Efficacy Of The Quadrivalent HPV Vaccine In Cervical Cancer Prevention Strategy In The Gambia

Bah Camara, H., Anyanwu, M., Banja, F., Mboob-Suun, K., Ceesay, F., Wright, E. and Kimmitt, P.T. 2017. Efficacy Of The Quadrivalent HPV Vaccine In Cervical Cancer Prevention Strategy In The Gambia. EUROGIN17. Amsterdam 08 - 11 Oct 2017

TitleEfficacy Of The Quadrivalent HPV Vaccine In Cervical Cancer Prevention Strategy In The Gambia
AuthorsBah Camara, H., Anyanwu, M., Banja, F., Mboob-Suun, K., Ceesay, F., Wright, E. and Kimmitt, P.T.
TypeConference poster
Abstract

Background and Objective: Persistent infection with high risk Human Papillomavirus (HR HPV) genotype causes 80% of cervical cancers. HR HPV 16 and 18 are responsible for 70% of cervical cancer cases, worldwide. Three prophylactic HPV vaccines have been developed to prevent HPV infections. In the Gambia, cervical cancer is the most frequent diagnosed cancer representing approximately 30% of all female cancers. The quadrivalent HPV vaccine, which targets genotypes 16,18, 6 and 11 was recently piloted in the West Coast Region where majority of cervical cancer cases were reported. In order to evaluate the potential efficacy of the quadrivalent vaccine, this study assessed regional genotype distribution to ensure the HPV vaccine prevention strategy would be effective in this population.
Methods: 232 endocervical samples were collected from women age 20-49 years old residing in Banjul and West Coast Region. DNA was isolated using the QIAamp DNA Mini Kit (Qiagen). HPV detection was carried out by PCR amplification using primer sets PGMY09/11, which targets the (L1) Major capsid gene of the virus. Genotyping was performed by Sanger sequencing technique.
Results: nine different HR- HPV genotypes were identified. HPV 52 (31%) was the most prevalent HR genotype, followed by 51, 58 and 66(each12.5%). HPV 16 accounts for 6% of the HR-HPV and was the eighth of all HPV genotype identified. HR- HPV 18 was not detected in any of the samples. HR-HPV distribution was higher in the 26-30 age group.HPV 61 was the most common low risk genotype isolated. Sequence analysis showed all HR genotypes detected were not homologous to African isolates but isolates that originated from America, Europe and Asia.
Conclusion: The success of a cervical cancer vaccine prevention strategy should consider the dominant circulating HR HPV type. In the Gambia, the vaccine currently available may be of limited value if the other HR-HPV types are responsible for cytological abnormalities in these women.

Year2017
ConferenceEUROGIN17

Related outputs

Human papillomavirus Genotype Distribution and Co-infection with Sexually Transmitted Pathogens in Reproductive age Women in Urban Gambia
Bah Camara, H. 2018. Human papillomavirus Genotype Distribution and Co-infection with Sexually Transmitted Pathogens in Reproductive age Women in Urban Gambia. PhD thesis University of Westminster Faculty of Science and Technology https://doi.org/10.34737/qx759

Human papilloma virus genotype distribution and risk factor analysis amongst reproductive aged women in urban Gambia
Bah Camara, H., Anyanwu, M., Wright, E. and Kimmitt, P.T. 2018. Human papilloma virus genotype distribution and risk factor analysis amongst reproductive aged women in urban Gambia. Journal of Medical Microbiology. 67, pp. 1645-1654. https://doi.org/10.1099/jmm.0.000848

Human Papillomavirus Sero-prevalence and Sexual Attitudes Amongst a Cohort of HIV Positive Women In The Gambia
Bah Camara, H., Anyanwu, M., Drammeh, J., Njie, A., Mattiuzzo, G., Gillard, L., Wright, E. and Kimmitt, P.T. 2018. Human Papillomavirus Sero-prevalence and Sexual Attitudes Amongst a Cohort of HIV Positive Women In The Gambia. ASM Microbe. Atlanta, Georgia 07 - 11 Jun 2018

Sexually Transmitted Diseases: Time to Revisit the Syndromic Management Approach
Bah Camara, H., Noho, A., Sanyang, A., Wright, E. and Kimmitt, P.T. 2018. Sexually Transmitted Diseases: Time to Revisit the Syndromic Management Approach. ASM Microbe. Atlanta, Georgia 07 - 11 Jun 2018

Gamification in Higher Education: Students and Academics Interest in Gaming
Kimmitt, P.T. 2017. Gamification in Higher Education: Students and Academics Interest in Gaming. 9th Annual International Conference on Education and New Learning Technologies. Barcelona, Spain 03 - 05 Jul 2017 IATED Academy. https://doi.org/10.21125/edulearn.2017.2258

A Preliminary Report: Cervical Human Papilloma Virus Genotype Distribution in Reproductive Aged Women Attending Primary Health Care in Urban Gambia
Bah Camara, H., Mboob -Suun, K., Banja, F., Ceesay, F., Anyanwu, M., Wright, E. and Kimmitt, P.T. 2017. A Preliminary Report: Cervical Human Papilloma Virus Genotype Distribution in Reproductive Aged Women Attending Primary Health Care in Urban Gambia. Microbiology Society Annual Conference 2017. Edinburgh 03 - 06 Apr 2017

Prevalance of Ureaplasma parvum and urealyticum in Urban Gambian Women
Bah Camara, H., Noho, A., Sanyang, A., Barrow, E., Wright, E. and Kimmitt, P.T. 2017. Prevalance of Ureaplasma parvum and urealyticum in Urban Gambian Women. Microbiology Society Annual Conference 2017. Edinburgh 03 - 06 Apr 2017

Planning for the unexpected: Ebola virus, Zika virus, what's next?
Welfare, W. and Wright, E. 2016. Planning for the unexpected: Ebola virus, Zika virus, what's next? British Journal of Hospital Medicine. 77 (12), pp. 704-707. https://doi.org/10.12968/hmed.2016.77.12.704

Ebolavirus pseudotypes as antigen surrogates for serological studies
Bentley, E., Mattiuzzo, G., Wash, R., Binter, S., Friedrich, M., Goulding, D., Kellam, P., Page, M. and Wright, E. 2016. Ebolavirus pseudotypes as antigen surrogates for serological studies. International Journal of Infectious Diseases. 53 (Supplement), p. 123. https://doi.org/10.1016/j.ijid.2016.11.306

Exploiting viral pseudotypes for emerging virus research
Grehan, K., Bentley, E., Mather, S., Kinsley, R., Scott, S.D., Wright, E. and Temperton, N.J. 2016. Exploiting viral pseudotypes for emerging virus research. International Journal of Infectious Diseases. 53 (Supplement), p. 8. https://doi.org/10.1016/j.ijid.2016.11.024

Minimal In Vivo Efficacy of Iminosugars in a Lethal Ebola Virus Guinea Pig Model
Miller, J.L., Spiro, S.G., Dowall, S.D., Taylor, I., Rule, A., Alonzi, D.S., Sayce, A.C., Wright, E., Bentley, E.M., Thom, R., Hall, G., Dwek, R.A., Hewson, R. and Zitzmann, N. 2016. Minimal In Vivo Efficacy of Iminosugars in a Lethal Ebola Virus Guinea Pig Model. PLoS ONE. 11 (11) e0167018. https://doi.org/10.1371/journal.pone.0167018

A monovalent chimpanzee adenovirus Ebola vaccine boosted with MVA
Ewer, K., Rampling, T., Venkatraman, N., Bowyer, G., Wright, D, Lambe, T., Imoukhuede, E.B., Payne, R., Fehling, S.K., Strecker, T., Biedenkopf, N., Krähling, V., Tully, C.M., Edwards, N.J., Bentley, E.M., Samuel, D., Labbé, G., Jin, J., Gibani, M., Minhinnick, A., Wilkie, M., Poulton, I., Lella, N., Roberts, R., Hartnell, F., Bliss, C., Sierra-Davidson, K., Powlson, J., Berrie, E., Tedder, R., Roman, F., De Ryck, I., Nicosia, A., Sullivan, N.J., Stanley, D.A., Mbaya, O.T., Ledgerwood, J.E., Schwartz, R.M., Siani, L., Colloca, S., Folgori, A., Di Marco, S., Cortese, R., Wright, E., Becker, S., Graham, B.S., Koup, R.A., Levine, M.M., Volkmann, A., Chaplin, P., Pollard, A.J., Draper, S.J., Ballou, W.R., Lawrie, A., Gilbert, S.C. and Hill, A.V.S. 2016. A monovalent chimpanzee adenovirus Ebola vaccine boosted with MVA. The New England Journal of Medicine. 374 (17), pp. 1635-1646. https://doi.org/10.1056/NEJMoa1411627

Development of broad-spectrum human monoclonal antibodies for rabies post-exposure prophylaxis
Wright, E., Benedictis Paola, D., Minola, A., Rota Nodari, E., Aiello, R., Zecchin, B., Salomoni, A., Foglierini, M., Agatic, G., Vanzetta, F., Lavenir, R., Lepelletier, A., Bentley, E., Weiss, R.A., Cattoli, G., Capua, I., Sallusto, F., Lanzavecchia, A., Bourhy, H., Corti, D. and De Benedictis, P. 2016. Development of broad-spectrum human monoclonal antibodies for rabies post-exposure prophylaxis. EMBO Molecular Medicine. 8 (4), pp. 407-421. https://doi.org/10.15252/emmm.201505986

Evaluation of the potential for virus dispersal during hand drying: a comparison of three methods
Kimmitt, P.T. and Redway, K. 2016. Evaluation of the potential for virus dispersal during hand drying: a comparison of three methods. Journal of Applied Microbiology. 120 (2), pp. 478-486. https://doi.org/10.1111/jam.13014

Technical considerations for the generation of novel pseudotyped viruses
King, B., Temperton, N.J., Grehan, K., Scott, S.D., Wright, E., Tarr, A.W. and Daly, J.M. 2016. Technical considerations for the generation of novel pseudotyped viruses. Future Virology. 11 (1), pp. 47-59. https://doi.org/10.2217/fvl.15.106

Application of RT-Bst to enhance detection of pathogenic viruses of the respiratory tract
Kabir, M.S., Clements, M.O., Atkins, M. and Kimmitt, P.T. 2015. Application of RT-Bst to enhance detection of pathogenic viruses of the respiratory tract. British Journal of Biomedical Science. 72 (3), pp. 128-134.

Comparison of virus dispersal and aerosolization by different hand-drying devices
Kimmitt, P.T. and Redway, K. 2015. Comparison of virus dispersal and aerosolization by different hand-drying devices. European Public Health Conference. Milan 14 Oct 2015

Retroviral Pseudotypes – From Scientific Tools to Clinical Utility
Wright, E., Temperton, N.J. and Scott, S.D. 2015. Retroviral Pseudotypes – From Scientific Tools to Clinical Utility. in: Encyclopedia of life sciences Chichester Wiley. pp. 1-11

The risk of viral dispersal and aerosolization by different hand-drying methods
Redway, K. and Kimmitt, P.T. 2015. The risk of viral dispersal and aerosolization by different hand-drying methods. 3rd International Conference on Prevention and Infection Control (ICPIC). Geneva 16 Jun 2015

In Vitro Assessment of the Synergy between Polymyxin B (PMB) and Polymyxin B Nonapeptide (PMBN) and Antibiotics on Biofilms from Diabetic Foot Infections
Gyamfi-Brobbey, George, Greenwell, P. and Kimmitt, P.T. 2015. In Vitro Assessment of the Synergy between Polymyxin B (PMB) and Polymyxin B Nonapeptide (PMBN) and Antibiotics on Biofilms from Diabetic Foot Infections. American Society for Microbiology. New Orleans 31 May 2015

F. necrophorum Ecotin Inhibits Human Plasma Kallikrein and Human Neutrophil Elastase
Wright Katie Greenwell Pamela, Greenwell, P. and Kimmitt, P.T. 2015. F. necrophorum Ecotin Inhibits Human Plasma Kallikrein and Human Neutrophil Elastase. American Society for Microbiology. New Orleans 31 May 2015

A quantitative evaluation of three hand drying methods and the potential for dissemination of virus particles into the environment
Kimmitt, P.T. and Redway, K. 2015. A quantitative evaluation of three hand drying methods and the potential for dissemination of virus particles into the environment. Society for General Microbiology. Birmingham 01 Apr 2015

Presence and characterisation of ecotin in F. necrophorum
Wright Katie Greenwell Pamela, Kimmitt, P.T. and Greenwell, P. 2015. Presence and characterisation of ecotin in F. necrophorum. Society for General Microbiology. Birmingham 30 Mar 2015

Comparison of virulence genes found in draft genomes of F. necrophorum
Wright Katie Greenwell Pamela, Kimmitt, P.T. and Greenwell, P. 2015. Comparison of virulence genes found in draft genomes of F. necrophorum. Society for General Microbiology. Birmingham, UK 30 Mar 2015

In vitro study of the effect of wound dressings on planktonic and biofilms from diabetic foot isolates
Omobolanle, Omotosho, Gyamfi-Brobbey, George, Kimmitt, P.T. and Greenwell, P. 2015. In vitro study of the effect of wound dressings on planktonic and biofilms from diabetic foot isolates. Society for General Microbiology. Birmingham 30 Mar 2015

Cinnamaldehyde increases the susceptibility of quorum-sensing-mediated biofilms to conventional antibiotics
Gyamfi-Brobbey, George, Kimmitt, P.T. and Greenwell, P. 2015. Cinnamaldehyde increases the susceptibility of quorum-sensing-mediated biofilms to conventional antibiotics. Society for General Microbiology. Birmingham 30 Mar 2015

The in vitro assessment of the synergistic effects of antibiotics and wound dressings on biofilms from diabetic foot pathogens
Gyamfi-Brobbey, George, Kimmitt, P.T. and Greenwell, P. 2015. The in vitro assessment of the synergistic effects of antibiotics and wound dressings on biofilms from diabetic foot pathogens. Society for General Microbiology. Birmingham 30 Mar 2015

RT-Bst: an integrated approach for reverse transcription and enrichment of cDNA from viral RNA
Kabir, Md. Shahidul, Kimmitt, P.T. and Clements, M.O. 2015. RT-Bst: an integrated approach for reverse transcription and enrichment of cDNA from viral RNA. British Journal of Biomedical Sciences. 72 (1), pp. 1-6.

Antiviral therapies against Ebola and other emerging viral diseases using existing medicines that block virus entry
Long, J., Wright, E., Molesti, E., Temperton, N. and Barclay, W. 2015. Antiviral therapies against Ebola and other emerging viral diseases using existing medicines that block virus entry. F1000Research. 4 (30). https://doi.org/10.12688/f1000research.6085.2

Bat and pig Interferon-Induced Transmembrane Protein 3 restrict cell entry by influenza virus and lyssaviruses
Benfield, C., Smith, S.E., Wright, E., Wash, R.S., Ferrara, F., Temperton, N.J. and Kellam, P. 2015. Bat and pig Interferon-Induced Transmembrane Protein 3 restrict cell entry by influenza virus and lyssaviruses. Journal of General Virology. 96 (5), pp. 991-1005. https://doi.org/10.1099/vir.0.000058

Hand drying method and risk of microbe dissemination: methods and benchmarks
Redway, K. and Kimmitt, P.T. 2014. Hand drying method and risk of microbe dissemination: methods and benchmarks. Hospital Infection Society. Lyon, France 18 Nov 2014

Differing methodologies to measure microbe dispersal during hand drying
Redway, K. and Kimmitt, P.T. 2014. Differing methodologies to measure microbe dispersal during hand drying. Hospital Infection Society. Lyon, France 17 Nov 2014

Demonstration of viral antibodies by pseudotype virus neutralisation
Wright, E. 2014. Demonstration of viral antibodies by pseudotype virus neutralisation. in: Rupprecht, C. and Nagarajan, T. (ed.) Current laboratory techniques in rabies diagnosis, research and prevention Elsevier. pp. 147-156

Multiplex evaluation of influenza neutralizing antibodies with potential applicability to in-field serological studies
Molesti, E., Wright, E., Terregino, C., Rahman, R., Cattoli, G. and Temperton, N.J. 2014. Multiplex evaluation of influenza neutralizing antibodies with potential applicability to in-field serological studies. Journal of Immunology Research. 2014 457932. https://doi.org/10.1155/2014/457932

Lyophilisation of influenza, rabies and Marburg lentiviral pseudotype viruses for the development and distribution of a neutralisation-assay based diagnostic kit
Mather, S., Wright, E., Scott, S. and Temperton, N.J. 2014. Lyophilisation of influenza, rabies and Marburg lentiviral pseudotype viruses for the development and distribution of a neutralisation-assay based diagnostic kit. Journal of Virological Methods. 210, pp. 51-58. https://doi.org/10.1016/j.jviromet.2014.09.021

Current progress with serological assays for exotic emerging/re-emerging viruses
Mather, S., Scott, S., Temperton, N.J., Wright, E., King, B. and Daly, J.M. 2013. Current progress with serological assays for exotic emerging/re-emerging viruses. Future Virology. 8 (8), pp. 745-755. https://doi.org/10.2217/fvl.13.60

Production, characterization, and antigen specificity of recombinant 62-71-3, a candidate monoclonal antibody for rabies prophylaxis in humans
Both, L., van Dolleweerd, C., Wright, E., Banyard, A.C., Bulmer-Thomas, B., Selden, D., Altmann, F., Fooks, A.R. and Ma, J.K.C. 2013. Production, characterization, and antigen specificity of recombinant 62-71-3, a candidate monoclonal antibody for rabies prophylaxis in humans. FASEB Journal. 27 (5), pp. 2055-2065. https://doi.org/10.1096/fj.12-219964

Development of a pseudotype-based neutralisation assay kit for in-field vaccine evaluation and sero-surveillance of highly pathogenic viruses
Temperton, N.J., Mather, S., Scott, S. and Wright, E. 2013. Development of a pseudotype-based neutralisation assay kit for in-field vaccine evaluation and sero-surveillance of highly pathogenic viruses. Influenza 2013: One Influenza, One World, One health. Oxford, UK September 2013

Development of a pseudotype neutralisation assay-based diagnostic kit for in-field vaccine evaluation and serosurveillance for highly pathogenic viruses
Mather, S., Temperton, N.J., Wright, E. and Scott, S. 2013. Development of a pseudotype neutralisation assay-based diagnostic kit for in-field vaccine evaluation and serosurveillance for highly pathogenic viruses. Society For General Microbiology Spring Meeting. Manchester, UK March 2013

Investigating the antibody neutralisation potential of a rabies virus lentiviral pseudotype: an international inter-laboratory trial
Healy, D.M., Horton, D.L., Banyard, A.C., Wright, E., Goddard, T., Evans, J., McElhinney, L.M. and Fooks, A.R. 2013. Investigating the antibody neutralisation potential of a rabies virus lentiviral pseudotype: an international inter-laboratory trial. Society For General Microbiology Spring Meeting. Manchester, UK March 2013

The lyssavirus glycoprotein: how significant are the currently characterised antigenic sites in the induction of neutralising antibodies?
Evans, J., Wright, E., Easton, A., Fooks, A.R. and Banyard, A.C. 2013. The lyssavirus glycoprotein: how significant are the currently characterised antigenic sites in the induction of neutralising antibodies? Society For General Microbiology Spring Meeting. Manchester, UK March 2013

Investigating the functionality and antigenicity of chimeric lyssavirus glycoproteins and their neutralisation profiles
Evans, J., Wright, E., Easton, A., Fooks, A.R. and Banyard, A.C. 2013. Investigating the functionality and antigenicity of chimeric lyssavirus glycoproteins and their neutralisation profiles. 15th International Negative Strand Virus Meeting. Granada, Spain June 2013

Investigating the functionality and antigenicity of chimeric lyssavirus glycoproteins and their neutralisation profiles
Evans, J., Wright, E., Easton, A., Fooks, A.R. and Banyard, A.C. 2013. Investigating the functionality and antigenicity of chimeric lyssavirus glycoproteins and their neutralisation profiles. Pseudotype viruses: applications and troubleshooting. London, UK October 2013

Characterization of a monoclonal antibody cocktail for human rabies prophylaxis
Both, L., van Dolleweerd, C., Banyard, A.C., Wright, E., Fooks, A.R. and Ma, J.K.C. 2013. Characterization of a monoclonal antibody cocktail for human rabies prophylaxis. Pseudotype viruses: applications and troubleshooting. London, UK October 2013

Monoclonal antibodies for prophylactic and therapeutic use against viral infections
Both, L., Banyard, A.C., van Dolleweerd, C., Wright, E., Ma, J.K.C. and Fooks, A.R. 2013. Monoclonal antibodies for prophylactic and therapeutic use against viral infections. Vaccine. 31 (12), pp. 1553-1559. https://doi.org/10.1016/j.vaccine.2013.01.025

Single domain antibody multimers confer protection against rabies infection
Boruah, B.M., Liu, D., Ye, D., Gu, T.J., Jiang, C.L., Qu, M., Wright, E., Wang, W., He, W., Liu, C. and Gao, B. 2013. Single domain antibody multimers confer protection against rabies infection. PLoS ONE. 8 (8) e71383. https://doi.org/10.1371/journal.pone.0071383

The construction of chimeric rabies virus glycoproteins rescues Arctic-like rabies pseudovirus production
Bentley, E., Ali, R., Horton, D.L., Banyard, A.C. and Wright, E. 2013. The construction of chimeric rabies virus glycoproteins rescues Arctic-like rabies pseudovirus production. Pseudotype viruses: applications and troubleshooting. London, UK October 2013

The construction of chimeric rabies virus glycoproteins rescues Arctic-like rabies pseudovirus production
Ali, R., Horton, D.L., Banyard, A.C. and Wright, E. 2013. The construction of chimeric rabies virus glycoproteins rescues Arctic-like rabies pseudovirus production. Society For General Microbiology Spring Meeting. Manchester, UK March 2013

Chicken IFITM3 restricts influenza viruses and lyssaviruses in vitro
Smith, S.E., Gibson, M.S., Wash, R.S., Ferrara, F., Wright, E., Temperton, N.J., Kellam, P. and Fife, M. 2013. Chicken IFITM3 restricts influenza viruses and lyssaviruses in vitro. Journal of Virology. 87 (23), pp. 12957 -12966. https://doi.org/10.1128/JVI.01443-13

Henipavirus neutralising antibodies in an isolated island population of African fruit bats
Peel, A.J., Baker, K.S., Crameri, G., Barr, J.A., Hayman, D.T.S., Wright, E., Broder, C.C., Fernández-Loras, A., Fooks, A.R., Wang, L.F., Cunningham, A.A. and Wood, J.L.N. 2012. Henipavirus neutralising antibodies in an isolated island population of African fruit bats. PLoS ONE. 7 (1) e30346. https://doi.org/10.1371/journal.pone.0030346

Investigating antigenic epitopes on the lyssavirus glycoprotein
Evans, J., Wright, E., Fooks, A.R., Easton, A. and Banyard, A.C. 2012. Investigating antigenic epitopes on the lyssavirus glycoprotein. Society For General Microbiology Spring Meeting. Dublin 2012

Coreceptor and cytokine concentrations may not explain differences in disease progression observed in HIV-1 clade A and D infected Ugandans
Wright, E., Mugaba, S., Grant, P., Parkes-Ratanshi, R., Van der Paal, L., Grosskurth, H. and Kaleebu, P. 2011. Coreceptor and cytokine concentrations may not explain differences in disease progression observed in HIV-1 clade A and D infected Ugandans. PLoS ONE. 6 (5) e19902. https://doi.org/10.1371/journal.pone.0019902

CL-184, a combination of two human monoclonal antibodies, for use as a vaccine for the potential postexposure prophylaxis of rabies
Wright, E. 2011. CL-184, a combination of two human monoclonal antibodies, for use as a vaccine for the potential postexposure prophylaxis of rabies. Thomson Reuters.

Characterization of a plant-derived monoclonal antibody cocktail for human rabies prophylaxis
Both, L., van Dolleweerd, C., Banyard, A.C., Wright, E., Fooks, A.R. and Ma, J.K.C. 2011. Characterization of a plant-derived monoclonal antibody cocktail for human rabies prophylaxis. Rabies In The Americas XXII. San Juan, Puerto Rico 2011

Characterization of a monoclonal antibody cocktail for human rabies prophylaxis
Both, L., van Dolleweerd, C., Banyard, A.C., Wright, E., Fooks, A.R. and Ma, J.K.C. 2011. Characterization of a monoclonal antibody cocktail for human rabies prophylaxis. 1. 4th International Conference in Plant-Based Vaccines and Antibodies. Porto, Portugal 2011

Pilot study of the utility and acceptability of tampon sampling for the diagnosis of Neisseria gonorrhoeae and Chlamydia trachomatis infections by duplex realtime polymerase chain reaction in United Kingdom sex workers
Kimmitt, P.T., Tabrizi, S.N., Crosatti, M., Garland, S.M., Schober, P.C., Rajakumar, Kumar and Chapman, Cordelia A. 2010. Pilot study of the utility and acceptability of tampon sampling for the diagnosis of Neisseria gonorrhoeae and Chlamydia trachomatis infections by duplex realtime polymerase chain reaction in United Kingdom sex workers. International Journal of STD & AIDS. 21 (4), pp. 279-282. https://doi.org/10.1258/ijsa.2009.009277

A two-tube combined TaqMan/SYBR green assay to identify Mycob acteria and detect single global lineage-defining polymorphisms in Mycobacterium tuberculosis
Cheah, E.S.G., Malkin, J., Free, R.C., Lee, S.M., Perera, N., Woltmann, G., Patel, H., Kimmitt, P.T., Smith, R.J., Rajakumar, Kumar and Barer, M.R. 2010. A two-tube combined TaqMan/SYBR green assay to identify Mycob acteria and detect single global lineage-defining polymorphisms in Mycobacterium tuberculosis. Journal of Molecular Diagnostics. 12 (2), pp. 250-256. https://doi.org/10.2353/jmoldx.2010.090030

The efficacy of current vaccines and novel Nanobody-based antivirals against highly pathogenic rabies and lyssaviruses
Wright, E., Hultberg, A., Rosseels, V., Vaughan, A., Saunders, M., Koenders, M., Verrips, T., Fooks, A.R., van Gucht, S., Weiss, R.A., de Haard, H.J. and Vanlandschoot, P. 2010. The efficacy of current vaccines and novel Nanobody-based antivirals against highly pathogenic rabies and lyssaviruses. Society For General Microbiology Spring 2010 Meeting. Edinburgh, UK 2010

The efficacy of current rabies vaccines and novel Nanobody®-based antivirals against highly pathogenic phylogroup -1 and -2 members of the Lyssavirus genus
Wright, E., Hultberg, A., Rosseels, V., Vaughan, A., Saunders, M., Koenders, M., Verrips, T., Fooks, A.R., Vanlandschoot, P., Weiss, R.A., van Gucht, S. and de Haard, H.J. 2010. The efficacy of current rabies vaccines and novel Nanobody®-based antivirals against highly pathogenic phylogroup -1 and -2 members of the Lyssavirus genus. Rabies In The Americas XXI. Guadalajara, Mexico 2010

Development of a novel serological assay for the detection of rabies virus neutralising antibodies using lentiviral pseudotypes
Armson, B.L., Wright, E., McElhinney, L.M., Banyard, A.C., Goddard, T., Healy, D.M., Voller, K., Weiss, R.A. and Fooks, A.R. 2010. Development of a novel serological assay for the detection of rabies virus neutralising antibodies using lentiviral pseudotypes. 4th Annual Meeting EPIZONE. Saint Malo, France 2010

Virus neutralising activity of African fruit bat (Eidolon helvum) sera against emerging lyssaviruses
Wright, E., Hayman, D.T.S., Vaughan, A., Temperton, N.J., Wood, J.L.N., Cunningham, A.A., Suu-Ire, R., Weiss, R.A. and Fooks, A.R. 2010. Virus neutralising activity of African fruit bat (Eidolon helvum) sera against emerging lyssaviruses. Virology. 408 (2), pp. 183-189. https://doi.org/10.1016/j.virol.2010.09.014

A robust lentiviral pseudotype neutralisation assay for in-field serosurveillance of rabies and lyssaviruses in Africa
Wright, E., McNabb, S., Goddard, T., Horton, D.L., Lembo, T., Nel, L.H., Weiss, R.A., Cleaveland, S. and Fooks, A.R. 2009. A robust lentiviral pseudotype neutralisation assay for in-field serosurveillance of rabies and lyssaviruses in Africa. Vaccine. 27 (51), pp. 7178-7186. https://doi.org/10.1016/j.vaccine.2009.09.024

Emerging technologies for the detection of rabies virus: challenges and hopes in the 21st century
Fooks, A.R., Johnson, N., Freuling, C.M., Wakeley, P.R., Banyard, A.C., McElhinney, L.M., Marston, D.A., Dastjerdi, A., Wright, E., Weiss, R.A. and Muller, T. 2009. Emerging technologies for the detection of rabies virus: challenges and hopes in the 21st century. PLoS Neglected Tropical Diseases. 3 (9) e530. https://doi.org/10.1371/journal.pntd.0000530

A robust lentiviral pseudotype neutralisation assay for rabies and lyssavirus serology
Wright, E., Temperton, N.J., Weiss, R.A., McNabb, S., Lembo, T., Cleaveland, S., Marston, D.A., Horton, D.L., McElhinney, L.M. and Fooks, A.R. 2009. A robust lentiviral pseudotype neutralisation assay for rabies and lyssavirus serology. Rabies In The Americas XX. Quebec, Canada 2009

The implications for ‘in-field’ sero-surveillance and evaluation of vaccines targeting rabies using lacZ based lentiviral pseudotypes
Wright, E., McNabb, S., Goddard, T., Horton, D.L., Weiss, R.A., Cleaveland, S. and Fooks, A.R. 2009. The implications for ‘in-field’ sero-surveillance and evaluation of vaccines targeting rabies using lacZ based lentiviral pseudotypes. Society For General Microbiology Spring 2009 Meeting. Harrogate, UK 2009

Retroviral pseudotypes
Temperton, N.J. and Wright, E. 2009. Retroviral pseudotypes. in: Encyclopaedia of Life Sciences Chichester Wiley.

HIV blocking antibodies following immunisation with chimaeric peptides coding a short N-terminal sequence of the CCR5 receptor
Chain, B.M., Noursadeghi, M., Gardener, M., Tsang, J. and Wright, E. 2008. HIV blocking antibodies following immunisation with chimaeric peptides coding a short N-terminal sequence of the CCR5 receptor. Vaccine. 26 (45), pp. 5752-5759. https://doi.org/10.1016/j.vaccine.2008.08.025

Investigating antibody neutralization of lyssaviruses using lentiviral pseudotypes: a cross-species comparison
Wright, E., Temperton, N.J., Marston, D.A., McElhinney, L.M., Fooks, A.R. and Weiss, R.A. 2008. Investigating antibody neutralization of lyssaviruses using lentiviral pseudotypes: a cross-species comparison. Journal of General Virology. 89 (9), pp. 2204-2213. https://doi.org/10.1099/vir.0.2008/000349-0

Identification of Streptococcus gallolyticus subsp. macedonicus as the etiological agent in a case of culture-negative multivalve infective endocarditis by 16S rDNA PCR analysis of resected valvular tissue
Malkin, J., Ou, Hong-Yu, Khare Milind, Deng, Zixin, Stephenson, Iain, Perera, N., Rajakumar, Kumar, Kimmitt, P.T., Bhasker, Pretti S. Santi and Sosnowski, Andrew W. 2008. Identification of Streptococcus gallolyticus subsp. macedonicus as the etiological agent in a case of culture-negative multivalve infective endocarditis by 16S rDNA PCR analysis of resected valvular tissue. Journal of Heart Valve Disease. 17 (5), pp. 589-592.

Identification of Neisseria gonorrhoeae as the causative agent in a case of culture-negative dermatitis-arthritis syndrome using real-time PCR
Kimmitt, P.T., Kirby Andrew, Perera, N., Schober, Paul C., Rajakumar, Kumar, Chapman, Cordelia A. and Nicholson, Karl G. 2008. Identification of Neisseria gonorrhoeae as the causative agent in a case of culture-negative dermatitis-arthritis syndrome using real-time PCR. Journal of Travel Medicine. 15 (5), pp. 369-371. https://doi.org/10.1111/j.1708-8305.2008.00240.x

Duffy Antigen Receptor for Chemokines mediates trans-infection of HIV-1 from red blood cells to target cells and affects HIV-AIDS susceptibility
He, W., Neil, S., Kulkarni, H., Wright, E., Agan, B.K., Marconi, V.C., Dolan, M.J., Weiss, R.A. and Ahuja, S.K. 2008. Duffy Antigen Receptor for Chemokines mediates trans-infection of HIV-1 from red blood cells to target cells and affects HIV-AIDS susceptibility. Cell Host and Microbe. 4 (1), pp. 52-62. https://doi.org/10.1016/j.chom.2008.06.002

A novel serological assay for the detection of rabies virus and lyssavirus neutralising antibodies
Wright, E., Temperton, N.J., Marston, D.A., Fooks, A.R. and Weiss, R.A. 2008. A novel serological assay for the detection of rabies virus and lyssavirus neutralising antibodies. Society For General Microbiology Spring 2008 Meeting. Edinburgh, UK 2008

The evaluation of antibody responses to rabies virus using retroviral pseudotypes and the implications for ‘in-field’ vaccine trials
Wright, E., Temperton, N.J., Marston, D.A., Fooks, A.R. and Weiss, R.A. 2008. The evaluation of antibody responses to rabies virus using retroviral pseudotypes and the implications for ‘in-field’ vaccine trials. BIT's First Annual World Vaccine Congress. Foshan, China 2008

Association between active GB virus-C (hepatitis G) infection and HIV-1 disease in Uganda
Yirrell, D.L., Wright, E., Shafer, L.A., Campbell, E., Van der Paal, L., Kaleebu, P., Grosskurth, H. and Whitworth, J.A. 2007. Association between active GB virus-C (hepatitis G) infection and HIV-1 disease in Uganda. International Journal of STD & AIDS. 18 (4), pp. 244-249. https://doi.org/10.1258/095646207780659006

A novel serological assay for detection of rabies virus neutralising antibodies
Wright, E., Temperton, N.J., Weiss, R.A., Marston, D.A., McElhinney, L.M. and Fooks, A.R. 2007. A novel serological assay for detection of rabies virus neutralising antibodies. Rabies In The Americas XVIII. Ciudad de Guanajuato, Mexico 2007

Characterisation of persistent viral infections in bats
Wright, E., Takeuchi, Y., Brookes, S., Fooks, A.R. and Weiss, R.A. 2007. Characterisation of persistent viral infections in bats. The First International Meeting on Emerging Diseases and Surveillance. Vienna, Austria 2007

Effect of Duffy antigen receptor for chemokine (DARC) polymorphisms on susceptibility to HIV infection and progression to AIDS
Wright, E., He, W., Neil, S., Kulkarni, H., Agan, B.K., Marconi, V.C., Dolan, M.J., Ahuja, S.K. and Weiss, R.A. 2007. Effect of Duffy antigen receptor for chemokine (DARC) polymorphisms on susceptibility to HIV infection and progression to AIDS. Institute Pasteur Genetics and Mechanisms of Susceptibility to Infectious Diseases. Paris, France 2007

A consensus on fungal polymerase chain reaction diagnosis?: A United Kingdom-Ireland evaluation of polymerase chain reaction methods for detection of systemic fungal infections
White, P.L., Barton, R., Guiver, M., Linton, C.J., Wilson, S., Smith, M., Gomez, B.L., Carr, M.J., Kimmitt, P.T., Seaton, S., Rajakumar, Kumar, Holyoake, T., Kibbler, C.C., Johnson, E., Hobson, R.P., Jones, B. and Barnes, R.A. 2006. A consensus on fungal polymerase chain reaction diagnosis?: A United Kingdom-Ireland evaluation of polymerase chain reaction methods for detection of systemic fungal infections. Journal of Molecular Diagnostics. 8 (3), pp. 376-384.

Ets-2 repressor factor recruits histone deacetylase to silence human cytomegalovirus immediate-early gene expression in non-permissive cells
Wright, E., Bain, M., Teague, L., Murphy, J. and Sinclair, J. 2005. Ets-2 repressor factor recruits histone deacetylase to silence human cytomegalovirus immediate-early gene expression in non-permissive cells. Journal of General Virology. 86 (3), pp. 535-544. https://doi.org/10.1099/vir.0.80352-0

Permalink - https://westminsterresearch.westminster.ac.uk/item/q317y/efficacy-of-the-quadrivalent-hpv-vaccine-in-cervical-cancer-prevention-strategy-in-the-gambia


Share this

Usage statistics

362 total views
0 total downloads
These values cover views and downloads from WestminsterResearch and are for the period from September 2nd 2018, when this repository was created.