, F., Tsirigos, K., Brunak, S., Vinuela, A., Mahajan, A., McDonald, T.J., Kokkola, T., Teare, H.J.A., Hansen, T.H., Fernandez, J., Jones, A., Jennison, C., Walker, M., McCarthy, M., Pedersen, O., Reutten, H., Forgie, I., Bell, J.D., Pearson, E., Franks, P.W., Adamski, J., Holmes, E. and Frost, G.S. 2020. Dietary metabolite profiling brings new insight into the relationship between nutrition and metabolic risk: An IMI Direct study. EBioMedicine. 58 102932. https://doi.org/10.1016/j.ebiom.2020.102932

2020

Predicting and elucidating the etiology of fatty liver disease: A machine learning modeling and validation study in the IMI DIRECT cohorts
Atabaki-Pasdar, N., Ohlsson, M., Viñuela, A., Frau, F., Pomares-Millan, H., Haid, M., Jones, A., Thomas, E.L., Koivula, R., Kurbasic, A., Mutie, P., Fitipaldi, H., Fernandez, J., Dawed, A., Giordano, G., Forgie, I., McDonald, T., Rutters, F., Cederberg, H., Chabanova, E., Dale, M., Masi, F., Thomas, C., Allin, K., Hansen, T., Heggie, A., Hong, M., Elders, P., Kennedy, G., Kokkola, T., Pedersen, H., Mahajan, A., McEvoy, D., Pattou, F., Raverdy, V., Häussler, R., Sharma, S., Thomsen, H., Vangipurapu, J., Vestergaard, H., ‘t Hart, L., Adamski, J., Musholt, P., Brage, S., Brunak, S., Dermitzakis, E., Frost, G., Hansen, T., Laakso, M., Pedersen, O., Ridderstråle, M., Ruetten, H., Hattersley, A., Walker, M., Beulens, J., Mari, A., Schwenk, J., Gupta, R., McCarthy, M., Pearson, E., Bell, J.D., Pavo, I. and Franks, P. 2020. Predicting and elucidating the etiology of fatty liver disease: A machine learning modeling and validation study in the IMI DIRECT cohorts. PLoS Medicine. 17 (6) e1003149. https://doi.org/10.1371/journal.pmed.1003149

2020

Ethnic differences in adiposity and diabetes risk – insights from genetic studies
Yaghootkar, H., Bell, J.D., Whitcher, B. and Thomas, E.L. 2020. Ethnic differences in adiposity and diabetes risk – insights from genetic studies. Journal of Internal Medicine. 288 (3), pp. 271-283. https://doi.org/10.1111/joim.13082

2020

Genome-wide and Mendelian randomisation studies of liver MRI yield insights into the pathogenesis of steatohepatitis
Parisinos, C.A., Wilman, H., Thomas, E.L., Kelly, M., Nicholls, R.C., McGonigle, J., Neubauer, S., Hingorani, A.D., Patel, R.S., Hemingway, H., Bell, J.D., Banerjee, R and Yaghootkar, H. 2020. Genome-wide and Mendelian randomisation studies of liver MRI yield insights into the pathogenesis of steatohepatitis. Journal of Hepatology. 73, pp. 241-51. https://doi.org/10.1016/j.jhep.2020.03.032

2020

The role of physical activity in metabolic homeostasis before and after the onset of type 2 diabetes: an IMI DIRECT study
Koivula, R.W., Atabaki-Pasdar, N, Giordano, G.N., White, T., Adamski, J., Bell, J.D., Beulens, J, Brage, S, Brunak, S., De Masi, F., Dermitzakis, E.T., Forgie, I.M., Frost, G.S., Hansen, T., Hansen, T.H., Hattersley, A., Kokkola, T., Kurbasic, A., Laakso, M., Mari, A., McDonald T.J., Pedersen, O., Rutters, F., Schwenk, J.M, Teare, H.J.A., Thomas, E.L., Vinuela, A., Mahajan, A., McCarthy, M.I., Ruetten, H., Walker, M., Pearson, E., Pavo, I. and Franks, P.W. 2020. The role of physical activity in metabolic homeostasis before and after the onset of type 2 diabetes: an IMI DIRECT study. Diabetologia. https://doi.org/10.1007/s00125-019-05083-6

2020

HDL-apoA-I kinetics in response to 16 weeks exercise training in men with non-alcoholic fatty liver disease (NAFLD)
Whyte, M.B, Shojaee-Moradie, F., Sharaf, S.E., Cuthbertson, D.J., Kemp, G.J., Barrett, M., Jackson, N.C., Herring, R.A, Wright, J., Thomas, E.L., Bell, J.D. and Umpleby, A.M. 2020. HDL-apoA-I kinetics in response to 16 weeks exercise training in men with non-alcoholic fatty liver disease (NAFLD). American Journal of Physiology - Endocrinology and Metabolism. 318 (6), pp. E839-E847. https://doi.org/10.1152/ajpendo.00019.2020

2020

Machine Learning Prediction of Susceptibility to Visceral Fat Associated Diseases
Aldraimli, M., Soria, D., Parkinson, J., Thomas, E.L., Bell, J.D., Dwek, M. and Chaussalet, T.J. 2020. Machine Learning Prediction of Susceptibility to Visceral Fat Associated Diseases. Health and Technology. 10, pp. 925-944. https://doi.org/10.1007/s12553-020-00446-1

2019

Genetic studies of abdominal MRI data identify genes regulating hepcidin as major determinants of liver iron concentration
Wilman, H.R., Parisinos, C.A., Atabaki-Pasdar, N., Kelly, M., Thomas, E.L., Neubauer, S., Mahajan, A., Hingorani, A.D., Patel, R.S., Hemingway, H., Franks, P.W., Bell, J.D., Banerjee, R. and Yaghootkar, H. 2019. Genetic studies of abdominal MRI data identify genes regulating hepcidin as major determinants of liver iron concentration. Journal of Hepatology. 71 (3), pp. 594-602. https://doi.org/10.1016/j.jhep.2019.05.032

2019

Discovery of biomarkers for glycaemic deterioration before and after the onset of type 2 diabetes: descriptive characteristics of the epidemiological studies within the IMI DIRECT Consortium
Koivula, R.W., Forgie, I.M., Kurbasic, A., Viñuela, A., Heggie, A., Giordano, G.N., Hansen, T.H., Hudson, M., Koopman, A.D., Rutters, F., Siloaho, M., Allin, K.H., Brage, S., Brorsson, C.A., Dawed, A.Y., De Masi, F., Groves, C.J., Kokkola, T., Mahajan, A., Perry, M.H., Rauh, S.P., Ridderstråle, M., Teare, H.J.A., Thomas, E.L., Tura, A., Vestergaard, H., White, T., Adamski, J., Bell, J.D., Beulens, J., Brunak, S., Dermitzakis, E.T., Froguel, P., Frost, G., Gupta, R., Hansen, T., Hattersley, A., Jablonka, B., Kaye, J., Laakso, M., McDonald, T.J., Pedersen, O., Schwenk, J.M., Pavo, I., Mari, A., McCarthy, M.I., Ruetten, H., Walker, M., Pearson, E. and Franks, P.W. 2019. Discovery of biomarkers for glycaemic deterioration before and after the onset of type 2 diabetes: descriptive characteristics of the epidemiological studies within the IMI DIRECT Consortium. Diabetologia. 62 (9), pp. 1601-1615. https://doi.org/10.1007/s00125-019-4906-1

2019

LEAP2 changes with body mass and food intake in humans and mice
Mani, B.K., Puzziferri, N., He, Z., Rodriguez, J.A., Osborne-Lawrence, S., Metzger, N.P., Chhina, N., Gaylinn, B.D., Thorner, M.O., Thomas, E.L., Bell, J.D., Williams, K.W., Goldstone, A.P. and Zigman, J.M. 2019. LEAP2 changes with body mass and food intake in humans and mice. Journal of Clinical Investigation. 129 (9), pp. 3909-3923. https://doi.org/10.1172/JCI125332

2019

Genome-wide and abdominal MRI-imaging data provides evidence that a genetically determined favourable adiposity phenotype is characterized by lower ectopic liver fat and lower risk of type 2 diabetes, heart disease and hypertension
Ji, Y., Yiorkas, A.M., Frau, F., Mook-Kanamori, D., Staiger, H., Thomas, E.L., Atabaki-Pasdar, N., Campbell, A., Tyrrell, J., Jones, S.E., Beaumont, R.N., Wood, A.R., Tuke, M.A., Ruth, K.S., Mahajan, A., Murray, A., Freathy, R.M., Weedon, M.N., Hattersley, A.T., Hayward, C., Machann, J., Häring, H.U., Franks, P.W., de Mutsert, R., Pearson, E., Stefan, N., Frayling, T.M., Allebrandt, K.V., Bell, J.D., Blakemore, A.I. and Yaghootkar, H. 2019. Genome-wide and abdominal MRI-imaging data provides evidence that a genetically determined favourable adiposity phenotype is characterized by lower ectopic liver fat and lower risk of type 2 diabetes, heart disease and hypertension. Diabetes. 68 (1), pp. 207-219. https://doi.org/10.2337/db18-0708

2019

A Framework for Automatic Morphological Feature Extraction and Analysis of Abdominal Organs in MRI Volumes
Asaturyan, H., Thomas, E.L., Bell, J.D. and Villarini, B. 2019. A Framework for Automatic Morphological Feature Extraction and Analysis of Abdominal Organs in MRI Volumes. Journal of Medical Systems. 43 334. https://doi.org/10.1007/s10916-019-1474-3

2019

Reference range of liver corrected T1 values in a population at low risk for fatty liver disease-a UK Biobank sub-study, with an appendix of interesting cases
Mojtahed, A., Kelly, C.J., Herlihy, A.H., Kin, S., Wilman, H.R., McKay, A., Kelly, M., Milanesi, M., Neubauer, S,, Thomas, E.L., Bell, J.D., Banerjee, R. and Harisinghani, M. 2019. Reference range of liver corrected T1 values in a population at low risk for fatty liver disease-a UK Biobank sub-study, with an appendix of interesting cases. Abdominal Radiology. 44 (1), pp. 72-84. https://doi.org/10.1007/s00261-018-1701-2

2019

Cannabidiol Affects Extracellular Vesicle Release, miR21 and miR126, and Reduces Prohibitin Protein in Glioblastoma Multiforme Cells
Kosgodage, U., Uysal Onganer, P., Maclatchy, A., Mould, R., Nunn, A.V.W., Guy, G.W., Kraev, I., Chatterton, N.P., Thomas, E.L., Inal, J.M., Bell, J.D. and Lange, S. 2019. Cannabidiol Affects Extracellular Vesicle Release, miR21 and miR126, and Reduces Prohibitin Protein in Glioblastoma Multiforme Cells. Translational Oncology. 12 (3), pp. 513-522. https://doi.org/10.1016/j.tranon.2018.12.004

2019

The effects of dietary supplementation with inulin and inulin-propionate ester on hepatic steatosis in adults with non-alcoholic fatty liver disease
Chambers, E.S., Byrne, C.S., Rugyendo, A., Morrison, D.J., Preston, T., Tedford, M.C., Bell, J.D., Thomas, E.L., Akbar, A.N., Riddell, N.E., Sharma, R., Thursz, M.R., Manousou, P. and Frost, G. 2019. The effects of dietary supplementation with inulin and inulin-propionate ester on hepatic steatosis in adults with non-alcoholic fatty liver disease. Diabetes, Obesity and Metabolism. 21 (2), pp. 372-376. https://doi.org/10.1111/dom.13500

2018

Measurement of liver iron by magnetic resonance imaging in the UK Biobank population
McKay, A., Wilman, H., Dennis, A., Kelly, M., Gyngell, M.L., Neubauer, S., Bell, J.D., Banerjee, R. and Thomas, E.L. 2018. Measurement of liver iron by magnetic resonance imaging in the UK Biobank population. PLoS ONE. 13 (12) e0209340. https://doi.org/10.1371/journal.pone.0209340

2018

Non-alcoholic fatty liver disease: relationship with cardiovascular risk markers and clinical endpoints
Buckley, A., Thomas, E.L., Lessan, N., Trovato, F.M., Trovato, G.M. and Taylor-Robinson, S.D. 2018. Non-alcoholic fatty liver disease: relationship with cardiovascular risk markers and clinical endpoints. Diabetes Research and Clinical Practice. 144, pp. 144-152. https://doi.org/10.1016/j.diabres.2018.08.011

2018

Body Composition Profiling in the UK Biobank Imaging Study
Linge, J., Borger Magnus, West, J., Tuthill, T., Miller, M.R., Dumitriu, A., Thomas, E.L., Romu, T., Tunón, P., Bell, J.D. and Leinhard, O.D. 2018. Body Composition Profiling in the UK Biobank Imaging Study. Obesity. 26 (11), pp. 1785-1795. https://doi.org/10.1002/oby.22210

2018

Plasma metabolome analysis identifies distinct human metabotypes in the postprandial state with different susceptibility to weight loss–mediated metabolic improvements
Fiamoncini, J., Rundle, M., Gibbons, H., Thomas, E.L., Geillinger-Kästle, K., Bunzel, D., Trezzi, J.P., Kiselova-Kaneva, J., Wopereis, S., Wahrheit, J., Kulling, S.E., Hiller, K., Sonntag, D., Ivanova, D., van Ommen, B, Frost, G., Brennan, L., Bell, J.D. and Daniel, H. 2018. Plasma metabolome analysis identifies distinct human metabotypes in the postprandial state with different susceptibility to weight loss–mediated metabolic improvements. FASEB Journal. 32 (10), p. 5447–5458. https://doi.org/10.1096/fj.201800330R

2018

Cannabidiol (CBD) is a Novel Inhibitor for Exosome and Microvesicle (EMV) Release in Cancer
Kosgodage, U., Mould, R., Henley, A., Nunn, A.V.W., Guy, G.W., Thomas, E.L., Inal, J.M., Bell, J.D. and Lange, S. 2018. Cannabidiol (CBD) is a Novel Inhibitor for Exosome and Microvesicle (EMV) Release in Cancer. Frontiers in Pharmacology. 9 889. https://doi.org/10.3389/fphar.2018.00889

2017

Characterisation of liver fat in the UK Biobank cohort
Wilman, H., Kelly, M., Garratt, S., Matthews, P., Milanesi, M., Herlihy, A.H., Gyngell, M, Neubauer, S, Bell, J.D., Banerjee, R and Thomas, E.L. 2017. Characterisation of liver fat in the UK Biobank cohort. PLoS ONE. 12 (2) e0172921. https://doi.org/10.1371/journal.pone.0172921

2017

Cationic lipid-based nanoparticles mediate functional delivery of acetate to tumor cells in vivo leading to significant anticancer effects
Brody, L.P., Sahuri Arisoylu, M., Parkinson, J.R., Parkes, H.G., So, P-W, Hajji, N, Thomas, E.L., Frost, G.S., Miller, A.D. and Bell, J.D. 2017. Cationic lipid-based nanoparticles mediate functional delivery of acetate to tumor cells in vivo leading to significant anticancer effects. International Journal of Nanomedicine. 12, pp. 6677-6685. https://doi.org/10.2147/IJN.S135968

2016

Efficacy and Safety of Cannabidiol and Tetrahydrocannabivarin on Glycemic and Lipid Parameters in Patients With Type 2 Diabetes: A Randomized, Double-Blind, Placebo-Controlled, Parallel Group Pilot Study
Jadoon, K.A., Ratcliffe, S.H., Barrett, D.A., Thomas, E.L., Stott, C., Bell, J.D., O’Sullivan S.E. and Tan, G.D. 2016. Efficacy and Safety of Cannabidiol and Tetrahydrocannabivarin on Glycemic and Lipid Parameters in Patients With Type 2 Diabetes: A Randomized, Double-Blind, Placebo-Controlled, Parallel Group Pilot Study. Diabetes Care. 39 (10), pp. 1777-1786. https://doi.org/10.2337/dc16-0650

2016

Reprogramming of hepatic fat accumulation and 'browning' of adipose tissue by the short-chain fatty acid acetate
Sahuri Arisoylu, M., Brody, L., Parkinson, J., Parkes, H.G., Navaratnam, N., Miller, A.D., Thomas, E.L., Frost, G.S. and Bell, J.D. 2016. Reprogramming of hepatic fat accumulation and 'browning' of adipose tissue by the short-chain fatty acid acetate. International Journal of Obesity. 40, p. 955–963. https://doi.org/10.1038/ijo.2016.23

2015

Dissociation between exercise-induced reduction in liver fat and changes in hepatic and peripheral glucose homeostasis in obese patients with Non-Alcoholic Fatty Liver Disease.
Cuthbertson, D.J., Shojaee-Moradie, F., Sprung, V.S., Jones, H., Pugh, C.J., Richardson, P., Kemp, G.J., Barrett, M., Jackson, N.C., Thomas, E.L., Bell, J.D. and Umpleby, A.M. 2015. Dissociation between exercise-induced reduction in liver fat and changes in hepatic and peripheral glucose homeostasis in obese patients with Non-Alcoholic Fatty Liver Disease. Clinical Science. 130 (2), pp. 93-104. https://doi.org/10.1042/CS20150447

2015

Effects of elevating colonic propionate on liver fat content in overweight adults with non-alcoholic fatty liver disease: a pilot study
Chambers, E.S., Viardot, A., Psichas, A., Morrison, D.J., Murphy, K.G., Zac-Varghese, S.E.K., MacDougall, K., Preston, T., Tedford, M.C., Bell, J. D., Thomas, E.L., Mt-Isa, S., Ashby, D., Dhillo, W.S., Bloom, S.R., Morley, W.G., Clegg, S. and Frost, G. 2015. Effects of elevating colonic propionate on liver fat content in overweight adults with non-alcoholic fatty liver disease: a pilot study. Proceedings of the Nutrition Society. 74 (Issue OCE1: Summer Meeting, 14–17 July 2014, Carbohydrates in health: friends or foes , 2015) E30. https://doi.org/10.1017/s0029665115000452

2015

A diet low in sugar reduces the production of atherogenic lipoproteins in men with high liver fat
Umpleby, M., Shojaee-Moradie, F., Fielding, B., Li, X., Isherwood, C., Jackson, N., Wilinska, G., Hovorka, R., Bell, J., Thomas, E. L., Wright, J., Frost, G. S. and Griffin, B. 2015. A diet low in sugar reduces the production of atherogenic lipoproteins in men with high liver fat. Atherosclerosis. 241 (1) E46. https://doi.org/10.1016/j.atherosclerosis.2015.04.164

2014

The short-chain fatty acid acetate reduces appetite via a central homeostatic mechanism
Frost, G.S., Sleeth Michelle, L., Sahuri-Arisoylu, Meliz, Lizarbe, Blanca, Cerdan, Sebastian, Brody, Leigh, Anastasovska, J., Ghourab, Samar, Hankir, M., Zhang Shuai, Carling, David, Swann, Jonathan, Gibson, G.R., Viardot, A., Morrison, Douglas, Thomas, E.L. and Bell, J.D. 2014. The short-chain fatty acid acetate reduces appetite via a central homeostatic mechanism. Nature Communications. 5 3611. https://doi.org/10.1038/ncomms4611

2014

Body Fat: our own Janus
Thomas, E.L. and Bell, J.D. 2014. Body Fat: our own Janus. Physiology News. 96, pp. 24-27. https://doi.org/10.36866/pn.96.24

2012

Improved Glycaemia correlates with liver fat reduction in obese, type 2 diabetes, patients given glucagon-like peptide-1 (GLP-1) receptor agonists
Cuthbertson, D.J., Irwin, A., Gardner, C.J., Daousi, C., Purewal, T, Furlong, N, Goenka, N, Thomas, E.L., Adams, V.L., Pushpakom, SP, Pirmohamed, M and Kemp, G.J. 2012. Improved Glycaemia correlates with liver fat reduction in obese, type 2 diabetes, patients given glucagon-like peptide-1 (GLP-1) receptor agonists. PLoS ONE. 7 (12) e50117. https://doi.org/10.1371/journal.pone.0050117

2012

Differential effects of two fermentable carbohydrates on central appetite regulation and body composition
Arora, T., Loo, R.L., Anastasovska, J., Gibson, G.R., Tuohy, K., Kumar Sharma, R., Swann Jonathan, Deaville, E.R., Sleeth Michelle, L., Thomas, E.L., Holmes, E., Bell, J.D. and Frost, G.S. 2012. Differential effects of two fermentable carbohydrates on central appetite regulation and body composition. PLoS ONE. 7 (8) e43263. https://doi.org/10.1371/journal.pone.0043263

2012

Intrahepatic insulin exposure, intrahepatocellular lipid and regional body fat in non-alcoholic fatty liver disease
Mehta, S.R., Godsland, I.F., Thomas, E.L., Pavitt, D.V., Morin, S.H.X., Bell, J.D., Taylor-Robinson, S.D. and Johnston, D.G. 2012. Intrahepatic insulin exposure, intrahepatocellular lipid and regional body fat in non-alcoholic fatty liver disease. Journal of Clinical Endocrinology and Metabolism. 97 (6), pp. 2151-2159. https://doi.org/10.1210/jc.2011-2430

2010

Impact of Maternal Body Mass Index on Offspring Liver Lipid Depends on Mode of Delivery
Murgasova, D., Logan, K., Hyde, M.J., Santhakumaran, S., Thomas, E.L., Bell, J.D. and Modi, N. 2010. Impact of Maternal Body Mass Index on Offspring Liver Lipid Depends on Mode of Delivery. Pediatric Research. 68 (Suppl 1) 30. https://doi.org/10.1203/00006450-201011001-00054

2010

Fatty acid oxidation rate is higher in obese women than obese men
Shojaee-Moradie, F., Backhouse, K., Sarac, I., Stoliniski, M., Robertson, D., Bell, J.D., Thomas, E.L., Russell-Jones, D. and Umpleby, M. 2010. Fatty acid oxidation rate is higher in obese women than obese men. Diabetologia. 53 (Supplement 1), p. Meeting Abstract 780.

2008

Reduction in Total Lung Capacity in Obese Men: Role of Trunk Fat
Watson, A., Pride, N.B., Ind, P.W., Thomas, E.L. and Bell, J.D. 2008. Reduction in Total Lung Capacity in Obese Men: Role of Trunk Fat. Thorax. 63, p. A31.

2007

Increased abdominal and visceral adiposity is manifest in Indian babies at birth
Yajnik, C., Umranikar, S., Lubree, H., Ganpule, A., McEwan, P., Thomas, E.L., Uthaya, S., Bell, J. and Modi, N. 2007. Increased abdominal and visceral adiposity is manifest in Indian babies at birth. Early Human Development. 83 (Supplement 1), pp. S66-S67. https://doi.org/10.1016/s0378-3782(07)70118-4

2007

Impaired insulin-mediated non-esterified fatty acid suppression in patients with hepatic steatosis quantified using proton magnetic resonance spectroscopy
Mehta, S.R., Barton, N., Godsland, I.F., Robinson, S., Bell, J.D., Thomas, E.L., Patel, N., Fitzpatrick, J., Durighel, G., Pavitt, D., Taylor-Robinson, S.D. and Johnston, D.G. 2007. Impaired insulin-mediated non-esterified fatty acid suppression in patients with hepatic steatosis quantified using proton magnetic resonance spectroscopy. Diabetologia. 50. https://doi.org/10.1007/s00125-007-0809-7

2006

Prediction of specific absorption rate in mother and fetus associated with MRI examinations during pregnancy
Hand, J.W., Li, Y., Thomas, E.L., Rutherford, M.A. and Hajnal, J.V. 2006. Prediction of specific absorption rate in mother and fetus associated with MRI examinations during pregnancy. Magnetic Resonance in Medicine. 55 (4), pp. 883-93. https://doi.org/10.1002/mrm.20824

2005

Hepatic triglyceride content and its relation to body adiposity: a magnetic resonance imaging and proton magnetic resonance spectroscopy study
Thomas, E.L., Hamilton, G., Patel, N., O'Dwyer, R., Doré, C.J., Goldin, R.D., Bell, J.D. and Taylor-Robinson, S.D. 2005. Hepatic triglyceride content and its relation to body adiposity: a magnetic resonance imaging and proton magnetic resonance spectroscopy study. Gut. 54 (1), pp. 122-127. https://doi.org/10.1136/gut.2003.036566

2004

Familial partial lipodystrophy associated with compound heterozygosity for novel mutations in the LMNA gene
Savage, D.B., McFarlane, I.A., Barroso, I., Soos, M.A., Powlson, A., Thomas, E.L., Bell, J.D., Scobie, I., Belchetz, P.E., Kelly, W.F., Halsall, D.J., Schafer, A.J. and O’Rahilly, S. 2004. Familial partial lipodystrophy associated with compound heterozygosity for novel mutations in the LMNA gene. Diabetologia. 47 (4), pp. 753-756. https://doi.org/10.1007/s00125-004-1360-4

1998

In vivo and in vitro hepatic phosphorus-31 magnetic resonance spectroscopy and electron microscopy in chronic ductopenic rejection of human liver allografts
Taylor-Robinson, S.D., Sargentoni, J., Bell, J.D., Thomas, E.L., Marcus, C.D., Changani, K.K., Saeed, N., Hodgson, H., Davidson, B.R., Burroughs, A.K., Rolles, K., Foster, C.S. and Cox, I.J. 1998. In vivo and in vitro hepatic phosphorus-31 magnetic resonance spectroscopy and electron microscopy in chronic ductopenic rejection of human liver allografts. Gut. 42 (5), pp. 735-43. https://doi.org/10.1136/gut.42.5.735

1996

An in vivo 13C magnetic resonance spectroscopic study of the relationship between diet and adipose tissue composition
Thomas, E.L., Frost, G.S., Barnard, M.L., Bryant, D.J., Taylor-Robinson, S.D., Simbrunner, J., Coutts, G.A., Burl, M., Bloom, S.R., Sales, K.D. and Bell, J.D. 1996. An in vivo 13C magnetic resonance spectroscopic study of the relationship between diet and adipose tissue composition. Lipids. 31 (2), pp. 145-151. https://doi.org/10.1007/BF02522613

2022

Correction: Disease consequences of higher adiposity uncoupled from its adverse metabolic effects using Mendelian randomisation
Martin, S., Tyrrell, Jessica, Thomas, E.L., Bown, Matthew J, Wood, Andrew R, Beaumont, Robin N, Tsoi, Lam C, Stuart, Philip E, Elder, James T, Law, Philip, Houlston, Richard, Kabrhel, Christopher, Papadimitriou, Nikos, Gunter, Marc J, Bull, Caroline J, Bell, Joshua A, Vincent, Emma E, Sattar, N., Dunlop, Malcolm G, Tomlinson, Ian PM, Bell, J.D., Frayling, T. and Yaghootkar, H. 2022. Correction: Disease consequences of higher adiposity uncoupled from its adverse metabolic effects using Mendelian randomisation. eLife. https://doi.org/10.7554/elife.80233

2021

Using Genetics to Uncouple Higher Adiposity from Its Adverse Metabolic Effects
Martin, Susan, Tyrrell, Jessica, Thomas, Elizabeth L., Bown, Matthew, Elder, James T., Kabrhel, Christopher, Papadimitriou, Nikos, Gunter, Marc, Vincent, Emma E., Bell, Jimmy D., Frayling, Timothy M. and Yaghootkar, Hanieh 2021. Using Genetics to Uncouple Higher Adiposity from Its Adverse Metabolic Effects. Diabetes. 70 (Supplement 1) 190-LB. https://doi.org/10.2337/db21-190-lb

2019

Genetic studies of MRI liver fat content identify susceptibility variants with variable metabolic effects
Parisinos, Constantinos, Wilman, Henry, Kelly, Matt, Neubauer, Stefan, Thomas, Louise, Bell, Jimmy, Hingorani, Aroon, Patel, Riyaz, Hemingway, Harry, Banerjee, Rajarshi and Yaghootkar, Hanieh 2019. Genetic studies of MRI liver fat content identify susceptibility variants with variable metabolic effects. Gut. 68 (Supplement 2), p. A110. https://doi.org/10.1136/gutjnl-2019-bsgabstracts.208

2019

PTU-028 Genome-wide association study of MRI liver iron content in UK biobank identifies 3 susceptibility variants
Parisinos, Constantinos, Wilman, Henry, Kelly, Matt, Neubauer, Stefan, Thomas, Louise, Bell, Jimmy, Hingorani, Aroon, Patel, Riyaz, Hemingway, Harry, Banerjee, Rajarshi and Yaghootkar, Hanieh 2019. PTU-028 Genome-wide association study of MRI liver iron content in UK biobank identifies 3 susceptibility variants. Gut. 68, pp. A125-A126. https://doi.org/10.1136/gutjnl-2019-bsgabstracts.237

2019

Genome-wide association study of MRI liver iron content in 9,800 individuals yields new insights into its link with hepatic and extrahepatic diseases
Wilman, H. R., Parisinos, C. A., Atabaki-Pasdar, N., Kelly, M., Thomas, E. L., Neubauer, S., Hingorani, A., Mahajan, A., Patel, R., Hemingway, H., Franks, P. W., Bell, J., Banerjee, R. and Yaghootkar, H. 2019. Genome-wide association study of MRI liver iron content in 9,800 individuals yields new insights into its link with hepatic and extrahepatic diseases. European Journal of Human Genetics. 27 (Supplment 2), p. 1148 Meeting Abstract C21.5.

2019

Subcutaneous Abdominal Fat Has a Stronger Association with Prediabetes than Visceral Fat in Young Indians
Wagh, Rucha H., Bawdekar, Rupali U., Alenaini, Wareed, Thomas, Elizabeth L., Bell, Jimmy David and Yajnik, Chittaranjan S. 2019. Subcutaneous Abdominal Fat Has a Stronger Association with Prediabetes than Visceral Fat in Young Indians. Diabetes. 68 (Supplement 1), pp. 2106-P. https://doi.org/10.2337/db19-2106-p

2019

Genome-wide association studies of abdominal MRI scans identifies loci associated with liver fat and liver iron in the UK Biobank
Wilman, Henry, Parisinos, Constantinos, Kelly, Matt, Neubauer, Stefan, Thomas, Louise, Bell, Jimmy, Banerjee, Rajarshi, Yaghootkar, Hanieh and Thomas, E. Louise 2019. Genome-wide association studies of abdominal MRI scans identifies loci associated with liver fat and liver iron in the UK Biobank. Journal of Hepatology. 70 (1, Supplement) E315. https://doi.org/10.1016/s0618-8278(19)30236-1

2018

Rifaximin in Non-Alcoholic Steatohepatitis: An Open-Label Pilot Study
Cobbold, J.F.L., Atkinson, S., Marchesi, J.R., Smith, A., Wai, S.N., Stove, J., Shojaee-Moradie, F., Jackson, N.C., Umpleby, A.M., Fitzpatrick, J., Thomas, E.L., Bell, J.D., Holmes, E., Taylor-Robinson, S.D., Goldin, R.D., Yee, M.S., Anstee, Q.M. and Thursz, M.R. 2018. Rifaximin in Non-Alcoholic Steatohepatitis: An Open-Label Pilot Study. Hepatology Research. 48 (1), pp. 69-77. https://doi.org/10.1111/hepr.12904

2018

Genome-Wide and Abdominal Imaging Data Characterizes Common Alleles Associated with Higher BMI and Subcutaneous Fat but Less Liver Fat and Lower Risk of Type 2 Diabetes
Yaghootkar, Hanieh, Ji, Yingjie, Yiorkas, Andrianos M., Frau, Francesca, Mook-Kanamori, Dennis, De Mutsert, Renee, Tyrrell, Jessica, Jones, Samuel E., Beaumont, Robert, Wood, Andrew R., Thomas, Louise, Allebrandt, Karla V., Stefan, Norbert, Staiger, Harald, Pearson, Ewan, Blakemore, Alex I., Bell, Jimmy D. and Frayling, Timothy M. 2018. Genome-Wide and Abdominal Imaging Data Characterizes Common Alleles Associated with Higher BMI and Subcutaneous Fat but Less Liver Fat and Lower Risk of Type 2 Diabetes. Diabetes. 67 (Supplement 1), pp. 20-OR. https://doi.org/10.2337/db18-20-or

2017

Impact of liver fat on the differential partitioning of hepatic triacylglycerol into VLDL subclasses on high and low sugar diets
Umpleby, A.M., Shoajee-Moradie, F., Fielding, F., Li, X., Marino, A., Alsini, N, Isherwood, C, Jackson, N.C., Ahmad, A., Stolinski, M., Lovegrove, J.A., Johnsen, S., Mendis, A., Wright, J., Wilinska, M.E., Hovorka, R., Bell, J.D., Thomas, E.L., Frost, G.S. and Griffin, B.A. 2017. Impact of liver fat on the differential partitioning of hepatic triacylglycerol into VLDL subclasses on high and low sugar diets. Clinical Science. 131 (21), pp. 2561-2573. https://doi.org/10.1042/CS20171208

2017

Psoas major cross-sectional area: A potential marker of cardiorespiratory fitness
Fitzpatrick, J., Chambers, E.S., Parkinson, J.R.C., Frost, G., Bell, J.D. and Thomas, E.L. 2017. Psoas major cross-sectional area: A potential marker of cardiorespiratory fitness. International Journal of Clinical and Experimental Physiology. 4 (1), pp. 15-20. https://doi.org/10.4103/ijcep.ijcep_6_17

2017

UK Biobank Study of Liver Iron Overload Shows Variable Penetrance of Different Genotypes
Mckay, Andrew G., Wilman, Henry R., Dennis, Andrea, Kelly, Matthew D., Thomas, Elizabeth L., Bell, Jimmy D., Neubauer, Stefan and Banerjee, Rajarshi 2017. UK Biobank Study of Liver Iron Overload Shows Variable Penetrance of Different Genotypes. Hepatology. 66 (Supplement 1), pp. 433A-434A.

2017

Non-invasive stratification of fatty liver disease with high-throughput multiparametric MRI
Kelly, Matthew D., Wilman, Henry R., Dennis, Andrea, Thomas, Elizabeth L., Bell, Jimmy D., Neubauer, Stefan, Banerjee, Rajarshi and Thomas, E.L. 2017. Non-invasive stratification of fatty liver disease with high-throughput multiparametric MRI. Hepatology. 66 (Supplement 1), p. 1112A.

2016

Effect of energy restriction and physical exercise intervention on phenotypic flexibility as examined by transcriptomics analyses of mRNA from adipose tissue and whole body magnetic resonance imaging
Lee, S., Norheim, F., Langleite, T.M., Noreng, H.J., Storås, T.H., Afman, L.A., Frost, G., Bell, J.D., Thomas, E.L., Kolnes, K.J., Tangen, D.S., Stadheim, H.K., Gilfillan, G.D., Gulseth, H.L., Birkeland, K.I., Jensen, J., Drevon, C.A. and Holen, T. 2016. Effect of energy restriction and physical exercise intervention on phenotypic flexibility as examined by transcriptomics analyses of mRNA from adipose tissue and whole body magnetic resonance imaging. Physiological Reports. 4 (21), p. e13019 e13019. https://doi.org/10.14814/phy2.13019

2016

Exercise Training Reduces Liver Fat and Increases Rates of VLDL Clearance, but not VLDL Production in NAFLD
Shojaee-Moradie, F., Cuthbertson, D.J., Barrett, M., Jackson, N.C., Herring, R, Thomas, E.L., Bell, J.D., Kemp, G.J., Wright, J. and Umpleby, A.M. 2016. Exercise Training Reduces Liver Fat and Increases Rates of VLDL Clearance, but not VLDL Production in NAFLD. Journal of Clinical Endocrinology and Metabolism. 101 (11), pp. 4219-4228. https://doi.org/10.1210/jc.2016-2353

2016

Feasibility of MR-Based Body Composition Analysis in Large Scale Population Studies
West, J., Leinhard, O.D., Romu, T., Collins, R., Garratt, S., Bell, J.D., Borga, M. and Thomas, E.L. 2016. Feasibility of MR-Based Body Composition Analysis in Large Scale Population Studies. PLoS ONE. 11 (9) e0163332. https://doi.org/10.1371/journal.pone.0163332

2016

Nutritional Evaluation and Optimisation in Neonates: a randomized, double-blind controlled trial of amino acid regimen and intravenous lipid composition in preterm parenteral nutrition
Uthaya, S.N., Liu, X., Babalis, D., Doré, C.J., Caroline, J., Warwick, J., Bell, J.D., Thomas, E.L., Ashby, D., Durighel, G., Ederies, A., Yanez-Lopez, M. and Modi, N. 2016. Nutritional Evaluation and Optimisation in Neonates: a randomized, double-blind controlled trial of amino acid regimen and intravenous lipid composition in preterm parenteral nutrition. American Journal of Clinical Nutrition. 106 (3), pp. 1443-1452. https://doi.org/10.3945/ajcn.115.125138

2016

Nutritional Evaluation and Optimisation in Neonates (NEON) trial of amino acid regimen and intravenous lipid composition in preterm parenteral nutrition: a randomised double-blind controlled trial
Uthaya, S.N., Liu, X., Babalis, D., Doré, C.J., Warwick, J., Bell, J.D., Thomas, E.L., Ashby, D., Durighel, G., Ederies, A., Yanez-Lopez, M. and Modi, N. 2016. Nutritional Evaluation and Optimisation in Neonates (NEON) trial of amino acid regimen and intravenous lipid composition in preterm parenteral nutrition: a randomised double-blind controlled trial. Efficacy and Mechanism Evaluation. 3 (2). https://doi.org/10.3310/eme03020

2016

Liver fat in adults with GH deficiency: comparison to matched controls and the effect of GH replacement
Meienberg, F., Yee, M., Johnston, D.G., Cox, J., Robinson, S., Bell, J.D., Thomas, E.L., Taylor-Robinson, S.D. and Godsland, I.F. 2016. Liver fat in adults with GH deficiency: comparison to matched controls and the effect of GH replacement. Clinical Endocrinology. 85 (1), pp. 76-84. https://doi.org/10.1111/cen.13042

2016

Investigating the lipodystrophy genetic score associations with insulin sensitivity, ectopic and visceral fat in people at risk or with diabetes: a DIRECT study
Frau, F., Mari, A., Thomas, E. L., Alenaini, W., Ruetten, H., 't Hart, L., Franks, P. W., Allebrandt, K. V., Bell, J. D. and Pearson, E. 2016. Investigating the lipodystrophy genetic score associations with insulin sensitivity, ectopic and visceral fat in people at risk or with diabetes: a DIRECT study. Diabetologia. 59 (Supplement 1), p. S175 Meeting Abstract 354.

2015

A randomized controlled trial: the effect of inulin on weight management and ectopic fat in subjects with prediabetes.
Guess, N.D., Dornhorst, A., Oliver, N., Bell, J.D., Thomas, E.L. and Frost, G.S. 2015. A randomized controlled trial: the effect of inulin on weight management and ectopic fat in subjects with prediabetes. Nutrition & Metabolism. 12 (36). https://doi.org/10.1186/s12986-015-0033-2

2015

Validation of a fast method for quantification of intra-abdominal and subcutaneous adipose tissue for large-scale human studies
Borga, M., Thomas, E.L., Romu, T., Rosander, J., Fitzpatrick, J., Leinhard, O.D., Bell, J.D. and Borger Magnus 2015. Validation of a fast method for quantification of intra-abdominal and subcutaneous adipose tissue for large-scale human studies. NMR in Biomedicine. 28 (12), pp. 1747-1753. https://doi.org/10.1002/nbm.3432

2015

Sexual dimorphism in relation to adipose tissue and intrahepatocellular lipid deposition in early infancy
Gale, C., Jeffries, Suzan, Santhakumaran, S., Uthaya, S.N., Durighel, G., Alavi, Afshin, Modi, N., Thomas, E.L., Logan, Karen M., Parkinson, J.R.C. and Bell, J.D. 2015. Sexual dimorphism in relation to adipose tissue and intrahepatocellular lipid deposition in early infancy. International Journal of Obesity. 39 (4), pp. 629-32. https://doi.org/10.1038/ijo.2015.4

2015

Effects of targeted delivery of propionate to the human colon on appetite regulation, body weight maintenance and adiposity in overweight adults.
Chambers, E.S., Viardot, A., Psichas, A., Morrison, D.J., Murphy, K.G., Zac-Varghese, S.E., MacDougall, K., Preston, T., Tedford, C., Finlayson, G.S., Blundell, J.E., Bell, J.D., Thomas, E.L., Mt-Isa, S., Ashby, D., Gibson, G.R., Kolida, S., Dhillo, W.S., Bloom, S.R., Morley, W., Clegg, S., Frost, G.S. and Sagen E K Zac-Varghese 2015. Effects of targeted delivery of propionate to the human colon on appetite regulation, body weight maintenance and adiposity in overweight adults. Gut. 64 (11), pp. 1744-54. https://doi.org/10.1136/gutjnl-2014-307913

2015

Circulating pancreatic polypeptide concentrations predict visceral and liver fat content
Sam Amir, H., Sleeth Michelle, L., Thomas, E.L., Daud Norlida, M., Chambers, Edward, Shojaee-Moradie, Fariba, Umpleby, A.M., le Roux, C.W., Bech, Paul, Busbridge, Mark, Laurie, Rosemary Cuthbertson Daniel, J., Buckley, Adam, Bloom, S.R., Frost, G.S., Bell, J.D., Murphy, K.G., Ismail, Nurhafzan, Shoajee-Moradie, Fariba, Goldstone, A.P., Cuthbertson, D.J. and Ghatei, M.A. 2015. Circulating pancreatic polypeptide concentrations predict visceral and liver fat content. Journal of Clinical Endocrinology and Metabolism. 100 (3), pp. 1048-1052. https://doi.org/10.1210/jc.2014-3450

2015

Body fat MRS
Thomas, E.L. and Bell, J.D. 2015. Body fat MRS. eMagRes. 4 (3), pp. 663-672. https://doi.org/10.1002/9780470034590.emrstm1478

2015

Effects of Elevating Colonic Propionate on Liver Fat Content in Adults with Non-Alcoholic Fatty Liver Disease
Chambers, Edward, Viardot, Alexander, Psichas, Arianna, Morrison, Douglas, Murphy, Kevin, Zac-Varghese, Sagen, Preston, Tom, Tedford, Catriona, Bell, Jimmy, Thomas, Louise, Dhillo, Waljit, Bloom, Stephen and Frost, Gary 2015. Effects of Elevating Colonic Propionate on Liver Fat Content in Adults with Non-Alcoholic Fatty Liver Disease. FASEB Journal. 29 (Supplement 1) Meeting Abstract 385.2. https://doi.org/10.1096/fasebj.29.1_supplement.385.2

2015

Exercise training alters VLDL TG and apoB metabolism in men with non-alcoholic liver disease (NAFLD)
Shojaee-Moradie, F., Cuthbertson, D. J., Kemp, G. J., Barrett, M., Jackson, N. C., Batt, J., Herring, R. A., Wright, J., Russell-Jones, D., Thomas, E. L., Bell, J. and Umpleby, A. M. 2015. Exercise training alters VLDL TG and apoB metabolism in men with non-alcoholic liver disease (NAFLD). Atherosclerosis. 241 (1) E103. https://doi.org/10.1016/j.atherosclerosis.2015.04.360

2014

External validation of the fatty liver index and lipid accumulation product indices, using 1H-magnetic resonance spectroscopy, to identify hepatic steatosis in healthy controls and obese, insulin-resistant individuals
Cuthbertson, D.J., Weickert, M.O., Lythgoe, D., Sprung, V.S., Dobson, R., Shoajee-Moradie Fariba, Umpleby, A.M., Pfeiffer, A.F.H., Thomas, E.L., Bell, J.D., Jones, H. and Kemp, G.J. 2014. External validation of the fatty liver index and lipid accumulation product indices, using 1H-magnetic resonance spectroscopy, to identify hepatic steatosis in healthy controls and obese, insulin-resistant individuals. European Journal of Endocrinology. 171 (5), pp. 561-569. https://doi.org/10.1530/EJE-14-0112

2014

The association between objectively measured sitting and standing with body composition: a pilot study using magnetic resonance imaging
Smith, L., Thomas, E.L., Bell, J.D. and Hamer, M. 2014. The association between objectively measured sitting and standing with body composition: a pilot study using magnetic resonance imaging. BMJ Open. 4 (6) e005476. https://doi.org/10.1136/bmjopen-2014-005476

2014

Preterm nutritional intake and MRI phenotype at term age: a prospective observational study
Vasu, V., Durighel, G., Malamateniou, C., Rutherford, M.A., Modi, N., Thomas, E.L. and Bell, J.D. 2014. Preterm nutritional intake and MRI phenotype at term age: a prospective observational study. BMJ Open. 4 (5) e005390. https://doi.org/10.1136/bmjopen-2014-005390

2014

Efficacy of increased resistant starch consumption in human type 2 diabetes
Bodinham, C.L., Smith, L., Thomas, E.L., Bell, J.D., Swann Jonathan, Costabile, A., Russell-Jones, D., Umpleby, A.M. and Robertson, M.D. 2014. Efficacy of increased resistant starch consumption in human type 2 diabetes. Endocrine Connections. 3 (2), pp. 75-84. https://doi.org/10.1530/EC-14-0036

2014

The impact of oligofructose on stimulation of gut hormones, appetite regulation and adiposity
Daud Norlida, M., Ismail Nurhafzan, Thomas, E.L., Fitzpatrick, J., Swann Jonathan, Costabile, A., Pedersen, C., Frost, G.S., Bell, J.D., Childs, C.E. and Goldstone, A.P. 2014. The impact of oligofructose on stimulation of gut hormones, appetite regulation and adiposity. Obesity (Silver Spring). 22 (6), pp. 1430-1438. https://doi.org/10.1002/oby.20754

2014

Adiposity and hepatic lipid in healthy full-term, breastfed, and formula-fed human infants: a prospective short-term longitudinal cohort study
Gale, C., Thomas, E.L., Jeffries, Suzan, Durighel, G., Logan, Karen M., Parkinson, J.R.C., Uthaya, S.N., Santhakumaran, S., Bell, J.D. and Modi, N. 2014. Adiposity and hepatic lipid in healthy full-term, breastfed, and formula-fed human infants: a prospective short-term longitudinal cohort study. American Journal of Clinical Nutition. 99 (5), pp. 1034-1040. https://doi.org/10.3945/ajcn.113.080200

2014

Targeted delivery of propionate to the human colon prevents body weight and intra-abdominal adipose tissue gain in overweight adults
Chambers, E.S., Viardot, A., Psichas, A., Morrison, D.J., Murphy, K.G., Zac-Varghese, S.E.K., MacDougall, K., Preston, T., Tedford, M.C., Bell, J.D., Thomas, E.L., Mt-Isa, S., Ashby, D., Dhillo, W.S., Bloom, S.R., Morley, W.G., Clegg, S. and Frost, G. 2014. Targeted delivery of propionate to the human colon prevents body weight and intra-abdominal adipose tissue gain in overweight adults. Proceedings of the Nutrition Society. 73 (Issue OCE1), p. E22. https://doi.org/10.1017/s0029665114000366

2013

A history of previous gestational diabetes mellitus is associated with adverse changes in insulin secretion and VLDL metabolism independently of increased intrahepatocellular lipid
Forbes, S., Godsland, I.F., Taylor-Robinson, S.D., Bell, J.D., Thomas, E.L., Patel, N., Hamilton, G., Parker, K.H., Marshall, I., Gray, C.D., Bedford, D.C., Caslake, M., Walker, B.R. and Johnston, D.G. 2013. A history of previous gestational diabetes mellitus is associated with adverse changes in insulin secretion and VLDL metabolism independently of increased intrahepatocellular lipid. Diabetologia. 56 (9), pp. 2021-2033. https://doi.org/10.1007/s00125-013-2956-3

2013

Early nutritional determinants of intrahepatocellular lipid deposition in preterm infants at term age
Vasu, V., Thomas, E.L., Durighel, G., Hyde, M.J., Bell, J.D. and Modi, N. 2013. Early nutritional determinants of intrahepatocellular lipid deposition in preterm infants at term age. International Journal of Obesity. 37 (4), pp. 500-504. https://doi.org/10.1038/ijo.2012.213

2013

Whole body fat: content and distribution
Thomas, E.L., Fitzpatrick, J., Malik, S.J., Taylor-Robinson, S.D. and Bell, J.D. 2013. Whole body fat: content and distribution. Progress in Nuclear Magnetic Resonance Spectroscopy. 73, pp. 56-80. https://doi.org/10.1016/j.pnmrs.2013.04.001

2012

Polycystic ovary syndrome with hyperandrogenism is characterized by an increased risk of hepatic steatosis compared to nonhyperandrogenic PCOS phenotypes and healthy controls, independent of obesity and insulin resistance
Jones, H., Sprung, V.S., Pugh, C.J.A., Daousi, C., Irwin, A., Aziz, N., Adams, V.L., Thomas, E.L., Bell, J.D., Kemp, G.J. and Cuthbertson, D.J. 2012. Polycystic ovary syndrome with hyperandrogenism is characterized by an increased risk of hepatic steatosis compared to nonhyperandrogenic PCOS phenotypes and healthy controls, independent of obesity and insulin resistance. Journal of Clinical Endocrinology and Metabolism. 97 (10), pp. 3709-3716. https://doi.org/10.1210/jc.2012-1382

2012

Gender differences in VLDL1 and VLDL2 triglyceride kinetics and fatty acid kinetics in obese postmenopausal women and obese men
Sarac, I., Backhouse, K., Shojaee-Moradie, F., Stolinski, M., Robertson, M.D., Bell, J.D., Thomas, E.L., Hovorka, R., Wright, J. and Umpleby, A.M. 2012. Gender differences in VLDL1 and VLDL2 triglyceride kinetics and fatty acid kinetics in obese postmenopausal women and obese men. Journal of Clinical Endocrinology and Metabolism. 97 (7), pp. 2475-2481. https://doi.org/10.1210/jc.2011-3248

2012

Fatty acid flux and oxidation are increased by rimonabant in obese women
Backhouse, K., Sarac, I., Shojaee-Moradie, F., Stolinski, M., Robertson, M.D., Frost, G.S., Bell, J.D., Thomas, E.L., Wright, J., Russell-Jones, D. and Umpleby, A.M. 2012. Fatty acid flux and oxidation are increased by rimonabant in obese women. Metabolism: Clinical and Experimental. 61 (9), pp. 1220-1223. https://doi.org/10.1016/j.metabol.2012.02.012

2012

Hepatic steatosis, GH deficiency and the effects of GH replacement: a Liverpool magnetic resonance spectroscopy study
Gardner, C.J., Irwin, A., Daousi, C., McFarlane, I.A., Joseph, F., Bell, J.D., Thomas, E.L., Adams, V.L., Kemp, G.J. and Cuthbertson, D.J. 2012. Hepatic steatosis, GH deficiency and the effects of GH replacement: a Liverpool magnetic resonance spectroscopy study. European Journal of Endocrinology. 166, pp. 993-1002. https://doi.org/10.1530/EJE-12-0002

2012

The missing risk: MRI and MRS phenotyping of abdominal adiposity and ectopic fat
Thomas, E.L., Parkinson, J.R.C., Frost, G.S., Goldstone, A.P., Doré, C.J., McCarthy, J., Collins, A.L., Fitzpatrick, J., Durighel, G., Taylor-Robinson, S.D. and Bell, J.D. 2012. The missing risk: MRI and MRS phenotyping of abdominal adiposity and ectopic fat. Obesity. 20 (1), pp. 76-87. https://doi.org/10.1038/oby.2011.142

2012

Fermentable carbohydrate alters hypothalamic neuronal activity and protects against the obesogenic environment
Anastasovska, J., Arora, T., Sanchez-Canon, G.J., Parkinson, J.R.C., Touhy, K., Gibson, G.R., Nadkarni, N., So, P.W., Goldstone, A.P., Thomas, E.L., Hankir, M., Van Loo, J., Modi, N., Bell, J.D. and Frost, G.S. 2012. Fermentable carbohydrate alters hypothalamic neuronal activity and protects against the obesogenic environment. Obesity. 20 (5), pp. 1016-1023. https://doi.org/10.1038/oby.2012.6

2012

Relation between trunk fat volume and reduction of total lung capacity in obese men
Watson, R.A., Pride, N.B., Thomas, E.L., Ind, P.W. and Bell, J.D. 2012. Relation between trunk fat volume and reduction of total lung capacity in obese men. Journal of Applied Physiology. 112 (1), pp. 118-126. https://doi.org/10.1152/japplphysiol.00217.2011

2012

Excess body fat in obese and normal weight subjects
Thomas, E.L., Frost, G.S., Taylor-Robinson, S.D. and Bell, J.D. 2012. Excess body fat in obese and normal weight subjects. Nutrition Research Reviews. 25 (1), pp. 150-161. https://doi.org/10.1017/S0954422412000054

2012

The effect of preterm birth on adiposity and metabolic pathways and the implications for later life
Thomas, E.L., Al Saud, N.B., Durighel, G., Frost, G.S. and Bell, J.D. 2012. The effect of preterm birth on adiposity and metabolic pathways and the implications for later life. Clinical Lipidology. 7 (3), pp. 275-288. https://doi.org/10.2217/clp.12.32

2012

Individuals with moderately raised liver fat show a greater increase in liver fat in response to a high sugar diet
Ahmad, A., Isherwood, C., Fielding, B.A., Bell, J.D., Thomas, E.L., Frost, G., Shojaee-Moradie, F., Umpleby, M. and Griffin, B.A. 2012. Individuals with moderately raised liver fat show a greater increase in liver fat in response to a high sugar diet. Proceedings of the Nutrition Society. 71 (Issue OCE2: Summer Meeting hosted by the Irish Section, 16–19 July 2012, Translational nutrition: integrating research, practice and policy) E31. https://doi.org/10.1017/s0029665112000882

2011

Pragmatic study of orlistat 60 mg on abdominal obesity
Thomas, E.L., Makwana, A., Newbould, R., Rao, A.W., Gambarota, G., Frost, G.S., Delafont, B., Mishra, R.G., Matthews, P.M., Berk, E.S., Schwartz, S.M., Bell, J.D. and Beaver, J.D. 2011. Pragmatic study of orlistat 60 mg on abdominal obesity. European Journal of Clinical Nutrition. 65, pp. 1256-1262. https://doi.org/10.1038/ejcn.2011.108

2011

Aberrant adiposity and ectopic lipid deposition characterize the adult phenotype of the preterm infant
Thomas, E.L., Parkinson, J.R.C., Hyde, M.J., Yap, I.K.S., Holmes, E., Doré, C.J., Bell, J.D. and Modi, N. 2011. Aberrant adiposity and ectopic lipid deposition characterize the adult phenotype of the preterm infant. Paediatric Research. 70 (5), pp. 507-512. https://doi.org/10.1203/PDR.0b013e31822d7860

2011

The influence of maternal body mass index on infant adiposity and hepatic lipid content
Modi, N., Murgasova, D., Ruager-Martin, R., Thomas, E.L., Hyde, M.J., Gale, C., Santhakumaran, S., Doré, C.J., Alavi, Afshin and Bell, J.D. 2011. The influence of maternal body mass index on infant adiposity and hepatic lipid content. Paediatric Research. 70 (3), pp. 287-291. https://doi.org/10.1203/PDR.0b013e318225f9b1

2011

Rapid reductions in left ventricular mass following a community based 12-week prevention programme are partially predicted by change in fat depots
Jenni, S., Tillin, T., Park, C.M., Baker, M.D., Thomas, E.L., Bell, J.D., Connolly, S.B., Wood, D.A., Hughes, A.D. and Chaturvedi, N. 2011. Rapid reductions in left ventricular mass following a community based 12-week prevention programme are partially predicted by change in fat depots. European Heart Journal.

2011

Mechanism for the Differential Effect of the Long-Acting Insulin Analog Detemir on Weight in Patients with Type 2 Diabetes
Sheldon, Ben, Alsini, Najlaa, Zachariah, Sunil, Shojaee-Moradie, Fariba, Bodinham, Caroline, Robertson, Denise, Bell, Jimmy, Thomas, E. Louise, Vidal, Hubert, Meugnier, Emmanuelle, Jones, Richard H., Umpleby, A.M. and Russell-Jones, David 2011. Mechanism for the Differential Effect of the Long-Acting Insulin Analog Detemir on Weight in Patients with Type 2 Diabetes. Diabetes. 60 (Supplement 1), pp. A263-A264. https://doi.org/10.2337/db11-868-1281

2011

Effects of 8 weeks oligofructose supplementation on appetite and body weight in overweight and obese adults
Daud, N.M., Ismail, N., Thomas, E.L., Scholtz, S., Durighel, G., Fitzpatrick, J.A., Goldstone, A.P., Bell, J.D., Bech, P.R., Chambers, E., Chhina, N., Ghatei, M.A., Pedersen, C. and Frost, G.S. 2011. Effects of 8 weeks oligofructose supplementation on appetite and body weight in overweight and obese adults. Proceedings of the Nutrition Society. 70 (Issue OCE6: Winter Meeting, 6–7 December 2011, 70th Anniversary: Body weight regulation – food, gut and brain signalling) E374. https://doi.org/10.1017/s0029665111004599

2011

Impact of liver fat on the response of plasma triacylglycerol to diets high and low in extrinsic sugars
Ahmad, A., Isherwood, C., Bell, J. D., Thomas, E. L., Frost, G., Umpleby, M. and Griffin, B. A. 2011. Impact of liver fat on the response of plasma triacylglycerol to diets high and low in extrinsic sugars. Proceedings of the Nutrition Society. 70 (Issue OCE6: Winter Meeting, 6–7 December 2011, 70th Anniversary: Body weight regulation – food, gut and brain signalling) E364. https://doi.org/10.1017/s0029665111004496

2010

Estimation of abdominal fat compartments by bioelectrical impedance: the validity of the ViScan measurement system in comparison with MRI
Thomas, E.L., Collins, A.L., McCarthy, J., Fitzpatrick, J., Durighel, G., Goldstone, A.P. and Bell, J.D. 2010. Estimation of abdominal fat compartments by bioelectrical impedance: the validity of the ViScan measurement system in comparison with MRI. European Journal of Clinical Nutrition. 64, pp. 525-533. https://doi.org/10.1038/ejcn.2010.18

2010

Proton magnetic resonance spectroscopy and ultrasound for hepatic fat quantification
Mehta, S.R., Thomas, E.L., Patel, N., Crofton, M.E., McCarthy, J., Eliahoo, J., Morin, S.H.X., Fitzpatrick, J., Durighel, G., Goldstone, A.P., Johnston, D.G., Bell, J.D. and Taylor-Robinson, S.D. 2010. Proton magnetic resonance spectroscopy and ultrasound for hepatic fat quantification. Hepatology Research. 40 (4), pp. 399-406. https://doi.org/10.1111/j.1872-034X.2009.00620.x

2010

Reduction of total lung capacity in obese men: comparison of total intrathoracic and gas volumes
Watson, R.A., Pride, N.B., Thomas, E.L., Fitzpatrick, J., Durighel, G., McCarthy, J., Morin, S.H.X., Ind, P.W. and Bell, J.D. 2010. Reduction of total lung capacity in obese men: comparison of total intrathoracic and gas volumes. Journal of Applied Physiology. 108 (6), pp. 1605-1612. https://doi.org/10.1152/japplphysiol.01267.2009

2010

Resistant starch improves insulin sensitivity in metabolic syndrome
Johnston, K.L., Thomas, E.L., Bell, J.D., Frost, G.S. and Robertson, M.D. 2010. Resistant starch improves insulin sensitivity in metabolic syndrome. Diabetic Medicine. 27 (4), pp. 391-397. https://doi.org/10.1111/j.1464-5491.2010.02923.x

2009

Fat distribution in men of different waist girth, fitness level and exercise habit
O'Donovan, G., Thomas, E.L., McCarthy, J., Fitzpatrick, J., Durighel, G., Mehta, S.R., Morin, S.H.X., Goldstone, A.P. and Bell, J.D. 2009. Fat distribution in men of different waist girth, fitness level and exercise habit. International Journal of Obesity. 33 (12), pp. 1356-1362. https://doi.org/10.1038/ijo.2009.189

2009

Whole body magnetic resonance imaging of healthy newborn infants demonstrates increased central adiposity in Asian Indians
Modi, N., Thomas, E.L., Uthaya, S.N., Umranikar, S., Bell, J.D. and Yajnik, C. 2009. Whole body magnetic resonance imaging of healthy newborn infants demonstrates increased central adiposity in Asian Indians. Paediatric Research. 65 (5), pp. 584-587. https://doi.org/10.1203/PDR.0b013e31819d98be

2009

Incidental findings in healthy control research subjects using whole-body MRI
Morin, S.H.X., Cobbold, J.F.L., Lim, A.K.P., Eliahoo, J., Thomas, E.L., Mehta, S.R., Durighel, G., Fitzpatrick, J., Bell, J.D. and Taylor-Robinson, S.D. 2009. Incidental findings in healthy control research subjects using whole-body MRI. European Journal of Radiology. 72 (3), pp. 529-533. https://doi.org/10.1016/j.ejrad.2008.08.006

2009

Obesity, diabetes and longevity in the Gulf: is there a Gulf metabolic syndrome?
Guy, G.W., Nunn, A.V.W., Thomas, E.L. and Bell, J.D. 2009. Obesity, diabetes and longevity in the Gulf: is there a Gulf metabolic syndrome? International Journal of Diabetes Mellitus. 1 (1), pp. 43-54. https://doi.org/10.1016/j.ijdm.2009.05.001

2009

Lean Body Mass is Reduced in Preterm Infants at Term Age
Vasu, V., Thomas, E.L., Durighel, G., Uthaya, S., Bell, J.D. and Modi, N. 2009. Lean Body Mass is Reduced in Preterm Infants at Term Age. Acta Paediatrica. 98 (s460). https://doi.org/10.1111/j.1651-2227.2009.01482_1.x

2008

Neonatal intrahepatocellular lipid
Thomas, E.L., Uthaya, S.N., Vasu, V., McCarthy, J., McEwan, P., Hamilton, G., Bell, J.D. and Modi, N. 2008. Neonatal intrahepatocellular lipid. Archives of Disease in Childhood. Fetal and Neonatal Edition. 93 (5), pp. F382-F383. https://doi.org/10.1136/adc.2007.127431

2008

Non-invasive means of measuring hepatic fat content
Mehta, S.R., Thomas, E.L., Bell, J.D., Johnston, D.G. and Taylor-Robinson, S.D. 2008. Non-invasive means of measuring hepatic fat content. World Journal of Gastroenterology. 14 (22), pp. 3476-3483. https://doi.org/10.3748/wjg.14.3476

2008

Intra-Hepatic Insulin Exposure is Increased in Subjects with Non-Alcoholic Fatty Liver Disease (NAFLD)
Mehta, S.R., Godsland, I.F., Bell, J.D., Thomas, E.L., McCarthy, J., Durighel, G., Fitzpatrick, J., Taylor-Robinson, S.D. and Johnston, D.G. 2008. Intra-Hepatic Insulin Exposure is Increased in Subjects with Non-Alcoholic Fatty Liver Disease (NAFLD). Atherosclerosis Supplements. 9 (1), p. 121. https://doi.org/10.1016/s1567-5688(08)70487-2

2008

Intra-hepatic insulin exposure but not percent extraction of newly-secreted insulin is increased in subjects with non-alcoholic fatty liver disease (NAFLD)
Mehta, S.R., Godsland, I.F., Barton, N., Bell, J.D., Thomas, E.L., Fitzpatrick, J., Durighel, G., McCarthy, J., Taylor-Robinson, S.D. and Johnston, D.G. 2008. Intra-hepatic insulin exposure but not percent extraction of newly-secreted insulin is increased in subjects with non-alcoholic fatty liver disease (NAFLD). Diabetic Medicine. 25 (s1) A64. https://doi.org/10.1111/j.1464-5491.2008.02389.x

2007

Pioglitazone added to conventional lipid lowering treatment in familial combined hyperlipidaemia improves parameters of metabolic control: relation to liver, muscle and regional body fat content
Thomas, E.L., Potter, E., Tosi, I., Fitzpatrick, J., Hamilton, G., Amber, V., Hughs, R., North, C., Holvoet, P., Seed, M., Betteridge, D.J., Bell, J.D. and Naoumova, R.P. 2007. Pioglitazone added to conventional lipid lowering treatment in familial combined hyperlipidaemia improves parameters of metabolic control: relation to liver, muscle and regional body fat content. Atherosclerosis. 195 (1), pp. e181-e190. https://doi.org/10.1016/j.atherosclerosis.2007.03.043

2007

Creatine supplements in patients with idiopathic inflammatory myopathies who are clinically weak after conventional pharmacologic treatment: Six-month, double-blind, randomized, placebo-controlled trial
Chung, Y.L., Alexanderson, H., Pipitone, N., Morrison, C., Dastmalchi, M., Ståhl-Hallengren, C., Richards, S., Thomas, E.L., Hamilton, G., Bell, J.D., Lundberg, I.E. and Scott, D.L. 2007. Creatine supplements in patients with idiopathic inflammatory myopathies who are clinically weak after conventional pharmacologic treatment: Six-month, double-blind, randomized, placebo-controlled trial. Arthritis & Rheumatism. 57 (4), pp. 694-702. https://doi.org/10.1002/art.22687

2007

Exercise training reduces fatty acid availability and improves the insulin sensitivity of glucose metabolism
Shojaee-Moradie, F., Baynes, K.C.R., Pentecost, C., Bell, J.D., Thomas, E.L., Jackson, N.C., Stolinski, M., Whyte, M., Lovell, D., Bowes, S.B., Gibney, J., Jones, R.H. and Umpleby, A.M. 2007. Exercise training reduces fatty acid availability and improves the insulin sensitivity of glucose metabolism. Diabetologia. 50 (2), pp. 404-413. https://doi.org/10.1007/s00125-006-0498-7

2007

Exploratory, randomised, double-blind, controlled trial of breast milk fortifier containing long chain polyunsaturated fatty acids (LCPUFA) in pre term (PT) infants: effects on term body composition
Uthaya, S., Buckley, E., McEwan, P., Thomas, E.L., Bell, J.D. and Modi, N. 2007. Exploratory, randomised, double-blind, controlled trial of breast milk fortifier containing long chain polyunsaturated fatty acids (LCPUFA) in pre term (PT) infants: effects on term body composition. Acta Paediatrica. 96.

2007

Relationship between intrahepatocellular lipid content and features of the metabolic syndrome in subjects with known nonalcoholic fatty liver disease and healthy volunteers
Mehta, S.R., Godsland, I.F., Thomas, E.L., Bell, J.D., Patel, N., Fitzpatrick, J., Durighel, G., Westerland, O., Anyakou, U., Pavitt, D., Taylor-Robinson, S.D. and Johnston, D.G. 2007. Relationship between intrahepatocellular lipid content and features of the metabolic syndrome in subjects with known nonalcoholic fatty liver disease and healthy volunteers. Diabetic Medicine. 24 (s1).

2006

Critical role for peptide YY in protein-mediated satiation and body-weight regulation
Batterham, R.L., Heffron, H., Kapoor, S., Chivers, J.E., Chandarana, K., Herzog, H., le Roux, C.W., Thomas, E.L., Bell, J.D. and Withers, D.J. 2006. Critical role for peptide YY in protein-mediated satiation and body-weight regulation. Cell Metabolism. 4 (3), pp. 223-233. https://doi.org/10.1016/j.cmet.2006.08.001

2006

Effect of nutritional counselling on hepatic, muscle and adipose tissue fat content and distribution in non-alcoholic fatty liver disease
Thomas, E.L., Brynes, A.E., Hamilton, G., Patel, N., Spong, A., Goldin, R.D., Frost, G.S., Bell, J.D. and Taylor-Robinson, S.D. 2006. Effect of nutritional counselling on hepatic, muscle and adipose tissue fat content and distribution in non-alcoholic fatty liver disease. World Journal of Gastroenterology. 12 (36), pp. 5813-5819. https://doi.org/10.3748/wjg.v12.i36.5813

2006

Determinants of adiposity during preweaning postnatal growth in appropriately grown and growth-restricted term infants
Modi, N., Thomas, E.L., Harrington, T.A.M., Uthaya, S.N., Doré, C.J. and Bell, J.D. 2006. Determinants of adiposity during preweaning postnatal growth in appropriately grown and growth-restricted term infants. Pediatric Research. 60 (3), pp. 345-348. https://doi.org/10.1203/01.pdr.0000232732.93000.52

2006

Intra-cellular fat accumulation: mechanisms and implications for health
Thomas, E.L. and Bell, J.D. 2006. Intra-cellular fat accumulation: mechanisms and implications for health. International Journal of Body Composition Research. 4 (1), pp. 27-37.

2006

Are ethnic differences in body composition present at birth?
McEwan, Peter, Uthaya, Sabita, Thomas, E. Louise, Bell, Jimmy and Modi, Neena 2006. Are ethnic differences in body composition present at birth? Early Human Development. 82 (9), p. 618. https://doi.org/10.1016/j.earlhumdev.2006.05.002

2005

Excess visceral and hepatic adipose tissue in Turner syndrome determined by magnetic resonance imaging: estrogen deficiency associated with hepatic adipose content
Ostberg, J.E., Thomas, E.L., Hamilton, G., Attar, M.J.H., Bell, J.D. and Conway, G.S. 2005. Excess visceral and hepatic adipose tissue in Turner syndrome determined by magnetic resonance imaging: estrogen deficiency associated with hepatic adipose content. Journal of Clinical Endocrinology and Metabolism. 90 (5), pp. 2631-2635. https://doi.org/10.1210/jc.2004-1939

2005

Altered adiposity after extremely preterm birth
Uthaya, S.N., Thomas, E.L., Hamilton, G., Doré, C.J., Bell, J.D. and Modi, N. 2005. Altered adiposity after extremely preterm birth. Pediatric Research. 57 (2), pp. 211-215. https://doi.org/10.1203/01.PDR.0000148284.58934.1C

2005

Preterm infants at term show increased intrahepatocellular lipid content on proton magnetic resonance spectroscopy
Uthaya, S., Thomas, E.L., Hamilton, G, Bell, J.D. and Modi, N. 2005. Preterm infants at term show increased intrahepatocellular lipid content on proton magnetic resonance spectroscopy. Pediatric Research. 58 (2), p. 420. https://doi.org/10.1203/00006450-200508000-00412

2004

Elevated fasting plasma ghrelin in Prader-Willi Syndrome adults is not solely explained by their reduced visceral adiposity and insulin resistance
Goldstone, A.P., Thomas, E.L., Brynes, A.E., Castroman, G., Edwards, R., Ghatei, M.A., Frost, G.S., Holland, A., Grossman, A.B., Korbonits, M., Bloom, S.R. and Bell, J.D. 2004. Elevated fasting plasma ghrelin in Prader-Willi Syndrome adults is not solely explained by their reduced visceral adiposity and insulin resistance. Journal of Clinical Endocrinology and Metabolism. 89 (4), pp. 1718-1726. https://doi.org/10.1210/jc.2003-031118

2004

Distribution of adipose tissue in the newborn
Harrington, T.A.M., Thomas, E.L., Modi, N., Frost, G.S. and Bell, J.D. 2004. Distribution of adipose tissue in the newborn. Pediatric Research. 55 (3), pp. 437-441. https://doi.org/10.1203/01.PDR.0000111202.29433.2D

2004

Determinants of altered adipose tissue deposition in preterm infants at term
Uthaya, S., Thomas, E.L., Bell, J.D. and Modi, N. 2004. Determinants of altered adipose tissue deposition in preterm infants at term. Pediatric Research. 56, p. 507. https://doi.org/10.1203/00006450-200409000-00281

2004

The effect of long term exercise on intrahepatic lipid and the insulin sensitivity of glucose and fatty acid metabolism in sedentary male subjects
Shojaee-Moradie, F., Baynes, K., Pentecost, C., Bell, J.D., Thomas, E.L., Jackson, N.C., Jackson, N.C., Stolinski, M., Whyte, M., Jones, R.H. and Umpleby, A.M. 2004. The effect of long term exercise on intrahepatic lipid and the insulin sensitivity of glucose and fatty acid metabolism in sedentary male subjects. Diabetologia. 47 (Supplement 1), p. A245. https://doi.org/10.1007/BF03375463

2003

Human metabolic syndrome resulting from dominant-negative mutations in the nuclear receptor peroxisome proliferator-activated receptor-γ
Savage, D.B., Tan, G.D., Acerini, C.L., Jebb, S.A., Agostini, M., Gurnell, M., Williams, R.L., Umpleby, A.M., Thomas, E.L., Bell, J.D., Dixon, A.K., Dunne, F., Boiani, R., Cinti, S., Vidal-Puig, A., Karpe, F., Chatterjee, V.K.K. and O'Rahilly, S. 2003. Human metabolic syndrome resulting from dominant-negative mutations in the nuclear receptor peroxisome proliferator-activated receptor-γ. Diabetes. 52 (4), p. 910. https://doi.org/10.2337/diabetes.52.4.910

2003

Carbohydrate-induced manipulation of insulin sensitivity independently of intramyocellular lipids
Goff, L.M., Frost, G.S., Hamilton, G., Thomas, E.L., Dhillo, W.S., Dornhorst, A. and Bell, J.D. 2003. Carbohydrate-induced manipulation of insulin sensitivity independently of intramyocellular lipids. British Journal of Nutrition. 89 (3), pp. 365-375. https://doi.org/10.1079/BJN2002789

2003

Influence of undersampling on magnetic resonance imaging measurements of intra-abdominal adipose tissue
Thomas, E.L. and Bell, J.D. 2003. Influence of undersampling on magnetic resonance imaging measurements of intra-abdominal adipose tissue. International Journal of Obesity. 27 (2), pp. 211-218. https://doi.org/10.1038/sj.ijo.802229

2003

Altered deposition of adipose tissue after extremely preterm birth
Uthaya, S., Thomas, E.L., Harrington, T.A.M., Bell, J.D. and Modi, N. 2003. Altered deposition of adipose tissue after extremely preterm birth. Pediatric Research. 54 (4), p. 570.

2002

Letter: Digenic inheritance of severe insulin resistance in a human pedigree
Savage, D.B., Agostini, M., Barroso, I., Gurnell, M., Luan, J.A., Meirhaeghe, A., Harding, A.H., Ihrke, G., Rajanayagam, O., Soos, M.A., George, S., Birger, D., Thomas, E.L., Bell, J.D., Meera, K., Ross, R.J., Vidal-Puig, A., Wareham, N.J., O'Rahilly, S., Chatterjee, V.K.K. and Schafer, A.J. 2002. Letter: Digenic inheritance of severe insulin resistance in a human pedigree. Nature Genetics. 31 (4), pp. 379-384. https://doi.org/10.1038/ng926

2002

Fast and reproducible method for the direct quantitation of adipose tissue in newborn infants
Harrington, T.A.M., Thomas, E.L., Modi, N., Frost, G.S., Coutts, G.A. and Bell, J.D. 2002. Fast and reproducible method for the direct quantitation of adipose tissue in newborn infants. Lipids. 37 (1), pp. 95-100. https://doi.org/10.1007/s11745-002-0868-4

2002

Resting metabolic rate, plasma leptin concentrations, leptin receptor expression, and adipose tissue measured by whole-body magnetic resonance imaging in women with Prader-Willi syndrome
Goldstone, A.P., Brynes, A.E., Thomas, E.L., Bell, J.D., Frost, G.S., Holland, A., Ghatei, M.A. and Bloom, S.R. 2002. Resting metabolic rate, plasma leptin concentrations, leptin receptor expression, and adipose tissue measured by whole-body magnetic resonance imaging in women with Prader-Willi syndrome. American Journal of Clinical Nutition. 75 (3), pp. 468-475. https://doi.org/10.1093/ajcn/75.3.468

2001

Visceral adipose tissue and metabolic complications of obesity are reduced in Prader-Willi syndrome female adults: evidence for novel influences on body fat distribution
Goldstone, A.P., Thomas, E.L., Brynes, A.E., Bell, J.D., Frost, G.S., Saeed, N., Hajnal, J.V., Howard, J.K., Holland, A. and Bloom, S.R. 2001. Visceral adipose tissue and metabolic complications of obesity are reduced in Prader-Willi syndrome female adults: evidence for novel influences on body fat distribution. Journal of Clinical Endocrinology and Metabolism. 86 (9), pp. 4330-4338. https://doi.org/10.1210/jc.86.9.4330

2000

In vivo evaluation of the effects of continuous exercise on skeletal muscle triglycerides in trained humans
Rico-Sanz, J., Moosavi, M., Thomas, E.L., McCarthy, J., Coutts, G.A., Saeed, N. and Bell, J.D. 2000. In vivo evaluation of the effects of continuous exercise on skeletal muscle triglycerides in trained humans. Lipids. 35 (12), pp. 1313-1315. https://doi.org/10.1007/s11745-000-0647-2

2000

Preferential loss of visceral fat following aerobic exercise, measured by magnetic resonance imaging
Thomas, E.L., Brynes, A.E., McCarthy, J., Goldstone, A.P., Hajnal, J.V., Saeed, N., Frost, G.S. and Bell, J.D. 2000. Preferential loss of visceral fat following aerobic exercise, measured by magnetic resonance imaging. Lipids. 35 (7), pp. 769-776. https://doi.org/10.1007/s11745-000-0584-0

1999

Angiotensin-converting-enzyme gene insertion/deletion polymorphism and response to physical training
Montgomery, H., Clarkson, P., Barnard, M.L., Bell, J.D., Brynes, A.E., Hajnal, J.V., Hemingway, H., Mercer, D., Jarman, P., Marshall, R., Prasad, K., Rayson, M., Saeed, N., Thomas, E.L., Jubb, M., World, M., Dollery, C., Talmud, P. and Humphries, S.E. 1999. Angiotensin-converting-enzyme gene insertion/deletion polymorphism and response to physical training. The Lancet. 353 (9152), pp. 541-545. https://doi.org/10.1016/S0140-6736(98)07131-1

1999

Diversity in levels of intracellular total creatine and triglycerides in human skeletal muscles observed by 1H-MRS
Rico-Sanz, J., Thomas, E.L., Jenkinson, G., Mierisová, Ŝ., Iles, R.A. and Bell, J.D. 1999. Diversity in levels of intracellular total creatine and triglycerides in human skeletal muscles observed by 1H-MRS. Journal of Applied Physiology. 87 (6), pp. 2068-2072. https://doi.org/10.1152/jappl.1999.87.6.2068

1999

Relation of triglyceride stores in skeletal muscle cells to central obesity and insulin sensitivity in European and South Asian men
Forouhi, N.G., Jenkinson, G., Thomas, E.L., Mullick, S., Mierisová, Ŝ., Bhonsle, U., McKeigue, P.M. and Bell, J.D. 1999. Relation of triglyceride stores in skeletal muscle cells to central obesity and insulin sensitivity in European and South Asian men. Diabetologia. 42 (8), pp. 932-935. https://doi.org/10.1007/s001250051250

1998

Magnetic resonance imaging of total body fat
Thomas, E.L., Saeed, N., Hajnal, J.V., Brynes, A.E., Goldstone, A.P., Frost, G.S. and Bell, J.D. 1998. Magnetic resonance imaging of total body fat. Journal of Applied Physiology. 85 (5), pp. 1778-1785.

1998

Critical assessment of in vivo13C NMR spectroscopy and gas–liquid chromatography in the study of adipose tissue composition
Thomas, E.L., Cunnane, S.C. and Bell, J.D. 1998. Critical assessment of in vivo13C NMR spectroscopy and gas–liquid chromatography in the study of adipose tissue composition. NMR in Biomedicine. 11 (6), pp. 290-296. https://doi.org/10.1002/(SICI)1099-1492(199810)11:6<290::AID-NBM524>3.0.CO;2-N

1998

Intracellular and extracellular skeletal muscle triglyceride metabolism during alternating intensity exercise in humans
Rico-Sanz, J., Hajnal, J.V., Thomas, E.L., Mierisová, Ŝ., Ala-Korpela, M. and Bell, J.D. 1998. Intracellular and extracellular skeletal muscle triglyceride metabolism during alternating intensity exercise in humans. Journal of Physiology. 510 (2), pp. 615-622. https://doi.org/10.1111/j.1469-7793.1998.615bk.x

1998

Human gene for physical performance
Montgomery, H., Marshall, R., Hemingway, H., Myerson, S., Clarkson, P., Dollery, C., Hayward, M., Holliman, D.E., Jubb, M., World, M., Thomas, E.L., Brynes, A.E., Saeed, N., Barnard, M.L., Bell, J.D., Prasad, K., Rayson, M., Talmud, P. and Humphries, S.E. 1998. Human gene for physical performance. Nature. 393 (6682), pp. 221-222. https://doi.org/10.1038/30374

1997

In vivo assessment of metabolic perturbations following alanine and glucagon administration using 31P-MRS in the rat
Changani, K.K., Barnard, M.L., Bell, J.D., Thomas, E.L., Williams, S.C.R., Bloom, S.R. and Iles, R.A. 1997. In vivo assessment of metabolic perturbations following alanine and glucagon administration using 31P-MRS in the rat. Biochimica et Biophysica Acta: general subjects. 1335 (3), pp. 290-304. https://doi.org/10.1016/S0304-4165(96)00148-1

1997

Noninvasive characterization of neonatal adipose tissue by 13C magnetic resonance spectroscopy
Thomas, E.L., Hanrahan, J.D., Ala-Korpela, M., Jenkinson, G., Azzopardi, D., Iles, R.A. and Bell, J.D. 1997. Noninvasive characterization of neonatal adipose tissue by 13C magnetic resonance spectroscopy. Lipids. 32 (6), pp. 645-651. https://doi.org/10.1007/s11745-997-0082-4

1997

Changes in adipose tissue composition in malnourished patients before and after liver transplantation: A carbon-13 magnetic resonance spectroscopy and gas-liquid chromatography study
Thomas, E.L., Taylor-Robinson, S.D., Barnard, M.L., Frost, G.S., Sargentoni, J., Davidson, B.R., Cunnane, S.C. and Bell, J.D. 1997. Changes in adipose tissue composition in malnourished patients before and after liver transplantation: A carbon-13 magnetic resonance spectroscopy and gas-liquid chromatography study. Hepatology. 25 (1), pp. 178-183. https://doi.org/10.1002/hep.510250133

1996

Effects of n-3 fatty acids on the NMR profile of plasma lipoproteins
Bell, J.D., Barnard, M.L., Parkes, H.G., Thomas, E.L., Brennan, C.H., Cunnane, S.C. and Dagnelie, P.C. 1996. Effects of n-3 fatty acids on the NMR profile of plasma lipoproteins. The Journal of Lipid Research. 37 (8), pp. 1664-1674.

1996

Development of a rapid and efficient magnetic resonance imaging technique for analysis of body fat distribution
Barnard, M.L., Schwieso, J.E., Thomas, E.L., Bell, J.D., Saeed, N., Frost, G.S., Bloom, S.R. and Hajnal, J.V. 1996. Development of a rapid and efficient magnetic resonance imaging technique for analysis of body fat distribution. NMR in Biomedicine. 9 (4), pp. 156-164. https://doi.org/10.1002/(SICI)1099-1492(199606)9:4<156::AID-NBM412>3.0.CO;2-B

1996

Automated feature extraction for the classification of human in vivo13C NMR spectra using statistical pattern recognition and wavelets
Tate, A.R., Watson, D., Eglen, S., Arvanitis, T.N., Thomas, E.L. and Bell, J.D. 1996. Automated feature extraction for the classification of human in vivo13C NMR spectra using statistical pattern recognition and wavelets. Magnetic Resonance in Medicine. 35 (6), pp. 834-840. https://doi.org/10.1002/mrm.1910350608

1995

Cirrhosis of the human liver: an in vitro 31P nuclear magnetic resonance study
Taylor-Robinson, S.D., Thomas, E.L., Sargentoni, J., Marcus, C.D., Davidson, B.R. and Bell, J.D. 1995. Cirrhosis of the human liver: an in vitro 31P nuclear magnetic resonance study. Biochimica et Biophysica Acta: Molecular Basis of Disease. 1272 (2), pp. 113-118. https://doi.org/10.1016/0925-4439(95)00074-E

2021

Mass Univariate Regression Analysis for Three-Dimensional Liver Image-Derived Phenotypes
Thanaj, M., Basty, N., Liu, Y., Cule, M., Sorokin, E., Thomas, E.L., Bell, J.D. and Whitcher, B. 2021. Mass Univariate Regression Analysis for Three-Dimensional Liver Image-Derived Phenotypes. Annual Conference on Medical Image Understanding and Analysis. University of Oxford 12 - 14 Jul 2021 Springer. https://doi.org/10.1007/978-3-030-80432-9_13

2021

3D Deep Learning for Anatomical Structure Segmentation in Multiple Imaging Modalities
Villarini, B., Asaturyan, H., Kurugol, S., Afacan, O., Bell, J.D. and Thomas, E.L. 2021. 3D Deep Learning for Anatomical Structure Segmentation in Multiple Imaging Modalities. O'Conner, L. (ed.) 34th IEEE CBMS International Symposium on Computer-Based Medical Systems. Online Event 07 - 09 Jun 2021 IEEE . https://doi.org/10.1109/CBMS52027.2021.00066

2020

Automated Measurement of Pancreatic Fat and Iron Concentration Using Multi-Echo and T1-Weghted MRI Data
Basty, N., Liu, Y., Cule, M., Thomas, E.L., Bell, J.D. and Whitcher, B. 2020. Automated Measurement of Pancreatic Fat and Iron Concentration Using Multi-Echo and T1-Weghted MRI Data. International Symposium on Biomedical Imaging 2020. Iowa City, USA 03 - 07 Apr 2020 IEEE . https://doi.org/10.1109/ISBI45749.2020.9098650

2019

Advancing Pancreas Segmentation in Multi-protocol MRI Volumes using Hausdorff-Sine Loss Function
Asaturyan, H., Thomas, E.L., Fitzpatrick, J., Bell, J.D. and Villarini, B. 2019. Advancing Pancreas Segmentation in Multi-protocol MRI Volumes using Hausdorff-Sine Loss Function. 10th International Workshop on Machine Learning in Medical Imaging (MLMI 2019) in conjunction with MICCAI 2019. Shenzen, China 13 Oct 2019 Springer. https://doi.org/10.1007/978-3-030-32692-0_4

2019

Machine Learning Classification of Females Susceptibility to Visceral Fat Associated Diseases
Aldraimli, M., Soria, D., Parkinson, J., Whitcher, B., Thomas, E.L., Bell, J.D., Chaussalet, T.J. and Dwek, M. 2019. Machine Learning Classification of Females Susceptibility to Visceral Fat Associated Diseases. MEDICON 2019: XV Mediterranean Conference on Medical and Biological Engineering and Computing. Coimbra, Portugal 26 - 28 Sep 2019 Springer. https://doi.org/10.1007/978-3-030-31635-8_81

2017

A Framework for Morphological Feature Extraction of Organs from MR Images for Detection and Classification of Abnormalities
Villarini, B., Asaturyan, H., Thomas, E.L., Mould, R. and Bell, J.D. 2017. A Framework for Morphological Feature Extraction of Organs from MR Images for Detection and Classification of Abnormalities. Proceedings of the 30th IEEE International Symposium on Computer-Based Medical Systems (CBMS’17). Thessaloniki, Greece 22 - 24 Jun 2017 IEEE . https://doi.org/10.1109/CBMS.2017.49

2013

Metabolic syndrome, overweight and fatty liver
Thomas, E.L., Fitzpatrick, J., Frost, G.S. and Bell, J.D. 2013. Metabolic syndrome, overweight and fatty liver. in: Berdanier, C.D., Dwyer, J.T. and Heber, D. (ed.) Handbook of nutrition and food, 3rd edition Boca Raton CRC Press. pp. 763-768

2003

Hypothalamic neuropeptides and regulation of fat mass in Prader-Willi syndrome
Goldstone, A.P., Unmehopa, U.A., Thomas, E.L., Brynes, A.E., Bell, J.D., Frost, G.S., Ghatei, M.A., Holland, A., Bloom, S.R. and Swaab, D.F. 2003. Hypothalamic neuropeptides and regulation of fat mass in Prader-Willi syndrome. in: Eiholzer, U., l’Allemand, D. and Zipf, W.B. (ed.) Prader-Willi syndrome as a model for obesity: international symposium, Zurich, October 18-19, 2002 Karger Medical and Scientific Publishers. pp. 31-43

1999

Body fat metabolism: observation by MR imaging and spectroscopy
Thomas, E.L. and Bell, J.D. 1999. Body fat metabolism: observation by MR imaging and spectroscopy. in: Young, I.R. (ed.) Magnetic resonance imaging and spectroscopy in medicine and biology Wiley.

1999

Magnetic resonance: in-vivo NMR, applications – other nuclei
Bell, J.D., Thomas, E.L. and Changani, K.K. 1999. Magnetic resonance: in-vivo NMR, applications – other nuclei. in: Lindon, J. (ed.) Encyclopedia of spectroscopy and spectrometry London Academic Press.

2024

Preprint: MRI assessment of adipose tissue fatty acid composition in the UK Biobank and its association with diet and disease
Marjola Thanaj, Nicolas Basty, Brandon Whitcher, Jimmy D. Bell and E. Louise Thomas 2024. Preprint: MRI assessment of adipose tissue fatty acid composition in the UK Biobank and its association with diet and disease. medRxiv. https://doi.org/10.1101/2024.03.27.24304957

2023

Preprint: Kidney Shape Statistical Analysis: Associations with Disease and Anthropometric Factors
Thanaj, M., Basty, N., Cule, M., Sorokin, E., Whitcher, B., Srinivasan, R., Lennon, R., Bell, J.D. and Thomas, E.L. 2023. Preprint: Kidney Shape Statistical Analysis: Associations with Disease and Anthropometric Factors. medRxiv. https://doi.org/10.1101/2023.06.26.23291901

2023

Preprint: Precision MRI phenotyping of muscle volume and quality at a population scale
Marjola Thanaj, Nicolas Basty, Brandon Whitcher, Elena P. Sorokin, Yi Liu, Ramprakash Srinivasan, Madeleine Cule, E. Louise Thomas and Jimmy D. Bell 2023. Preprint: Precision MRI phenotyping of muscle volume and quality at a population scale. medRxiv. https://doi.org/10.1101/2023.03.02.23286689

2023

Preprint: Cardiovascular measures from abdominal MRI provide insights into abdominal vessel genetic architecture
Nicolas Basty, Elena P. Sorokin, Marjola Thanaj, Brandon Whitcher, Yi Liu, Jimmy D. Bell, E. Louise Thomas and Madeleine Cule 2023. Preprint: Cardiovascular measures from abdominal MRI provide insights into abdominal vessel genetic architecture. medRxiv. https://doi.org/10.1101/2022.08.02.22278060

2023

Preprint: Liver Shape Analysis using Statistical Parametric Maps at Population Scale
Thanaj, M., Basty, N., Cule, M., Sorokin, E.P., Whitcher, B., Bell, J.D. and Thomas, E.L. 2023. Preprint: Liver Shape Analysis using Statistical Parametric Maps at Population Scale. medRxiv. https://doi.org/10.1101/2022.08.18.22278951

2021

Preprint: Swap-Free Fat-Water Separation in Dixon MRI using Conditional Generative Adversarial Networks
Basty, Nicolas, Thanaj, Marjola, Cule, Madeleine, Sorokin, Elena, Liu, Yi, Bell, Jimmy D., Thomas, E. Louise and Whitcher, Brandon 2021. Preprint: Swap-Free Fat-Water Separation in Dixon MRI using Conditional Generative Adversarial Networks. arXiv. https://doi.org/10.48550/arXiv.2107.14175

2021

Preprint: Body fat volumes and distribution in chronic schizophrenia compared to healthy controls; a cross-sectional MR study
Osimo, E.F., Brugger, S.P., Thomas, E.L. and Howes, O.D. 2021. Preprint: Body fat volumes and distribution in chronic schizophrenia compared to healthy controls; a cross-sectional MR study. medRxiv. https://doi.org/10.1101/2021.09.20.21263820

2021

Preprint: Using genetics to uncouple higher adiposity from its adverse metabolic effects and understand its role in metabolic and non-metabolic disease
Hanieh Yaghootkar, Susan Martin, Jessica Tyrrell, Elizabeth Thomas, Matthew Bown, Andrew Wood, Robin Beaumont, Lam Tsoi, Philip E Stuart, James Elder, Philip Law, Richard Houlston, Christopher Kabrhel, Nikos Papadimitriou, Marc Gunter, Caroline Bull, Joshua Bell, Emma Vincent, Naveed Sattar, Jimmy Bell and Timothy Frayling 2021. Preprint: Using genetics to uncouple higher adiposity from its adverse metabolic effects and understand its role in metabolic and non-metabolic disease. Research Square. https://doi.org/10.21203/rs.3.rs-537397/v1

2020

Preprint: Image Processing and Quality Control for Abdominal Magnetic Resonance Imaging in the UK Biobank
Basty, N., Liu, Yi, Cule, M., Thomas, E. Louise, Bell, J.D. and Whitcher, B. 2020. Preprint: Image Processing and Quality Control for Abdominal Magnetic Resonance Imaging in the UK Biobank. arXiv.

2020

Preprint: Predicting and elucidating the etiology of fatty liver disease using a machine learning-based approach: an IMI DIRECT study
Atabaki-Pasdar, N., Ohlsson, M., Vinuela, A., Frau, F., Pomares-Millan, H., Haid, M., Jones, A. G., Thomas, E. L., Koivula, R. W., Kurbasic, A., Mutie, P. M., Fitipaldi, H., Fernandez, J., Dawed, A. Y., Giordano, G. N., Forgie, I. M., McDonald, T. J., Rutters, F., Cederberg, H., Chabanova, E., Dale, M., Masi, F. D., Thomas, C. E., Allin, K. H., Hansen, T. H., Heggie, A., Hong, M.-G., Elders, P. J., Kennedy, G., Kokkola, T., Pedersen, H. K., Mahajan, A., McEvoy, D., Pattou, F., Raverdy, V., Haussler, R. S., Sharma, S., Thomsen, H. S., Vangipurapu, J., Vestergaard, H., 't Hart, L. M. and Adamski, J. 2020. Preprint: Predicting and elucidating the etiology of fatty liver disease using a machine learning-based approach: an IMI DIRECT study. medRxiv. https://doi.org/10.1101/2020.02.10.20021147


Usage Statistics
31892 total views of outputs
12947 total downloads of outputs
These values cover views and downloads from WestminsterResearch and are for the period from September 2nd 2018, when this repository was created.