Research Centre for Optimal Health

Ji, Y., Yiorkas, A.M., Frau, F., Mook-Kanamori, D., Staiger, H., Thomas, E.L., Atabaki-Pasdar, N., Campbell, A., Tyrrell, J., Jones, S.E., Beaumont, R.N., Wood, A.R., Tuke, M.A., Ruth, K.S., Mahajan, A., Murray, A., Freathy, R.M., Weedon, M.N., Hattersley, A.T., Hayward, C., Machann, J., Häring, H.U., Franks, P.W., de Mutsert, R., Pearson, E., Stefan, N., Frayling, T.M., Allebrandt, K.V., Bell, J.D., Blakemore, A.I. and Yaghootkar, H. 2019. Genome-wide and abdominal MRI-imaging data provides evidence that a genetically determined favourable adiposity phenotype is characterized by lower ectopic liver fat and lower risk of type 2 diabetes, heart disease and hypertension. Diabetes. 68 (1), pp. 207-219. https://doi.org/10.2337/db18-0708

Chambers, E.S., Byrne, C.S., Rugyendo, A., Morrison, D.J., Preston, T., Tedford, M.C., Bell, J.D., Thomas, E.L., Akbar, A.N., Riddell, N.E., Sharma, R., Thursz, M.R., Manousou, P. and Frost, G. 2019. The effects of dietary supplementation with inulin and inulin-propionate ester on hepatic steatosis in adults with non-alcoholic fatty liver disease. Diabetes, Obesity and Metabolism. 21 (2), pp. 372-376. https://doi.org/10.1111/dom.13500

Mojtahed, A., Kelly, C.J., Herlihy, A.H., Kin, S., Wilman, H.R., McKay, A., Kelly, M., Milanesi, M., Neubauer, S,, Thomas, E.L., Bell, J.D., Banerjee, R. and Harisinghani, M. 2019. Reference range of liver corrected T1 values in a population at low risk for fatty liver disease-a UK Biobank sub-study, with an appendix of interesting cases. Abdominal Radiology. 44 (1), pp. 72-84. https://doi.org/10.1007/s00261-018-1701-2

Agapouda, A., Booker, A., Kiss, T., Hohmann, J., Heinrich, M. and Csupor, D. 2019. Quality Control of Hypericum perforatum L. Analytical challenges and recent progress. Journal of Pharmacy and Pharmacology. 71 (1), pp. 15-37. https://doi.org/10.1111/jphp.12711

Jagoda, E., Lawson, D.J., Wall, J.D., Lambert, D., Muller, C., Westaway, M., Leavesley, M., Capellini, T.D., Lahr, M.M., Gerbault, P., Thomas, M.G., Migliano, A.B., Willerslev, E., Metspalu , M. and Pagani, L. 2018. Disentangling Immediate Adaptive Introgression from Selection on Standing Introgressed Variation in Humans. Molecular Biology and Evolution. 35 (3), pp. 623-630. https://doi.org/10.1093/molbev/msx314

Mole, D.J., Fallowfield, J.A., Kendall, T.J., Welsh, F., Semple, S.I., Bachtiar, V., Kelly, M., Wigmore, S.J., Garden, O.J., Wilman, H.R., Banerjee, R., Rees, M. and Brady, M. 2018. Study protocol: HepaT1ca - an observational clinical cohort study to quantify liver health in surgical candidates for liver malignancies. BMC Cancer . 18, p. 890 890. https://doi.org/10.1186/s12885-018-4737-3.

McKay, A., Wilman, H., Dennis, A., Kelly, M., Gyngell, M.L., Neubauer, S., Bell, J.D., Banerjee, R. and Thomas, E.L. 2018. Measurement of liver iron by magnetic resonance imaging in the UK Biobank population. PLoS ONE. 13 (12) e0209340. https://doi.org/10.1371/journal.pone.0209340

Buckley, A., Thomas, E.L., Lessan, N., Trovato, F.M., Trovato, G.M. and Taylor-Robinson, S.D. 2018. Non-alcoholic fatty liver disease: relationship with cardiovascular risk markers and clinical endpoints. Diabetes Research and Clinical Practice. 144, pp. 144-152. https://doi.org/10.1016/j.diabres.2018.08.011

Kosgodage, U., Mould, R., Henley, A., Nunn, A.V.W., Guy, G.W., Thomas, E.L., Inal, J.M., Bell, J.D. and Lange, S. 2018. Cannabidiol (CBD) is a Novel Inhibitor for Exosome and Microvesicle (EMV) Release in Cancer. Frontiers in Pharmacology. 9 889. https://doi.org/10.3389/fphar.2018.00889

Fiamoncini, J., Rundle, M., Gibbons, H., Thomas, E.L., Geillinger-Kästle, K., Bunzel, D., Trezzi, J.P., Kiselova-Kaneva, J., Wopereis, S., Wahrheit, J., Kulling, S.E., Hiller, K., Sonntag, D., Ivanova, D., van Ommen, B, Frost, G., Brennan, L., Bell, J.D. and Daniel, H. 2018. Plasma metabolome analysis identifies distinct human metabotypes in the postprandial state with different susceptibility to weight loss–mediated metabolic improvements. FASEB Journal. 32 (10), p. 5447–5458. https://doi.org/10.1096/fj.201800330R

Linge, J., Borger Magnus, West, J., Tuthill, T., Miller, M.R., Dumitriu, A., Thomas, E.L., Romu, T., Tunón, P., Bell, J.D. and Leinhard, O.D. 2018. Body Composition Profiling in the UK Biobank Imaging Study. Obesity. 26 (11), pp. 1785-1795. https://doi.org/10.1002/oby.22210

Borga, M., West, J., Bell, J.D., Harvey, N.C., Romu, T., Heymsfield, S.B. and Leinhard, O.D. 2018. Advanced body composition assessment: from body mass index to body composition profiling. Journal of Investigative Medicine. 66 (5), pp. 887-895. https://doi.org/10.1136/jim-2018-000722

Cobbold, J.F.L., Atkinson, S., Marchesi, J.R., Smith, A., Wai, S.N., Stove, J., Shojaee-Moradie, F., Jackson, N.C., Umpleby, A.M., Fitzpatrick, J., Thomas, E.L., Bell, J.D., Holmes, E., Taylor-Robinson, S.D., Goldin, R.D., Yee, M.S., Anstee, Q.M. and Thursz, M.R. 2018. Rifaximin in Non-Alcoholic Steatohepatitis: An Open-Label Pilot Study. Hepatology Research. 48 (1), pp. 69-77. https://doi.org/10.1111/hepr.12904

Brooks, L., Viardot, A., Tsakmaki, A., Stolarczyk, E., Howard, J., Cani, P., Everard, A., Sleeth, M., Psichas, A., Anastasovskaj, J., Bell, J.D., Bell-Anderson, K., Mackay, C., Ghatei, M., Bloom, S., Frost, G. and Bewick, G. 2017. Fermentable carbohydrate stimulates FFAR2-dependent colonic PYY cell expansion to increase satiety. Molecular Metabolism. 6 (1), pp. 48-60. https://doi.org/10.1016/J.MOLMET.2016.10.011

Umpleby, A.M., Shoajee-Moradie, F., Fielding, F., Li, X., Marino, A., Alsini, N, Isherwood, C, Jackson, N.C., Ahmad, A., Stolinski, M., Lovegrove, J.A., Johnsen, S., Mendis, A., Wright, J., Wilinska, M.E., Hovorka, R., Bell, J.D., Thomas, E.L., Frost, G.S. and Griffin, B.A. 2017. Impact of liver fat on the differential partitioning of hepatic triacylglycerol into VLDL subclasses on high and low sugar diets. Clinical Science. 131 (21), pp. 2561-2573. https://doi.org/10.1042/CS20171208

Brody, L.P., Sahuri Arisoylu, M., Parkinson, J.R., Parkes, H.G., So, P-W, Hajji, N, Thomas, E.L., Frost, G.S., Miller, A.D. and Bell, J.D. 2017. Cationic lipid-based nanoparticles mediate functional delivery of acetate to tumor cells in vivo leading to significant anticancer effects. International Journal of Nanomedicine. 12, pp. 6677-6685. https://doi.org/10.2147/IJN.S135968

Nunn, A.V.W., Guy, G.W. and Bell, J.D. 2017. The Hormesis of Thinking: A Deeper Quantum Thermodynamic Perspective? International Journal of Neurorehabilitation. 4 (3), p. 272 272. https://doi.org/10.4172/2376-0281.1000272

Hameed, S., Patterson, M., Dhillo, W.S., Rahman, S.A., Ma, Y., Holton, C., Gogakos, A., Yeo, G.S.H., Lam, B.Y.H., Polex-Wolf, J., Fenske, W., Bell, J.D., Anastasovska, J., Samarut, J., Bloom, S.R., Bassett, J.H.D., Williams, G.R. and Gardiner, J.V. 2017. Thyroid Hormone Receptor Beta in the Ventromedial Hypothalamus Is Essential for the Physiological Regulation of Food Intake and Body Weight. Cell Reports. 19 (11), pp. 2202-2219. https://doi.org/10.1016/j.celrep.2017.05.066

Fitzpatrick, J., Chambers, E.S., Parkinson, J.R.C., Frost, G., Bell, J.D. and Thomas, E.L. 2017. Psoas major cross-sectional area: A potential marker of cardiorespiratory fitness. International Journal of Clinical and Experimental Physiology. 4 (1), pp. 15-20. https://doi.org/10.4103/ijcep.ijcep_6_17

Schofield, S.E., Parkinson, J., Henley, A., Sahuri Arisoylu, M., Sanchez-Canon, G.J. and Bell, J.D. 2017. Metabolic dysfunction following weight cycling in male mice. International Journal of Obesity. 41 (3), pp. 402-411. https://doi.org/10.1038/ijo.2016.193

Wilman, H., Kelly, M., Garratt, S., Matthews, P., Milanesi, M., Herlihy, A.H., Gyngell, M, Neubauer, S, Bell, J.D., Banerjee, R and Thomas, E.L. 2017. Characterisation of liver fat in the UK Biobank cohort. PLoS ONE. 12 (2) e0172921. https://doi.org/10.1371/journal.pone.0172921

Gerbault, P. 2016. Genomic analyses inform on migration events during the peopling of Eurasia. Nature. 538 (7624), pp. 238-242. https://doi.org/10.1038/nature19792

West, J., Leinhard, O.D., Romu, T., Collins, R., Garratt, S., Bell, J.D., Borga, M. and Thomas, E.L. 2016. Feasibility of MR-Based Body Composition Analysis in Large Scale Population Studies. PLoS ONE. 11 (9) e0163332. https://doi.org/10.1371/journal.pone.0163332

Bell, J.D., Nunn, A.V.W. and Guy, G.W. 2016. The Quantum Mitochondrion and Optimal Health. Biochemical Society Transactions. 44 (4), pp. 1101-1110. https://doi.org/10.1042/BST20160096

Goldstone, A.P., Miras, A.D., Scholtz, S., Jackson, S., Neff, K.J., Pénicaud, L., Geoghegan, J., Chhina, N., Durighel, G., Bell, J.D., Meillon, S. and le Roux, C.W. 2016. Link between increased gut hormones signaling satiety and reduced food reward following gastric bypass surgery for obesity. Journal of Clinical Endocrinology and Metabolism. 101 (2), pp. 599-609. https://doi.org/10.1210/jc.2015-2665

Alzoubi, S., Brody, L., Rahman, S., Mahul-Mellier, A.L., Mercado, N., Ito, K., El-Bahrawy, M., Silver, A., Boobis, A., Bell, J.D. and Hajji, N. 2016. Synergy between histone deacetylase inhibitors and DNA- damaging agents is mediated by histone deacetylase 2 in colorectal cancer. Oncotarget . 7 (28), pp. 44505-44521. https://doi.org/10.18632/oncotarget.9887

Shojaee-Moradie, F., Cuthbertson, D.J., Barrett, M., Jackson, N.C., Herring, R, Thomas, E.L., Bell, J.D., Kemp, G.J., Wright, J. and Umpleby, A.M. 2016. Exercise Training Reduces Liver Fat and Increases Rates of VLDL Clearance, but not VLDL Production in NAFLD. Journal of Clinical Endocrinology and Metabolism. 101 (11), pp. 4219-4228. https://doi.org/10.1210/jc.2016-2353

Jadoon, K.A., Ratcliffe, S.H., Barrett, D.A., Thomas, E.L., Stott, C., Bell, J.D., O’Sullivan S.E. and Tan, G.D. 2016. Efficacy and Safety of Cannabidiol and Tetrahydrocannabivarin on Glycemic and Lipid Parameters in Patients With Type 2 Diabetes: A Randomized, Double-Blind, Placebo-Controlled, Parallel Group Pilot Study. Diabetes Care. 39 (10), pp. 1777-1786. https://doi.org/10.2337/dc16-0650

Inkster, B., Rao, A.W., Ridler, K., Filippini, N., Whitcher, B., Nichols, T.E., Wetten, S., Gibson, R.A., Borrie, M., Kertesz, A., Guzman, D.A., Loy-English, I., Williams, J., Saemann, P.G., Auer, D.P., Holsboer, F., Tozzi, F., Muglia, P., Merlo-Pich, E. and Matthews, P.M. 2012. Genetic variation in GOLM1 and prefrontal cortical volume in Alzheimer's disease. Neurobiology of Aging. https://doi.org/10.1016/j.neurobiolaging.2010.04.018

Arora, T., Loo, R.L., Anastasovska, J., Gibson, G.R., Tuohy, K., Kumar Sharma, R., Swann Jonathan, Deaville, E.R., Sleeth Michelle, L., Thomas, E.L., Holmes, E., Bell, J.D. and Frost, G.S. 2012. Differential effects of two fermentable carbohydrates on central appetite regulation and body composition. PLoS ONE. 7 (8) e43263. https://doi.org/10.1371/journal.pone.0043263

Cuthbertson, D.J., Irwin, A., Gardner, C.J., Daousi, C., Purewal, T, Furlong, N, Goenka, N, Thomas, E.L., Adams, V.L., Pushpakom, SP, Pirmohamed, M and Kemp, G.J. 2012. Improved Glycaemia correlates with liver fat reduction in obese, type 2 diabetes, patients given glucagon-like peptide-1 (GLP-1) receptor agonists. PLoS ONE. 7 (12) e50117. https://doi.org/10.1371/journal.pone.0050117

Hand, J.W., Li, Y., Thomas, E.L., Rutherford, M.A. and Hajnal, J.V. 2006. Prediction of specific absorption rate in mother and fetus associated with MRI examinations during pregnancy. Magnetic Resonance in Medicine. 55 (4), pp. 883-93. https://doi.org/10.1002/mrm.20824

Taylor-Robinson, S.D., Sargentoni, J., Bell, J.D., Thomas, E.L., Marcus, C.D., Changani, K.K., Saeed, N., Hodgson, H., Davidson, B.R., Burroughs, A.K., Rolles, K., Foster, C.S. and Cox, I.J. 1998. In vivo and in vitro hepatic phosphorus-31 magnetic resonance spectroscopy and electron microscopy in chronic ductopenic rejection of human liver allografts. Gut. 42 (5), pp. 735-43. https://doi.org/10.1136/gut.42.5.735