Characterization of a monoclonal antibody cocktail for human rabies prophylaxis

Both, L., van Dolleweerd, C., Banyard, A.C., Wright, E., Fooks, A.R. and Ma, J.K.C. 2011. Characterization of a monoclonal antibody cocktail for human rabies prophylaxis. 1. 4th International Conference in Plant-Based Vaccines and Antibodies. Porto, Portugal 2011

TitleCharacterization of a monoclonal antibody cocktail for human rabies prophylaxis
AuthorsBoth, L., van Dolleweerd, C., Banyard, A.C., Wright, E., Fooks, A.R. and Ma, J.K.C.
TypeConference paper
Abstract

Rabies continues to kill many thousands of people throughout the developing world every year. The murine monoclonal antibody (mAb) 62-71-3 was recently identified for its potential application in rabies post-exposure-prophylaxis (PEP). The purpose here was to establish a plant-based production system for a chimeric mouse-human version of mAb 62-71-3, to characterize the recombinant antibody and investigate at a molecular level its interaction with the rabies virus (RV) glycoprotein. The chimeric mAb 62-71-3 was successfully expressed in Nicotiana benthamiana and functionality was analyzed by antigen binding ELISA and by neutralization of a panel of lyssavirus pseudotypes. The antibody-antigen interaction was investigated using pseudotype virus expressing mutagenized RV glycoproteins. A critical role for antigenic site I of the glycoprotein, in particular for two specific amino acid residues, was identified.

Year2011
Conference1. 4th International Conference in Plant-Based Vaccines and Antibodies
Publication dates
Published2011

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