The potential for application of downdraught cooling in the United States of America (U.S.) depends on its climatic characteristics. However, due to the large geographic span of the country, it varies due to differences in latitude, and a range of geographic features influencing climate, including altitude, topography and terrain. This study describes the development of climatic applicability maps of downdraught cooling in the U.S., which can aid designers in the initial identification of the correct cooling strategy for the geographic area of interest. The proposed approach is based on a set of maps, which are derived from two related climatic indexes: dry bulb temperature to wet bulb temperature depression (DBT−WBT), representing the climatic opportunity, and 26ºC minus wet bulb temperature (26ºC−WBT), representing the climatic opportunity against the theoretical cooling requirement for each location. The downdraught cooling strategy and degree of applicability is classified in the map, based on the aforementioned climatic and cooling parameters. Finally, four representative buildings in four different regions with different climatic conditions were selected for climatic analysis. This resulted in the identification of some climate zones for downdraught cooling application in the U.S. and the suggestion of appropriate design strategies for each of them.