Title | Association between active GB virus-C (hepatitis G) infection and HIV-1 disease in Uganda |
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Authors | Yirrell, D.L., Wright, E., Shafer, L.A., Campbell, E., Van der Paal, L., Kaleebu, P., Grosskurth, H. and Whitworth, J.A. |
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Abstract | Although not linked to a disease, GB virus-C viraemia has been associated with an improved prognosis in HIV-1-co-infected individuals. Most studies have been conducted on men (men who have sex with men or injection drug users) infected with HIV-1 subtype B, whereas here we report on both male and female subjects from rural Uganda, predominantly infected via the heterosexual route with HIV-1 subtypes A and D. In a longitudinal study of 272 participants, 47 were GBV-C positive and 181 negative, as determined by reverse transcription-polymerase chain reaction, in both of two plasma samples taken a median of 5.0 years apart. The remainder either acquired (25) or cleared (19) infection. Multilevel regression analyses and Cox survival analyses revealed that participants chronically infected with GBV-C had a slower decline in CD4+ T cells (P<0.001) and increased survival time (P=0.041) compared with GBV-C RNA-negative, HIV-positive adults. We show that the association between active GBV-C co-infection and improved survival of HIV-1-infected adults is not restricted to HIV subtype B, but is also observed in both males and females infected with HIV subtypes A and D. |
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Journal | International Journal of STD & AIDS |
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Journal citation | 18 (4), pp. 244-249 |
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ISSN | 0956-4624 |
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Year | Apr 2007 |
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Publisher | Royal Society of Medicine Press |
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Digital Object Identifier (DOI) | https://doi.org/10.1258/095646207780659006 |
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Publication dates |
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Published | Apr 2007 |
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