Retroviral Pseudotypes – From Scientific Tools to Clinical Utility

Wright, E., Temperton, N.J. and Scott, S.D. 2015. Retroviral Pseudotypes – From Scientific Tools to Clinical Utility. in: Encyclopedia of life sciences Chichester Wiley. pp. 1-11

Chapter titleRetroviral Pseudotypes – From Scientific Tools to Clinical Utility
AuthorsWright, E., Temperton, N.J. and Scott, S.D.
Abstract

Retroviral pseudotypes are important research
and diagnostic tools for basic and clinical virology
studies, facilitating the detailed investigation
of individual genes, cellular receptors, antibody
responses, serosurveillance and antiviral therapies.
Importantly, pseudotypes enable the study
of highly pathogenic viruses, without the need
for high containment. Their use as gene therapy
vectors is widely documented, but other uses, once
less well known, are becoming more prominent.
The substitution of envelope proteins expressed
on the virion surface enables pseudotypes to be
employed as surrogates for wildtype viruses in
antibody neutralisation or antiviral screening
assays and for the study of cell–virus receptor
interactions. In addition, they are increasingly
being utilised as vaccine immunogens, expressing
the antigen either on the particle surface or as a
transfer gene for cellular expression. These studies
demonstrate the potential for using pseudotypes
for both scientific and clinical applications.

Book titleEncyclopedia of life sciences
Page range1-11
Year2015
PublisherWiley
Publication dates
Published15 Jun 2015
Place of publicationChichester
Digital Object Identifier (DOI)https://doi.org/10.1002/9780470015902.a0021549.pub2

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